AU2007257883B2 - Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino] methyl]phenyl]-2E-2-propenamide and starting materials therefor - Google Patents

Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino] methyl]phenyl]-2E-2-propenamide and starting materials therefor Download PDF

Info

Publication number
AU2007257883B2
AU2007257883B2 AU2007257883A AU2007257883A AU2007257883B2 AU 2007257883 B2 AU2007257883 B2 AU 2007257883B2 AU 2007257883 A AU2007257883 A AU 2007257883A AU 2007257883 A AU2007257883 A AU 2007257883A AU 2007257883 B2 AU2007257883 B2 AU 2007257883B2
Authority
AU
Australia
Prior art keywords
methyl
phenyl
indol
propenamide
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007257883A
Other languages
English (en)
Other versions
AU2007257883A1 (en
Inventor
Murat Acemoglu
Joginder S. Bajwa
David John Parker
Joel Slade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Secura Bio Inc
Original Assignee
Secura Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38832681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2007257883(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Secura Bio Inc filed Critical Secura Bio Inc
Publication of AU2007257883A1 publication Critical patent/AU2007257883A1/en
Application granted granted Critical
Publication of AU2007257883B2 publication Critical patent/AU2007257883B2/en
Assigned to SECURA BIO INC. reassignment SECURA BIO INC. Request for Assignment Assignors: NOVARTIS AG
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2007257883A 2006-06-12 2007-06-07 Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino] methyl]phenyl]-2E-2-propenamide and starting materials therefor Ceased AU2007257883B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80452706P 2006-06-12 2006-06-12
US60/804,527 2006-06-12
US86787806P 2006-11-30 2006-11-30
US60/867,878 2006-11-30
PCT/US2007/070564 WO2007146718A2 (en) 2006-06-12 2007-06-07 Process for making n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino] methyl]phenyl]-2e-2-propenamide and starting materials therefor

Publications (2)

Publication Number Publication Date
AU2007257883A1 AU2007257883A1 (en) 2007-12-21
AU2007257883B2 true AU2007257883B2 (en) 2011-09-29

Family

ID=38832681

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007257883A Ceased AU2007257883B2 (en) 2006-06-12 2007-06-07 Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino] methyl]phenyl]-2E-2-propenamide and starting materials therefor

Country Status (31)

Country Link
US (2) US20090306405A1 (enExample)
EP (2) EP2032533B8 (enExample)
JP (2) JP5431926B2 (enExample)
KR (2) KR101493530B1 (enExample)
CN (4) CN103086944A (enExample)
AR (1) AR061296A1 (enExample)
AU (1) AU2007257883B2 (enExample)
BR (1) BRPI0712847A2 (enExample)
CA (1) CA2653657C (enExample)
CL (2) CL2007001691A1 (enExample)
DK (1) DK2032533T3 (enExample)
EC (1) ECSP088978A (enExample)
ES (2) ES2416286T3 (enExample)
GT (1) GT200800282A (enExample)
HR (1) HRP20130798T1 (enExample)
IL (2) IL195211A (enExample)
IN (1) IN2015DN00910A (enExample)
JO (1) JO2900B1 (enExample)
MA (1) MA30513B1 (enExample)
MX (2) MX366213B (enExample)
MY (1) MY147576A (enExample)
NO (1) NO341870B1 (enExample)
NZ (1) NZ572707A (enExample)
PE (2) PE20080851A1 (enExample)
PL (1) PL2032533T3 (enExample)
PT (1) PT2032533E (enExample)
RU (1) RU2448090C2 (enExample)
TN (1) TNSN08507A1 (enExample)
TW (1) TWI395734B (enExample)
WO (1) WO2007146718A2 (enExample)
ZA (1) ZA200809490B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000004075A1 (it) 2020-02-27 2021-08-27 Flamma Spa Processo per la preparazione di panobinostat

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022577A2 (en) * 2000-09-01 2002-03-21 Novartis Ag Hydroxamate derivatives useful as deacetylase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB146260A (en) 1918-07-11 1921-08-11 Elektro Osmose Ag A process for preparing proteids charged with immune substances
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
AU2002237261A1 (en) 2001-01-09 2002-07-24 Novartis Pharma Gmbh Rapid method for screening compounds for in vivo activity
KR100937064B1 (ko) 2001-11-06 2010-01-15 노파르티스 아게 시클로옥시게나제-2 억제제/히스톤 데아세틸라제 억제제복합제제
MY147013A (en) * 2006-06-12 2012-10-15 Novartis Ag Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022577A2 (en) * 2000-09-01 2002-03-21 Novartis Ag Hydroxamate derivatives useful as deacetylase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Grandberg et al. Chemistry of Heterocyclic Compounds (1968) vol. 4, pages 632-633 *

Also Published As

Publication number Publication date
AU2007257883A1 (en) 2007-12-21
KR101493530B1 (ko) 2015-02-13
NO341870B1 (no) 2018-02-12
KR20090015969A (ko) 2009-02-12
HK1126759A1 (en) 2009-09-11
DK2032533T3 (da) 2013-07-01
EP2032533B1 (en) 2013-04-03
GT200800282A (es) 2009-03-09
KR20140117703A (ko) 2014-10-07
PL2032533T3 (pl) 2013-08-30
RU2448090C2 (ru) 2012-04-20
US20120010418A1 (en) 2012-01-12
TW200815345A (en) 2008-04-01
JP5809223B2 (ja) 2015-11-10
AR061296A1 (es) 2008-08-20
MX2008015898A (es) 2009-01-12
HRP20130798T1 (en) 2013-09-30
HK1162029A1 (en) 2012-08-17
PT2032533E (pt) 2013-06-28
ES2553255T3 (es) 2015-12-07
JO2900B1 (en) 2015-09-15
IL195211A0 (en) 2009-08-03
WO2007146718A2 (en) 2007-12-21
US20090306405A1 (en) 2009-12-10
IL233836A0 (en) 2014-09-30
EP2032533B8 (en) 2013-12-11
CN103086944A (zh) 2013-05-08
WO2007146718A3 (en) 2008-06-19
CN102174008A (zh) 2011-09-07
CA2653657A1 (en) 2007-12-21
PE20080851A1 (es) 2008-08-18
MA30513B1 (fr) 2009-06-01
ZA200809490B (en) 2009-10-28
CN102167678B (zh) 2013-08-28
CN101466674A (zh) 2009-06-24
ES2416286T3 (es) 2013-07-31
TNSN08507A1 (en) 2010-04-14
NO20090137L (no) 2009-03-03
CN102167678A (zh) 2011-08-31
US8536346B2 (en) 2013-09-17
IN2015DN00910A (enExample) 2015-07-10
EP2032533A2 (en) 2009-03-11
CA2653657C (en) 2015-10-27
NZ572707A (en) 2011-12-22
EP2394991A1 (en) 2011-12-14
CL2010000973A1 (es) 2011-07-01
IL233836A (en) 2017-05-29
PE20120221A1 (es) 2012-03-21
JP2009540008A (ja) 2009-11-19
MY147576A (en) 2012-12-31
TWI395734B (zh) 2013-05-11
IL195211A (en) 2014-08-31
ECSP088978A (es) 2009-01-30
JP5431926B2 (ja) 2014-03-05
RU2008151726A (ru) 2010-07-20
JP2014058532A (ja) 2014-04-03
BRPI0712847A2 (pt) 2012-08-07
EP2394991B1 (en) 2015-09-23
MX366213B (es) 2019-07-01
CL2007001691A1 (es) 2008-05-16
KR101540194B1 (ko) 2015-07-28

Similar Documents

Publication Publication Date Title
CA3077888C (en) Indacaterol free base in solid form
AU2007257882B2 (en) Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide
HUP0104957A2 (hu) Eljárás 3-alkanoil- és 3-alkil-indolok előállítására
AU2007257883B2 (en) Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino] methyl]phenyl]-2E-2-propenamide and starting materials therefor
JPH11292844A (ja) 光学的に活性なインドリン―２―カルボン酸またはその誘導体の製造法
HK1162029B (en) Process for making starting materials for n-hydroxy-3-[4-[2-(2-methyl-1 h-indol-3-yl)-ethylaminomethyl]-phenyl]-2e-2-propenamide
HK1126759B (en) Process for making n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide and starting materials therefor
AU778663B2 (en) Acylation process
CN87105873A (zh) 二氢吲哚的制备方法
JPWO1999045000A1 (ja) ４−チアゾリルメチル誘導体の製造方法
JP2010530397A (ja) アミド形成の改善方法
HU213634B (en) Method for producing 5-chlorine-2,3-dihydro-2-oxo-indole
JPH07267913A (ja) 置換フェニルヒドラゾンの製造方法
HK1034970B (en) Acylation process
HU215208B (hu) Eljárás 5-klór-2-nitro-fenil-ecetsav-alkil-észterek előállítására

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: SECURA BIO INC.

Free format text: FORMER OWNER(S): NOVARTIS AG

MK14 Patent ceased section 143(a) (annual fees not paid) or expired