AR052557A1 - Procedimientos para preparar eteres de pirazolo[3,4-d] pirimidina - Google Patents
Procedimientos para preparar eteres de pirazolo[3,4-d] pirimidinaInfo
- Publication number
- AR052557A1 AR052557A1 ARP060100122A ARP060100122A AR052557A1 AR 052557 A1 AR052557 A1 AR 052557A1 AR P060100122 A ARP060100122 A AR P060100122A AR P060100122 A ARP060100122 A AR P060100122A AR 052557 A1 AR052557 A1 AR 052557A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- cycloalkyl
- haloalkyl
- halogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- -1 pyrazolo [3,4-d] pyrimidine ethers Chemical class 0.000 abstract 14
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 11
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 11
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 11
- 229910052736 halogen Inorganic materials 0.000 abstract 11
- 150000002367 halogens Chemical class 0.000 abstract 11
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 10
- 125000003282 alkyl amino group Chemical group 0.000 abstract 9
- 125000005431 alkyl carboxamide group Chemical group 0.000 abstract 9
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 9
- 125000001072 heteroaryl group Chemical group 0.000 abstract 9
- 125000002252 acyl group Chemical group 0.000 abstract 8
- 125000004422 alkyl sulphonamide group Chemical group 0.000 abstract 8
- 125000004414 alkyl thio group Chemical group 0.000 abstract 8
- 125000005392 carboxamide group Chemical class NC(=O)* 0.000 abstract 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 8
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 8
- 125000005432 dialkylcarboxamide group Chemical group 0.000 abstract 8
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 abstract 7
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 7
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 7
- 125000004771 (C1-C4) haloalkylsulfinyl group Chemical group 0.000 abstract 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 7
- 125000004423 acyloxy group Chemical group 0.000 abstract 7
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 5
- 125000005363 dialkylsulfonamide group Chemical group 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000004153 glucose metabolism Effects 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
- 150000003003 phosphines Chemical class 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64371205P | 2005-01-13 | 2005-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052557A1 true AR052557A1 (es) | 2007-03-21 |
Family
ID=36463499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100122A AR052557A1 (es) | 2005-01-13 | 2006-01-12 | Procedimientos para preparar eteres de pirazolo[3,4-d] pirimidina |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7425630B2 (enExample) |
| EP (1) | EP1838713A2 (enExample) |
| JP (1) | JP2008526975A (enExample) |
| KR (1) | KR20070114126A (enExample) |
| CN (1) | CN101142216A (enExample) |
| AR (1) | AR052557A1 (enExample) |
| AU (1) | AU2006204940A1 (enExample) |
| BR (1) | BRPI0606115A2 (enExample) |
| CA (1) | CA2593345A1 (enExample) |
| CR (1) | CR9224A (enExample) |
| DO (1) | DOP2006000009A (enExample) |
| EA (1) | EA013968B1 (enExample) |
| GT (1) | GT200600011A (enExample) |
| HN (1) | HN2006001493A (enExample) |
| IL (1) | IL184365A0 (enExample) |
| MX (1) | MX2007008381A (enExample) |
| NO (1) | NO20074052L (enExample) |
| PA (1) | PA8659701A1 (enExample) |
| PE (1) | PE20061118A1 (enExample) |
| TW (1) | TW200637865A (enExample) |
| WO (1) | WO2006076455A2 (enExample) |
| ZA (1) | ZA200705279B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| DE602004009295T2 (de) | 2003-01-14 | 2008-07-03 | Arena Pharmaceuticals, Inc., San Diego | 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie |
| EP2292620A3 (en) * | 2003-07-14 | 2011-06-22 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prohylaxis and treatment of disorders related thereto |
| US7923465B2 (en) * | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| JP5498392B2 (ja) | 2007-11-30 | 2014-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用 |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| US8822480B2 (en) | 2008-07-16 | 2014-09-02 | Merck Sharp & Dohme Corp. | Bicyclic heterocycle derivatives and use thereof as GPR119 modulators |
| WO2010026214A1 (en) | 2008-09-08 | 2010-03-11 | Boehringer Ingelheim International Gmbh | Pyrazolopyrimidines and their use for the treatment of cns disorders |
| DK2414363T3 (da) | 2009-03-31 | 2014-01-27 | Boehringer Ingelheim Int | 1-heterocyklyl-1,5-dihydro-pyrazol[3,4-d]pyrimidin-4-on-derivater og anvendelse af disse som PDE9A-modulatorer. |
| US20100285145A1 (en) * | 2009-05-08 | 2010-11-11 | Pfizer Inc | Gpr 119 modulators |
| NZ596467A (en) * | 2009-06-05 | 2014-01-31 | Pfizer | L- ( piperidin-4-yl) -pyrazole derivatives as gpr 119 modulators |
| SG10201500639TA (en) | 2010-01-27 | 2015-03-30 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| WO2012020022A1 (en) | 2010-08-12 | 2012-02-16 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors |
| PH12013500547A1 (en) | 2010-09-22 | 2013-06-10 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
| EA031618B1 (ru) | 2011-06-09 | 2019-01-31 | Ризен Фармасьютикалз Са | Соединения-модуляторы gpr-119 |
| JP6567276B2 (ja) | 2014-05-13 | 2019-08-28 | ソニーセミコンダクタソリューションズ株式会社 | 固体撮像素子、および電子機器 |
| HK1243936A1 (zh) * | 2014-12-06 | 2018-07-27 | Intra-Cellular Therapies, Inc. | 有机化合物 |
| ES2995737T3 (en) | 2015-01-06 | 2025-02-11 | Arena Pharm Inc | Compound for use in treating conditions related to the s1p1 receptor |
| MA42807A (fr) | 2015-06-22 | 2018-07-25 | Arena Pharm Inc | Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1 |
| WO2018151873A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
| JP2019122134A (ja) | 2018-01-04 | 2019-07-22 | Ntn株式会社 | スイッチング電源の力率改善用ｐｗｍ制御装置 |
| EP3801459B1 (en) | 2018-06-06 | 2024-08-07 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| CA3219597A1 (en) * | 2021-06-23 | 2022-12-29 | F. Hoffmann-La Roche Ag | Novel process |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3070304D1 (en) | 1980-04-28 | 1985-04-25 | Teijin Ltd | Thiazolo(3,2-a)pyrimidine derivatives, process for preparing same, and drug containing same |
| EP0053678A1 (de) | 1980-12-05 | 1982-06-16 | BASF Aktiengesellschaft | 5-Amino-1-phenyl-4-cyanpyrazole, diese enthaltende herbizide Mittel, Verfahren zu ihrer Herstellung und ihre Anwendung als Herbizide |
| US4612376A (en) | 1983-03-25 | 1986-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent |
| GB9114760D0 (en) | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
| JP4022271B2 (ja) * | 1995-10-31 | 2007-12-12 | 富士フイルム株式会社 | ピラゾリルアゾフエノール色素 |
| DE60004685T2 (de) * | 1999-09-17 | 2004-07-29 | Abbott Gmbh & Co. Kg | Pyrazolopyrimidine als arzneimittel |
| US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
| DE10219435A1 (de) * | 2002-05-02 | 2003-11-13 | Bayer Cropscience Ag | Substituierte Pyrazolo-pyrimidin-4-one |
| WO2004009602A1 (en) * | 2002-07-23 | 2004-01-29 | Smithkline Beecham Corporation | Pyrazolopyrimidines as kinase inhibitors |
| EP2292620A3 (en) * | 2003-07-14 | 2011-06-22 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prohylaxis and treatment of disorders related thereto |
| GB0425035D0 (en) | 2004-11-12 | 2004-12-15 | Novartis Ag | Organic compounds |
-
2006
- 2006-01-05 DO DO2006000009A patent/DOP2006000009A/es unknown
- 2006-01-09 TW TW095100806A patent/TW200637865A/zh unknown
- 2006-01-10 PE PE2006000054A patent/PE20061118A1/es not_active Application Discontinuation
- 2006-01-11 GT GT200600011A patent/GT200600011A/es unknown
- 2006-01-12 JP JP2007551363A patent/JP2008526975A/ja not_active Withdrawn
- 2006-01-12 AU AU2006204940A patent/AU2006204940A1/en not_active Withdrawn
- 2006-01-12 BR BRPI0606115-0A patent/BRPI0606115A2/pt not_active IP Right Cessation
- 2006-01-12 CA CA002593345A patent/CA2593345A1/en not_active Withdrawn
- 2006-01-12 PA PA20068659701A patent/PA8659701A1/es unknown
- 2006-01-12 EP EP06718131A patent/EP1838713A2/en not_active Withdrawn
- 2006-01-12 MX MX2007008381A patent/MX2007008381A/es active IP Right Grant
- 2006-01-12 WO PCT/US2006/001020 patent/WO2006076455A2/en not_active Ceased
- 2006-01-12 HN HN2006001493A patent/HN2006001493A/es unknown
- 2006-01-12 CN CNA2006800064543A patent/CN101142216A/zh not_active Withdrawn
- 2006-01-12 EA EA200701500A patent/EA013968B1/ru not_active IP Right Cessation
- 2006-01-12 AR ARP060100122A patent/AR052557A1/es not_active Application Discontinuation
- 2006-01-12 KR KR1020077018365A patent/KR20070114126A/ko not_active Withdrawn
- 2006-01-12 US US11/331,372 patent/US7425630B2/en not_active Expired - Fee Related
-
2007
- 2007-07-02 IL IL184365A patent/IL184365A0/en unknown
- 2007-07-03 CR CR9224A patent/CR9224A/es unknown
- 2007-07-06 ZA ZA200705279A patent/ZA200705279B/xx unknown
- 2007-08-06 NO NO20074052A patent/NO20074052L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA013968B1 (ru) | 2010-08-30 |
| IL184365A0 (en) | 2007-10-31 |
| KR20070114126A (ko) | 2007-11-29 |
| DOP2006000009A (es) | 2006-08-15 |
| US20060154940A1 (en) | 2006-07-13 |
| US7425630B2 (en) | 2008-09-16 |
| CR9224A (es) | 2007-10-23 |
| HN2006001493A (es) | 2010-08-19 |
| WO2006076455A2 (en) | 2006-07-20 |
| NO20074052L (no) | 2007-09-12 |
| PE20061118A1 (es) | 2006-10-13 |
| EP1838713A2 (en) | 2007-10-03 |
| BRPI0606115A2 (pt) | 2009-06-02 |
| CA2593345A1 (en) | 2006-07-20 |
| WO2006076455A8 (en) | 2006-11-02 |
| CN101142216A (zh) | 2008-03-12 |
| TW200637865A (en) | 2006-11-01 |
| GT200600011A (es) | 2006-08-10 |
| EA200701500A1 (ru) | 2007-12-28 |
| JP2008526975A (ja) | 2008-07-24 |
| PA8659701A1 (es) | 2006-09-08 |
| ZA200705279B (en) | 2008-11-26 |
| MX2007008381A (es) | 2007-09-07 |
| AU2006204940A1 (en) | 2006-07-20 |
| WO2006076455A3 (en) | 2006-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |