AR058807A1 - 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5 - Google Patents
5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5Info
- Publication number
- AR058807A1 AR058807A1 ARP060104038A ARP060104038A AR058807A1 AR 058807 A1 AR058807 A1 AR 058807A1 AR P060104038 A ARP060104038 A AR P060104038A AR P060104038 A ARP060104038 A AR P060104038A AR 058807 A1 AR058807 A1 AR 058807A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- phenylysoxazoletoxi
- piridines
- mglur5
- triazol
- Prior art date
Links
- 101150087728 Grm5 gene Proteins 0.000 title 1
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 208000027520 Somatoform disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 208000027753 pain disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72152705P | 2005-09-29 | 2005-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058807A1 true AR058807A1 (es) | 2008-02-27 |
Family
ID=37745801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104038A AR058807A1 (es) | 2005-09-29 | 2006-09-15 | 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5 |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US7476684B2 (OSRAM) |
| EP (1) | EP1934209A1 (OSRAM) |
| JP (2) | JP2009510064A (OSRAM) |
| KR (1) | KR20080050421A (OSRAM) |
| CN (1) | CN101273037A (OSRAM) |
| AR (1) | AR058807A1 (OSRAM) |
| AU (1) | AU2006297462A1 (OSRAM) |
| BR (1) | BRPI0616228A2 (OSRAM) |
| CA (1) | CA2623009A1 (OSRAM) |
| EC (1) | ECSP088283A (OSRAM) |
| IL (1) | IL189990A0 (OSRAM) |
| NO (1) | NO20081434L (OSRAM) |
| RU (1) | RU2008108219A (OSRAM) |
| TW (1) | TW200800976A (OSRAM) |
| UA (1) | UA92503C2 (OSRAM) |
| UY (1) | UY29796A1 (OSRAM) |
| WO (1) | WO2007040982A1 (OSRAM) |
| ZA (1) | ZA200802163B (OSRAM) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL375256A1 (en) * | 2002-08-09 | 2005-11-28 | Astra Zeneca Ab | 1,2,4-oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| US7585881B2 (en) * | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| UY29796A1 (es) * | 2005-09-29 | 2007-04-30 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor |
| TW200821305A (en) * | 2006-10-05 | 2008-05-16 | Astrazeneca Ab | MGluR5 modulators |
| KR20100090777A (ko) | 2007-10-19 | 2010-08-17 | 아스트라제네카 아베 | 대사성 글루타메이트 수용체 (ｍｇｌｕｒ)의 조절제로서의 테트라졸 유도체 |
| CN101918399A (zh) * | 2007-10-26 | 2010-12-15 | 阿斯利康(瑞典)有限公司 | 作为mglur5调节剂的氨基1,2,4-三唑衍生物 |
| TW201011016A (en) * | 2008-08-12 | 2010-03-16 | Astrazeneca Ab | New compounds 501 |
| JP2011530589A (ja) * | 2008-08-12 | 2011-12-22 | アストラゼネカ・アクチエボラーグ | ４−（５−｛（１ｒ）−１−［５−（３−クロロフェニル）イソオキサゾール−３−イル］エトキシ｝−４−メチル−４ｈ−１，２，４−トリアゾール−３−イル）ピリジンの新規な結晶形態 |
| AU2009307825A1 (en) * | 2008-10-22 | 2010-04-29 | Rick FRIEDMAN | Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor |
| JP2012511570A (ja) * | 2008-12-12 | 2012-05-24 | アストラゼネカ・アクチエボラーグ | ４−［４−メチル−５−（ｃ１−１０アルキルチオ／ｃ５−１０アリール−ｃ１−６アルキルチオ）−４ｈ−１，２，４−トリアゾール−３−イル］ピリジンの新規製造方法 |
| CN102256967A (zh) * | 2008-12-18 | 2011-11-23 | 阿斯利康(瑞典)有限公司 | 制备3-{4-甲基-5-[(1r)-1-(2-(3-甲基苯基-2h-四唑-5-基)-乙氧基]-4h-[1,2,4]三唑-3-基}-吡啶、4-甲基-3-甲基硫基-5-(吡啶-3-基)-1,2,4-三唑和(1r)-1-[2-(3-甲基苯基)-2h-四唑-5-基]乙醇的方法 |
| MX2011005982A (es) * | 2008-12-18 | 2011-06-27 | Astrazeneca Ab | Nuevo proceso para preparar 1-[5-(3-clorofenil)isoxazol-3-il]etano na y (r)-1-[5-(3-clorofenil)isoxazol-3-il]etanol. |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| US8883827B2 (en) | 2009-06-05 | 2014-11-11 | Oslo University Hospital Hf | Azole derivatives as WTN pathway inhibitors |
| CA2784768C (en) | 2009-12-29 | 2015-02-03 | Eli Lilly And Company | Tetrahydrotriazolopyridine compounds as selective mglu5 receptor potentiators useful for the treatment of schizophrenia |
| EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
| US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
| UA112418C2 (uk) * | 2010-09-07 | 2016-09-12 | Астеллас Фарма Інк. | Терапевтичний болезаспокійливий засіб |
| JP2013544874A (ja) | 2010-12-08 | 2013-12-19 | オスロ ユニヴァーシティー ホスピタル エイチエフ | Ｗｎｔシグナル伝達経路阻害薬としてのトリアゾール誘導体 |
| MX2013010698A (es) | 2011-03-18 | 2014-02-17 | Novartis Ag | Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson. |
| WO2016163754A1 (en) * | 2015-04-07 | 2016-10-13 | Medpacto Inc. | Pharmaceutical composition for preventing or treating cancer and method using thereof |
| KR20160120157A (ko) | 2015-04-07 | 2016-10-17 | 주식회사 메드팩토 | 암 예방 또는 치료용 약학적 조성물 및 이를 이용한 방법 |
| KR102027368B1 (ko) * | 2018-05-29 | 2019-10-01 | 서울대학교산학협력단 | 통증의 강도를 측정하는 방법 |
| AU2019384074B2 (en) | 2018-11-20 | 2025-04-10 | Sparrow Pharmaceuticals, Inc. | Methods for administering corticosteroids |
| JP7444901B2 (ja) * | 2019-05-15 | 2024-03-06 | スーリン、クラース | 動物の疼痛の予防及び／又は治療に使用するための４－［５－［（ｒａｃ）－１－［５－（３－クロロフェニル）－３－イソキサゾリル］エトキシ］－４－メチル－４ｈ－１，２，４－トリアゾール－３－イル］ピリジン |
| MX2022005312A (es) | 2019-11-05 | 2022-05-26 | Claes Thulin | 4-[5-[(rac)-1-[5-(3-clorofenil)-3-isoxazolil]etoxi]-4-metil-4h-1, 2,4- triazol-3-il]piridina para el uso en la prevencion y/o tratamiento de la fatiga nerviosa en un mamifero. |
| CA3250533A1 (en) | 2022-05-16 | 2023-11-23 | Sparrow Pharmaceuticals, Inc. | METHODS AND COMPOSITIONS FOR TREATING EXCESS GLUCOCORTICOIDS |
| WO2024088712A1 (en) | 2022-10-28 | 2024-05-02 | Orphelion Ab | Mglur5 receptor antagonists for use in prevention and/or treatment of bone marrow lesions (bml) and/or osteoporosis, cartilage loss, osteosclerosis, osteitis in a mammal |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0202757A3 (en) | 1999-08-19 | 2006-03-28 | Nps Pharmaceuticals Inc Salt L | Heteropolycyclic compounds, pharmaceutical compositions containing them and their use as metabotropic glutamate receptor antagonists |
| UA74419C2 (uk) | 2001-02-21 | 2005-12-15 | Ен Пі Ес Фармасьютікалс, Інк. | Заміщені піридини та їх застосування як антагоністів рецептору метаботропного глутамату |
| US20040132726A1 (en) | 2002-08-09 | 2004-07-08 | Astrazeneca Ab And Nps Pharmaceuticals, Inc. | New compounds |
| AU2003264018A1 (en) | 2002-08-09 | 2004-02-25 | Astrazeneca Ab | Compounds having an activity at metabotropic glutamate receptors |
| PL375256A1 (en) * | 2002-08-09 | 2005-11-28 | Astra Zeneca Ab | 1,2,4-oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| WO2005060971A1 (en) | 2003-12-18 | 2005-07-07 | Astrazeneca Ab | Treatment of reflux-related diseases |
| CN1906187A (zh) | 2003-12-19 | 2007-01-31 | 阿斯利康(瑞典)有限公司 | 作为代谢型谷氨酸受体－5配体的5－氟－,氯－和氰基－吡啶－2－基－四唑类化合物 |
| WO2005077368A2 (en) * | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Treatment of gastro-esophageal reflux disease (gerd) |
| WO2005077345A1 (en) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Compounds for the treatment of gastro-esophageal reflux disease |
| CA2556268A1 (en) | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists |
| UA85576C2 (ru) | 2004-02-18 | 2009-02-10 | Астразенека Аб | Тетразольные соединения и их применение в качестве метаботропических антагонистов рецепторов глутамата |
| SI1716152T1 (sl) | 2004-02-18 | 2008-12-31 | Astrazeneca Ab | Kondenzirane heterociklične spojine in njihova uporaba kot antagonisti metabotropnega receptorja za zdravljenje gastrointestinalnih motenj |
| RU2006127575A (ru) | 2004-02-18 | 2008-03-27 | Астразенека Аб (Se) | Соединение триазола и их применение в качестве антагонистов метаботропного рецептора глутамата |
| NZ548693A (en) | 2004-02-18 | 2010-05-28 | Astrazeneca Ab | Polyheterocyclic compounds and their use as metabotropic glutamate receptor antagonists |
| US7585881B2 (en) | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| UY29796A1 (es) * | 2005-09-29 | 2007-04-30 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor |
-
2006
- 2006-09-15 UY UY29796A patent/UY29796A1/es not_active Application Discontinuation
- 2006-09-15 AR ARP060104038A patent/AR058807A1/es not_active Application Discontinuation
- 2006-09-19 TW TW095134584A patent/TW200800976A/zh unknown
- 2006-09-20 AU AU2006297462A patent/AU2006297462A1/en not_active Abandoned
- 2006-09-20 BR BRPI0616228-2A patent/BRPI0616228A2/pt not_active IP Right Cessation
- 2006-09-20 UA UAA200802884A patent/UA92503C2/ru unknown
- 2006-09-20 CN CNA2006800343984A patent/CN101273037A/zh active Pending
- 2006-09-20 US US11/523,717 patent/US7476684B2/en not_active Expired - Fee Related
- 2006-09-20 JP JP2008533434A patent/JP2009510064A/ja active Pending
- 2006-09-20 US US12/067,270 patent/US20080227824A1/en not_active Abandoned
- 2006-09-20 CA CA002623009A patent/CA2623009A1/en not_active Abandoned
- 2006-09-20 WO PCT/US2006/036423 patent/WO2007040982A1/en not_active Ceased
- 2006-09-20 KR KR1020087006537A patent/KR20080050421A/ko not_active Withdrawn
- 2006-09-20 EP EP06803836A patent/EP1934209A1/en not_active Withdrawn
- 2006-09-20 RU RU2008108219/04A patent/RU2008108219A/ru not_active Application Discontinuation
-
2007
- 2007-07-27 US US11/829,866 patent/US20070270468A1/en not_active Abandoned
- 2007-07-27 US US11/829,867 patent/US20070270469A1/en not_active Abandoned
-
2008
- 2008-03-06 IL IL189990A patent/IL189990A0/en unknown
- 2008-03-07 ZA ZA200802163A patent/ZA200802163B/xx unknown
- 2008-03-14 EC EC2008008283A patent/ECSP088283A/es unknown
- 2008-03-19 NO NO20081434A patent/NO20081434L/no not_active Application Discontinuation
-
2009
- 2009-09-14 JP JP2009211258A patent/JP2010013476A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP088283A (es) | 2008-04-28 |
| ZA200802163B (en) | 2009-09-30 |
| IL189990A0 (en) | 2008-08-07 |
| US20070270469A1 (en) | 2007-11-22 |
| US7476684B2 (en) | 2009-01-13 |
| US20070129408A1 (en) | 2007-06-07 |
| UY29796A1 (es) | 2007-04-30 |
| US20070270468A1 (en) | 2007-11-22 |
| UA92503C2 (ru) | 2010-11-10 |
| TW200800976A (en) | 2008-01-01 |
| JP2010013476A (ja) | 2010-01-21 |
| CA2623009A1 (en) | 2007-04-12 |
| RU2008108219A (ru) | 2009-11-10 |
| KR20080050421A (ko) | 2008-06-05 |
| CN101273037A (zh) | 2008-09-24 |
| JP2009510064A (ja) | 2009-03-12 |
| BRPI0616228A2 (pt) | 2011-06-14 |
| US20080227824A1 (en) | 2008-09-18 |
| NO20081434L (no) | 2008-05-19 |
| WO2007040982A1 (en) | 2007-04-12 |
| AU2006297462A1 (en) | 2007-04-12 |
| EP1934209A1 (en) | 2008-06-25 |
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| FA | Abandonment or withdrawal |