CL2007002988A1 - Proceso para la preparacion de un isomero individual de rapamicina 42 ester con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) monopegilado. - Google Patents

Proceso para la preparacion de un isomero individual de rapamicina 42 ester con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) monopegilado.

Info

Publication number
CL2007002988A1
CL2007002988A1 CL2007002988A CL2007002988A CL2007002988A1 CL 2007002988 A1 CL2007002988 A1 CL 2007002988A1 CL 2007002988 A CL2007002988 A CL 2007002988A CL 2007002988 A CL2007002988 A CL 2007002988A CL 2007002988 A1 CL2007002988 A1 CL 2007002988A1
Authority
CL
Chile
Prior art keywords
monopegylated
cci
rapamycin
hydroxymethyl
hydroxy
Prior art date
Application number
CL2007002988A
Other languages
English (en)
Inventor
Jerauld Stanley Skotnicki
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CL2007002988A1 publication Critical patent/CL2007002988A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

Proceso para la preparación de un isomero individual de rapamicina 42 ester con ácido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) monopegilado.
CL2007002988A 2006-10-18 2007-10-18 Proceso para la preparacion de un isomero individual de rapamicina 42 ester con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) monopegilado. CL2007002988A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85254306P 2006-10-18 2006-10-18

Publications (1)

Publication Number Publication Date
CL2007002988A1 true CL2007002988A1 (es) 2008-01-18

Family

ID=39092934

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2007002988A CL2007002988A1 (es) 2006-10-18 2007-10-18 Proceso para la preparacion de un isomero individual de rapamicina 42 ester con acido 3-hidroxi-2-(hidroximetil)-2-metilpropionico (cci-779) monopegilado.

Country Status (6)

Country Link
US (1) US7605258B2 (es)
AR (1) AR063310A1 (es)
CL (1) CL2007002988A1 (es)
PE (1) PE20081465A1 (es)
TW (1) TW200824713A (es)
WO (1) WO2008048611A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044677A (zh) * 2012-12-28 2013-04-17 上海景宇生物科技有限公司 一种异端基遥爪聚乙二醇及其制备方法
WO2016023082A1 (en) 2014-08-12 2016-02-18 Monash University Lymph directing prodrugs
CN108137482B (zh) 2015-09-08 2024-03-15 莫纳什大学 定向淋巴的前药
US11883497B2 (en) 2017-08-29 2024-01-30 Puretech Lyt, Inc. Lymphatic system-directing lipid prodrugs
US11304954B2 (en) 2017-12-19 2022-04-19 Puretech Lyt, Inc. Lipid prodrugs of mycophenolic acid and uses thereof
WO2019126374A1 (en) * 2017-12-19 2019-06-27 Ariya Therapeutics, Inc. Lipid prodrugs of rapamycin and its analogs and uses thereof
US11608345B1 (en) 2017-12-19 2023-03-21 Puretech Lyt, Inc. Lipid prodrugs of rapamycin and its analogs and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5780462A (en) * 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
WO2002024706A2 (en) * 2000-09-19 2002-03-28 Wyeth Water soluble rapamycin esters
JP2007522091A (ja) * 2003-07-16 2007-08-09 ワイス Ｃｃｉ−７７９アイソマーｃ
KR20060057605A (ko) * 2003-08-07 2006-05-26 와이어쓰 Ｃｃｉ-779의 위치선택적 합성 방법
JP2008517874A (ja) * 2004-08-10 2008-05-29 ワイス Ｃｃｉ−７７９誘導体及びそれらの作製法
HN2005035605A (es) * 2004-12-20 2010-08-05 Wyeth Corp Analogos de rapamicina y los usos de los mismos en el tratamiento de trastornos neurologicos, proliferativos e inflamatorios
RU2007119585A (ru) * 2004-12-20 2009-01-27 Вайет (Us) Производные рапамицина и их применение при лечении неврологических заболеваний
MX2007009590A (es) * 2005-02-09 2007-09-12 Wyeth Corp Polimorfo cci-779 y uso del mismo.
AU2006322024A1 (en) * 2005-12-07 2007-06-14 Wyeth Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate
MX2008011458A (es) * 2006-03-07 2008-09-24 Wyeth Corp Procedimiento para preparar conjugados de polietilenglicol solubles en agua de inmunosupresores de macrolidos.

Also Published As

Publication number Publication date
US7605258B2 (en) 2009-10-20
TW200824713A (en) 2008-06-16
PE20081465A1 (es) 2008-11-24
AR063310A1 (es) 2009-01-21
US20080097093A1 (en) 2008-04-24
WO2008048611A1 (en) 2008-04-24

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