AR062726A1 - Composiciones que comprenden compuestos marcados con 18f y metodos relacionados - Google Patents
Composiciones que comprenden compuestos marcados con 18f y metodos relacionadosInfo
- Publication number
- AR062726A1 AR062726A1 ARP070103993A ARP070103993A AR062726A1 AR 062726 A1 AR062726 A1 AR 062726A1 AR P070103993 A ARP070103993 A AR P070103993A AR P070103993 A ARP070103993 A AR P070103993A AR 062726 A1 AR062726 A1 AR 062726A1
- Authority
- AR
- Argentina
- Prior art keywords
- anion
- heteroaryl
- aryl
- alkyl
- group
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- -1 perchlorate anion Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 229910004679 ONO2 Inorganic materials 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000002059 diagnostic imaging Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 abstract 1
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 abstract 1
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06090166A EP1897885A1 (en) | 2006-09-08 | 2006-09-08 | Compounds and methods for F labelled agents |
| EP07090079A EP1985624A3 (en) | 2007-04-23 | 2007-04-23 | Single step method of radiofluorination of biologically active compounds or biomolecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062726A1 true AR062726A1 (es) | 2008-11-26 |
Family
ID=39031005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103993A AR062726A1 (es) | 2006-09-08 | 2007-09-10 | Composiciones que comprenden compuestos marcados con 18f y metodos relacionados |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8557776B2 (enExample) |
| EP (5) | EP2289564A3 (enExample) |
| JP (2) | JP5603074B2 (enExample) |
| KR (1) | KR20090058553A (enExample) |
| AR (1) | AR062726A1 (enExample) |
| AU (1) | AU2007294124A1 (enExample) |
| BR (1) | BRPI0716554A2 (enExample) |
| CA (2) | CA2662449A1 (enExample) |
| CL (1) | CL2007002620A1 (enExample) |
| CO (1) | CO6150196A2 (enExample) |
| CR (1) | CR10654A (enExample) |
| IL (4) | IL197363A0 (enExample) |
| MA (1) | MA30780B1 (enExample) |
| MX (1) | MX2009002492A (enExample) |
| NO (1) | NO20091428L (enExample) |
| PE (1) | PE20080850A1 (enExample) |
| RU (1) | RU2009112716A (enExample) |
| TN (1) | TN2009000063A1 (enExample) |
| TW (1) | TW200829277A (enExample) |
| WO (1) | WO2008028688A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2289564A3 (en) | 2006-09-08 | 2012-11-14 | Piramal Imaging SA | Derivatives of aniline as precursors for F18-labeling |
| MX2009009291A (es) * | 2007-03-01 | 2009-12-14 | Bayer Schering Pharma Ag | Compuestos activos biologicamente marcados con fluoro-benzoilo 18f como agentes de diagnostico por imagenes asi como precursores de benzotriazol-1-iloxi-benzoilo, 2,5-dioxo-pirrolidin-1-iloxi benzoilo y trimetilamonio benzoilo. |
| GB201013808D0 (en) | 2010-08-18 | 2010-09-29 | Ge Healthcare Ltd | Peptide radiotracer compositions |
| WO2012094334A1 (en) * | 2011-01-04 | 2012-07-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | One-step 18f labeling of biological substrates and uses of 18f labeled biological substrates |
| JP2014526952A (ja) * | 2011-06-09 | 2014-10-09 | ジーイー・ヘルスケア・リミテッド | 蒸留装置及び方法 |
| DK3560937T3 (da) * | 2013-03-15 | 2023-02-13 | Cancer Targeted Tech Llc | Fremgangsmåder til fremstilling af 18f-mærkede psma-målrettede billeddannelsesmidler og diagnostiske fremgangsmåder dermed |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| WO2018152339A1 (en) * | 2017-02-17 | 2018-08-23 | Yale University | Radiolabeled pharmaceuticals and methods of making and using same |
| AR112756A1 (es) | 2017-07-11 | 2019-12-11 | Synthorx Inc | Incorporación de nucleótidos no naturales, y su método |
| MX2020001336A (es) | 2017-08-03 | 2020-08-20 | Synthorx Inc | Conjugados de citoquina para el tratamiento de enfermedades autoinmunes. |
| JP2021522196A (ja) * | 2018-04-20 | 2021-08-30 | ザ ジェネラル ホスピタル コーポレイション | 血液脳関門を越えて送達するためのアセチル化プロドラッグ |
| JP7702872B2 (ja) | 2019-02-06 | 2025-07-04 | シンソークス， インコーポレイテッド | Ｉｌ－２コンジュゲートおよびその使用方法 |
| CN113150065B (zh) * | 2021-03-11 | 2022-07-08 | 武汉英纳氏药业有限公司 | 一种合成肽及其应用 |
| US20240277876A1 (en) * | 2021-05-20 | 2024-08-22 | The Regents Of The University Of California | Pet imaging tracers |
| KR20250164815A (ko) | 2023-03-31 | 2025-11-25 | 닛산 가가쿠 가부시키가이샤 | 피라졸 화합물 및 유해 생물 방제제 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723578A (en) * | 1987-09-24 | 1998-03-03 | The Administrators Of Tulane Educational Fund | Peptide analogs of bombesin |
| US5084555A (en) * | 1989-08-21 | 1992-01-28 | The Administrators Of The Tulane Educational Fund | An octapeptide bombesin analog |
| WO1989002897A1 (en) | 1987-09-24 | 1989-04-06 | The Administrators Of The Tulane Educational Fund | Therapeutic peptides |
| MC2144A1 (fr) * | 1988-10-14 | 1992-02-19 | Univ Tulane | Peptides therapeutiques |
| DE69023500D1 (de) * | 1989-06-02 | 1995-12-14 | Univ Georgetown | Verfahren zum nachweis von antikörpern gegen streptokinase. |
| US6232071B1 (en) | 1990-06-11 | 2001-05-15 | Gilead Sciences, Inc. | Tenascin-C nucleic acid ligands |
| US5244883A (en) | 1990-11-29 | 1993-09-14 | The Administrators Of The Tulane Educational Fund | Nonapeptide bombesin antagonists |
| TW432073B (en) | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| WO1999033792A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| WO1999033795A1 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| EE200000386A (et) | 1997-12-24 | 2001-12-17 | Vertex Pharmaceuticals Incorporated | Aspartüülproteaasi inhibiitorite eelravimid |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
| CA2375920A1 (en) | 1999-06-14 | 2000-12-21 | Eli Lilly And Company | Compounds |
| US7115766B2 (en) | 2000-11-30 | 2006-10-03 | Indiana University Research & Technology Corp. | Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds |
| GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
| GB0206750D0 (en) | 2002-03-22 | 2002-05-01 | Amersham Plc | Radiofluorination methods |
| WO2003087069A2 (en) | 2002-04-09 | 2003-10-23 | Eli Lilly And Company | Dipeptidic growth hormone secretagogues |
| JP4563806B2 (ja) * | 2002-08-09 | 2010-10-13 | アステラス ファルマ ユーロープ ベスローテン フェンノートシャップ | Ｐ−セレクチンに対する結合性化合物 |
| US20080063599A1 (en) | 2002-11-18 | 2008-03-13 | Jorge Setoain Quinquer | Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils |
| EP1597270A2 (en) | 2003-02-20 | 2005-11-23 | University of South Florida | Peptidomimetic inhibitors of stat3 activity and their medical uses |
| GB0305704D0 (en) | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| WO2006083424A2 (en) | 2004-12-28 | 2006-08-10 | The Trustees Of Columbia University In The City Of New York | Radiolabeled compounds and uses thereof |
| EP1912634A4 (en) | 2005-07-29 | 2010-06-09 | Bayer Healthcare Llc | PREPARATION AND USE OF BIPHENYL AMINOACIDAL DERIVATIVES TO TREAT OBESITY |
| US20080029548A1 (en) | 2006-05-05 | 2008-02-07 | Ann De Wree | Fabric treatment dispensing package |
| EP2289564A3 (en) | 2006-09-08 | 2012-11-14 | Piramal Imaging SA | Derivatives of aniline as precursors for F18-labeling |
-
2007
- 2007-09-07 EP EP20100183074 patent/EP2289564A3/en not_active Withdrawn
- 2007-09-07 AU AU2007294124A patent/AU2007294124A1/en not_active Abandoned
- 2007-09-07 JP JP2009527069A patent/JP5603074B2/ja active Active
- 2007-09-07 RU RU2009112716/15A patent/RU2009112716A/ru not_active Application Discontinuation
- 2007-09-07 CA CA002662449A patent/CA2662449A1/en not_active Abandoned
- 2007-09-07 KR KR1020097007141A patent/KR20090058553A/ko not_active Ceased
- 2007-09-07 BR BRPI0716554-4A2A patent/BRPI0716554A2/pt not_active IP Right Cessation
- 2007-09-07 EP EP10183062.8A patent/EP2279759A3/en not_active Withdrawn
- 2007-09-07 EP EP07802326.4A patent/EP2063918B1/en active Active
- 2007-09-07 MX MX2009002492A patent/MX2009002492A/es not_active Application Discontinuation
- 2007-09-07 WO PCT/EP2007/008042 patent/WO2008028688A2/en not_active Ceased
- 2007-09-07 EP EP16153790.7A patent/EP3056509A1/en not_active Ceased
- 2007-09-07 US US11/851,910 patent/US8557776B2/en active Active
- 2007-09-07 CA CA2858907A patent/CA2858907A1/en not_active Abandoned
- 2007-09-07 EP EP11193716.5A patent/EP2455105B1/en active Active
- 2007-09-10 CL CL200702620A patent/CL2007002620A1/es unknown
- 2007-09-10 TW TW096133780A patent/TW200829277A/zh unknown
- 2007-09-10 PE PE2007001212A patent/PE20080850A1/es not_active Application Discontinuation
- 2007-09-10 AR ARP070103993A patent/AR062726A1/es unknown
-
2009
- 2009-02-27 TN TN2009000063A patent/TN2009000063A1/fr unknown
- 2009-03-03 IL IL197363A patent/IL197363A0/en unknown
- 2009-03-05 CR CR10654A patent/CR10654A/es not_active Application Discontinuation
- 2009-03-06 CO CO09023386A patent/CO6150196A2/es unknown
- 2009-04-06 MA MA31764A patent/MA30780B1/fr unknown
- 2009-04-07 NO NO20091428A patent/NO20091428L/no not_active Application Discontinuation
-
2011
- 2011-02-03 IL IL211033A patent/IL211033A0/en unknown
- 2011-03-03 IL IL211526A patent/IL211526A0/en unknown
- 2011-03-03 IL IL211527A patent/IL211527A0/en unknown
-
2013
- 2013-08-16 JP JP2013169253A patent/JP5722966B2/ja active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |