ZA200809490B - Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefor - Google Patents

Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefor

Info

Publication number
ZA200809490B
ZA200809490B ZA200809490A ZA200809490A ZA200809490B ZA 200809490 B ZA200809490 B ZA 200809490B ZA 200809490 A ZA200809490 A ZA 200809490A ZA 200809490 A ZA200809490 A ZA 200809490A ZA 200809490 B ZA200809490 B ZA 200809490B
Authority
ZA
South Africa
Prior art keywords
methyl
propenamide
indol
hydroxy
phenyl
Prior art date
Application number
ZA200809490A
Other languages
English (en)
Inventor
Acemoglu Murat
Joginder S Bajwa
Parker David John
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38832681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200809490(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA200809490B publication Critical patent/ZA200809490B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200809490A 2006-06-12 2008-11-06 Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefor ZA200809490B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80452706P 2006-06-12 2006-06-12
US86787806P 2006-11-30 2006-11-30

Publications (1)

Publication Number Publication Date
ZA200809490B true ZA200809490B (en) 2009-10-28

Family

ID=38832681

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200809490A ZA200809490B (en) 2006-06-12 2008-11-06 Process for making N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide and starting materials therefor

Country Status (31)

Country Link
US (2) US20090306405A1 (enExample)
EP (2) EP2032533B8 (enExample)
JP (2) JP5431926B2 (enExample)
KR (2) KR101493530B1 (enExample)
CN (4) CN102167678B (enExample)
AR (1) AR061296A1 (enExample)
AU (1) AU2007257883B2 (enExample)
BR (1) BRPI0712847A2 (enExample)
CA (1) CA2653657C (enExample)
CL (2) CL2007001691A1 (enExample)
DK (1) DK2032533T3 (enExample)
EC (1) ECSP088978A (enExample)
ES (2) ES2553255T3 (enExample)
GT (1) GT200800282A (enExample)
HR (1) HRP20130798T1 (enExample)
IL (2) IL195211A (enExample)
IN (1) IN2015DN00910A (enExample)
JO (1) JO2900B1 (enExample)
MA (1) MA30513B1 (enExample)
MX (2) MX2008015898A (enExample)
MY (1) MY147576A (enExample)
NO (1) NO341870B1 (enExample)
NZ (1) NZ572707A (enExample)
PE (2) PE20120221A1 (enExample)
PL (1) PL2032533T3 (enExample)
PT (1) PT2032533E (enExample)
RU (1) RU2448090C2 (enExample)
TN (1) TNSN08507A1 (enExample)
TW (1) TWI395734B (enExample)
WO (1) WO2007146718A2 (enExample)
ZA (1) ZA200809490B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000004075A1 (it) 2020-02-27 2021-08-27 Flamma Spa Processo per la preparazione di panobinostat

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB146260A (en) 1918-07-11 1921-08-11 Elektro Osmose Ag A process for preparing proteids charged with immune substances
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
AU2002237261A1 (en) 2001-01-09 2002-07-24 Novartis Pharma Gmbh Rapid method for screening compounds for in vivo activity
NZ544689A (en) 2001-11-06 2007-08-31 Novartis Ag Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination
AU2007257882B2 (en) * 2006-06-12 2011-09-08 Secura Bio Inc. Process for making salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide

Also Published As

Publication number Publication date
CN103086944A (zh) 2013-05-08
EP2394991A1 (en) 2011-12-14
PL2032533T3 (pl) 2013-08-30
JP5809223B2 (ja) 2015-11-10
KR20140117703A (ko) 2014-10-07
JP5431926B2 (ja) 2014-03-05
HK1126759A1 (en) 2009-09-11
NO341870B1 (no) 2018-02-12
IL233836A0 (en) 2014-09-30
AU2007257883A1 (en) 2007-12-21
PE20120221A1 (es) 2012-03-21
NZ572707A (en) 2011-12-22
CN102167678B (zh) 2013-08-28
US8536346B2 (en) 2013-09-17
CL2010000973A1 (es) 2011-07-01
CN102174008A (zh) 2011-09-07
WO2007146718A2 (en) 2007-12-21
CN102167678A (zh) 2011-08-31
KR101540194B1 (ko) 2015-07-28
BRPI0712847A2 (pt) 2012-08-07
ES2553255T3 (es) 2015-12-07
TW200815345A (en) 2008-04-01
RU2008151726A (ru) 2010-07-20
KR101493530B1 (ko) 2015-02-13
MX2008015898A (es) 2009-01-12
HK1162029A1 (en) 2012-08-17
DK2032533T3 (da) 2013-07-01
WO2007146718A3 (en) 2008-06-19
HRP20130798T1 (en) 2013-09-30
RU2448090C2 (ru) 2012-04-20
JO2900B1 (en) 2015-09-15
EP2032533B1 (en) 2013-04-03
GT200800282A (es) 2009-03-09
ECSP088978A (es) 2009-01-30
PE20080851A1 (es) 2008-08-18
NO20090137L (no) 2009-03-03
ES2416286T3 (es) 2013-07-31
AR061296A1 (es) 2008-08-20
KR20090015969A (ko) 2009-02-12
US20090306405A1 (en) 2009-12-10
CN101466674A (zh) 2009-06-24
TNSN08507A1 (en) 2010-04-14
PT2032533E (pt) 2013-06-28
EP2394991B1 (en) 2015-09-23
US20120010418A1 (en) 2012-01-12
CA2653657A1 (en) 2007-12-21
MY147576A (en) 2012-12-31
JP2014058532A (ja) 2014-04-03
TWI395734B (zh) 2013-05-11
MX366213B (es) 2019-07-01
IL195211A (en) 2014-08-31
EP2032533B8 (en) 2013-12-11
IL195211A0 (en) 2009-08-03
CL2007001691A1 (es) 2008-05-16
IN2015DN00910A (enExample) 2015-07-10
MA30513B1 (fr) 2009-06-01
IL233836A (en) 2017-05-29
EP2032533A2 (en) 2009-03-11
JP2009540008A (ja) 2009-11-19
AU2007257883B2 (en) 2011-09-29
CA2653657C (en) 2015-10-27

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