CO5080727A1 - Ligandos azabiciclicos de receptores 5 ht1 - Google Patents
Ligandos azabiciclicos de receptores 5 ht1Info
- Publication number
- CO5080727A1 CO5080727A1 CO99021093A CO99021093A CO5080727A1 CO 5080727 A1 CO5080727 A1 CO 5080727A1 CO 99021093 A CO99021093 A CO 99021093A CO 99021093 A CO99021093 A CO 99021093A CO 5080727 A1 CO5080727 A1 CO 5080727A1
- Authority
- CO
- Colombia
- Prior art keywords
- ring
- alkyl
- branched
- linear
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Luminescent Compositions (AREA)
Abstract
Un compuesto de la fórmula (I):<EMI FILE="99021093_1" ID="1" IMF=JPEG >En la que R3, R4 y Z se seleccionan, independientemente, entre hidrógeno, halo (por ejemplo, cloro, flúor, bromo y yodo), alquilo (C1-C4) opcionalmente sustituido con uno a tres átomos de flúor, alcoxi (C1-C4) opcionalmente sustituido con uno a tres átomos de flúor, y alcoxi (C1-C4)-alquilo (C1-C4 ), donde cada uno de los radicales alquilo puede estar opcionalmente sustituido con uno a tres átomos de flúor;W es -CH2-O-alquilo (C1-C6) donde el radical alquilo puede ser lineal o ramificado; o W wa-CH2NR1R2 , donde R1 y R2 se seleccionan independientemente entre hidrógeno y alquilo (C1-C6) lineal o ramificado;o R1 y R2 , junto con el nitrógeno al que están unidos, forman un anillo monocíclico no aromático saturado o insaturado de cuatro a siete miembros o un anillo bicíclico de siete a diez miembros que opcionalmente puede contener uno o dos heteroátomos además del nitrógeno de NR1R2, donde dichos heteroátomos se seleccionan independientemente entre oxígeno, nitro y azufre, y donde de uno a tres de los átomos de carbono del anillo, o uno de los átomos de nitrógeno del anillo, pueden estar sustituidos opcional e independientemente con alquilo (C1-C4) lineal o ramificado, alcoxi (C1-C6) lineal o ramificado, alquil (C1-C3) lineal o ramificado -cicloalquilo (C3-C7), hidroxi, amino, ciano, halo, aril-alquilo (C1-C3) lineal o ramificado o heteroaril-alquilo (C1-C3) lineal o ramificado, donde dicho arilo se selecciona entre fenilo y naftilo y dicho heteroarilo se selecciona entre oxazolilo, isoxazolilo, tiazolilo, isoziazolilo, furanilo, pirazolilo, pirrolilo, tetrazolilo, triazolilo, tienilo, imidazolilo, pirazinilo, pirazolilo, indolilo, isoindolilo, pirazinilo, cinnolinilo, piridinilo y pirimidinilo;con la condición de que en cualquier anillo formado por NR1 R2 : (a) no puede haber más de un átomo de oxígeno en el anillo; (b) no puede haber ningún radical hidroxi, alcoxi, alcoximetilo, ciano, amino o alquilamino unido directamente a ningún átomo de nitrógeno; y (c) ningún carbono del anillo que esté unido mediante un doble enlace a otro carbono del anillo y no forme parte de un sistema de anillo aromático, puede estar unido a un átomo de oxígeno del anillo o un átomo de nitrógeno del anillo; y las sales farmacéuticamente aceptables de tales compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8123798P | 1998-04-09 | 1998-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5080727A1 true CO5080727A1 (es) | 2001-09-25 |
Family
ID=22162936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99021093A CO5080727A1 (es) | 1998-04-09 | 1999-04-09 | Ligandos azabiciclicos de receptores 5 ht1 |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US6525048B1 (es) |
| EP (1) | EP1070065B1 (es) |
| JP (1) | JP3496759B2 (es) |
| KR (1) | KR100378931B1 (es) |
| CN (1) | CN1117092C (es) |
| AP (1) | AP1175A (es) |
| AR (1) | AR015751A1 (es) |
| AT (1) | ATE248838T1 (es) |
| AU (1) | AU749254B2 (es) |
| BG (1) | BG104915A (es) |
| BR (1) | BR9909522A (es) |
| CA (1) | CA2327782A1 (es) |
| CO (1) | CO5080727A1 (es) |
| CZ (1) | CZ20003684A3 (es) |
| DE (1) | DE69910997T2 (es) |
| DK (1) | DK1070065T3 (es) |
| DZ (1) | DZ2756A1 (es) |
| EA (1) | EA003400B1 (es) |
| ES (1) | ES2204154T3 (es) |
| HK (1) | HK1035719A1 (es) |
| HR (1) | HRP20000653A2 (es) |
| HU (1) | HUP0102400A3 (es) |
| ID (1) | ID26086A (es) |
| IL (1) | IL138629A0 (es) |
| IS (1) | IS5641A (es) |
| MA (1) | MA26619A1 (es) |
| MY (1) | MY133390A (es) |
| NO (1) | NO20005004L (es) |
| NZ (1) | NZ507010A (es) |
| OA (1) | OA11496A (es) |
| PA (1) | PA8469101A1 (es) |
| PE (1) | PE20000413A1 (es) |
| PL (1) | PL343408A1 (es) |
| PT (1) | PT1070065E (es) |
| SK (1) | SK14782000A3 (es) |
| TN (1) | TNSN99056A1 (es) |
| TR (1) | TR200002932T2 (es) |
| TW (1) | TW555758B (es) |
| WO (1) | WO1999052907A1 (es) |
| YU (1) | YU59400A (es) |
| ZA (1) | ZA992596B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6231833B1 (en) | 1999-08-05 | 2001-05-15 | Pfizer Inc | 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors |
| UA62015C2 (en) | 1998-12-28 | 2003-12-15 | Pfizer Prod Inc | Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants) |
| EP1889614A3 (en) | 1999-09-03 | 2010-09-22 | APBI Holdings, LLC | Methods of using rapid-onset selective serotonin reuptake inhibitors for treating sexual dysfunction |
| GB2362826A (en) * | 2000-06-02 | 2001-12-05 | Lilly Co Eli | A pharmaceutical composition comprising a serotonin transport inhibitor and a serotonin recptor antagonist |
| ATE409475T1 (de) * | 2001-02-20 | 2008-10-15 | Dinan Timothy Gerard | Behandlung von fibromyalgie mit pindolol |
| AP2005003390A0 (en) | 2003-03-12 | 2005-09-30 | Pfizer Prod Inc | Pyridyloxymethyl and benzisoxazole azabicyclic derivatives. |
| CA2555172A1 (en) * | 2004-01-29 | 2005-09-09 | Pfizer Products Inc. | Combinations of an atypical antipsychotic and an aminomethylpyridyloxymethyl/benzisoxazole azabicyclic derivatives for treating cns disorders |
| JP4559749B2 (ja) * | 2004-02-16 | 2010-10-13 | あすか製薬株式会社 | ピペラジニルピリジン誘導体 |
| AR049478A1 (es) | 2004-03-25 | 2006-08-09 | Solvay Pharm Bv | Un procedimiento para la preparacion de 3-amino-8-(1-piperazinil)-2h-1-benzopiran-2-ona. sales e hidratos y composiciones farmaceuticas. |
| AR048112A1 (es) * | 2004-03-25 | 2006-03-29 | Solvay Pharm Bv | Derivados de 1-(2h-1-benzopiran-2-on-8-il)-piperazina para el tratamiento de dolor |
| BRPI0512567A (pt) * | 2004-06-22 | 2008-03-25 | Pfizer Prod Inc | compostos antagonistas de receptor de histamina-3 diazabicìclico e respectivas composições farmacêuticas |
| EP1792629A4 (en) | 2004-08-25 | 2010-08-25 | Takeda Pharmaceutical | PREVENTIVE / REMEDY AGENTS FOR INCONTINENCE OF STRESS AND SELECETING METHOD THEREOF |
| EP1791540A2 (en) * | 2004-09-10 | 2007-06-06 | Pfizer Products Incorporated | Methods of treating cognitive disorders using pyridyloxymethyl and benzisoxazole azabicyclic derivatives |
| EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106849A (en) * | 1988-05-24 | 1992-04-21 | American Home Products Corporation | Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders |
| MX19222A (es) * | 1989-01-23 | 1993-12-01 | Pfizer | Agentes ansioliticos bis-aza-biciclicos |
| US5157034A (en) | 1991-02-27 | 1992-10-20 | Pfizer Inc. | Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines |
| JPH08827B2 (ja) * | 1991-09-25 | 1996-01-10 | フアイザー・インコーポレイテツド | 精神弛緩剤の２−置換パーヒドロ−１Ｈ−ピリド［１，２−ａピラジン |
| US5262428A (en) * | 1992-03-13 | 1993-11-16 | Wake Forest University | Biologically active tropane derivatives |
| JP2753146B2 (ja) * | 1992-06-16 | 1998-05-18 | ファイザー・インコーポレーテッド | ビス−アザー二環式抗不安薬の製法および中間体 |
| GB9410512D0 (en) * | 1994-05-25 | 1994-07-13 | Smithkline Beecham Plc | Novel treatment |
| WO1996010570A1 (en) * | 1994-09-30 | 1996-04-11 | Pfizer Inc. | NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES |
| US5614523A (en) * | 1995-01-17 | 1997-03-25 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
-
1999
- 1999-03-17 PA PA19998469101A patent/PA8469101A1/es unknown
- 1999-03-18 US US09/403,892 patent/US6525048B1/en not_active Expired - Fee Related
- 1999-03-18 DE DE69910997T patent/DE69910997T2/de not_active Expired - Fee Related
- 1999-03-18 DK DK99945686T patent/DK1070065T3/da active
- 1999-03-18 AT AT99945686T patent/ATE248838T1/de not_active IP Right Cessation
- 1999-03-18 IL IL13862999A patent/IL138629A0/xx unknown
- 1999-03-18 BR BR9909522-0A patent/BR9909522A/pt not_active Application Discontinuation
- 1999-03-18 PL PL99343408A patent/PL343408A1/xx not_active Application Discontinuation
- 1999-03-18 NZ NZ507010A patent/NZ507010A/en unknown
- 1999-03-18 EP EP99945686A patent/EP1070065B1/en not_active Expired - Lifetime
- 1999-03-18 SK SK1478-2000A patent/SK14782000A3/sk unknown
- 1999-03-18 KR KR10-2000-7011167A patent/KR100378931B1/ko not_active IP Right Cessation
- 1999-03-18 HU HU0102400A patent/HUP0102400A3/hu unknown
- 1999-03-18 ID IDW20002017A patent/ID26086A/id unknown
- 1999-03-18 PT PT99945686T patent/PT1070065E/pt unknown
- 1999-03-18 CA CA002327782A patent/CA2327782A1/en not_active Abandoned
- 1999-03-18 EA EA200000910A patent/EA003400B1/ru not_active IP Right Cessation
- 1999-03-18 WO PCT/IB1999/000457 patent/WO1999052907A1/en active IP Right Grant
- 1999-03-18 CN CN99807195A patent/CN1117092C/zh not_active Expired - Fee Related
- 1999-03-18 CZ CZ20003684A patent/CZ20003684A3/cs unknown
- 1999-03-18 YU YU59400A patent/YU59400A/sh unknown
- 1999-03-18 TR TR2000/02932T patent/TR200002932T2/xx unknown
- 1999-03-18 JP JP2000543464A patent/JP3496759B2/ja not_active Expired - Fee Related
- 1999-03-18 AU AU32687/99A patent/AU749254B2/en not_active Ceased
- 1999-03-18 ES ES99945686T patent/ES2204154T3/es not_active Expired - Lifetime
- 1999-04-02 TW TW088105301A patent/TW555758B/zh not_active IP Right Cessation
- 1999-04-05 PE PE1999000270A patent/PE20000413A1/es not_active Application Discontinuation
- 1999-04-07 TN TNTNSN99056A patent/TNSN99056A1/fr unknown
- 1999-04-07 DZ DZ990057A patent/DZ2756A1/xx active
- 1999-04-07 AR ARP990101572A patent/AR015751A1/es unknown
- 1999-04-07 MA MA25527A patent/MA26619A1/fr unknown
- 1999-04-07 MY MYPI99001344A patent/MY133390A/en unknown
- 1999-04-08 ZA ZA9902596A patent/ZA992596B/xx unknown
- 1999-04-08 AP APAP/P/1999/001502A patent/AP1175A/en active
- 1999-04-09 CO CO99021093A patent/CO5080727A1/es unknown
-
2000
- 2000-09-26 IS IS5641A patent/IS5641A/is unknown
- 2000-10-04 HR HR20000653A patent/HRP20000653A2/hr not_active Application Discontinuation
- 2000-10-04 NO NO20005004A patent/NO20005004L/no not_active Application Discontinuation
- 2000-10-06 OA OA1200000273A patent/OA11496A/en unknown
- 2000-11-07 BG BG104915A patent/BG104915A/xx unknown
-
2001
- 2001-09-04 HK HK01106215A patent/HK1035719A1/xx not_active IP Right Cessation
-
2003
- 2003-02-11 US US10/364,804 patent/US6887905B2/en not_active Expired - Fee Related
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