AR058079A1 - Proceso para la sintesis de compuestos para la inhibicion de selectina - Google Patents
Proceso para la sintesis de compuestos para la inhibicion de selectinaInfo
- Publication number
- AR058079A1 AR058079A1 ARP060104394A ARP060104394A AR058079A1 AR 058079 A1 AR058079 A1 AR 058079A1 AR P060104394 A ARP060104394 A AR P060104394A AR P060104394 A ARP060104394 A AR P060104394A AR 058079 A1 AR058079 A1 AR 058079A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- thioalkyl
- compound
- formula
- perhaloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se refiere al campo de sustancias antiinflamatorias, y más particularmente a la preparacion de compuestos que actuan como antagonistas de las proteínas de adhesion de mamífero conocidas como selectinas. En algunas realizaciones, la presente proporciona métodos para preparar compuestos para tratar trastornos mediados por selectina. Reivindicacion 1: Un método para la preparacion de un compuesto de formula (1) donde cada R1 se selecciona independientemente entre H, halogeno, OH, CN, SH, NH2, alquilo C1-6, Oalquilo C1-6, perhaloalquilo C1-6, alquilsulfonamida C1-6, monoalquilamina C1-6, dialquilamina C1-6, y tioalquilo C1-6; R2 se selecciona entre H, halogeno, OH, CN, SH, alquilo C1-6, Oalquilo C1-6, perhaloalquilo C1-6, tioalquilo C1-6, arilo C6-14, y heteroarilo de 5-14 miembros; donde dicho arilo C6-14 y dicho heteroarilo de 5-14 miembros puede cada uno opcionalmente estar sustituido con hasta 3 sustituyentes seleccionados entre halogeno, OH, CN, SH, NH2, alquilo C1-6, Oalquilo C1-6, perhaloalquilo C1-6 y tioalquilo C1-6; y donde dicho alquilo C1-6, Oalquilo C1-6 y tioalquilo C1-6 puede cada uno opcionalmente estar sustituido con hasta 3 sustituyentes seleccionados entre halogeno, OH, CN, SH, NH2, Oalquilo C1-6, perhaloalquilo C1-6 y tioalquilo C1-6; cada R3 se selecciona independientemente entre H, halogeno, OH, CN, SH, NH2, Oalquilo C1-6, perhaloalquilo C1-6 y tioalquilo C1-6; y p y q son cada uno independientemente 1, 2 o 3; comprendiendo el método: hidrolizar un compuesto de formula (2) para proporcionar un compuesto de formula (3) donde R1 y q son segun lo definido anteriormente; y R4 es alquilo C6-18, alquenilo C6-18, alquinilo C6-18, arilo C6-10, arilalquilo C6-14, alquilarilo C6-14, un éter que tiene entre aproximadamente 6 y aproximadamente 18 átomos de C, o un poliéter que tiene entre aproximadamente 6 y aproximadamente 24 átomos de C; y acoplar el compuesto de formula (3) con un compuesto de formula (4) donde R2, R3, y p son segun lo definido anteriormente; para proporcionar un compuesto de formula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72373405P | 2005-10-05 | 2005-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058079A1 true AR058079A1 (es) | 2008-01-23 |
Family
ID=37672216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104394A AR058079A1 (es) | 2005-10-05 | 2006-10-05 | Proceso para la sintesis de compuestos para la inhibicion de selectina |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20070082923A1 (es) |
| EP (1) | EP1931638A1 (es) |
| JP (1) | JP2009511488A (es) |
| KR (1) | KR20080053389A (es) |
| CN (1) | CN101277936A (es) |
| AR (1) | AR058079A1 (es) |
| AU (1) | AU2006302375A1 (es) |
| BR (1) | BRPI0616906A2 (es) |
| CA (1) | CA2624552A1 (es) |
| CR (1) | CR9854A (es) |
| EC (1) | ECSP088340A (es) |
| GT (1) | GT200600447A (es) |
| IL (1) | IL190435A0 (es) |
| NO (1) | NO20081548L (es) |
| PE (1) | PE20070590A1 (es) |
| RU (1) | RU2008112191A (es) |
| TW (1) | TW200738639A (es) |
| WO (1) | WO2007044475A1 (es) |
| ZA (1) | ZA200802990B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009010384A (es) * | 2007-03-30 | 2009-10-16 | Wyeth Corp | Derivados de quinolina y composiciones farmaceuticas que los comprenden para la inhibicion de selectinas. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239280B1 (en) * | 1999-06-30 | 2001-05-29 | Merck & Co., Inc. | Process for synthesizing biaryl inhibitors of farnesyl-protein transferase |
| PE20051021A1 (es) * | 2003-11-10 | 2005-12-28 | Wyeth Corp | Derivados de quinolina como inhibidores de selectina |
-
2006
- 2006-10-04 TW TW095136879A patent/TW200738639A/zh unknown
- 2006-10-04 PE PE2006001208A patent/PE20070590A1/es not_active Application Discontinuation
- 2006-10-05 JP JP2008534685A patent/JP2009511488A/ja not_active Withdrawn
- 2006-10-05 AR ARP060104394A patent/AR058079A1/es not_active Application Discontinuation
- 2006-10-05 BR BRPI0616906-6A patent/BRPI0616906A2/pt not_active IP Right Cessation
- 2006-10-05 CA CA002624552A patent/CA2624552A1/en not_active Abandoned
- 2006-10-05 KR KR1020087009930A patent/KR20080053389A/ko not_active Application Discontinuation
- 2006-10-05 WO PCT/US2006/039000 patent/WO2007044475A1/en active Application Filing
- 2006-10-05 AU AU2006302375A patent/AU2006302375A1/en not_active Abandoned
- 2006-10-05 GT GT200600447A patent/GT200600447A/es unknown
- 2006-10-05 RU RU2008112191/04A patent/RU2008112191A/ru not_active Application Discontinuation
- 2006-10-05 CN CNA2006800369096A patent/CN101277936A/zh active Pending
- 2006-10-05 EP EP06825519A patent/EP1931638A1/en not_active Withdrawn
- 2006-10-05 US US11/543,390 patent/US20070082923A1/en not_active Abandoned
-
2008
- 2008-03-25 IL IL190435A patent/IL190435A0/en unknown
- 2008-03-31 NO NO20081548A patent/NO20081548L/no not_active Application Discontinuation
- 2008-04-01 CR CR9854A patent/CR9854A/es not_active Application Discontinuation
- 2008-04-02 EC EC2008008340A patent/ECSP088340A/es unknown
- 2008-04-04 ZA ZA200802990A patent/ZA200802990B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009511488A (ja) | 2009-03-19 |
| ECSP088340A (es) | 2008-06-30 |
| ZA200802990B (en) | 2008-12-31 |
| NO20081548L (no) | 2008-04-28 |
| KR20080053389A (ko) | 2008-06-12 |
| RU2008112191A (ru) | 2009-11-10 |
| BRPI0616906A2 (pt) | 2011-07-05 |
| AU2006302375A1 (en) | 2007-04-19 |
| CA2624552A1 (en) | 2007-04-19 |
| TW200738639A (en) | 2007-10-16 |
| IL190435A0 (en) | 2008-11-03 |
| WO2007044475A1 (en) | 2007-04-19 |
| CR9854A (es) | 2008-05-21 |
| EP1931638A1 (en) | 2008-06-18 |
| CN101277936A (zh) | 2008-10-01 |
| GT200600447A (es) | 2007-05-08 |
| US20070082923A1 (en) | 2007-04-12 |
| PE20070590A1 (es) | 2007-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |