AR053760A1 - Procedimiento de preparacion de derivados de diarilcicloalquilo y compuestos intermediarios - Google Patents
Procedimiento de preparacion de derivados de diarilcicloalquilo y compuestos intermediariosInfo
- Publication number
- AR053760A1 AR053760A1 ARP050103522A ARP050103522A AR053760A1 AR 053760 A1 AR053760 A1 AR 053760A1 AR P050103522 A ARP050103522 A AR P050103522A AR P050103522 A ARP050103522 A AR P050103522A AR 053760 A1 AR053760 A1 AR 053760A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- alkyl
- reacted
- atoms
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 31
- 238000000034 method Methods 0.000 title abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000006239 protecting group Chemical group 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 239000003377 acid catalyst Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000004678 hydrides Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004040736A DE102004040736B4 (de) | 2004-08-23 | 2004-08-23 | Verfahren zur Herstellung von Diarylcycloalkylderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053760A1 true AR053760A1 (es) | 2007-05-23 |
Family
ID=35745474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103522A AR053760A1 (es) | 2004-08-23 | 2005-08-22 | Procedimiento de preparacion de derivados de diarilcicloalquilo y compuestos intermediarios |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7803950B2 (https=) |
| EP (1) | EP1786913B1 (https=) |
| JP (1) | JP4991543B2 (https=) |
| KR (1) | KR20070048741A (https=) |
| CN (1) | CN101014714B (https=) |
| AR (1) | AR053760A1 (https=) |
| AT (1) | ATE520785T1 (https=) |
| AU (1) | AU2005276642B2 (https=) |
| BR (1) | BRPI0514000A (https=) |
| CA (1) | CA2578342A1 (https=) |
| CY (1) | CY1112080T1 (https=) |
| DE (1) | DE102004040736B4 (https=) |
| DK (1) | DK1786913T3 (https=) |
| ES (1) | ES2371762T3 (https=) |
| IL (1) | IL181339A0 (https=) |
| MA (1) | MA28796B1 (https=) |
| MX (1) | MX2007001872A (https=) |
| NO (1) | NO20071316L (https=) |
| NZ (1) | NZ553602A (https=) |
| PL (1) | PL1786913T3 (https=) |
| PT (1) | PT1786913E (https=) |
| RU (1) | RU2414459C2 (https=) |
| SI (1) | SI1786913T1 (https=) |
| TW (1) | TW200621734A (https=) |
| UY (1) | UY29082A1 (https=) |
| WO (1) | WO2006021420A2 (https=) |
| ZA (1) | ZA200700635B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050232972A1 (en) * | 2004-04-15 | 2005-10-20 | Steven Odrich | Drug delivery via punctal plug |
| CN101381302B (zh) * | 2007-09-07 | 2013-04-03 | 上海睿智化学研究有限公司 | 2-溴甲基-6-甲基苯甲酰氯/溴的制备方法 |
| ES2601852T3 (es) * | 2008-01-25 | 2017-02-16 | Xenoport, Inc. | Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728899A (en) * | 1995-03-27 | 1998-03-17 | Hoechst Marion Roussel Inc. | Preparation of cis-4-O-protected-2-cyclopentenol derivatives |
| US6884812B2 (en) * | 2001-08-31 | 2005-04-26 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmaceuticals |
| AU2002333456B2 (en) * | 2001-08-31 | 2008-07-17 | Sanofi-Aventis Deutschland Gmbh | Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as PPAR activators |
| AU2003217274A1 (en) * | 2002-02-25 | 2003-09-09 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
| DE10308350B4 (de) * | 2003-02-27 | 2006-06-01 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 1,3-Cyclohexandiol-Derivaten |
| DE10308353A1 (de) * | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7094795B2 (en) * | 2003-02-27 | 2006-08-22 | Sanofi-Aventis Deutschland Gmbh | Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives |
| WO2005040394A1 (fr) * | 2003-10-22 | 2005-05-06 | Rhodia Chimie | Procede de fabrication de compose comprenant un groupement hydroxyle libre et un groupement hydroxyle protégé par une fonction ester par reaction enzymatique |
| DE102004038403B4 (de) * | 2004-08-07 | 2006-08-31 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten |
-
2004
- 2004-08-23 DE DE102004040736A patent/DE102004040736B4/de not_active Expired - Fee Related
-
2005
- 2005-08-22 TW TW094128546A patent/TW200621734A/zh unknown
- 2005-08-22 AR ARP050103522A patent/AR053760A1/es not_active Application Discontinuation
- 2005-08-23 NZ NZ553602A patent/NZ553602A/en not_active IP Right Cessation
- 2005-08-23 AU AU2005276642A patent/AU2005276642B2/en not_active Ceased
- 2005-08-23 RU RU2007110644/04A patent/RU2414459C2/ru not_active IP Right Cessation
- 2005-08-23 ES ES05782434T patent/ES2371762T3/es not_active Expired - Lifetime
- 2005-08-23 JP JP2007528733A patent/JP4991543B2/ja not_active Expired - Fee Related
- 2005-08-23 KR KR1020077004449A patent/KR20070048741A/ko not_active Ceased
- 2005-08-23 BR BRPI0514000-5A patent/BRPI0514000A/pt not_active IP Right Cessation
- 2005-08-23 EP EP05782434A patent/EP1786913B1/de not_active Expired - Lifetime
- 2005-08-23 WO PCT/EP2005/009095 patent/WO2006021420A2/de not_active Ceased
- 2005-08-23 CN CN200580028364XA patent/CN101014714B/zh not_active Expired - Fee Related
- 2005-08-23 UY UY29082A patent/UY29082A1/es unknown
- 2005-08-23 CA CA002578342A patent/CA2578342A1/en not_active Abandoned
- 2005-08-23 DK DK05782434.4T patent/DK1786913T3/da active
- 2005-08-23 PL PL05782434T patent/PL1786913T3/pl unknown
- 2005-08-23 SI SI200531403T patent/SI1786913T1/sl unknown
- 2005-08-23 PT PT05782434T patent/PT1786913E/pt unknown
- 2005-08-23 AT AT05782434T patent/ATE520785T1/de active
- 2005-08-23 MX MX2007001872A patent/MX2007001872A/es active IP Right Grant
-
2007
- 2007-01-23 ZA ZA200700635A patent/ZA200700635B/xx unknown
- 2007-02-08 MA MA29674A patent/MA28796B1/fr unknown
- 2007-02-14 IL IL181339A patent/IL181339A0/en unknown
- 2007-02-20 US US11/676,721 patent/US7803950B2/en not_active Expired - Fee Related
- 2007-03-12 NO NO20071316A patent/NO20071316L/no not_active Application Discontinuation
- 2007-10-31 US US11/930,244 patent/US20080051583A1/en not_active Abandoned
-
2011
- 2011-11-17 CY CY20111101110T patent/CY1112080T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |