AR046318A1 - Sales de tiotropio, procedimientos para su preparacion y composiciones farmaceuticas que las contienen. - Google Patents

Sales de tiotropio, procedimientos para su preparacion y composiciones farmaceuticas que las contienen.

Info

Publication number
AR046318A1
AR046318A1 ARP040104039A ARP040104039A AR046318A1 AR 046318 A1 AR046318 A1 AR 046318A1 AR P040104039 A ARP040104039 A AR P040104039A AR P040104039 A ARP040104039 A AR P040104039A AR 046318 A1 AR046318 A1 AR 046318A1
Authority
AR
Argentina
Prior art keywords
salts
pharmaceutical compositions
compositions containing
tiotrope
procedures
Prior art date
Application number
ARP040104039A
Other languages
English (en)
Inventor
Banholzer Rolf Dr
Pfrengle Waldemar Dr
Sieger Peter Dr
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530661&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR046318(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR046318A1 publication Critical patent/AR046318A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Abstract

La presente se refiere a sales de tiotropio como tales y composiciones farmacéuticas que las contienen. Reivindicación 1: Procedimiento para preparar nuevas sales de tiotropio de la fórmula (1) en la cual X- significa un anión, caracterizado porque se hace reaccionar una sal de tiotropio de la fórmula (29 en donde Y- un anión distinto de X-, seleccionado del grupo de los halogenuros con una sal AgX, en la cual X puede tener los significados indicados con anterioridad, en un disolvente apropiado.
ARP040104039A 2003-11-03 2004-11-03 Sales de tiotropio, procedimientos para su preparacion y composiciones farmaceuticas que las contienen. AR046318A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025076 2003-11-03

Publications (1)

Publication Number Publication Date
AR046318A1 true AR046318A1 (es) 2005-11-30

Family

ID=34530661

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104039A AR046318A1 (es) 2003-11-03 2004-11-03 Sales de tiotropio, procedimientos para su preparacion y composiciones farmaceuticas que las contienen.

Country Status (29)

Country Link
US (1) US20050096341A1 (es)
EP (5) EP2319844A1 (es)
JP (1) JP5165245B2 (es)
KR (1) KR20060102561A (es)
CN (3) CN1875020B (es)
AR (1) AR046318A1 (es)
AT (1) ATE478071T1 (es)
AU (1) AU2004285685B2 (es)
CA (1) CA2544357A1 (es)
CO (1) CO5690554A2 (es)
DE (1) DE502004011562D1 (es)
DK (2) DK1682543T3 (es)
EA (1) EA012369B1 (es)
EC (2) ECSP066544A (es)
ES (2) ES2350981T3 (es)
HK (1) HK1099753A1 (es)
IL (1) IL175127A (es)
MY (1) MY145166A (es)
NO (1) NO20061441L (es)
NZ (1) NZ547523A (es)
PE (1) PE20050485A1 (es)
PL (1) PL2083007T3 (es)
RS (1) RS20060293A (es)
SG (1) SG149876A1 (es)
TW (1) TW200523263A (es)
UA (1) UA82414C2 (es)
UY (1) UY28589A1 (es)
WO (1) WO2005042528A1 (es)
ZA (1) ZA200602343B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1682541E (pt) 2003-11-03 2010-04-14 Boehringer Ingelheim Int Processo para a preparação de sais de tiotrópio
AU2006259202B2 (en) * 2005-06-15 2012-05-10 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
CA2611907A1 (en) * 2005-06-17 2006-12-21 Boehringer Ingelheim International Gmbh Mrp iv inhibitors for the treatment of respiratory diseases
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
WO2007075838A2 (en) * 2005-12-19 2007-07-05 Sicor Inc. Pure and stable tiotropium bromide
EP2123650B1 (en) * 2005-12-19 2012-04-04 Sicor, Inc. Novel form of tiotropium bromide and process for preparation thereof
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
EP2411008B1 (en) * 2009-03-27 2017-03-22 Mahmut Bilgic Complexes of tiotropium with improved properties of solubility and stability
PL388070A1 (pl) * 2009-05-19 2010-11-22 Adamed Spółka Z Ograniczoną Odpowiedzialnością Nowe sole tiotropium
CZ201241A3 (cs) * 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2013127738A1 (de) * 2012-02-28 2013-09-06 Boehringer Ingelheim International Gmbh Neue treibgashaltige tiotropium-formulierung

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2597329A (en) * 1947-08-06 1952-05-20 Merck & Co Inc Process for anion exchange of thiamin salts
US3551492A (en) * 1967-10-31 1970-12-29 Ciba Geigy Corp N,n'-diaminoalkoxy-benzyl-diamino-alkanes and the salts thereof
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
FI88112C (fi) 1985-07-30 1993-04-13 Glaxo Group Ltd Anordning foer administrering av laekemedel till patienter
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
DE19536902A1 (de) 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
JP4023086B2 (ja) * 1999-12-27 2007-12-19 和光純薬工業株式会社 スルホニウム塩化合物
TR200402579T4 (tr) * 2000-10-12 2004-12-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristalin monohidrat, bunun imalat yöntemi ve bir ilaç maddesinin imalatında kullanımı
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
ES2227268T3 (es) * 2000-10-12 2005-04-01 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO.KG Nuevos polvos para inhalacion con contenido en tiotropio.
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
EA007604B1 (ru) * 2000-10-31 2006-12-29 Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг Ингаляционная композиция в виде раствора с солью тиотропия
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193393A1 (en) * 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
DE10061877A1 (de) * 2000-12-12 2002-06-13 Basf Ag Verfahren zur Herstellung wässriger Copolymerisatdispersionen von Copolymerisaten aus Kohlenmonoxid und wenigstens einer olefinisch ungesättigten Verbindung
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
DE10111843A1 (de) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von inflammatorischen Erkrankungen
US20020193394A1 (en) * 2001-03-13 2002-12-19 Bernd Disse Compounds for treating inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US6608055B2 (en) * 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US20030229227A1 (en) * 2002-03-16 2003-12-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US6908055B2 (en) * 2003-02-27 2005-06-21 Tandberg Data Asa System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
US20050030040A1 (en) * 2003-06-27 2005-02-10 Mitch Budniak Electrical testing device having voice annunciator
PT1682541E (pt) * 2003-11-03 2010-04-14 Boehringer Ingelheim Int Processo para a preparação de sais de tiotrópio
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
AU2006259202B2 (en) * 2005-06-15 2012-05-10 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
ES2350981T3 (es) 2011-01-28
ECSP066545A (es) 2006-10-17
UA82414C2 (uk) 2008-04-10
CN102964344A (zh) 2013-03-13
EP2083007B1 (de) 2013-04-24
EP2336127A1 (de) 2011-06-22
CN101648950B (zh) 2014-05-07
CN102964344B (zh) 2014-12-31
RS20060293A (en) 2008-08-07
EP1682543B1 (de) 2010-08-18
JP2007509895A (ja) 2007-04-19
CN1875020B (zh) 2010-04-28
CO5690554A2 (es) 2006-10-31
EP1682543A1 (de) 2006-07-26
DK2083007T3 (da) 2013-07-29
EP2319844A1 (de) 2011-05-11
DK1682543T3 (da) 2010-12-13
TW200523263A (en) 2005-07-16
AU2004285685B2 (en) 2011-03-24
CA2544357A1 (en) 2005-05-12
HK1099753A1 (en) 2007-08-24
ZA200602343B (en) 2007-12-27
UY28589A1 (es) 2005-06-30
WO2005042528A1 (de) 2005-05-12
US20050096341A1 (en) 2005-05-05
ES2422730T3 (es) 2013-09-13
ECSP066544A (es) 2006-10-17
NZ547523A (en) 2009-07-31
EA200600854A1 (ru) 2006-10-27
IL175127A (en) 2011-10-31
EA012369B1 (ru) 2009-10-30
JP5165245B2 (ja) 2013-03-21
EP2322522A1 (de) 2011-05-18
ATE478071T1 (de) 2010-09-15
AU2004285685A1 (en) 2005-05-12
CN101648950A (zh) 2010-02-17
KR20060102561A (ko) 2006-09-27
DE502004011562D1 (de) 2010-09-30
PL2083007T3 (pl) 2013-09-30
SG149876A1 (en) 2009-02-27
MY145166A (en) 2011-12-30
EP2083007A1 (de) 2009-07-29
NO20061441L (no) 2006-07-12
PE20050485A1 (es) 2005-10-05
CN1875020A (zh) 2006-12-06
IL175127A0 (en) 2006-09-05

Similar Documents

Publication Publication Date Title
AR046318A1 (es) Sales de tiotropio, procedimientos para su preparacion y composiciones farmaceuticas que las contienen.
AR116523A1 (es) Proceso de elaboración de un compuesto para inhibir la actividad de la shp2, así como productos producidos por la adición de ácido
CL2017002609A1 (es) Compuestos derivados de pirazolopiridina hidrogenadas, inhibidores p2x7, composición farmacéutica que los comprende; proceso de preparación de estos; y su uso en el tratamiento de enfermedades oseas, sns, cardiovasculares, entre otras (divisional de cl 2655-2015)
BR112015020772A2 (pt) compostos de pirimidina e piridina e seu uso
AR049401A1 (es) Aza-biciclononanos
BR112012013511A2 (pt) derivados de difenil-pirazolopiridinas, sua preparação e seu uso como não moduladores do receptor nuclear
BR112017027831A2 (pt) derivados de hidroxiácido, um processo para sua preparação e composições farmacêuticas contendo-os
UY29002A1 (es) Nuevos derivados de hidantoína, procesos parasu preparación, composiciones farmacéuticas que los contienen y su uso en terapia
JP2015520143A5 (es)
AR086319A1 (es) Compuestos heterociclicos fusionados como moduladores de canal ionico
AR057032A1 (es) Tigeciclina y metodos de preparacion
AR079205A1 (es) Morfolinotiazoles como moduladores alostericos positivos alfa 7
AR057067A1 (es) Procedimiento para preparar sales de tiotropio, sales de tiotropio como tales y composiciones farmaceuticas de las mismas
BR112014016648A8 (pt) derivados policíclicos, processo de preparação e uso farmacêutico dos mesmos
AR060690A1 (es) Polimeros que contienen magnesio para la hiperfosfatemia
BR112012029647A2 (pt) novos derivados de pirimidinas
UY29003A1 (es) Nuevos derivados de hidantoína, procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia
AR080802A1 (es) Compuestos de complejos de fe (iii) para el tratamiento y la profilaxis de los sintomas de deficiencia de hierro y anemias por deficiencia de hierro
CA2920410C (en) Thienopiperidine derivative and use thereof
CU20130047A7 (es) Conjugado de naloxol-peg cristalino
BR112022001330A2 (pt) Derivados de 3,6-diamino-piridazin-3-ila, composições farmacêuticas contendo-os e seus usos como agentes pró-apoptóticos
GEP20125548B (en) New dihidroindolone compounds, a process for its preparation and pharmaceutical compositions containing them
BR112016000968A2 (pt) Processo para a preparação de bifenilanilidas halogenadas
MX2016001095A (es) Sales de dasatinib en forma cristalina.
AR069306A1 (es) Derivados de metil- bencimidazol como moduladores de receptor x de farnesoide(fxr)

Legal Events

Date Code Title Description
FA Abandonment or withdrawal