FR2689508B1 - Derives de l'imidazole, leur procede de preparation et leur application en therapeutique. - Google Patents
Derives de l'imidazole, leur procede de preparation et leur application en therapeutique.Info
- Publication number
- FR2689508B1 FR2689508B1 FR929203944A FR9203944A FR2689508B1 FR 2689508 B1 FR2689508 B1 FR 2689508B1 FR 929203944 A FR929203944 A FR 929203944A FR 9203944 A FR9203944 A FR 9203944A FR 2689508 B1 FR2689508 B1 FR 2689508B1
- Authority
- FR
- France
- Prior art keywords
- preparation process
- therapeutic application
- imidazole derivatives
- imidazole
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/62—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with triarylmethyl radicals attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR929203944A FR2689508B1 (fr) | 1992-04-01 | 1992-04-01 | Derives de l'imidazole, leur procede de preparation et leur application en therapeutique. |
TW082102193A TW232012B (fr) | 1992-04-01 | 1993-03-24 | |
AU35546/93A AU3554693A (en) | 1992-04-01 | 1993-03-29 | Imidazole derivatives, their method of preparation and their application in therapeutics |
CA002092852A CA2092852A1 (fr) | 1992-04-01 | 1993-03-29 | Derives d'imidazole, methode d'obtention et applications therapeutiques |
FI931414A FI931414A (fi) | 1992-04-01 | 1993-03-29 | Imidazolderivat, foerfarande foer deras framstaellning samt deras anvaendning i terapi |
NO93931186A NO931186L (no) | 1992-04-01 | 1993-03-30 | Terapeutisk aktive imidazolderivater, fremgangsmaate for deres fremstilling og anvendelse derav |
HU9300942A HUT64752A (en) | 1992-04-01 | 1993-03-31 | Process for the production of imidazole derivatives and of medical preparatives containing them |
EP93400833A EP0564356A1 (fr) | 1992-04-01 | 1993-03-31 | Dérivés de 4-phénylaminométhylimidazole, procédé de préparation, antagonistes des récepteurs angiotensin II et leur application en thérapeutique |
JP5095158A JPH06263743A (ja) | 1992-04-01 | 1993-03-31 | イミダゾール誘導体、その調製方法及び治療への 応用 |
KR1019930005246A KR930021622A (ko) | 1992-04-01 | 1993-03-31 | 이미다졸 유도체, 그의 제조방법 및 이 화합물을 함유하는 치료제 |
CN93104521A CN1081438A (zh) | 1992-04-01 | 1993-04-01 | 咪唑衍生物及其制备方法和在治疗学上的应用 |
ZA932351A ZA932351B (en) | 1992-04-01 | 1993-04-01 | Imidazole derivatives their method of preparation and their application in therapeutics |
MX9301882A MX9301882A (es) | 1992-04-01 | 1993-04-01 | Derivados de imidazol, su procedimiento de preparacion y su aplicacion en terapeutica. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR929203944A FR2689508B1 (fr) | 1992-04-01 | 1992-04-01 | Derives de l'imidazole, leur procede de preparation et leur application en therapeutique. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2689508A1 FR2689508A1 (fr) | 1993-10-08 |
FR2689508B1 true FR2689508B1 (fr) | 1994-06-17 |
Family
ID=9428340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR929203944A Expired - Fee Related FR2689508B1 (fr) | 1992-04-01 | 1992-04-01 | Derives de l'imidazole, leur procede de preparation et leur application en therapeutique. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0564356A1 (fr) |
JP (1) | JPH06263743A (fr) |
KR (1) | KR930021622A (fr) |
CN (1) | CN1081438A (fr) |
AU (1) | AU3554693A (fr) |
CA (1) | CA2092852A1 (fr) |
FI (1) | FI931414A (fr) |
FR (1) | FR2689508B1 (fr) |
HU (1) | HUT64752A (fr) |
MX (1) | MX9301882A (fr) |
NO (1) | NO931186L (fr) |
TW (1) | TW232012B (fr) |
ZA (1) | ZA932351B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6015817A (en) * | 1996-12-05 | 2000-01-18 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
DE10023486C1 (de) * | 2000-05-09 | 2002-03-14 | Schering Ag | Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel |
CA2453396A1 (fr) * | 2001-07-11 | 2003-01-23 | Yale University | Composes et procedes d'inhibition de trypanosoma cruzi |
US7615565B2 (en) | 2002-07-31 | 2009-11-10 | Bayer Schering Pharma Aktiengesellschaft | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
UA89035C2 (ru) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
EP1655295A1 (fr) | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinurées comme inhibiteurs de kinase du récepteur VEGF |
EP1657241A1 (fr) | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Nouveaux urées d' anthranylamide pyridine ayant une activité inhibitrice de kinase du récepteur de VEGF |
US7906533B2 (en) | 2004-11-03 | 2011-03-15 | Bayer Schering Pharma Ag | Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors |
EP1752450A1 (fr) | 2005-08-01 | 2007-02-14 | Merck Sante | Dérives d'imidazole comme inhibiteurs de la fructose-1,6-bisphosphatase et composés pharmaceutiques les contenant |
KR20100031113A (ko) | 2007-05-24 | 2010-03-19 | 엘드러그 에스.에이. | 1,(3),5-치환된 이미다졸, 이의 고혈압 치료 용도 및 이의 제조 방법 |
GR1006917B (el) * | 2007-10-24 | 2010-07-30 | Ελληνικα Φαρμακα Ερευνα Και Αναπτυξη Eldrug Α.Ε., | Ανταγωνιστες του υποδοχεα της αγγειοτενσινης ιι με βαση την ισταμινη (και παραγωγα αυτης) με ιδιοτητες καταστολης του συμπαθητικου συστηματος και συνθετικες μεθοδοι στη θεραπεια της υπερτασης και αλλων καρδιοαγγειακων ασθενειων. |
EP2188279A2 (fr) * | 2007-08-01 | 2010-05-26 | Eldrug S.A. | Imidazoles substitués en 1,3 et 1,3,5 comme antihypertensives |
TW201010702A (en) | 2008-08-27 | 2010-03-16 | Leo Pharma As | Novel VEGF-2 receptor and protein tyrosine kinase inhibitors and pharmaceutical use thereof |
CN102584709B (zh) * | 2011-12-19 | 2016-08-17 | 浙江华海药业股份有限公司 | 一种改进的依普罗沙坦中间体芳基咪唑醛的制备工艺 |
JP7197880B2 (ja) * | 2017-10-19 | 2022-12-28 | 学校法人 名城大学 | エステル化剤及びその利用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2110663B (en) * | 1981-12-04 | 1985-08-07 | Farmos Group Ltd | Imidazole derivatives |
CA1334092C (fr) * | 1986-07-11 | 1995-01-24 | David John Carini | Imidazoles bloquant les recepteurs de l'angiotensine ii |
CA1338238C (fr) * | 1988-01-07 | 1996-04-09 | David John Carini | Imidazoles bloquant les recepteurs de l'angiotensine ii et combinaisons de ces imidazoles avec des diuretiques et des anti-inflammatoires non steroidiens |
CA2018443A1 (fr) * | 1989-06-14 | 1990-12-14 | Joseph A. Finkelstein | Acides imidazolyl-alkenoiques |
DE69033469T2 (de) * | 1989-06-14 | 2000-09-07 | Smithkline Beecham Corp | Imidazoalkensäure |
AU640417B2 (en) * | 1989-10-25 | 1993-08-26 | Smithkline Beecham Corporation | Substituted 5-((tetrazolyl)alkenyl)imidazoles |
CA2028925A1 (fr) * | 1989-11-06 | 1991-05-07 | Gerald R. Girard | Derives substitues de la n-(imidazolyl)alkylalanine |
GB8927928D0 (en) * | 1989-12-11 | 1990-02-14 | Roussel Lab Ltd | Chemical compounds |
NZ239161A (en) * | 1990-07-31 | 1994-01-26 | Smithkline Beecham Corp | Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments, |
-
1992
- 1992-04-01 FR FR929203944A patent/FR2689508B1/fr not_active Expired - Fee Related
-
1993
- 1993-03-24 TW TW082102193A patent/TW232012B/zh active
- 1993-03-29 CA CA002092852A patent/CA2092852A1/fr not_active Abandoned
- 1993-03-29 FI FI931414A patent/FI931414A/fi not_active Application Discontinuation
- 1993-03-29 AU AU35546/93A patent/AU3554693A/en not_active Abandoned
- 1993-03-30 NO NO93931186A patent/NO931186L/no unknown
- 1993-03-31 KR KR1019930005246A patent/KR930021622A/ko not_active Application Discontinuation
- 1993-03-31 EP EP93400833A patent/EP0564356A1/fr not_active Withdrawn
- 1993-03-31 JP JP5095158A patent/JPH06263743A/ja active Pending
- 1993-03-31 HU HU9300942A patent/HUT64752A/hu unknown
- 1993-04-01 MX MX9301882A patent/MX9301882A/es unknown
- 1993-04-01 ZA ZA932351A patent/ZA932351B/xx unknown
- 1993-04-01 CN CN93104521A patent/CN1081438A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
HUT64752A (en) | 1994-02-28 |
TW232012B (fr) | 1994-10-11 |
EP0564356A1 (fr) | 1993-10-06 |
FI931414A (fi) | 1993-10-02 |
MX9301882A (es) | 1994-06-30 |
FR2689508A1 (fr) | 1993-10-08 |
JPH06263743A (ja) | 1994-09-20 |
CA2092852A1 (fr) | 1993-10-02 |
CN1081438A (zh) | 1994-02-02 |
AU3554693A (en) | 1993-10-07 |
KR930021622A (ko) | 1993-11-22 |
HU9300942D0 (en) | 1993-06-28 |
FI931414A0 (fi) | 1993-03-29 |
NO931186L (no) | 1993-10-04 |
NO931186D0 (no) | 1993-03-30 |
ZA932351B (en) | 1994-10-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |