TW200829277A - Compounds and methods for 18F labeled agents - Google Patents
Compounds and methods for 18F labeled agents Download PDFInfo
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- TW200829277A TW200829277A TW096133780A TW96133780A TW200829277A TW 200829277 A TW200829277 A TW 200829277A TW 096133780 A TW096133780 A TW 096133780A TW 96133780 A TW96133780 A TW 96133780A TW 200829277 A TW200829277 A TW 200829277A
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- 239000011550 stock solution Substances 0.000 description 1
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- 229960002317 succinimide Drugs 0.000 description 1
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- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
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- 208000001608 teratocarcinoma Diseases 0.000 description 1
- FRACPXUHUTXLCX-BELIEFIBSA-N tert-butyl N-{1-[(1S)-1-{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl}-2-cyclopropylethyl]-2-oxopyridin-3-yl}carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=CN(C1=O)[C@@H](CC2CC2)C(=O)N[C@@H](C[C@@H]3CCNC3=O)[C@H](C(=O)NCC4=CC=CC=C4)O FRACPXUHUTXLCX-BELIEFIBSA-N 0.000 description 1
- NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 description 1
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- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
- XDLNRRRJZOJTRW-UHFFFAOYSA-N thiohypochlorous acid Chemical compound ClS XDLNRRRJZOJTRW-UHFFFAOYSA-N 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- PPPHYGCRGMTZNA-UHFFFAOYSA-N trifluoromethyl hydrogen sulfate Chemical compound OS(=O)(=O)OC(F)(F)F PPPHYGCRGMTZNA-UHFFFAOYSA-N 0.000 description 1
- PPPHYGCRGMTZNA-UHFFFAOYSA-M trifluoromethyl sulfate Chemical compound [O-]S(=O)(=O)OC(F)(F)F PPPHYGCRGMTZNA-UHFFFAOYSA-M 0.000 description 1
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- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06090166A EP1897885A1 (en) | 2006-09-08 | 2006-09-08 | Compounds and methods for F labelled agents |
| EP07090079A EP1985624A3 (en) | 2007-04-23 | 2007-04-23 | Single step method of radiofluorination of biologically active compounds or biomolecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200829277A true TW200829277A (en) | 2008-07-16 |
Family
ID=39031005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW096133780A TW200829277A (en) | 2006-09-08 | 2007-09-10 | Compounds and methods for 18F labeled agents |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8557776B2 (enExample) |
| EP (5) | EP2289564A3 (enExample) |
| JP (2) | JP5603074B2 (enExample) |
| KR (1) | KR20090058553A (enExample) |
| AR (1) | AR062726A1 (enExample) |
| AU (1) | AU2007294124A1 (enExample) |
| BR (1) | BRPI0716554A2 (enExample) |
| CA (2) | CA2662449A1 (enExample) |
| CL (1) | CL2007002620A1 (enExample) |
| CO (1) | CO6150196A2 (enExample) |
| CR (1) | CR10654A (enExample) |
| IL (4) | IL197363A0 (enExample) |
| MA (1) | MA30780B1 (enExample) |
| MX (1) | MX2009002492A (enExample) |
| NO (1) | NO20091428L (enExample) |
| PE (1) | PE20080850A1 (enExample) |
| RU (1) | RU2009112716A (enExample) |
| TN (1) | TN2009000063A1 (enExample) |
| TW (1) | TW200829277A (enExample) |
| WO (1) | WO2008028688A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2289564A3 (en) | 2006-09-08 | 2012-11-14 | Piramal Imaging SA | Derivatives of aniline as precursors for F18-labeling |
| MX2009009291A (es) * | 2007-03-01 | 2009-12-14 | Bayer Schering Pharma Ag | Compuestos activos biologicamente marcados con fluoro-benzoilo 18f como agentes de diagnostico por imagenes asi como precursores de benzotriazol-1-iloxi-benzoilo, 2,5-dioxo-pirrolidin-1-iloxi benzoilo y trimetilamonio benzoilo. |
| GB201013808D0 (en) | 2010-08-18 | 2010-09-29 | Ge Healthcare Ltd | Peptide radiotracer compositions |
| WO2012094334A1 (en) * | 2011-01-04 | 2012-07-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | One-step 18f labeling of biological substrates and uses of 18f labeled biological substrates |
| JP2014526952A (ja) * | 2011-06-09 | 2014-10-09 | ジーイー・ヘルスケア・リミテッド | 蒸留装置及び方法 |
| DK3560937T3 (da) * | 2013-03-15 | 2023-02-13 | Cancer Targeted Tech Llc | Fremgangsmåder til fremstilling af 18f-mærkede psma-målrettede billeddannelsesmidler og diagnostiske fremgangsmåder dermed |
| GB201314936D0 (en) | 2013-08-21 | 2013-10-02 | Ge Healthcare Ltd | Radiolabelling method |
| GB201322456D0 (en) | 2013-12-18 | 2014-02-05 | Ge Healthcare Ltd | Radiotracer compositions and methods |
| WO2018152339A1 (en) * | 2017-02-17 | 2018-08-23 | Yale University | Radiolabeled pharmaceuticals and methods of making and using same |
| AR112756A1 (es) | 2017-07-11 | 2019-12-11 | Synthorx Inc | Incorporación de nucleótidos no naturales, y su método |
| MX2020001336A (es) | 2017-08-03 | 2020-08-20 | Synthorx Inc | Conjugados de citoquina para el tratamiento de enfermedades autoinmunes. |
| JP2021522196A (ja) * | 2018-04-20 | 2021-08-30 | ザ ジェネラル ホスピタル コーポレイション | 血液脳関門を越えて送達するためのアセチル化プロドラッグ |
| JP7702872B2 (ja) | 2019-02-06 | 2025-07-04 | シンソークス, インコーポレイテッド | Il-2コンジュゲートおよびその使用方法 |
| CN113150065B (zh) * | 2021-03-11 | 2022-07-08 | 武汉英纳氏药业有限公司 | 一种合成肽及其应用 |
| US20240277876A1 (en) * | 2021-05-20 | 2024-08-22 | The Regents Of The University Of California | Pet imaging tracers |
| KR20250164815A (ko) | 2023-03-31 | 2025-11-25 | 닛산 가가쿠 가부시키가이샤 | 피라졸 화합물 및 유해 생물 방제제 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5723578A (en) * | 1987-09-24 | 1998-03-03 | The Administrators Of Tulane Educational Fund | Peptide analogs of bombesin |
| US5084555A (en) * | 1989-08-21 | 1992-01-28 | The Administrators Of The Tulane Educational Fund | An octapeptide bombesin analog |
| WO1989002897A1 (en) | 1987-09-24 | 1989-04-06 | The Administrators Of The Tulane Educational Fund | Therapeutic peptides |
| MC2144A1 (fr) * | 1988-10-14 | 1992-02-19 | Univ Tulane | Peptides therapeutiques |
| DE69023500D1 (de) * | 1989-06-02 | 1995-12-14 | Univ Georgetown | Verfahren zum nachweis von antikörpern gegen streptokinase. |
| US6232071B1 (en) | 1990-06-11 | 2001-05-15 | Gilead Sciences, Inc. | Tenascin-C nucleic acid ligands |
| US5244883A (en) | 1990-11-29 | 1993-09-14 | The Administrators Of The Tulane Educational Fund | Nonapeptide bombesin antagonists |
| TW432073B (en) | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| WO1999033792A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| WO1999033795A1 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| EE200000386A (et) | 1997-12-24 | 2001-12-17 | Vertex Pharmaceuticals Incorporated | Aspartüülproteaasi inhibiitorite eelravimid |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| US6639076B1 (en) | 1998-08-18 | 2003-10-28 | Eli Lilly And Company | Growth hormone secretagogues |
| CA2375920A1 (en) | 1999-06-14 | 2000-12-21 | Eli Lilly And Company | Compounds |
| US7115766B2 (en) | 2000-11-30 | 2006-10-03 | Indiana University Research & Technology Corp. | Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds |
| GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
| GB0206750D0 (en) | 2002-03-22 | 2002-05-01 | Amersham Plc | Radiofluorination methods |
| WO2003087069A2 (en) | 2002-04-09 | 2003-10-23 | Eli Lilly And Company | Dipeptidic growth hormone secretagogues |
| JP4563806B2 (ja) * | 2002-08-09 | 2010-10-13 | アステラス ファルマ ユーロープ ベスローテン フェンノートシャップ | P−セレクチンに対する結合性化合物 |
| US20080063599A1 (en) | 2002-11-18 | 2008-03-13 | Jorge Setoain Quinquer | Compounds Which Can Be Used To Diagnose And Monitor Diseases Associated With The Formation Of Amyloid Protein Fibrils |
| EP1597270A2 (en) | 2003-02-20 | 2005-11-23 | University of South Florida | Peptidomimetic inhibitors of stat3 activity and their medical uses |
| GB0305704D0 (en) | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
| WO2006083424A2 (en) | 2004-12-28 | 2006-08-10 | The Trustees Of Columbia University In The City Of New York | Radiolabeled compounds and uses thereof |
| EP1912634A4 (en) | 2005-07-29 | 2010-06-09 | Bayer Healthcare Llc | PREPARATION AND USE OF BIPHENYL AMINOACIDAL DERIVATIVES TO TREAT OBESITY |
| US20080029548A1 (en) | 2006-05-05 | 2008-02-07 | Ann De Wree | Fabric treatment dispensing package |
| EP2289564A3 (en) | 2006-09-08 | 2012-11-14 | Piramal Imaging SA | Derivatives of aniline as precursors for F18-labeling |
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2007
- 2007-09-07 EP EP20100183074 patent/EP2289564A3/en not_active Withdrawn
- 2007-09-07 AU AU2007294124A patent/AU2007294124A1/en not_active Abandoned
- 2007-09-07 JP JP2009527069A patent/JP5603074B2/ja active Active
- 2007-09-07 RU RU2009112716/15A patent/RU2009112716A/ru not_active Application Discontinuation
- 2007-09-07 CA CA002662449A patent/CA2662449A1/en not_active Abandoned
- 2007-09-07 KR KR1020097007141A patent/KR20090058553A/ko not_active Ceased
- 2007-09-07 BR BRPI0716554-4A2A patent/BRPI0716554A2/pt not_active IP Right Cessation
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- 2007-09-07 EP EP07802326.4A patent/EP2063918B1/en active Active
- 2007-09-07 MX MX2009002492A patent/MX2009002492A/es not_active Application Discontinuation
- 2007-09-07 WO PCT/EP2007/008042 patent/WO2008028688A2/en not_active Ceased
- 2007-09-07 EP EP16153790.7A patent/EP3056509A1/en not_active Ceased
- 2007-09-07 US US11/851,910 patent/US8557776B2/en active Active
- 2007-09-07 CA CA2858907A patent/CA2858907A1/en not_active Abandoned
- 2007-09-07 EP EP11193716.5A patent/EP2455105B1/en active Active
- 2007-09-10 CL CL200702620A patent/CL2007002620A1/es unknown
- 2007-09-10 TW TW096133780A patent/TW200829277A/zh unknown
- 2007-09-10 PE PE2007001212A patent/PE20080850A1/es not_active Application Discontinuation
- 2007-09-10 AR ARP070103993A patent/AR062726A1/es unknown
-
2009
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- 2009-03-03 IL IL197363A patent/IL197363A0/en unknown
- 2009-03-05 CR CR10654A patent/CR10654A/es not_active Application Discontinuation
- 2009-03-06 CO CO09023386A patent/CO6150196A2/es unknown
- 2009-04-06 MA MA31764A patent/MA30780B1/fr unknown
- 2009-04-07 NO NO20091428A patent/NO20091428L/no not_active Application Discontinuation
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2011
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- 2011-03-03 IL IL211526A patent/IL211526A0/en unknown
- 2011-03-03 IL IL211527A patent/IL211527A0/en unknown
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2013
- 2013-08-16 JP JP2013169253A patent/JP5722966B2/ja active Active
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