GT200500216A - Derivados de cci-779 y metodos para su preparacion - Google Patents

Derivados de cci-779 y metodos para su preparacion

Info

Publication number
GT200500216A
GT200500216A GT200500216A GT200500216A GT200500216A GT 200500216 A GT200500216 A GT 200500216A GT 200500216 A GT200500216 A GT 200500216A GT 200500216 A GT200500216 A GT 200500216A GT 200500216 A GT200500216 A GT 200500216A
Authority
GT
Guatemala
Prior art keywords
derivatives
methods
cci
preparation
cci779
Prior art date
Application number
GT200500216A
Other languages
English (en)
Inventor
Ping Cai
Mark Ruppen
Russ Tsao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200500216A publication Critical patent/GT200500216A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PROPORCIONA UN MÉTODO PARA GENERAR METABOLITOS SINTÉTICOS DE CCI779, SE DESCRIBEN CINCO DERIVADOS DE CCI779 NOVEDOSOS, COMO ASÍ TAMBIÉN MÉTODOS PARA LA UTILIZACIÓN DE ESTOS DERIVADOS PARA DETECTAR METABOLITOS DE CCI779 EN MUESTRAS.
GT200500216A 2004-08-10 2005-08-09 Derivados de cci-779 y metodos para su preparacion GT200500216A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60033704P 2004-08-10 2004-08-10

Publications (1)

Publication Number Publication Date
GT200500216A true GT200500216A (es) 2006-03-02

Family

ID=35159738

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200500216A GT200500216A (es) 2004-08-10 2005-08-09 Derivados de cci-779 y metodos para su preparacion

Country Status (15)

Country Link
US (2) US7332601B2 (es)
EP (1) EP1776370A1 (es)
JP (1) JP2008517874A (es)
CN (1) CN1993368A (es)
AR (1) AR050452A1 (es)
AU (1) AU2005292647A1 (es)
BR (1) BRPI0514206A (es)
CA (1) CA2577011A1 (es)
GT (1) GT200500216A (es)
MX (1) MX2007001676A (es)
PA (1) PA8641501A1 (es)
PE (1) PE20060642A1 (es)
SV (1) SV2006002188A (es)
TW (1) TW200616633A (es)
WO (1) WO2006038972A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101131794B1 (ko) * 2002-07-30 2012-03-30 와이어쓰 엘엘씨 Ｃｃｉ-779 공용매 농축액, 비경구 ｃｃｉ-779 제형 및 비경구 ｃｃｉ-779 제형의 제조방법
EP1776370A1 (en) * 2004-08-10 2007-04-25 Wyeth a Corporation of the State of Delaware Cci-779 derivatives and methods of making same
KR20080077618A (ko) * 2005-12-07 2008-08-25 와이어쓰 정제된 결정체 ｃｃｉ-779 의 제조 방법
WO2007067560A2 (en) * 2005-12-07 2007-06-14 Wyeth Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate
KR20080077147A (ko) * 2005-12-07 2008-08-21 와이어쓰 결정성 라파마이신의 제조 방법 및 시차 주사 열량계를사용하는 라파마이신 화합물의 결정화도의 측정 방법
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
MX2014005927A (es) 2011-11-15 2014-06-05 Novartis Ag Combinacion de un inhibidor de la fosfoinositida-3-cinasa y un modulador de la senda del transductor y activador de la señal de transcripcion 5 de la cinasa janus 2.
US20150224190A1 (en) 2012-07-06 2015-08-13 Mohamed Bentires-Alj Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the IL-8/CXCR interaction

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316885A (en) 1980-08-25 1982-02-23 Ayerst, Mckenna And Harrison, Inc. Acyl derivatives of rapamycin
US5102876A (en) 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin
US5256790A (en) 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9307491D0 (en) * 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
AU686629B2 (en) * 1993-04-23 1998-02-12 Wyeth Rapamycin Conjugates and Antibodies
US7279561B1 (en) * 1993-04-23 2007-10-09 Wyeth Anti-rapamycin monoclonal antibodies
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
TWI256395B (en) 1999-09-29 2006-06-11 Wyeth Corp Regioselective synthesis of rapamycin derivatives
US6277983B1 (en) 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
ATE365169T1 (de) 2003-08-07 2007-07-15 Wyeth Corp Regioselektive synthese von cci-779
RU2387657C2 (ru) 2004-04-14 2010-04-27 Вайет Региоспецифический синтез производных 42-эфира рапамицина
BRPI0509810A (pt) 2004-04-14 2007-09-18 Wyeth Corp método para a sìntese regioespecìfica de um 42-hemiéster de rapamicina ou um 32-hemiéster de fk-506 com um ácido dicarboxìlico, 42-hemiéster de rapamicina regioespecìfica, anticorpo de rapamicina, produto, e, 32-hemiéster de fk506 regioespecìfico
WO2005100366A1 (en) 2004-04-14 2005-10-27 Wyeth Proline cci-779 (proline-rapamycin 42-ester with 2,2-bis (hydroxymethyl) propionic acid) and two-step enzymatic synthesis of proline cci-779 and cci-779 using microbial lipase
BRPI0510277A (pt) 2004-04-27 2007-10-30 Wyeth Corp método para marcar especificamente uma rapamicina, rapamicina especificamente marcada, composição, e, kit
EP1776370A1 (en) * 2004-08-10 2007-04-25 Wyeth a Corporation of the State of Delaware Cci-779 derivatives and methods of making same
WO2007056175A2 (en) 2005-11-04 2007-05-18 Wyeth 41-methoxy isotope labeled rapamycin 42-ester
BRPI0708562A2 (pt) 2006-03-07 2011-06-07 Wyeth Corp processos para preparar conjugados de polietileno glicor de macrolìdeos imunossupressores, um macrolìdeo imunossupressor peguilado, uma rapamicina peguilada, um everolimus peguilado, um cci-779 peguilado e um tacrolimus peguilado, e, produto

Also Published As

Publication number Publication date
US20060036091A1 (en) 2006-02-16
US7332601B2 (en) 2008-02-19
SV2006002188A (es) 2006-03-15
AU2005292647A1 (en) 2006-04-13
PA8641501A1 (es) 2006-09-08
MX2007001676A (es) 2007-04-12
EP1776370A1 (en) 2007-04-25
BRPI0514206A (pt) 2008-06-03
PE20060642A1 (es) 2006-08-01
TW200616633A (en) 2006-06-01
WO2006038972A1 (en) 2006-04-13
AR050452A1 (es) 2006-10-25
CA2577011A1 (en) 2006-04-13
CN1993368A (zh) 2007-07-04
JP2008517874A (ja) 2008-05-29
US20100279364A1 (en) 2010-11-04

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