PE20070590A1 - PROCESO PARA LA SINTESIS DE COMPUESTOS 3-HIDROXI-7,8,9,10-TETRAHIDROBENZO[h]QUINOLIN-4-CARBOXILICO SUSTITUIDOS COMO INHIBIDORES DE SELECTINA - Google Patents
PROCESO PARA LA SINTESIS DE COMPUESTOS 3-HIDROXI-7,8,9,10-TETRAHIDROBENZO[h]QUINOLIN-4-CARBOXILICO SUSTITUIDOS COMO INHIBIDORES DE SELECTINAInfo
- Publication number
- PE20070590A1 PE20070590A1 PE2006001208A PE2006001208A PE20070590A1 PE 20070590 A1 PE20070590 A1 PE 20070590A1 PE 2006001208 A PE2006001208 A PE 2006001208A PE 2006001208 A PE2006001208 A PE 2006001208A PE 20070590 A1 PE20070590 A1 PE 20070590A1
- Authority
- PE
- Peru
- Prior art keywords
- tetrahidrobenzo
- quinolin
- hydroxy
- synthesis
- compounds substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A PROCESOS DE PREPARACION DE COMPUESTOS 3-HIDROXI-7,8,9,10-TETRAHIDROBENZO[h]QUINOLIN-4-CARBOXILICO SUSTITUIDOS DE FORMULA (VI) EN DONDE R1 ES INDEPENDIENTEMENTE H, HALOGENO, OH, CN, ENTRE OTROS; R2 ES H, HALOGENO, OH, CN, ALQUILO(C1-C6) ENTRE OTROS; R3 INDEPENDIENTEMENTE H, HALOGENO, ENTRE OTROS; p Y q SON INDEPENDIENTEMENTE 1, 2 O 3. TAL COMO ACIDO 2-(4-CLOROBENCIL)-3-HIDROXI-7,8,9,10-TETRAHIDROBENZO[h]QUINOLIN-4-CARBOXILICO, QUE CONSISTE EN HIDROLIZAR EN UN MEDIO ACIDO UN COMPUESTO (III), Y LUEGO ACOPLAR EN UN MEDIO QUE COMPRENDE ALCOHOL Y UNA BASE, EL PRODUCTO OBTENIDO CON UN COMPUESTO (V) OBTENIENDOSE DE ESTA FORMA EL COMPUESTO VI. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE SELECTINA Y SON UTILES PARA EL TRATAMIENTO DE PROCESOS DE INFLAMACION Y ADHESION O ATEROSCLEROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72373405P | 2005-10-05 | 2005-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070590A1 true PE20070590A1 (es) | 2007-07-11 |
Family
ID=37672216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001208A PE20070590A1 (es) | 2005-10-05 | 2006-10-04 | PROCESO PARA LA SINTESIS DE COMPUESTOS 3-HIDROXI-7,8,9,10-TETRAHIDROBENZO[h]QUINOLIN-4-CARBOXILICO SUSTITUIDOS COMO INHIBIDORES DE SELECTINA |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20070082923A1 (es) |
| EP (1) | EP1931638A1 (es) |
| JP (1) | JP2009511488A (es) |
| KR (1) | KR20080053389A (es) |
| CN (1) | CN101277936A (es) |
| AR (1) | AR058079A1 (es) |
| AU (1) | AU2006302375A1 (es) |
| BR (1) | BRPI0616906A2 (es) |
| CA (1) | CA2624552A1 (es) |
| CR (1) | CR9854A (es) |
| EC (1) | ECSP088340A (es) |
| GT (1) | GT200600447A (es) |
| IL (1) | IL190435A0 (es) |
| NO (1) | NO20081548L (es) |
| PE (1) | PE20070590A1 (es) |
| RU (1) | RU2008112191A (es) |
| TW (1) | TW200738639A (es) |
| WO (1) | WO2007044475A1 (es) |
| ZA (1) | ZA200802990B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090127183A (ko) * | 2007-03-30 | 2009-12-09 | 와이어쓰 | 퀴놀린 유도체, 및 이를 포함하는 셀렉틴 억제용 제약 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239280B1 (en) * | 1999-06-30 | 2001-05-29 | Merck & Co., Inc. | Process for synthesizing biaryl inhibitors of farnesyl-protein transferase |
| PA8616901A1 (es) * | 2003-11-10 | 2005-05-24 | Wyeth Corp | Metodos y composiciones para la inhibicion de selectina |
-
2006
- 2006-10-04 PE PE2006001208A patent/PE20070590A1/es not_active Application Discontinuation
- 2006-10-04 TW TW095136879A patent/TW200738639A/zh unknown
- 2006-10-05 AR ARP060104394A patent/AR058079A1/es not_active Application Discontinuation
- 2006-10-05 RU RU2008112191/04A patent/RU2008112191A/ru not_active Application Discontinuation
- 2006-10-05 US US11/543,390 patent/US20070082923A1/en not_active Abandoned
- 2006-10-05 KR KR1020087009930A patent/KR20080053389A/ko not_active Application Discontinuation
- 2006-10-05 BR BRPI0616906-6A patent/BRPI0616906A2/pt not_active IP Right Cessation
- 2006-10-05 EP EP06825519A patent/EP1931638A1/en not_active Withdrawn
- 2006-10-05 WO PCT/US2006/039000 patent/WO2007044475A1/en active Application Filing
- 2006-10-05 GT GT200600447A patent/GT200600447A/es unknown
- 2006-10-05 CA CA002624552A patent/CA2624552A1/en not_active Abandoned
- 2006-10-05 CN CNA2006800369096A patent/CN101277936A/zh active Pending
- 2006-10-05 AU AU2006302375A patent/AU2006302375A1/en not_active Abandoned
- 2006-10-05 JP JP2008534685A patent/JP2009511488A/ja not_active Withdrawn
-
2008
- 2008-03-25 IL IL190435A patent/IL190435A0/en unknown
- 2008-03-31 NO NO20081548A patent/NO20081548L/no not_active Application Discontinuation
- 2008-04-01 CR CR9854A patent/CR9854A/es not_active Application Discontinuation
- 2008-04-02 EC EC2008008340A patent/ECSP088340A/es unknown
- 2008-04-04 ZA ZA200802990A patent/ZA200802990B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200738639A (en) | 2007-10-16 |
| ZA200802990B (en) | 2008-12-31 |
| BRPI0616906A2 (pt) | 2011-07-05 |
| AR058079A1 (es) | 2008-01-23 |
| NO20081548L (no) | 2008-04-28 |
| CA2624552A1 (en) | 2007-04-19 |
| WO2007044475A1 (en) | 2007-04-19 |
| ECSP088340A (es) | 2008-06-30 |
| CR9854A (es) | 2008-05-21 |
| CN101277936A (zh) | 2008-10-01 |
| AU2006302375A1 (en) | 2007-04-19 |
| JP2009511488A (ja) | 2009-03-19 |
| IL190435A0 (en) | 2008-11-03 |
| EP1931638A1 (en) | 2008-06-18 |
| GT200600447A (es) | 2007-05-08 |
| US20070082923A1 (en) | 2007-04-12 |
| KR20080053389A (ko) | 2008-06-12 |
| RU2008112191A (ru) | 2009-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |