AR047087A1 - Derivados de 4-aril-piperidinas con actividad antagonista de la mch1 y composiciones farmaceuticas que las contienen como principio activo. - Google Patents
Derivados de 4-aril-piperidinas con actividad antagonista de la mch1 y composiciones farmaceuticas que las contienen como principio activo.Info
- Publication number
- AR047087A1 AR047087A1 ARP050100036A ARP050100036A AR047087A1 AR 047087 A1 AR047087 A1 AR 047087A1 AR P050100036 A ARP050100036 A AR P050100036A AR P050100036 A ARP050100036 A AR P050100036A AR 047087 A1 AR047087 A1 AR 047087A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutically acceptable
- mch1
- derivatives
- alkyl
- independently
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de 4-aril piperidinas y compuestos heterocíclicos relacionados que son antagonistas selectivos para los receptores de la hormona-1 concentradora de melanina (MCH1). Una composicion farmacéutica que comprende una cantidad terapéuticamente eficaz de estos compuestos y un portador farmacéuticamente aceptable. También se provee una composicion farmacéutica preparada mediante la combinacion de una cantidad terapéuticamente eficaz del compuesto y un portador farmacéuticamente aceptable. Y un procedimiento para la preparacion de una composicion farmacéutica que comprende combinar una cantidad terapéuticamente eficaz del compuesto considerado y un portador farmacéuticamente aceptable. Las 4-aril-piperidinas consideradas poseen actividad reductora de la masa corporal de un individuo. Estos compuestos pueden ser utilizados para el tratamiento de un individuo que sufre de depresion y/o ansiedad. Reivindicacion 1: Un compuesto que tiene la estructura (1) donde cada X es independientemente CR1 o N, con la condicion de que si una X es N entonces los X remanentes son CR1; donde cada R1 es independientemente -H, -F, -Cl. -Br, -I, -CN, -NO2, alquilo C1-7 de cadena recta o ramificada, alquiloxi, monofluoralquilo o polifluoralquilo, o cicloalquilo C3-6-alquilo C1-7; donde cada R2 es independientemente -H, -F, -Cl. -Br, -I, -CN, -NO2 o alquilo C1-7 de cadena recta o ramificada, monofluoralquilo o polifluoralquilo; donde n es un numero entero de 2 a 6 inclusive; donde B es CH2, CHOH, O o CO; donde Y es C o N; donde Z es O, S, SO, SO2, CH2, CO, CHOH o nada; y en el cual A es fenilo o heteroarilo, donde el fenilo o heteroarilo está opcionalmente sustituido con tres o menos R2; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/757,962 US20050154020A1 (en) | 2004-01-14 | 2004-01-14 | 4-Aryl piperidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR047087A1 true AR047087A1 (es) | 2006-01-04 |
Family
ID=34740114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100036A AR047087A1 (es) | 2004-01-14 | 2005-01-06 | Derivados de 4-aril-piperidinas con actividad antagonista de la mch1 y composiciones farmaceuticas que las contienen como principio activo. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20050154020A1 (es) |
| EP (1) | EP1708704A4 (es) |
| JP (1) | JP2007517906A (es) |
| KR (1) | KR20060125825A (es) |
| CN (1) | CN1909904A (es) |
| AR (1) | AR047087A1 (es) |
| AU (1) | AU2005206873A1 (es) |
| BR (1) | BRPI0506814A (es) |
| CA (1) | CA2552362A1 (es) |
| EA (1) | EA011029B1 (es) |
| IL (1) | IL176791A0 (es) |
| MX (1) | MXPA06007660A (es) |
| NO (1) | NO20063650L (es) |
| UA (1) | UA85575C2 (es) |
| WO (1) | WO2005069834A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050154022A1 (en) * | 2004-01-14 | 2005-07-14 | H. Lundbeck A/S | 4-aryl piperidines |
| EP1845081A4 (en) * | 2005-02-01 | 2009-03-25 | Takeda Pharmaceutical | amide |
| KR100893394B1 (ko) * | 2007-05-11 | 2009-04-17 | 한국화학연구원 | 아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물 |
| EP2583965B1 (en) | 2010-07-15 | 2017-01-25 | Takeda Pharmaceutical Company Limited | Heterocyclic ring compound |
| GB201419976D0 (en) | 2014-11-10 | 2014-12-24 | Univ Newcastle | Biomarkers for disease progression in melanoma |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2058061T3 (es) * | 1985-10-25 | 1994-11-01 | Beecham Group Plc | Derivado de piperidina, su preparacion y su uso como medicamento. |
| US5382583A (en) * | 1989-04-22 | 1995-01-17 | John Wyeth & Brother, Limited | Piperazine derivatives |
| US6326381B1 (en) * | 1998-12-17 | 2001-12-04 | American Home Products Corporation | Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates |
| UA77536C2 (en) * | 2002-07-03 | 2006-12-15 | Lundbeck & Co As H | Secondary aminoaniline piperidines as mch1 antagonists and their use |
-
2004
- 2004-01-14 US US10/757,962 patent/US20050154020A1/en not_active Abandoned
-
2005
- 2005-01-06 AR ARP050100036A patent/AR047087A1/es not_active Application Discontinuation
- 2005-01-13 AU AU2005206873A patent/AU2005206873A1/en not_active Abandoned
- 2005-01-13 EP EP05711430A patent/EP1708704A4/en not_active Withdrawn
- 2005-01-13 CA CA002552362A patent/CA2552362A1/en not_active Abandoned
- 2005-01-13 JP JP2006549604A patent/JP2007517906A/ja not_active Withdrawn
- 2005-01-13 KR KR1020067013180A patent/KR20060125825A/ko not_active Application Discontinuation
- 2005-01-13 MX MXPA06007660A patent/MXPA06007660A/es unknown
- 2005-01-13 EA EA200601315A patent/EA011029B1/ru not_active IP Right Cessation
- 2005-01-13 BR BRPI0506814-2A patent/BRPI0506814A/pt not_active IP Right Cessation
- 2005-01-13 UA UAA200608045A patent/UA85575C2/ru unknown
- 2005-01-13 WO PCT/US2005/001131 patent/WO2005069834A2/en active Application Filing
- 2005-01-13 CN CNA200580002257XA patent/CN1909904A/zh active Pending
-
2006
- 2006-07-11 IL IL176791A patent/IL176791A0/en unknown
- 2006-08-11 NO NO20063650A patent/NO20063650L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1708704A4 (en) | 2009-08-05 |
| BRPI0506814A (pt) | 2007-06-05 |
| EA011029B1 (ru) | 2008-12-30 |
| WO2005069834A3 (en) | 2006-04-27 |
| JP2007517906A (ja) | 2007-07-05 |
| KR20060125825A (ko) | 2006-12-06 |
| CN1909904A (zh) | 2007-02-07 |
| CA2552362A1 (en) | 2005-08-04 |
| AU2005206873A1 (en) | 2005-08-04 |
| IL176791A0 (en) | 2006-10-31 |
| EA200601315A1 (ru) | 2006-12-29 |
| EP1708704A2 (en) | 2006-10-11 |
| WO2005069834A2 (en) | 2005-08-04 |
| NO20063650L (no) | 2006-08-11 |
| MXPA06007660A (es) | 2006-09-04 |
| UA85575C2 (en) | 2009-02-10 |
| US20050154020A1 (en) | 2005-07-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |