AR047165A1 - Derivados de piperazin sulfonilo y composiciones farmaceuticas - Google Patents

Derivados de piperazin sulfonilo y composiciones farmaceuticas

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Publication number
AR047165A1
AR047165A1 ARP040104871A ARP040104871A AR047165A1 AR 047165 A1 AR047165 A1 AR 047165A1 AR P040104871 A ARP040104871 A AR P040104871A AR P040104871 A ARP040104871 A AR P040104871A AR 047165 A1 AR047165 A1 AR 047165A1
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AR
Argentina
Prior art keywords
alkyl
heteroaryl
cycloalkyl
aryl
alkoxy
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Application number
ARP040104871A
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English (en)
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Amgen Sf Llc
Japan Tobacco Inc
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Application filed by Amgen Sf Llc, Japan Tobacco Inc filed Critical Amgen Sf Llc
Publication of AR047165A1 publication Critical patent/AR047165A1/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
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  • Obesity (AREA)
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Abstract

La presente se refiere a derivados de piperazin sulfonilo y composiciones farmacéuticas. Reivindicacion 1: Un compuesto que tiene la formula (1), o sales, solvatos, estereoisomeros o profármacos del mismo farmacéuticamente aceptables, donde: R1, R2 y R3 están independientemente seleccionados de -H, -halo, -OH, -CN, -NO2, -alquilo C1-8, -alquenilo C2-8, -alquinilo C2-8, -alcoxi, -haloalquilo, -hidroxialquilo, -cicloalquilo, -heterocicloalquilo, -heteroarilo y -arilo, y por lo menos uno de R1, R2 y R3 es distinto de -H; R4 es -H, -halo, -CN, -NO2, -alquilo C1-8, -alquenilo C2-8, -alquinilo C2-8, -alcoxi, -haloalquilo, -hidroxialquilo C2-8, -cicloalquilo, -heterocicloalquilo, -heteroarilo, -arilo, -cicloalquil-(alquilo C1-6), -heterociclo- (alquilo C1-6), -heteroaril-(alquilo C1-6), -aril-(alquilo C1-6), -C(O)R', -C(O)OR', -C(O)N(R')2, -C(OR')R', -OR', -SR', -OC(O)R', -C(O)N(R')2, -S(O)R', -SO2R', -SO2N(R')2, -N(R')2 o -NR'C(O)R'; R5 es -H, -halo, -CN, -NO2, -alquilo C1-8, -alquenilo C2-8, -alquinilo C2-8, -alcoxi, -haloalquilo, -hidroxialquilo, -cicloalquilo, -heterocicloalquilo, -heteroarilo, -arilo, -cicloalquil-(alquilo C1-6), -heterociclo-(alquilo C1-6), -heteroaril-(alquilo C1-6), -aril-(alquilo C1-6), -C(O)R', -C(O)OR', - C(O)N(R')2, -C(OR')R', - OR', -SR', -OC(O)R', -C(O)N(R')2, -S(O)R', -SO2R', -SO2N(R')2, -N(R')2 o -NR'C(O)R' o R5 o R5 y R6, juntamente con el átomo de carbono al cual están unidos, se unen para formar un anillo cicloalcano opcionalmente sustituido; R6 está seleccionado de -H, -halo, -CN, -NO2, -alquilo C1-8, -alquenilo C2-8, -alquinilo C2-8, -alcoxi, -haloalquilo, -hidroxialquilo, -cicloalquilo, -heterocicloalquilo, -heteroarilo, -arilo, -cicloalquil-(alquilo C1-6), -heterociclo-(alquilo C1- 6), -heteroaril-(alquilo C1-6), -aril-(alquilo C1-6), -C(O)R', -C(O)OR', -C(O)N(R')2, -C(OR')R', -OR', -SR', -OC(O)R', -C(O)N(R')2, -S(O)R', -SO2R', -SO2N(R')2, -N(R')2 o -NR'C(O)R'; R7 está seleccionado del grupo que consiste en -H, -halo, -CN, - NO2, -amino y -alquilo C1-8; Q está seleccionado del grupo que consiste en -H, -halo, -CN, -NO2, -alquilo C1-8, -alquenilo C2-8, -alquinilo C2-8, -alcoxi, -haloalquilo, -hidroxialquilo, -cicloalquilo, -heterocicloalquilo, -heteroarilo, -arilo, - cicloalquil-(alquilo C1-6), -heterociclo-(alquilo C1-6), -heteroaril-(alquilo C1-6), -aril-(alquilo C1-6), -C(O)R', -C(O)OR', -C(O)N(R')2, -C(OR')R', -OR', -SR', -OC(O)R', -C(O)N(R')2, -S(O)R', -SO2R', -SO2N(R')2, -N(R')2 o -NR'C(O)R'; L1 es un enlace directo, -alquileno C1-7- o -heteroalquileno C1-7-; L2 es un enlace directo, -alquileno C1-7- o -heteroalquileno C1-7-; cada vez que aparece R' es independientemente -H, -alquilo C1-8, -alquenilo C2-8, -alquinilo C2-8, -alcoxi, - alcoxialquilo, -haloalquilo, -hidroxialquilo, -cicloalquilo, -heterocicloalquilo, -heteroarilo, -arilo, -cicloalquil-(alquilo C1-6), -heterociclo-(alquilo C1-6), -heteroaril-(alquilo C1-6) o -aril-(alquilo C1-6) o dos grupos R' cuando están unidos al mismo átomo de nitrogeno, pueden combinarse con el átomo de nitrogeno al cual están unidos para formar un grupo heterocíclico o heteroarílico; y donde cuando R1, R2 y R3 son cada uno -F o -CH3, R4 es distinto de -H; y dicho compuesto es distinto del resto del grupo de formulas (2), donde Ra está seleccionado de 4-metoxifenilo, -4-clorofenilo y 4-bromofenilo y Rb es 4-fluorfenilo o 4-bromofenilo.
ARP040104871A 2003-12-22 2004-12-22 Derivados de piperazin sulfonilo y composiciones farmaceuticas AR047165A1 (es)

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US (1) US7365075B2 (es)
EP (1) EP1703908A4 (es)
JP (1) JP2007515490A (es)
AR (1) AR047165A1 (es)
AU (1) AU2004308932A1 (es)
CA (1) CA2548309A1 (es)
TW (1) TW200533335A (es)
WO (1) WO2005063247A1 (es)

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