AR047619A1 - Producto farmaceutico estabilizado - Google Patents

Producto farmaceutico estabilizado

Info

Publication number
AR047619A1
AR047619A1 ARP040101868A ARP040101868A AR047619A1 AR 047619 A1 AR047619 A1 AR 047619A1 AR P040101868 A ARP040101868 A AR P040101868A AR P040101868 A ARP040101868 A AR P040101868A AR 047619 A1 AR047619 A1 AR 047619A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical product
product according
stable pharmaceutical
medicament
adsorbent material
Prior art date
Application number
ARP040101868A
Other languages
English (en)
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Publication of AR047619A1 publication Critical patent/AR047619A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/06—Packaging for specific medical equipment

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Mechanical Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

El uso de un adsorbente y un envase hermético (por ejemplo una envoltura superior) para proteger un producto farmacéutico en estado solido en presencia de un azucar reductor. Reivindicacion 1: Un producto farmacéutico estable que comprende: a) una composicion farmacéutica en estado solido, que comprende un medicamento y un azucar reductor; b) una cantidad efectiva de un material adsorbente; y c) un envase hermético que es sustancialmente impermeable a la humedad, que encierra un volumen dentro del cual se encuentran la composicion farmacéutica y el material adsorbente. Reivindicacion 2: El producto farmacéutico estable de acuerdo con la reivindicacion 1, que además comprende un inhalador de polvo seco que alberga a dicha composicion farmacéutica. Reivindicacion 10: El producto farmacéutico estable de acuerdo con cualquiera de las reivindicaciones 1 a 9, en el cual se utiliza dicho medicamento en el tratamiento de una enfermedad respiratoria. Reivindicacion 11: El producto farmacéutico estable de acuerdo con la reivindicacion 10, en el cual dicho medicamento comprende un anti-inflamatorio, un agonista beta 2, un anticolinérgico o una combinacion de los mismos. Reivindicacion 12: El producto farmacéutico estable de acuerdo a la reivindicacion 11, en el cual dicho anti-inflamatorio comprende un corticoesteroide, un estabilizador de mastocitos o un modificador del leucotrieno. Reivindicacion 14: El producto farmacéutico estable de acuerdo con cualquiera de las reivindicaciones 1 a 13, en el cual dicho medicamento es formoterol. Reivindicacion 29: El producto farmacéutico estable de acuerdo con la reivindicacion 12 o la reivindicacion 26, en el cual dicho corticoesteroide es ciclesonida. Reivindicacion 34: El producto farmacéutico estable de acuerdo con la reivindicacion 11 o la reivindicacion 25, en el cual dicho anticolinérgico es seleccionado entre el grupo que consiste en bromuro de ipratropio, bromuro de tiotropio y una mezcla de los mismos. Reivindicacion 35: El producto farmacéutico estable de acuerdo estable de acuerdo con cualquiera de las reivindicaciones 1 a 34, en el cual dicho material adsorbente es seleccionado entre el grupo que consiste en un tamiz molecular, una arcilla activada, un carbon vegetal, una alumina activada, sílice, una zeolita, una bauxita y una mezcla de los mismos. Reivindicacion 46: Un método para prevenir la formacion de uno o más productos de Maillard debido a una reaccion química entre un medicamento de un producto farmacéutico de acuerdo con la reivindicacion 1, método que comprende los siguientes pasos: (i) colocar una cantidad efectiva del material adsorbente y la composicion farmacéutica dentro de un envase hermético; (ii) cerrar el envase para formar el envase hermético de tal manera que la composicion farmacéutica y el material adsorbente se encuentren en el volumen confinado al interior del envase; y (iii) adsorber la humedad en un envase a fin de prevenir la formacion de uno o más productos de Maillard.
ARP040101868A 2003-05-28 2004-05-28 Producto farmaceutico estabilizado AR047619A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0312148.0A GB0312148D0 (en) 2003-05-28 2003-05-28 Stabilized pharmaceutical products

Publications (1)

Publication Number Publication Date
AR047619A1 true AR047619A1 (es) 2006-02-01

Family

ID=9958829

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101868A AR047619A1 (es) 2003-05-28 2004-05-28 Producto farmaceutico estabilizado

Country Status (22)

Country Link
US (4) US7736673B2 (es)
EP (1) EP1626913B1 (es)
JP (1) JP5175048B2 (es)
KR (1) KR20060023539A (es)
CN (1) CN1832890A (es)
AR (1) AR047619A1 (es)
AT (1) ATE457163T1 (es)
AU (1) AU2004243223A1 (es)
BR (1) BRPI0410701A (es)
CA (1) CA2527088C (es)
DE (1) DE602004025463D1 (es)
ES (1) ES2340681T3 (es)
GB (1) GB0312148D0 (es)
MA (1) MA27804A1 (es)
MX (1) MXPA05012757A (es)
NO (1) NO20055443L (es)
PL (1) PL1626913T3 (es)
RS (1) RS20050882A (es)
RU (1) RU2337667C2 (es)
TW (1) TW200509989A (es)
WO (1) WO2004105727A2 (es)
ZA (1) ZA200509099B (es)

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GB0312148D0 (en) * 2003-05-28 2003-07-02 Aventis Pharma Ltd Stabilized pharmaceutical products
US8435497B2 (en) 2003-06-13 2013-05-07 Takeda Gmbh Formoterol of and ciclesonide combination
GB0315889D0 (en) 2003-07-08 2003-08-13 Aventis Pharma Ltd Stable pharmaceutical products
EP1803457A1 (en) * 2005-12-30 2007-07-04 Krka Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical composition containing montelukast
EP1976522B2 (en) * 2005-12-30 2019-07-03 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition containing montelukast
WO2007109606A2 (en) * 2006-03-17 2007-09-27 Csp Technologies, Inc. Moisture-tight primary packaging for a dry powder inhaler
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KR101851425B1 (ko) 2011-09-02 2018-04-23 네스텍 소시에테아노님 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링
WO2013109212A1 (en) * 2012-01-16 2013-07-25 Mahmut Bilgic Dry powder formulations comprising ciclesonide
KR20130140358A (ko) 2012-06-14 2013-12-24 한미약품 주식회사 살메테롤 지나포산염, 플루티카손 프로피오네이트 및 티오트로피움 브로마이드를 포함하는 흡입 제형용 건조 분말 및 이의 제조방법
EP2954329A1 (en) 2013-02-05 2015-12-16 Nestec S.A. Methods of selecting combination therapy for colorectal cancer patients
CN104644618A (zh) * 2013-11-19 2015-05-27 上海医药工业研究院 一种干粉吸入剂及其制备方法
PL3681475T3 (pl) * 2017-10-16 2021-07-05 Faes Farma, S.A. Wodne kompozycje zawierające bilastynę i mometazon
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
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Also Published As

Publication number Publication date
US20110308975A1 (en) 2011-12-22
KR20060023539A (ko) 2006-03-14
US20100247585A1 (en) 2010-09-30
EP1626913A2 (en) 2006-02-22
MA27804A1 (fr) 2006-03-01
DE602004025463D1 (de) 2010-03-25
BRPI0410701A (pt) 2006-06-13
US20120247982A1 (en) 2012-10-04
ES2340681T3 (es) 2010-06-08
RU2005136869A (ru) 2006-06-10
US8440210B2 (en) 2013-05-14
US8163299B2 (en) 2012-04-24
CA2527088A1 (en) 2004-12-09
US20060147537A1 (en) 2006-07-06
WO2004105727A2 (en) 2004-12-09
US8029811B2 (en) 2011-10-04
US7736673B2 (en) 2010-06-15
JP2007504277A (ja) 2007-03-01
PL1626913T3 (pl) 2010-07-30
RU2337667C2 (ru) 2008-11-10
JP5175048B2 (ja) 2013-04-03
AU2004243223A1 (en) 2004-12-09
WO2004105727A3 (en) 2005-06-16
CA2527088C (en) 2011-03-01
MXPA05012757A (es) 2006-02-13
NO20055443L (no) 2005-11-17
TW200509989A (en) 2005-03-16
EP1626913B1 (en) 2010-02-10
ATE457163T1 (de) 2010-02-15
GB0312148D0 (en) 2003-07-02
ZA200509099B (en) 2006-08-30
RS20050882A (en) 2007-12-31
CN1832890A (zh) 2006-09-13

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