AR057756A1 - Derivados de 3-sulfonilindazoles sustituidos, como ligandos de receptores 5-ht6 - Google Patents
Derivados de 3-sulfonilindazoles sustituidos, como ligandos de receptores 5-ht6Info
- Publication number
- AR057756A1 AR057756A1 ARP060103549A ARP060103549A AR057756A1 AR 057756 A1 AR057756 A1 AR 057756A1 AR P060103549 A ARP060103549 A AR P060103549A AR P060103549 A ARP060103549 A AR P060103549A AR 057756 A1 AR057756 A1 AR 057756A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- aryl
- substituted alkyl
- heteroaryl group
- cycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Método de preparacion, composiciones farmacéuticas que los contienen, y usos como agentes terapéuticos en una variedad de trastornos del sistema nervioso central, relacionados con receptores 5-HT6. Reivindicacion 1: Un compuesto de formula (1), en donde: X es O, S, NR, CH2, CH2Y, CH2Z, CO, CONR o NRCO; Y es O, S o NR; Z es CO; n es 0 o un entero de 1, 2, 3, 4, 5 o 6 cuando X es CH2; n es un entero de 1, 2, 3, 4, 5 o 6 cuando X es CH2Z, CO o NRCO; n es un entero de 2, 3, 4, 5 o 6 cuando X es O, S, NR, CH2Y o CONR; R es H o un grupo alquilo opcionalmente sustituido; R1 es H o un grupo alquilo, cicloalquilo, arilo o heteroarilo cada uno opcionalmente sustituido; R2 es un grupo alquilo, cicloalquilo, arilo o heteroarilo opcionalmente sustituidos un sistema de anillo bicíclico o tricíclico de 8- a 13-miembros opcionalmente sustituido que tiene un átomo N en el cabezal del puente y opcionalmente contiene 1, 2 o 3 heteroátomos seleccionados entre N, O o S; R3 y R4 son cada uno independientemente H, o un grupo alquilo opcionalmente sustituido; R5 y R6 son cada uno independientemente H, o un grupo alquilo, alquenilo, alquinilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido, o R5 y R6 pueden ser tomados juntos con el átomo al cual ellos están ligados para formar un anillo de 3- a 7- opcionalmente sustituido que contiene opcionalmente un heteroátomo adicional seleccionado entre O, N o S; R7 es H, halogeno, CN, OR8, CO2R9, CONR10R11, o un grupo alquilo, alquenilo, alquinilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido; m es un entero de 0, 1, 2 o 3; R8 es H, COR12 o un grupo alquilo, alquenilo, alquinilo, arilo o heteroarilo cada uno opcionalmente sustituido; R9 es H o un alquilo C1-6, o un grupo arilo o heteroarilo cada uno opcionalmente sustituido; R10 y R11 son cada uno independientemente H o un grupo alquilo opcionalmente sustituido; y R12 es un alquilo C1-6, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo; o un estereoisomero del mismo o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70831505P | 2005-08-15 | 2005-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057756A1 true AR057756A1 (es) | 2007-12-19 |
Family
ID=37668440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103549A AR057756A1 (es) | 2005-08-15 | 2006-08-14 | Derivados de 3-sulfonilindazoles sustituidos, como ligandos de receptores 5-ht6 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7723329B2 (es) |
| EP (1) | EP1931640A2 (es) |
| JP (1) | JP5146766B2 (es) |
| KR (1) | KR20080039994A (es) |
| CN (1) | CN101282938A (es) |
| AR (1) | AR057756A1 (es) |
| AU (1) | AU2006280091A1 (es) |
| BR (1) | BRPI0614343A2 (es) |
| CA (1) | CA2619010C (es) |
| CR (1) | CR9734A (es) |
| EC (1) | ECSP088189A (es) |
| GT (1) | GT200600376A (es) |
| IL (1) | IL189476A0 (es) |
| NO (1) | NO20080937L (es) |
| NZ (1) | NZ565872A (es) |
| PE (1) | PE20070354A1 (es) |
| RU (1) | RU2429231C2 (es) |
| SA (1) | SA06270314B1 (es) |
| TW (1) | TW200740766A (es) |
| UA (1) | UA94053C2 (es) |
| WO (1) | WO2007021711A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7645752B2 (en) * | 2006-01-13 | 2010-01-12 | Wyeth Llc | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors |
| PE20071143A1 (es) * | 2006-01-13 | 2008-01-20 | Wyeth Corp | Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6 |
| MX2008013053A (es) * | 2006-04-12 | 2008-10-17 | Wyeth Corp | Derivados de dihidri[1,4]oxazino[2,3,4-hi]indazol-sustituidos como ligandos de 5-hidroxitriptamina-6. |
| WO2007120599A2 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | Dihydro[1,4]oxazino[2,3,4-hi]indazole derivatives as 5-hydroxytryptamine-6 ligands |
| WO2007120596A1 (en) * | 2006-04-12 | 2007-10-25 | Wyeth | DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS |
| US20090012308A1 (en) * | 2007-06-13 | 2009-01-08 | Wyeth | Process for the manufacture of benzylsulfonylarenes |
| CN103102348B (zh) * | 2011-11-14 | 2016-06-08 | 上海交通大学 | 噁二唑类化合物及其制备方法、药物组合物及其用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1028946A1 (en) | 1997-11-04 | 2000-08-23 | Pfizer Products Inc. | Indazole bioisostere replacement of catechol in therapeutically active compounds |
| CA2378047A1 (en) | 1999-07-15 | 2001-01-25 | Methvin Isaac | Heterocyclic compounds for the treatment of migraine |
| JP4184077B2 (ja) | 2000-11-02 | 2008-11-19 | ワイス | ５−ヒドロキシトリプトアミン−６リガンドとしての１−アリールまたは１−アルキルスルホニル−ヘテロシクリルベンザゾール |
| MXPA03005433A (es) | 2000-12-22 | 2003-09-10 | Wyeth Corp | Compuestos de heterociclilalquilindol o-azaindol como ligandos de 5-hidroxitriptamina-6. |
| EA200300717A1 (ru) | 2000-12-22 | 2003-12-25 | Уайт | Гетероциклилиндазольные и -азаиндазольные соединения в качестве 5-гидрокситриптамин-6-лигандов |
| TW593278B (en) | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| EA200301143A1 (ru) | 2001-04-20 | 2004-02-26 | Уайт | Производные гетероциклилалкокси-, алкилтио- и -алкиламинобензазола в качестве лигандов 5-гидрокситриптамина-6 |
| CA2444095A1 (en) | 2001-04-20 | 2002-10-31 | Wyeth | Heterocyclyloxy-, -thioxy- and -aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| MXPA03011244A (es) * | 2001-06-07 | 2004-02-27 | Hoffmann La Roche | Nuevos derivados de indol con afinidad por el receptor 5-ht6. |
| JPWO2002100833A1 (ja) | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Ｒｈｏキナーゼ阻害剤 |
| US20050113283A1 (en) | 2002-01-18 | 2005-05-26 | David Solow-Cordero | Methods of treating conditions associated with an EDG-4 receptor |
| TW200400177A (en) | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| JP4754821B2 (ja) | 2002-06-20 | 2011-08-24 | プロキシマゲン・リミテッド | 肥満症、ｉｉ型糖尿病およびｃｎｓ障害の治療に有用な新規化合物 |
| TW200403243A (en) | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| TW200401641A (en) | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| ATE344030T1 (de) * | 2002-10-18 | 2006-11-15 | Hoffmann La Roche | 4-piperazinylbenzolsulfonyl-indole mit 5-ht6 rezeptor-affinität |
| TWI284124B (en) * | 2002-12-03 | 2007-07-21 | Hoffmann La Roche | Aminoalkoxyindoles |
| MXPA05008441A (es) | 2003-02-14 | 2005-10-19 | Wyeth Corp | Derivados de heterociclil-3-sulfonilindazol o azaindazol como ligandos de 5-hidroxitriptamina-6. |
| KR20050101551A (ko) | 2003-02-14 | 2005-10-24 | 와이어쓰 | 5-하이드록시트립타민-6 리간드로서의헤테로사이클릴-3-설포닐인다졸 |
| CA2557268A1 (en) | 2004-02-27 | 2005-09-15 | F. Hoffmann-La Roche Ag | Indazole derivatives and pharmaceutical compositions containing them |
| AU2006291414A1 (en) | 2005-08-15 | 2007-03-22 | Wyeth | Azinyl-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands |
-
2006
- 2006-08-08 CN CNA2006800374446A patent/CN101282938A/zh active Pending
- 2006-08-08 CA CA2619010A patent/CA2619010C/en not_active Expired - Fee Related
- 2006-08-08 JP JP2008526995A patent/JP5146766B2/ja not_active Expired - Fee Related
- 2006-08-08 NZ NZ565872A patent/NZ565872A/en unknown
- 2006-08-08 WO PCT/US2006/030965 patent/WO2007021711A2/en active Application Filing
- 2006-08-08 BR BRPI0614343-1A patent/BRPI0614343A2/pt not_active IP Right Cessation
- 2006-08-08 UA UAA200801842A patent/UA94053C2/ru unknown
- 2006-08-08 EP EP06801007A patent/EP1931640A2/en not_active Withdrawn
- 2006-08-08 KR KR1020087006267A patent/KR20080039994A/ko not_active Application Discontinuation
- 2006-08-08 RU RU2008105807/04A patent/RU2429231C2/ru not_active IP Right Cessation
- 2006-08-08 AU AU2006280091A patent/AU2006280091A1/en not_active Abandoned
- 2006-08-14 US US11/504,350 patent/US7723329B2/en not_active Expired - Fee Related
- 2006-08-14 PE PE2006000984A patent/PE20070354A1/es not_active Application Discontinuation
- 2006-08-14 GT GT200600376A patent/GT200600376A/es unknown
- 2006-08-14 AR ARP060103549A patent/AR057756A1/es unknown
- 2006-08-14 TW TW095129795A patent/TW200740766A/zh unknown
- 2006-09-09 SA SA6270314A patent/SA06270314B1/ar unknown
-
2008
- 2008-02-12 IL IL189476A patent/IL189476A0/en unknown
- 2008-02-15 CR CR9734A patent/CR9734A/es not_active Application Discontinuation
- 2008-02-15 EC EC2008008189A patent/ECSP088189A/es unknown
- 2008-02-25 NO NO20080937A patent/NO20080937L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101282938A (zh) | 2008-10-08 |
| KR20080039994A (ko) | 2008-05-07 |
| PE20070354A1 (es) | 2007-04-04 |
| US7723329B2 (en) | 2010-05-25 |
| US20070037802A1 (en) | 2007-02-15 |
| NO20080937L (no) | 2008-04-30 |
| WO2007021711A3 (en) | 2007-05-03 |
| RU2429231C2 (ru) | 2011-09-20 |
| NZ565872A (en) | 2011-06-30 |
| TW200740766A (en) | 2007-11-01 |
| AU2006280091A1 (en) | 2007-02-22 |
| EP1931640A2 (en) | 2008-06-18 |
| JP5146766B2 (ja) | 2013-02-20 |
| CA2619010C (en) | 2013-10-01 |
| BRPI0614343A2 (pt) | 2011-03-22 |
| JP2009504739A (ja) | 2009-02-05 |
| WO2007021711A2 (en) | 2007-02-22 |
| IL189476A0 (en) | 2008-08-07 |
| UA94053C2 (ru) | 2011-04-11 |
| RU2008105807A (ru) | 2009-09-27 |
| GT200600376A (es) | 2007-03-29 |
| SA06270314B1 (ar) | 2011-07-20 |
| CR9734A (es) | 2008-04-03 |
| CA2619010A1 (en) | 2007-02-22 |
| ECSP088189A (es) | 2008-04-28 |
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