PA8641501A1 - Derivados de cci-779 y metodo para su preparacion - Google Patents

Derivados de cci-779 y metodo para su preparacion

Info

Publication number
PA8641501A1
PA8641501A1 PA20058641501A PA8641501A PA8641501A1 PA 8641501 A1 PA8641501 A1 PA 8641501A1 PA 20058641501 A PA20058641501 A PA 20058641501A PA 8641501 A PA8641501 A PA 8641501A PA 8641501 A1 PA8641501 A1 PA 8641501A1
Authority
PA
Panama
Prior art keywords
cci
derivatives
preparation
metabolites
novedosos
Prior art date
Application number
PA20058641501A
Other languages
English (en)
Inventor
Ping Cai
Mark Ruppen
Russ Tsao
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PA8641501A1 publication Critical patent/PA8641501A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

SE PROPORCIONA UN METODO PARA GENERAR METABOLITOS SINTETICOS DE CCI-779. SE DESCRIBEN CINCO DERIVADOS DE CCI-779 NOVEDOSOS, COMO ASI TAMBIEN METODOS PARA LA UTILIZACION DE ESTOS DERIVADOS PARA DETECTAR METABOLITOS DE CCI-779 EN MUESTRAS.
PA20058641501A 2004-08-10 2005-08-09 Derivados de cci-779 y metodo para su preparacion PA8641501A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60033704P 2004-08-10 2004-08-10

Publications (1)

Publication Number Publication Date
PA8641501A1 true PA8641501A1 (es) 2006-09-08

Family

ID=35159738

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058641501A PA8641501A1 (es) 2004-08-10 2005-08-09 Derivados de cci-779 y metodo para su preparacion

Country Status (15)

Country Link
US (2) US7332601B2 (es)
EP (1) EP1776370A1 (es)
JP (1) JP2008517874A (es)
CN (1) CN1993368A (es)
AR (1) AR050452A1 (es)
AU (1) AU2005292647A1 (es)
BR (1) BRPI0514206A (es)
CA (1) CA2577011A1 (es)
GT (1) GT200500216A (es)
MX (1) MX2007001676A (es)
PA (1) PA8641501A1 (es)
PE (1) PE20060642A1 (es)
SV (1) SV2006002188A (es)
TW (1) TW200616633A (es)
WO (1) WO2006038972A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100402031C (zh) 2002-07-30 2008-07-16 惠氏公司 含有瑞帕霉素羟基酯的胃肠外制剂
WO2006038972A1 (en) * 2004-08-10 2006-04-13 Wyeth Cci-779 derivatives and methods of making same
EP1957500A1 (en) * 2005-12-07 2008-08-20 Wyeth a Corporation of the State of Delaware Process for the preparation of purified crystalline cci-779
US7622578B2 (en) * 2005-12-07 2009-11-24 Wyeth Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate
AR058283A1 (es) * 2005-12-07 2008-01-30 Wyeth Corp Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido
TW200824713A (en) * 2006-10-18 2008-06-16 Wyeth Corp Processes for the synthesis of individual isomers of mono-PEG CCI-779
TW200845960A (en) * 2007-04-05 2008-12-01 Wyeth Corp Wortmannin-rapalog conjugate and uses thereof
JP2014533294A (ja) 2011-11-15 2014-12-11 ノバルティス アーゲー ホスホイノシチド３−キナーゼ阻害剤およびヤヌスキナーゼ２−シグナル伝達兼転写活性化因子５経路の調節剤の組合せ
WO2014006115A1 (en) 2012-07-06 2014-01-09 Novartis Ag Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316885A (en) 1980-08-25 1982-02-23 Ayerst, Mckenna And Harrison, Inc. Acyl derivatives of rapamycin
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin
US5256790A (en) * 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
GB9307491D0 (en) * 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
WO1994025022A1 (en) * 1993-04-23 1994-11-10 Abbott Laboratories Rapamycin conjugates and antibodies
US7279561B1 (en) * 1993-04-23 2007-10-09 Wyeth Anti-rapamycin monoclonal antibodies
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6277983B1 (en) 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
TWI256395B (en) 1999-09-29 2006-06-11 Wyeth Corp Regioselective synthesis of rapamycin derivatives
WO2005016935A2 (en) 2003-08-07 2005-02-24 Wyeth Regioselective synthesis of cci-779
AU2005238432A1 (en) 2004-04-14 2005-11-10 Wyeth Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
US7202256B2 (en) 2004-04-14 2007-04-10 Wyeth Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
WO2005105811A1 (en) 2004-04-14 2005-11-10 Wyeth Regiospecific synthesis of rapamycin 42-ester derivatives
JP2007534337A (ja) 2004-04-27 2007-11-29 ワイス ラパマイシン特異的メチラーゼを用いるラパマイシンの標識
WO2006038972A1 (en) * 2004-08-10 2006-04-13 Wyeth Cci-779 derivatives and methods of making same
US7538119B2 (en) 2005-11-04 2009-05-26 Wyeth 41-Methoxy isotope labeled rapamycin 42-ester
BRPI0708562A2 (pt) 2006-03-07 2011-06-07 Wyeth Corp processos para preparar conjugados de polietileno glicor de macrolìdeos imunossupressores, um macrolìdeo imunossupressor peguilado, uma rapamicina peguilada, um everolimus peguilado, um cci-779 peguilado e um tacrolimus peguilado, e, produto

Also Published As

Publication number Publication date
BRPI0514206A (pt) 2008-06-03
AU2005292647A1 (en) 2006-04-13
AR050452A1 (es) 2006-10-25
MX2007001676A (es) 2007-04-12
JP2008517874A (ja) 2008-05-29
CN1993368A (zh) 2007-07-04
CA2577011A1 (en) 2006-04-13
US7332601B2 (en) 2008-02-19
US20100279364A1 (en) 2010-11-04
EP1776370A1 (en) 2007-04-25
PE20060642A1 (es) 2006-08-01
SV2006002188A (es) 2006-03-15
GT200500216A (es) 2006-03-02
US20060036091A1 (en) 2006-02-16
TW200616633A (en) 2006-06-01
WO2006038972A1 (en) 2006-04-13

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