BRPI0606115A2 - processos para a preparação de compostos éteres de pirazol [3,4-d] pirimidina - Google Patents

processos para a preparação de compostos éteres de pirazol [3,4-d] pirimidina

Info

Publication number
BRPI0606115A2
BRPI0606115A2 BRPI0606115-0A BRPI0606115A BRPI0606115A2 BR PI0606115 A2 BRPI0606115 A2 BR PI0606115A2 BR PI0606115 A BRPI0606115 A BR PI0606115A BR PI0606115 A2 BRPI0606115 A2 BR PI0606115A2
Authority
BR
Brazil
Prior art keywords
processes
pyrazol
ether compounds
preparation
pyrimidine
Prior art date
Application number
BRPI0606115-0A
Other languages
English (en)
Inventor
Tawfik Gharbaqui
Edward A Lally
Naomi S Kato
Marlon Carlos
Natalie Rodriguez
Dipanjan Sengupta
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of BRPI0606115A2 publication Critical patent/BRPI0606115A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

PROCESSOS PARA A PREPARAçãO DE COMPOSTOS DE éTERES DE PIRAZOL[3,4-d]PIRIMIDINA. A presente invenção refere-se a processos para preparação de compostos de éteres de pirazol[3,4-d]pirimidina que são moduladores de metabolismo de glicose e, portanto, úteis no tratamento de doenças metabólicas, tais como diabetes e obesidade.
BRPI0606115-0A 2005-01-13 2006-01-12 processos para a preparação de compostos éteres de pirazol [3,4-d] pirimidina BRPI0606115A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64371205P 2005-01-13 2005-01-13
PCT/US2006/001020 WO2006076455A2 (en) 2005-01-13 2006-01-12 Processes for preparing pyrazolo[3,4-d]pyrimidine ethers

Publications (1)

Publication Number Publication Date
BRPI0606115A2 true BRPI0606115A2 (pt) 2009-06-02

Family

ID=36463499

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606115-0A BRPI0606115A2 (pt) 2005-01-13 2006-01-12 processos para a preparação de compostos éteres de pirazol [3,4-d] pirimidina

Country Status (22)

Country Link
US (1) US7425630B2 (pt)
EP (1) EP1838713A2 (pt)
JP (1) JP2008526975A (pt)
KR (1) KR20070114126A (pt)
CN (1) CN101142216A (pt)
AR (1) AR052557A1 (pt)
AU (1) AU2006204940A1 (pt)
BR (1) BRPI0606115A2 (pt)
CA (1) CA2593345A1 (pt)
CR (1) CR9224A (pt)
DO (1) DOP2006000009A (pt)
EA (1) EA013968B1 (pt)
GT (1) GT200600011A (pt)
HN (1) HN2006001493A (pt)
IL (1) IL184365A0 (pt)
MX (1) MX2007008381A (pt)
NO (1) NO20074052L (pt)
PA (1) PA8659701A1 (pt)
PE (1) PE20061118A1 (pt)
TW (1) TW200637865A (pt)
WO (1) WO2006076455A2 (pt)
ZA (1) ZA200705279B (pt)

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DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
ATE374766T1 (de) 2003-01-14 2007-10-15 Arena Pharm Inc 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie
MXPA06000554A (es) * 2003-07-14 2006-07-03 Arena Pharm Inc Derivados arilo y heteroarilo fusionados como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con los mismos.
US7923465B2 (en) * 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
CA2706018C (en) 2007-11-30 2015-11-24 Boehringer Ingelheim International Gmbh 1, 5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators for the treatment of cns disorders
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
EP2318404B1 (en) * 2008-07-16 2013-08-21 Merck Sharp & Dohme Corp. Bicyclic heterocycle derivatives and use thereof as gpr119 modulators
US9079905B2 (en) 2008-09-08 2015-07-14 Boehringer Ingelheim International Gmbh Compounds for the treatment of CNS disorders
MY156377A (en) 2009-03-31 2016-02-15 Boehringer Ingelheim Int 1-heterocycl-1, 5-dihydro-pyrazolo [3 , 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
US20100285145A1 (en) * 2009-05-08 2010-11-11 Pfizer Inc Gpr 119 modulators
KR20120061063A (ko) * 2009-06-05 2012-06-12 화이자 인코포레이티드 Ｇｐｒ 119 조절제로서의 ｌ-(피페리딘-4-일)-피라졸 유도체
EP3378854B1 (en) 2010-01-27 2022-12-21 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
GEP20156217B (en) 2010-08-12 2015-01-12 Boehringer Ingelheim Int 6-cycloalkyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors
BR112013008100A2 (pt) 2010-09-22 2016-08-09 Arena Pharm Inc "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
AU2012267556B9 (en) 2011-06-09 2017-05-11 Rhizen Pharmaceuticals Sa Novel compounds as modulators of GPR-119
JP6567276B2 (ja) * 2014-05-13 2019-08-28 ソニーセミコンダクタソリューションズ株式会社 固体撮像素子、および電子機器
RU2709786C2 (ru) * 2014-12-06 2019-12-20 Интра-Селлулар Терапиз, Инк. Органические соединения
US11007175B2 (en) 2015-01-06 2021-05-18 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
NZ738862A (en) 2015-06-22 2023-12-22 Arena Pharm Inc Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(compound1) for use in sipi receptor-associated disorders
CA3053418A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
JP2019122134A (ja) 2018-01-04 2019-07-22 Ntn株式会社 スイッチング電源の力率改善用ｐｗｍ制御装置
WO2022268935A2 (en) * 2021-06-23 2022-12-29 F. Hoffmann-La Roche Ag Novel process

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3070304D1 (en) 1980-04-28 1985-04-25 Teijin Ltd Thiazolo(3,2-a)pyrimidine derivatives, process for preparing same, and drug containing same
EP0053678A1 (de) * 1980-12-05 1982-06-16 BASF Aktiengesellschaft 5-Amino-1-phenyl-4-cyanpyrazole, diese enthaltende herbizide Mittel, Verfahren zu ihrer Herstellung und ihre Anwendung als Herbizide
US4612376A (en) 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
GB9114760D0 (en) 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
JP4022271B2 (ja) 1995-10-31 2007-12-12 富士フイルム株式会社 ピラゾリルアゾフエノール色素
US6921763B2 (en) * 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
CA2385747A1 (en) * 1999-09-17 2001-03-22 Gavin C. Hirst Pyrazolopyrimidines as therapeutic agents
DE10219435A1 (de) 2002-05-02 2003-11-13 Bayer Cropscience Ag Substituierte Pyrazolo-pyrimidin-4-one
AU2003261204A1 (en) 2002-07-23 2004-02-09 Smithkline Beecham Corporation Pyrazolopyrimidines as kinase inhibitors
MXPA06000554A (es) * 2003-07-14 2006-07-03 Arena Pharm Inc Derivados arilo y heteroarilo fusionados como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con los mismos.
GB0425035D0 (en) 2004-11-12 2004-12-15 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
ZA200705279B (en) 2008-11-26
WO2006076455A3 (en) 2006-12-07
GT200600011A (es) 2006-08-10
NO20074052L (no) 2007-09-12
HN2006001493A (es) 2010-08-19
DOP2006000009A (es) 2006-08-15
JP2008526975A (ja) 2008-07-24
AR052557A1 (es) 2007-03-21
PE20061118A1 (es) 2006-10-13
CR9224A (es) 2007-10-23
US20060154940A1 (en) 2006-07-13
CA2593345A1 (en) 2006-07-20
US7425630B2 (en) 2008-09-16
IL184365A0 (en) 2007-10-31
EP1838713A2 (en) 2007-10-03
CN101142216A (zh) 2008-03-12
EA200701500A1 (ru) 2007-12-28
WO2006076455A2 (en) 2006-07-20
TW200637865A (en) 2006-11-01
AU2006204940A1 (en) 2006-07-20
WO2006076455A8 (en) 2006-11-02
KR20070114126A (ko) 2007-11-29
MX2007008381A (es) 2007-09-07
EA013968B1 (ru) 2010-08-30
PA8659701A1 (es) 2006-09-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012.