AR046618A1 - Compuestos de pirazolo [1,2 a] pirazolona inhibidores de citoquinas. composiciones farmaceuticas. - Google Patents
Compuestos de pirazolo [1,2 a] pirazolona inhibidores de citoquinas. composiciones farmaceuticas.Info
- Publication number
- AR046618A1 AR046618A1 ARP040104133A ARP040104133A AR046618A1 AR 046618 A1 AR046618 A1 AR 046618A1 AR P040104133 A ARP040104133 A AR P040104133A AR P040104133 A ARP040104133 A AR P040104133A AR 046618 A1 AR046618 A1 AR 046618A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- alkyl
- mixtures
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto que incluye todas las formas enantioméricas y diastereoméricas y las sales farmacéuticamente aceptables de éstas; dicho compuesto tiene la fórmula (1), en donde R es: a) -O[CH2]kR3; o b) -NR4aR4b; R3 es alquilo C1-4 sustituido o no sustituido, carbocíclico sustituido o no sustituido, heterocíclico sustituido o no sustituido, arilo o alquilenarilo sustituido o no sustituido, heteroarilo o alquilenheteroarilo sustituido o no sustituido; el índice k es de 0 a 5; cada R4a y R4b es independientemente: a) hidrógeno; o b) -[C(R5aR5b)]mR6; cada R5a y R5b es independientemente hidrógeno, -OR7, -N(R7)2, -CO2R7, -CON(R7)2; alquilo C1-4 lineal, ramificado o cíclico y mezclas de éstos; R6 es hidrógeno, -OR7, -N(R7)2, -CO2R7, - CON(R7)2; alquilo sustituido o no sustituido C1-4, heterociclo sustituido o no sustituido, arilo sustituido o no sustituido o heteroarilo sustituido o no sustituido; R7 es hidrógeno, un catión hidrosoluble, alquilo C1-4 o arilo sustituido o no sustituido; el subíndice m tiene un valor de 0 a 5; R1 es: a) arilo sustituido o no sustituido; o b) heteroarilo sustituido o no sustituido; L es un grupo de enlace escogido de: i) -[C(R12)2]n-; ii) -[C(R12)2]nNR12[C(R12)2]n-; y iii) [C(R12)2]nO[C(R12)2]n-; R12 es hidrógeno, alquilo C1-4, y mezclas de éstos; o dos unidades R12 se pueden tomar juntas para formar una unidad carbonilo; el índice n es una unidad de 0 a 2; cada unidad R2 se escoge independientemente de: a) hidrógeno; b) -(CH2)kO(CH2)jR8; c) -(CH2)jNR9aR9b; d) -(CH2)jCO2R10; e) -(CH2)jOCO2R10; f) -(CH2)jCON(R10)2; g) -(CH2)jOCON(R10)2; h) dos unidades R2 se pueden unir entre sí para formar una unidad carbonilo; i) y mezclas de éstos; cada R8, R9a, R9b, y R10 se escogen independientemente de hidrógeno, alquilo C1-4, y mezclas de éstos; R9a y R9b se pueden tomar juntas para formar un anillo carbocíclico o heterocíclico que comprende de 3 a 7 átomos; dos unidades de R10 se pueden tomar juntas para formar un anillo carbocíclico o heterocíclico que comprende de 3 a 7 átomos; j es un índice de 0 a 5; z es 0 es O, S, NR11 o NOR11; R11 es hidrógeno o alquilo C1-4. Una composición que comprende una o más pirazolonas bicíclicas incluyendo todas las formas enantioméricas y diastereoméricas y las sales farmacéuticamente aceptables de éstas. Una composición farmacéutica que comprende: a) una cantidad eficaz de una o más pirazolonas bicíclicas incluidas todas las formas enantioméricas y diasterioméricas y sales farmacéuticamente aceptables de las mismas y b) uno o más excipientes farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51888603P | 2003-11-10 | 2003-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046618A1 true AR046618A1 (es) | 2005-12-14 |
Family
ID=34590314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040104133A AR046618A1 (es) | 2003-11-10 | 2004-11-09 | Compuestos de pirazolo [1,2 a] pirazolona inhibidores de citoquinas. composiciones farmaceuticas. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7482356B2 (es) |
| EP (1) | EP1682551A2 (es) |
| JP (1) | JP2007510739A (es) |
| KR (1) | KR100835152B1 (es) |
| CN (1) | CN1878772A (es) |
| AR (1) | AR046618A1 (es) |
| AU (1) | AU2004289691B2 (es) |
| BR (1) | BRPI0416358A (es) |
| CA (1) | CA2545781A1 (es) |
| IL (1) | IL175151A0 (es) |
| MA (1) | MA28154A1 (es) |
| NO (1) | NO20062639L (es) |
| PE (1) | PE20050578A1 (es) |
| RU (1) | RU2358976C2 (es) |
| SG (1) | SG147476A1 (es) |
| TW (1) | TW200518754A (es) |
| WO (1) | WO2005047287A2 (es) |
| ZA (1) | ZA200603582B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101182114B1 (ko) * | 2010-03-05 | 2012-09-12 | 한림제약(주) | 유효성분으로서 레바미피드를 함유하는 골관절염 예방 또는 치료용 약학 조성물 |
| AR110401A1 (es) * | 2016-12-21 | 2019-03-27 | Chiesi Farm Spa | Derivados dihidropirimidina bicíclica-carboxamida como inhibidores de rho-quinasa |
| CN115286635B (zh) * | 2022-08-22 | 2023-10-24 | 河南师范大学 | 一种手性并环吡唑啉酮类化合物的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1124982A (en) * | 1965-02-09 | 1968-08-21 | Lepetit Spa | Diazabicyclo octanes and derivatives thereof |
| CH529153A (fr) | 1969-10-27 | 1972-10-15 | Lepetit Spa | Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones |
| US6472416B1 (en) * | 1999-08-27 | 2002-10-29 | Abbott Laboratories | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors |
| US6849627B2 (en) * | 2001-09-20 | 2005-02-01 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US7087615B2 (en) * | 2001-09-20 | 2006-08-08 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia |
| US6730668B2 (en) | 2001-09-20 | 2004-05-04 | The Procter & Gamble Company | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US6566357B1 (en) * | 2001-09-20 | 2003-05-20 | The Procter & Gamble Co. | Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines |
| US6677337B2 (en) | 2002-03-19 | 2004-01-13 | The Procter & Gamble Company | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines |
-
2004
- 2004-11-05 US US10/983,114 patent/US7482356B2/en not_active Expired - Fee Related
- 2004-11-09 RU RU2006114580/04A patent/RU2358976C2/ru not_active IP Right Cessation
- 2004-11-09 BR BRPI0416358-3A patent/BRPI0416358A/pt not_active IP Right Cessation
- 2004-11-09 CN CNA2004800328398A patent/CN1878772A/zh active Pending
- 2004-11-09 EP EP04810572A patent/EP1682551A2/en not_active Withdrawn
- 2004-11-09 JP JP2006539725A patent/JP2007510739A/ja active Pending
- 2004-11-09 SG SG200808004-6A patent/SG147476A1/en unknown
- 2004-11-09 WO PCT/US2004/037264 patent/WO2005047287A2/en active Application Filing
- 2004-11-09 KR KR1020067008849A patent/KR100835152B1/ko not_active IP Right Cessation
- 2004-11-09 CA CA002545781A patent/CA2545781A1/en not_active Abandoned
- 2004-11-09 AR ARP040104133A patent/AR046618A1/es not_active Application Discontinuation
- 2004-11-09 PE PE2004001091A patent/PE20050578A1/es not_active Application Discontinuation
- 2004-11-09 AU AU2004289691A patent/AU2004289691B2/en not_active Expired - Fee Related
- 2004-11-10 TW TW093134336A patent/TW200518754A/zh unknown
-
2006
- 2006-04-24 IL IL175151A patent/IL175151A0/en unknown
- 2006-05-05 ZA ZA200603582A patent/ZA200603582B/en unknown
- 2006-05-11 MA MA29018A patent/MA28154A1/fr unknown
- 2006-06-08 NO NO20062639A patent/NO20062639L/no not_active Application Discontinuation
-
2008
- 2008-11-06 US US12/291,084 patent/US20090069355A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090069355A1 (en) | 2009-03-12 |
| NO20062639L (no) | 2006-06-08 |
| ZA200603582B (en) | 2007-04-25 |
| SG147476A1 (en) | 2008-11-28 |
| AU2004289691B2 (en) | 2009-04-23 |
| KR20060086391A (ko) | 2006-07-31 |
| EP1682551A2 (en) | 2006-07-26 |
| PE20050578A1 (es) | 2005-09-26 |
| JP2007510739A (ja) | 2007-04-26 |
| BRPI0416358A (pt) | 2007-05-08 |
| US7482356B2 (en) | 2009-01-27 |
| US20050113392A1 (en) | 2005-05-26 |
| RU2358976C2 (ru) | 2009-06-20 |
| CN1878772A (zh) | 2006-12-13 |
| TW200518754A (en) | 2005-06-16 |
| KR100835152B1 (ko) | 2008-06-09 |
| IL175151A0 (en) | 2006-09-05 |
| WO2005047287A2 (en) | 2005-05-26 |
| WO2005047287A3 (en) | 2005-07-28 |
| CA2545781A1 (en) | 2005-05-26 |
| RU2006114580A (ru) | 2007-12-20 |
| MA28154A1 (fr) | 2006-09-01 |
| AU2004289691A1 (en) | 2005-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |