AU2007294124A1 - Compounds and methods for 18F labeled agents - Google Patents

Info

Publication number

AU2007294124A1

AU2007294124A1 AU2007294124A AU2007294124A AU2007294124A1 AU 2007294124 A1 AU2007294124 A1 AU 2007294124A1 AU 2007294124 A AU2007294124 A AU 2007294124A AU 2007294124 A AU2007294124 A AU 2007294124A AU 2007294124 A1 AU2007294124 A1 AU 2007294124A1

Authority

AU

Australia

Prior art keywords

ala

trp

leu

gly

gin

Prior art date

2006-09-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

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• 238000000034 method Methods 0.000 title claims description 74
• 229910052757 nitrogen Inorganic materials 0.000 claims description 185
• 229910052731 fluorine Inorganic materials 0.000 claims description 177
• 229910052739 hydrogen Inorganic materials 0.000 claims description 172
• 239000000203 mixture Substances 0.000 claims description 144
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 133
• 239000000126 substance Substances 0.000 claims description 123
• -1 30 -O-(Cl-C 4 alkyl) Chemical group 0.000 claims description 97
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 66
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 60
• 239000003795 chemical substances by application Substances 0.000 claims description 53
• YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 50
• 239000011737 fluorine Substances 0.000 claims description 50
• 230000008685 targeting Effects 0.000 claims description 44
• 150000001413 amino acids Chemical group 0.000 claims description 42
• 235000001014 amino acid Nutrition 0.000 claims description 40
• 125000000217 alkyl group Chemical group 0.000 claims description 38
• 238000003384 imaging method Methods 0.000 claims description 36
• 229940002612 prodrug Drugs 0.000 claims description 34
• 239000000651 prodrug Substances 0.000 claims description 34
• 150000003839 salts Chemical class 0.000 claims description 34
• 125000003118 aryl group Chemical group 0.000 claims description 32
• 150000002148 esters Chemical class 0.000 claims description 31
• 150000007524 organic acids Chemical class 0.000 claims description 31
• 150000001408 amides Chemical class 0.000 claims description 30
• 230000008878 coupling Effects 0.000 claims description 29
• 238000010168 coupling process Methods 0.000 claims description 29
• 238000005859 coupling reaction Methods 0.000 claims description 29
• 125000001153 fluoro group Chemical group F* 0.000 claims description 28
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