AR051334A1 - Derivados de 2- amido-4-feniltiazol - Google Patents
Derivados de 2- amido-4-feniltiazolInfo
- Publication number
- AR051334A1 AR051334A1 ARP050104349A ARP050104349A AR051334A1 AR 051334 A1 AR051334 A1 AR 051334A1 AR P050104349 A ARP050104349 A AR P050104349A AR P050104349 A ARP050104349 A AR P050104349A AR 051334 A1 AR051334 A1 AR 051334A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- group
- cycloalkyl
- trifluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Composiciones farmacéuticas que los contienen, usos terapéuticos y método de preparacion. Reivindicacion 1: Compuesto de formula (1), en la cual: R1 representa un átomo de hidrogeno o de halogeno, un grupo alquilo-C1-4, trifluoro-alquilo-C1-4, hidroxilo, alcoxi-C1-4, trifluoro-alcoxi-C1-4, cicloalquil-C3-10-alcoxi-C1-4, cicloalquiloxi-C3-10, aliloxi, alquiltio-C1-4; R2 representa un átomo de hidrogeno o de halogeno, un grupo hidroxilo, alquilo-C1-4, trifluoro-alquilo-C1-4, perfluoro- alquilo-C1-4, cicloalquilo-C3-10, alcoxi-C1-4, cicloalquil-C3-10-alcoxi-C1-4, cicloalquiloxi-C3-10, aliloxi, cicloalquil-C3-8-alquilo-C1-4; Y representa un átomo de hidrogeno o un halogeno; y R3 representa: un grupo fenilo, sustituido por uno o varios átomos de halogeno y/o por uno o varios grupos; alquilo-C1-6; alcoxi-C1-6; -NO2; ciano; -COR4; -SO2R4; -CO2R4, en el cual R4 representa un grupo alquilo-C1-4; y -(CH2)qNR5R6 en el cual R5 y r6 representan independientemente el uno del otro un átomo de hidrogeno, un grupo alquilo-C1-4 o R5 y R6 forman juntos con el átomo de nitrogeno al cual están unidos un grupo cicloalquilo de 5 o 6 eslabones y q representan 0, 1 o 2; un grupo heterociclo eventualmente sustituido por uno o varios halogenos y/o por uno o varios grupos: alquilo-C1-4; hidroxilo; alcoxi-C1-4; ciano; morfolino; trifluoro-alquilo-C1-4; -COR4; -SO2R4, en el cual R4 es tal como se define en lo que se precede, -(CH2)qNR5R6, en el cual R5, R6 y q son tales como se definen en lo que precede; fenilo; piridina; y -SCH3; estando el o los átomos de nitrogeno del grupo heterocíclico eventualmente sustituido por un grupo alquilo-C1-4; estando el o los átomos de nitrogeno del grupo heterocíclico eventualmente bajo su forma de N-oxido; un grupo heterobicíclico eventualmente sustituido por uno o varios halogenos y/o por uno o varios grupos hidroxilos, alquilo-C1-4 o alcoxi-C1-4; m representa 2, 3 o 4; n representa 0, 1 o 2; y p representa 0, 1, 2 o 3; en el estado de base o de sal de adicion a un ácido farmacéuticamente aceptable, en estado de hidratos o de solvatos, así como en forma de enantiomeros, de diastereoisomeros y su mezcla.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0411083A FR2876692B1 (fr) | 2004-10-19 | 2004-10-19 | Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051334A1 true AR051334A1 (es) | 2007-01-03 |
Family
ID=34950743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104349A AR051334A1 (es) | 2004-10-19 | 2005-10-18 | Derivados de 2- amido-4-feniltiazol |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7598392B2 (es) |
| EP (1) | EP1807421B1 (es) |
| JP (1) | JP2008517042A (es) |
| KR (1) | KR20070085395A (es) |
| CN (1) | CN101065376A (es) |
| AR (1) | AR051334A1 (es) |
| AT (1) | ATE502035T1 (es) |
| AU (1) | AU2005296958A1 (es) |
| BR (1) | BRPI0518231A2 (es) |
| CA (1) | CA2584774A1 (es) |
| DE (1) | DE602005026964D1 (es) |
| EA (1) | EA200700901A1 (es) |
| EC (1) | ECSP077402A (es) |
| FR (1) | FR2876692B1 (es) |
| GT (1) | GT200500292A (es) |
| IL (1) | IL182624A0 (es) |
| MA (1) | MA29017B1 (es) |
| MX (1) | MX2007004740A (es) |
| NO (1) | NO20072515L (es) |
| PA (1) | PA8649901A1 (es) |
| PE (1) | PE20060585A1 (es) |
| SV (1) | SV2006002274A (es) |
| TN (1) | TNSN07145A1 (es) |
| TW (1) | TW200630364A (es) |
| UY (1) | UY29169A1 (es) |
| WO (1) | WO2006042954A1 (es) |
| ZA (1) | ZA200703876B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2854158B1 (fr) | 2003-04-25 | 2006-11-17 | Sanofi Synthelabo | Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique |
| FR2872813B1 (fr) | 2004-07-09 | 2007-01-19 | Sanofi Synthelabo | Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique |
| WO2007070600A2 (en) * | 2005-12-12 | 2007-06-21 | Genelabs Technologies, Inc. | N-(5-membered heteroaromatic ring)-amido anti-viral compounds |
| FR2895989B1 (fr) | 2006-01-06 | 2010-04-30 | Sanofi Aventis | Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique |
| US20100331298A1 (en) * | 2007-12-10 | 2010-12-30 | Cytopathfinder, Inc. | Carboxamide Compounds and Their Use |
| CN101925383A (zh) | 2007-12-11 | 2010-12-22 | 赛特帕斯凡德株式会社 | 甲酰胺化合物及其作为趋化因子受体激动剂的应用 |
| WO2010007046A2 (en) * | 2008-07-15 | 2010-01-21 | Novartis Ag | Organic compounds |
| KR101680818B1 (ko) * | 2008-12-22 | 2016-11-29 | 케모센트릭스, 인크. | Ｃ5ａｒ 길항제 |
| PE20140471A1 (es) | 2011-01-04 | 2014-04-13 | Novartis Ag | Moduladores de la via del complemento y usos de los mismos |
| ES2648962T3 (es) | 2012-06-28 | 2018-01-09 | Novartis Ag | Derivados de pirrolidina y su uso como moduladores de la vía del complemento |
| EP2867225B1 (en) | 2012-06-28 | 2017-08-09 | Novartis AG | Pyrrolidine derivatives and their use as complement pathway modulators |
| WO2014002053A1 (en) | 2012-06-28 | 2014-01-03 | Novartis Ag | Pyrrolidine derivatives and their use as complement pathway modulators |
| EP2867226B1 (en) | 2012-06-28 | 2018-11-14 | Novartis AG | Complement pathway modulators and uses thereof |
| WO2014002058A2 (en) | 2012-06-28 | 2014-01-03 | Novartis Ag | Complement pathway modulators and uses thereof |
| WO2014009833A2 (en) | 2012-07-12 | 2014-01-16 | Novartis Ag | Complement pathway modulators and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2146898A (en) * | 1937-12-06 | 1939-02-14 | Int Harvester Co | Potato digger |
| FR2406634A1 (fr) | 1977-10-19 | 1979-05-18 | Fabre Sa Pierre | Immunostimulants derives d'amino thiazoles |
| FR2677356B1 (fr) | 1991-06-05 | 1995-03-17 | Sanofi Sa | Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant. |
| WO1993000342A1 (en) | 1991-06-21 | 1993-01-07 | Boehringer Mannheim Italia S.P.A. | 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract |
| US6506751B1 (en) | 1999-11-12 | 2003-01-14 | Millennium Pharmaceuticals, Inc. | Thiazolidinone compounds useful as chemokine inhibitors |
| US6852752B2 (en) * | 1999-12-17 | 2005-02-08 | Vicuron Pharmaceuticals Inc. | Urea compounds, compositions and methods of use and preparation |
| US6797820B2 (en) * | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
| WO2002051397A1 (fr) | 2000-12-22 | 2002-07-04 | Ishihara Sangyo Kaisha, Ltd. | Derives d'aniline ou sels de ceux-ci, ainsi qu'inhibiteurs de production de cytokine contenant ces derives |
| WO2003015778A1 (en) | 2001-08-17 | 2003-02-27 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| FR2854158B1 (fr) | 2003-04-25 | 2006-11-17 | Sanofi Synthelabo | Derives de 2-acylamino-4-phenylethiazole, leur preparation et leur application en therapeutique |
| TW200423931A (en) | 2003-04-30 | 2004-11-16 | Hoffmann La Roche | Novel aniline derivatives, their manufacture and use as pharmaceutical agents |
| FR2872813B1 (fr) | 2004-07-09 | 2007-01-19 | Sanofi Synthelabo | Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique |
| BRPI0519288A2 (pt) | 2004-12-24 | 2009-01-06 | Astrazeneca Ab | compostos heterocÍclicos como antagonistas de ccr2b |
| FR2895989B1 (fr) | 2006-01-06 | 2010-04-30 | Sanofi Aventis | Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique |
-
2004
- 2004-10-19 FR FR0411083A patent/FR2876692B1/fr not_active Expired - Fee Related
-
2005
- 2005-10-17 CA CA002584774A patent/CA2584774A1/fr not_active Abandoned
- 2005-10-17 KR KR1020077011308A patent/KR20070085395A/ko not_active Application Discontinuation
- 2005-10-17 UY UY29169A patent/UY29169A1/es not_active Application Discontinuation
- 2005-10-17 JP JP2007537324A patent/JP2008517042A/ja active Pending
- 2005-10-17 WO PCT/FR2005/002565 patent/WO2006042954A1/fr active Application Filing
- 2005-10-17 EP EP05809089A patent/EP1807421B1/fr active Active
- 2005-10-17 MX MX2007004740A patent/MX2007004740A/es not_active Application Discontinuation
- 2005-10-17 DE DE602005026964T patent/DE602005026964D1/de active Active
- 2005-10-17 GT GT200500292A patent/GT200500292A/es unknown
- 2005-10-17 BR BRPI0518231-0A patent/BRPI0518231A2/pt not_active IP Right Cessation
- 2005-10-17 AT AT05809089T patent/ATE502035T1/de not_active IP Right Cessation
- 2005-10-17 ZA ZA200703876A patent/ZA200703876B/xx unknown
- 2005-10-17 CN CNA2005800396968A patent/CN101065376A/zh active Pending
- 2005-10-17 AU AU2005296958A patent/AU2005296958A1/en not_active Withdrawn
- 2005-10-17 EA EA200700901A patent/EA200700901A1/ru unknown
- 2005-10-18 AR ARP050104349A patent/AR051334A1/es unknown
- 2005-10-18 TW TW094136365A patent/TW200630364A/zh unknown
- 2005-10-18 PA PA20058649901A patent/PA8649901A1/es unknown
- 2005-10-19 PE PE2005001227A patent/PE20060585A1/es not_active Application Discontinuation
- 2005-10-19 SV SV2005002274A patent/SV2006002274A/es unknown
-
2007
- 2007-04-17 IL IL182624A patent/IL182624A0/en unknown
- 2007-04-18 EC EC2007007402A patent/ECSP077402A/es unknown
- 2007-04-18 US US11/736,770 patent/US7598392B2/en not_active Expired - Fee Related
- 2007-04-19 TN TNP2007000145A patent/TNSN07145A1/fr unknown
- 2007-05-11 MA MA29894A patent/MA29017B1/fr unknown
- 2007-05-16 NO NO20072515A patent/NO20072515L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GT200500292A (es) | 2006-05-11 |
| TNSN07145A1 (fr) | 2008-11-21 |
| CA2584774A1 (fr) | 2006-04-27 |
| CN101065376A (zh) | 2007-10-31 |
| NO20072515L (no) | 2007-06-28 |
| TW200630364A (en) | 2006-09-01 |
| AU2005296958A1 (en) | 2006-04-27 |
| EP1807421B1 (fr) | 2011-03-16 |
| JP2008517042A (ja) | 2008-05-22 |
| MX2007004740A (es) | 2007-06-18 |
| ATE502035T1 (de) | 2011-04-15 |
| EP1807421A1 (fr) | 2007-07-18 |
| UY29169A1 (es) | 2006-05-31 |
| IL182624A0 (en) | 2007-07-24 |
| FR2876692B1 (fr) | 2007-02-23 |
| SV2006002274A (es) | 2006-06-28 |
| EA200700901A1 (ru) | 2007-10-26 |
| ZA200703876B (en) | 2008-12-31 |
| PE20060585A1 (es) | 2006-08-18 |
| MA29017B1 (fr) | 2007-11-01 |
| WO2006042954A8 (fr) | 2008-03-13 |
| US7598392B2 (en) | 2009-10-06 |
| BRPI0518231A2 (pt) | 2008-11-11 |
| FR2876692A1 (fr) | 2006-04-21 |
| WO2006042954A1 (fr) | 2006-04-27 |
| PA8649901A1 (es) | 2006-06-02 |
| ECSP077402A (es) | 2007-05-30 |
| KR20070085395A (ko) | 2007-08-27 |
| DE602005026964D1 (de) | 2011-04-28 |
| US20070259847A1 (en) | 2007-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |