AR037878A1 - Procedimientos para preparar inhibidores de tipo-1 de intercambiador sodio-hidrogeno - Google Patents
Procedimientos para preparar inhibidores de tipo-1 de intercambiador sodio-hidrogenoInfo
- Publication number
- AR037878A1 AR037878A1 ARP020104909A ARP020104909A AR037878A1 AR 037878 A1 AR037878 A1 AR 037878A1 AR P020104909 A ARP020104909 A AR P020104909A AR P020104909 A ARP020104909 A AR P020104909A AR 037878 A1 AR037878 A1 AR 037878A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- formula
- mixture
- compound
- sodium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a procedimientos de preparación de inhibidores de tipo 1 (NHE-1) de intercambiador sodio-hidrógeno de fórmula (1), y a procedimientos de preparación de composiciones farmacéuticas que comprenden tales inhibidores NHE-1. Reivindicaciones 1: Un método de preparación de un compuesto de fórmula (1), caracterizado porque comprende: combinar una mezcla de acetonitrilo y un compuesto de la fórmula (2), con cloruro de tionilo para formar una mezcla que comprende un compuesto de fórmula (3), evaporar el exceso de cloruro de tionilo de dicha mezcla para formar una mezcla evaporada; y combinar dicha mezcla evaporada con guanidina para formar un compuesto de fórmula (1), enla que R1 es metilsulfonilo o hidrógeno; R2 es hidrógeno o un halógeno; R3 es hidrógeno; R4 es hidrógeno o un halógeno; o R3 y R4, junto con los átomos de carbono a los que están unidos, forman un anillo de seis miembros completamente insaturado que tiene un heteroátomo que es nitrógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34288801P | 2001-12-19 | 2001-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037878A1 true AR037878A1 (es) | 2004-12-09 |
Family
ID=23343711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104909A AR037878A1 (es) | 2001-12-19 | 2002-12-17 | Procedimientos para preparar inhibidores de tipo-1 de intercambiador sodio-hidrogeno |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6627643B2 (es) |
| EP (1) | EP1456181A1 (es) |
| JP (1) | JP2005511787A (es) |
| AR (1) | AR037878A1 (es) |
| AU (1) | AU2002337460A1 (es) |
| BR (1) | BR0215002A (es) |
| CA (1) | CA2469305A1 (es) |
| MX (1) | MXPA04004685A (es) |
| TW (1) | TW200304819A (es) |
| WO (1) | WO2003051845A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2594221C (en) * | 2004-12-27 | 2010-09-21 | Yuyu Inc. | Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same |
| ES2369389T3 (es) | 2005-04-05 | 2011-11-30 | F. Hoffmann-La Roche Ag | 1h-pirazol-4-carboxamidas, su preparación y su empleo como inhibidores de 11-beta- hidroxiesteroide dehidrogenasa. |
| WO2007107470A2 (en) | 2006-03-22 | 2007-09-27 | F. Hoffmann-La Roche Ag | Pyrazoles as 11-beta-hsd-1 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU739403B2 (en) | 1998-02-27 | 2001-10-11 | Pfizer Products Inc. | N-((substituted five-membered di- or triaza diunsaturated ring)carbonyl) guanidine derivatives for the treatment of ischemia |
| US6441176B1 (en) * | 1999-10-29 | 2002-08-27 | Pfizer Inc. | Method for preparing sodium-hydrogen exchanger type 1 inhibitor |
| PL357765A1 (en) * | 2000-04-28 | 2004-07-26 | Pfizer Products Inc. | Sodium-hydrogen exchanger type 1 inhibitor (nhe-1) |
| EP1337508A1 (en) * | 2000-11-28 | 2003-08-27 | Pfizer Products Inc. | Preparation of sodium-hydrogen exchanger type-1 inhibitors |
-
2002
- 2002-10-10 EP EP02772734A patent/EP1456181A1/en not_active Withdrawn
- 2002-10-10 CA CA002469305A patent/CA2469305A1/en not_active Abandoned
- 2002-10-10 MX MXPA04004685A patent/MXPA04004685A/es unknown
- 2002-10-10 BR BR0215002-6A patent/BR0215002A/pt not_active IP Right Cessation
- 2002-10-10 AU AU2002337460A patent/AU2002337460A1/en not_active Abandoned
- 2002-10-10 JP JP2003552731A patent/JP2005511787A/ja active Pending
- 2002-10-10 WO PCT/IB2002/004191 patent/WO2003051845A1/en not_active Application Discontinuation
- 2002-12-13 TW TW091136093A patent/TW200304819A/zh unknown
- 2002-12-16 US US10/320,186 patent/US6627643B2/en not_active Expired - Fee Related
- 2002-12-17 AR ARP020104909A patent/AR037878A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0215002A (pt) | 2004-11-09 |
| TW200304819A (en) | 2003-10-16 |
| US6627643B2 (en) | 2003-09-30 |
| MXPA04004685A (es) | 2004-08-12 |
| US20030119873A1 (en) | 2003-06-26 |
| CA2469305A1 (en) | 2003-06-26 |
| AU2002337460A1 (en) | 2003-06-30 |
| WO2003051845A1 (en) | 2003-06-26 |
| EP1456181A1 (en) | 2004-09-15 |
| JP2005511787A (ja) | 2005-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |