AR061296A1 - Procedimiento para hacer n-hidroxi-3- [4-[ [ [2- ( 2-metil-1h-indol-3-il) etil] amino] metil] fenil] -2e-2-propenamida y materiales de partida para la misma - Google Patents
Procedimiento para hacer n-hidroxi-3- [4-[ [ [2- ( 2-metil-1h-indol-3-il) etil] amino] metil] fenil] -2e-2-propenamida y materiales de partida para la mismaInfo
- Publication number
- AR061296A1 AR061296A1 ARP070102498A ARP070102498A AR061296A1 AR 061296 A1 AR061296 A1 AR 061296A1 AR P070102498 A ARP070102498 A AR P070102498A AR P070102498 A ARP070102498 A AR P070102498A AR 061296 A1 AR061296 A1 AR 061296A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- phenyl
- propenamide
- indol
- ethyl
- Prior art date
Links
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
- 239000007858 starting material Substances 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- FPOHNWQLNRZRFC-ZHACJKMWSA-N panobinostat Chemical compound CC=1NC2=CC=CC=C2C=1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FPOHNWQLNRZRFC-ZHACJKMWSA-N 0.000 abstract 2
- -1 2-methyl-1H-indole-3-yl Chemical group 0.000 abstract 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 abstract 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 abstract 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80452706P | 2006-06-12 | 2006-06-12 | |
| US86787806P | 2006-11-30 | 2006-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061296A1 true AR061296A1 (es) | 2008-08-20 |
Family
ID=38832681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102498A AR061296A1 (es) | 2006-06-12 | 2007-06-08 | Procedimiento para hacer n-hidroxi-3- [4-[ [ [2- ( 2-metil-1h-indol-3-il) etil] amino] metil] fenil] -2e-2-propenamida y materiales de partida para la misma |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US20090306405A1 (enExample) |
| EP (2) | EP2032533B8 (enExample) |
| JP (2) | JP5431926B2 (enExample) |
| KR (2) | KR101493530B1 (enExample) |
| CN (4) | CN102167678B (enExample) |
| AR (1) | AR061296A1 (enExample) |
| AU (1) | AU2007257883B2 (enExample) |
| BR (1) | BRPI0712847A2 (enExample) |
| CA (1) | CA2653657C (enExample) |
| CL (2) | CL2007001691A1 (enExample) |
| DK (1) | DK2032533T3 (enExample) |
| EC (1) | ECSP088978A (enExample) |
| ES (2) | ES2553255T3 (enExample) |
| GT (1) | GT200800282A (enExample) |
| HR (1) | HRP20130798T1 (enExample) |
| IL (2) | IL195211A (enExample) |
| IN (1) | IN2015DN00910A (enExample) |
| JO (1) | JO2900B1 (enExample) |
| MA (1) | MA30513B1 (enExample) |
| MX (2) | MX2008015898A (enExample) |
| MY (1) | MY147576A (enExample) |
| NO (1) | NO341870B1 (enExample) |
| NZ (1) | NZ572707A (enExample) |
| PE (2) | PE20120221A1 (enExample) |
| PL (1) | PL2032533T3 (enExample) |
| PT (1) | PT2032533E (enExample) |
| RU (1) | RU2448090C2 (enExample) |
| TN (1) | TNSN08507A1 (enExample) |
| TW (1) | TWI395734B (enExample) |
| WO (1) | WO2007146718A2 (enExample) |
| ZA (1) | ZA200809490B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000004075A1 (it) | 2020-02-27 | 2021-08-27 | Flamma Spa | Processo per la preparazione di panobinostat |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB146260A (en) | 1918-07-11 | 1921-08-11 | Elektro Osmose Ag | A process for preparing proteids charged with immune substances |
| GB8531612D0 (en) * | 1985-12-23 | 1986-02-05 | Beecham Wuelfing Gmbh & Co Kg | Compounds |
| PE20020354A1 (es) * | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| AU2002237261A1 (en) | 2001-01-09 | 2002-07-24 | Novartis Pharma Gmbh | Rapid method for screening compounds for in vivo activity |
| NZ544689A (en) | 2001-11-06 | 2007-08-31 | Novartis Ag | Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination |
| AU2007257882B2 (en) * | 2006-06-12 | 2011-09-08 | Secura Bio Inc. | Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide |
-
2007
- 2007-06-07 IN IN910DEN2015 patent/IN2015DN00910A/en unknown
- 2007-06-07 WO PCT/US2007/070564 patent/WO2007146718A2/en not_active Ceased
- 2007-06-07 CN CN2011100629486A patent/CN102167678B/zh active Active
- 2007-06-07 US US12/302,572 patent/US20090306405A1/en not_active Abandoned
- 2007-06-07 MX MX2008015898A patent/MX2008015898A/es active IP Right Grant
- 2007-06-07 CA CA2653657A patent/CA2653657C/en active Active
- 2007-06-07 CN CN2012103501544A patent/CN103086944A/zh active Pending
- 2007-06-07 MX MX2012002221A patent/MX366213B/es unknown
- 2007-06-07 KR KR20087030232A patent/KR101493530B1/ko not_active Expired - Fee Related
- 2007-06-07 KR KR1020147026120A patent/KR101540194B1/ko not_active Expired - Fee Related
- 2007-06-07 BR BRPI0712847-9A patent/BRPI0712847A2/pt not_active IP Right Cessation
- 2007-06-07 PL PL07784350T patent/PL2032533T3/pl unknown
- 2007-06-07 AU AU2007257883A patent/AU2007257883B2/en not_active Ceased
- 2007-06-07 CN CN2011100630820A patent/CN102174008A/zh active Pending
- 2007-06-07 EP EP07784350.6A patent/EP2032533B8/en active Active
- 2007-06-07 NZ NZ572707A patent/NZ572707A/en not_active IP Right Cessation
- 2007-06-07 ES ES11179043.2T patent/ES2553255T3/es active Active
- 2007-06-07 ES ES07784350T patent/ES2416286T3/es active Active
- 2007-06-07 PT PT77843506T patent/PT2032533E/pt unknown
- 2007-06-07 DK DK07784350.6T patent/DK2032533T3/da active
- 2007-06-07 RU RU2008151726/04A patent/RU2448090C2/ru active
- 2007-06-07 JP JP2009515575A patent/JP5431926B2/ja active Active
- 2007-06-07 EP EP11179043.2A patent/EP2394991B1/en active Active
- 2007-06-07 CN CNA2007800217257A patent/CN101466674A/zh active Pending
- 2007-06-07 HR HRP20130798TT patent/HRP20130798T1/hr unknown
- 2007-06-08 PE PE2011002097A patent/PE20120221A1/es active IP Right Grant
- 2007-06-08 AR ARP070102498A patent/AR061296A1/es unknown
- 2007-06-08 PE PE2007000720A patent/PE20080851A1/es active IP Right Grant
- 2007-06-11 TW TW096120985A patent/TWI395734B/zh not_active IP Right Cessation
- 2007-06-11 CL CL200701691A patent/CL2007001691A1/es unknown
- 2007-06-12 JO JO2007219A patent/JO2900B1/en active
-
2008
- 2008-11-06 ZA ZA200809490A patent/ZA200809490B/xx unknown
- 2008-11-10 IL IL195211A patent/IL195211A/en active IP Right Grant
- 2008-11-28 MY MYPI20084865A patent/MY147576A/en unknown
- 2008-12-05 TN TNP2008000507A patent/TNSN08507A1/en unknown
- 2008-12-10 GT GT200800282A patent/GT200800282A/es unknown
- 2008-12-12 EC EC2008008978A patent/ECSP088978A/es unknown
- 2008-12-12 MA MA31472A patent/MA30513B1/fr unknown
-
2009
- 2009-01-09 NO NO20090137A patent/NO341870B1/no not_active IP Right Cessation
-
2010
- 2010-09-13 CL CL2010000973A patent/CL2010000973A1/es unknown
-
2011
- 2011-09-23 US US13/243,001 patent/US8536346B2/en active Active
-
2013
- 2013-10-25 JP JP2013222442A patent/JP5809223B2/ja active Active
-
2014
- 2014-07-28 IL IL233836A patent/IL233836A/en active IP Right Grant
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2023000223A1 (es) | Nuevos inhibidores selectivos de hdac6 basados en oxadiazol | |
| AR061298A1 (es) | Sales de n-hidroxi -3- [4- [ [ [2- (2-metil-1h-indol-3-il) etil] amino] metil] fenil] -2e-2- propenamida.composciones farmaceuticas. | |
| NO20081796L (no) | Sulfonylpyrrolhydrokloridsalter som histondeacetylaseinhibitorer | |
| BR112015023399A2 (pt) | inibidores de hdac | |
| CN1056683A (zh) | 草酰氨基酸衍生物，其制备方法及其用作抑制脯氨酸羟化酶的药物 | |
| EA200800700A1 (ru) | Новые сульфонилпирролы как ингибиторы гдац (гистондезацетилазы) | |
| PE20140879A1 (es) | Antagonistas del receptor de acido lisofosfatidico para el tratamiento de fibrosis | |
| SG156687A1 (en) | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | |
| WO2006066133A3 (en) | Histone deacetylase inhibitors | |
| UY31986A (es) | Derivados n- sustituídos de la 2-metil-propionamida;{1-[5-sustiuido-4-sustituido-tiazol-2-il-carbamoil]-1-metil-etil} amidas de ácidos carboxílicos sustituidos, derivados farmacéuticamente aceptables de los mismos, composiciones y aplicaciones. | |
| WO2007084390A3 (en) | Histone deacetylase inhibitors | |
| PE20061426A1 (es) | Derivados de indol como inhibidores de la fosfolipasa a2 citosolica | |
| NZ596863A (en) | Alkanoylamino benzamide aniline hdac inhibitor compounds | |
| CO6260079A2 (es) | Nuevos cristales y procesos para elaborar 5-({[2-amino-3-(4carbamoil-2,6-dimetilfenil)-propionil]-[1-(4-fenil-1h-imidazol-2-yl)-etil]-amino}-2-acido metoxibenzoico | |
| NO20090135L (no) | Polymorfer av N-hydroksy-3-[4-[[[-(2-metyl-1H-indol-3-yl)etyl]amino]metyl]fenyl]2E-2-propenamid | |
| ECSP088957A (es) | Composición farmacéutica estable que contiene docetaxel y método para su fabricación | |
| BRPI0509982A (pt) | cepa isolada de escherichia coli, e, método para produzir um composto | |
| DK1776358T3 (da) | Substituerede propenylpiperazinderivater som nye inhibitorer af histondeacetylase | |
| ES2545076T3 (es) | Uso del inhibidor de HDAC panobinostat para el tratamiento de mieloma | |
| MX2021000468A (es) | Inhibidores de la histona desacetilasa. | |
| EA200701970A1 (ru) | Гидроксаматы как ингибиторы гистондеацетилазы и содержащие их фармацевтические композиции | |
| WO2004071401A3 (en) | Hydroxamic acid derivatives as histone deacetylase inhibitors (hdca) | |
| SV2006002109A (es) | Una composicion farmaceutica antimicobacteriana | |
| PE20091190A1 (es) | Sales de adicion de inhibidores de la enzima de conversion de la angiotensina con acidos donadores de no, su procedimiento de preparacion y composiciones farmaceuticas que los contienen | |
| PE20120221A1 (es) | Procedimiento para hacer n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida y materiales de partida para la misma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |