WO2009140101A3 - Imidazopyridine compounds useful as mmp-13 inhibitors - Google Patents

Imidazopyridine compounds useful as mmp-13 inhibitors Download PDF

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Publication number
WO2009140101A3
WO2009140101A3 PCT/US2009/042770 US2009042770W WO2009140101A3 WO 2009140101 A3 WO2009140101 A3 WO 2009140101A3 US 2009042770 W US2009042770 W US 2009042770W WO 2009140101 A3 WO2009140101 A3 WO 2009140101A3
Authority
WO
WIPO (PCT)
Prior art keywords
mmp
inhibitors
compounds useful
imidazopyridine compounds
imidazopyridine
Prior art date
Application number
PCT/US2009/042770
Other languages
French (fr)
Other versions
WO2009140101A2 (en
Inventor
Neil Alexander Farrow
Daniel R. Goldberg
Alexander Heim-Riether
Lana Louise Smith Keenan
Kenneth Michael Meyers
Bernd Wellenzohn
Dieter Wiedenmayer
Yang Yu
Zhonghua Zhang
Original Assignee
Boehringer Ingelheim International Gmbh
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh, Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim International Gmbh
Publication of WO2009140101A2 publication Critical patent/WO2009140101A2/en
Publication of WO2009140101A3 publication Critical patent/WO2009140101A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.
PCT/US2009/042770 2008-05-12 2009-05-05 Imidazopyridine compounds useful as mmp-13 inhibitors WO2009140101A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5236008P 2008-05-12 2008-05-12
US61/052,360 2008-05-12

Publications (2)

Publication Number Publication Date
WO2009140101A2 WO2009140101A2 (en) 2009-11-19
WO2009140101A3 true WO2009140101A3 (en) 2010-02-25

Family

ID=41319256

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/042770 WO2009140101A2 (en) 2008-05-12 2009-05-05 Imidazopyridine compounds useful as mmp-13 inhibitors

Country Status (1)

Country Link
WO (1) WO2009140101A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU1000676D0 (en) 2010-12-17 2011-02-28 Pharmahungary 2000 Kft Inhibitors of matrix metalloproteinase, pharmaceutical compositions thereof and use of them for preventing and treating diseases where the activation of mmp is involved
US20160185774A1 (en) * 2013-08-02 2016-06-30 Institut Pasteur Korea Anti-Infective Compounds
JP7065951B2 (en) 2017-09-22 2022-05-12 ジュビラント エピパッド エルエルシー Heterocyclic compound as a PAD inhibitor
AU2018352142B2 (en) 2017-10-18 2022-08-25 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
SG11202004537UA (en) 2017-11-24 2020-06-29 Jubilant Episcribe Llc Heterocyclic compounds as prmt5 inhibitors
KR20200131845A (en) 2018-03-13 2020-11-24 주빌런트 프로델 엘엘씨 Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003049738A1 (en) * 2001-12-08 2003-06-19 Aventis Pharma Deutschland Gmbh Use of pyridine-2,4-dicarboxylic acid diamides and of pyrimidine-4,6-dicarboxylic acid diamides for selective collagenase inhibition
WO2007022529A2 (en) * 2005-08-19 2007-02-22 Array Biopharma Inc. Method of treating inflammatory diseases
WO2007139860A2 (en) * 2006-05-22 2007-12-06 Alantos Pharmaceuticals, Inc. Heterobicylic metalloprotease inhibitors
WO2008066789A2 (en) * 2006-11-27 2008-06-05 H. Lundbeck A/S Heteroaryl amide derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003049738A1 (en) * 2001-12-08 2003-06-19 Aventis Pharma Deutschland Gmbh Use of pyridine-2,4-dicarboxylic acid diamides and of pyrimidine-4,6-dicarboxylic acid diamides for selective collagenase inhibition
WO2007022529A2 (en) * 2005-08-19 2007-02-22 Array Biopharma Inc. Method of treating inflammatory diseases
WO2007139860A2 (en) * 2006-05-22 2007-12-06 Alantos Pharmaceuticals, Inc. Heterobicylic metalloprotease inhibitors
WO2008066789A2 (en) * 2006-11-27 2008-06-05 H. Lundbeck A/S Heteroaryl amide derivatives

Also Published As

Publication number Publication date
WO2009140101A2 (en) 2009-11-19

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