AR046785A1 - Esteres de acido hidroxamico y uso farmaceutico de los mismos - Google Patents

Esteres de acido hidroxamico y uso farmaceutico de los mismos

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Publication number
AR046785A1
AR046785A1 ARP040104494A ARP040104494A AR046785A1 AR 046785 A1 AR046785 A1 AR 046785A1 AR P040104494 A ARP040104494 A AR P040104494A AR P040104494 A ARP040104494 A AR P040104494A AR 046785 A1 AR046785 A1 AR 046785A1
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AR
Argentina
Prior art keywords
alkoxy
heteroaryl
heterocycloalkyl
heterocycloalkenyl
amino
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ARP040104494A
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English (en)
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Leo Pharma As
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Publication of AR046785A1 publication Critical patent/AR046785A1/es

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Abstract

Compuestos de la fórmula general (1) en la cual R1 representa H o un radical hidrocarbonado saturado o insaturado recto o ramificado y/o cíclico, opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo que consiste en halógeno, hidroxilo, amino, nitro, y ciano; D representa N o C-R2; e representa N o C-R3; F representa N o C-R4; G representa N o C-R5; R2, R3, R4 y R5 son iguales o diferentes e individualmente representan H, halógeno, hidroxilo, amino, nitro, carboxi, ciano, alcoxi, alquiltio, alcoxicarbonilo, alquilcarboniloxi, alcoxicarboniloxi, alquilcarbonilo, alcoxisulfoniloxi, aminosulfonilo, alquilsulfonilamino, formilo, aminocarbonilo, alquilcarbonilamino, o un radical hidrocarbonado saturado o insaturado recto o ramificado, opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados del grupo que consiste en halógeno, hidroxilo, amino, nitro, carboxi, ciano, alcoxi, alquiltio, alcoxicarbonilo, alquilcarboniloxi, alcoxicarboniloxi, alquilcarbonilo, alcoxisulfoniloxi, aminosulfonilo, alquilsulfonilamino, formilo, aminocarbonilo y alquilcarbonilamino, o R2 y R3 o R3 y R4, o R4 y R5 conjuntamente con los átomos C a los cuales están unidos forman un anillo carbocíclico o heterocíclico de 5 o 6 miembros; W representa O, S, dos átomos de H, =CH2, =N-O-R6 o el grupo =N(R6); R6 representa H, cicloalquilo, heterocicloalquilo, heterocicloalquenilo, cicloalquenilo, arilo, heteroarilo, alquenilo, alquinilo, o alquilo, X e Y representan independientemente un radical de la fórmula -(CH2)i-NH-C(O)-(CH2)j-, -(CH2)k-C(O)-(CH2)m-, -(CH2)n-, -(CH2)p-CH=CH-(CH2)q-, -(CH2)r-O-(CH2)s-, -(CH2)t-NH-(CH2)u-, -(CH2)w-C(O)-NH-(CH2)z- donde i, j, k, m, n, p, q, r, s, t, u, w, y z son números enteros de 0-6, donde dichos radicales están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados del grupo que consiste en R7; R7representa H, oxo, tioxo, halógeno, hidroxilo, amino, imino, nitro, carboxi, carbamoílo, ciano, cicloalquilo, alquilo, arilo, heteroarilo, heterocicloalquilo, heterocicloalquenilo, heterocicloalquil-heteroarilo, heterocicloalquilcarbonilamino, cicloalquenilo, alquenilo, alquinilo, alcoxi, alcoxiimino, alquiltio, alcoxicarbonilo, alquilcarboniloxi, alquenilcarboniloxi, alcoxicarboniloxi, alquilureido, alquiltioureido, alquilcarbonilo, alcoxisulfoniloxi, aminosulfonilo, alquilsulfonilamino, alquilsulfonilo, arilsulfonilo, formilo, aminocarbonilo, y alquilcarbonilamino, donde dicho amino, imino, cicloalquilo, alquilo, arilo, heteroarilo, heterocicloalquilo, heterocicloalquenilo, heterocicloalquil-heteroarilo, heterocicloalquilcarbonilamino, cicloalquenilo, alquenilo, alquinilo, alcoxi, alcoxiimino, alquiltio, alcoxicarbonilo, alquilcarboniloxi, alquenilcarboniloxi, alcoxicarboniloxi, alquilureido, alquiltioureido, alquilcarbonilo, alcoxisulfoniloxi, aminosulfonilo, alquilsulfonilamino, alquilsulfonilo, arilsulfonilo, aminocarbonilo y alquilcarbonilamino están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados del grupo que consiste en H, halógeno, oxo, tioxo, hidroxilo, amino, imino, nitro, carboxi, ciano, alcoxi, alquiltio, alcoxicarbonilo, alquilcarboniloxi, alcoxicarboniloxi, alquilcarbonilo, alcoxisulfoniloxi, aminosulfonilo, alquilsulfonilamino, alquilsulfonilo, arilsulfonilo, aminocarboniloxi, heteroarilsulfonilamino, formilo, aminocarbonilo, trifluormetilo, alquilcarbonilamino, heterocicloalquilo, heterocicloalquenilo, arilo, alquiltioureido, heteroarilo, cicloalquilo, alquilo, cicloalquenilo, alquenilo, alquinilo, y alquilaminocarbonilo, B representa arilo, heteroarilo, heterocicloalquenilo, cicloalquilo, o cicloalquenilo, todos los cuales están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados del grupo que consiste en R8; R8 representa H, halógeno, hidroxilo, amino, imino, oxo, tioxo, nitro, carboxi, ciano, alcoxi, fenoxi, alquiltio, alcoxicarbonilo, alcoxicarbamoílo, alquilcarboniloxi, alcoxicarboniloxi, alquilcarbonilo, alcoxisulfoniloxi, aminosulfonilo, arilsulfonilo, alquilsulfonilamino, formilo, aminocarbonilo, alquilureido, alquiltioureido, aminocarboniloxi, alquilcarbonilamino, heterocicloalquilcarbonilamino, heterocicloalquilo, heterocicloalquenilo, arilo, heteroarilo, alquilaminocarbonilo, y un radical hidrocarbonado saturado o insaturado recto o ramificado donde dicho amino, alcoxi, fenoxi, alquiltio, alcoxicarbonilo, alcoxicarbamoílo, alquilcarboniloxi, alcoxicarboniloxi, alquilcarbonilo, alcoxisulfoniloxi, aminosulfonilo, arilsulfonilo, alquilsulfonilamino, aminocarbonilo, alquilureido, alquiltioureido, aminocarboniloxi, alquilcarbonilamino, heterocicloalquilcarbonilamino, heterocicloalquilo, heterocicloalquenilo, arilo, heteroarilo, alquilaminocarbonilo, y un radical hidrocarbonado saturado o insaturado recto o ramificado están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados del grupo que consiste en R7; A representa a un radical hidrocarbonado saturado o insaturado recto o ramificado y/o cíclico, un heterocicloalquilo, un heterocicloalquenilo, o un heteroarilo, todos los cuales están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados del grupo que consiste en R9; R9 representa H, oxo, halógeno, trifluormetilo, hidroxilo, amino, nitro, carboxi, ciano, alcoxi, alquiltio, alcoxicarbonilo, alquilcarboniloxi, alcoxicarboniloxi, alquilureido, alquiltioureido, alquilcarbonilo, alcoxisulfoniloxi, aminosulfonilo, arilsulfonilo, alquilsulfonilamino, arilsulfonilamino, heteroarilsulfonilamino, alquilsulfonilo, formilo, aminocarbonilo, alquilcarbonilamino, alquilaminocarbonilo, aminocarboniloxi, heterocicloalquilo, heterocicloalquenilo, heteroarilo y un radical hidrocarbonado saturado o insaturado recto o ramificado donde dicho amino, alcoxi, alquiltio, alcoxicarbonilo, alquilcarboniloxi, alcoxicarboniloxi, alquilureido, alquiltioureido, alquilcarbonilo, alcoxisulfoniloxi, aminosulfonilo, arilsulfonilo, alquilsulfonilamino, arilsulfonilamino, heteroarilsulfonilamino, alquilsulfonilo, aminocarbonilo, alquilcarbonilamino, alquilaminocarbonilo, aminocarboniloxi, heterocicloalquilo, heterocicloalquenilo, heteroarilo y un radical hidrocarbonado saturado o insaturado recto o ramificado están opcionalmente sustituidos con uno o más sustituyentes independientemente seleccionados del grupo que consiste en R7; y sales, hidratos o solvatos de los mismos farmacéuticamente aceptables, para ser usados -solos o en combinación con uno o más de otros compuestos farmacéuticamente activos- en terapia, para tratar enfermedades asociadas con angiogénesis desregulada, tal como cáncer.
ARP040104494A 2003-12-03 2004-12-02 Esteres de acido hidroxamico y uso farmaceutico de los mismos AR046785A1 (es)

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