AR069306A1 - Derivados de metil- bencimidazol como moduladores de receptor x de farnesoide(fxr) - Google Patents
Derivados de metil- bencimidazol como moduladores de receptor x de farnesoide(fxr)Info
- Publication number
- AR069306A1 AR069306A1 ARP080104952A ARP080104952A AR069306A1 AR 069306 A1 AR069306 A1 AR 069306A1 AR P080104952 A ARP080104952 A AR P080104952A AR P080104952 A ARP080104952 A AR P080104952A AR 069306 A1 AR069306 A1 AR 069306A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- fluor
- heterocyclyl
- cycloalkyl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Proceso para obtenerlos, composicion farmacéutica y uso para fabricar medicamentos para tratar niveles altos de lípidos y colesterol, cáncer gastrointestinal, osteoporosis, Parkinson y Alzheimer. Reivindicacion 1: Compuestos de la formula (1) en la que R1 es cicloalquilo, alquilo inferior, cicloalquil-alquilo inferior, arilo, aril-alquilo inferior, heteroarilo, heteroaril-alquilo inferior, heterociclilo o heterociclil-alquil inferior, dichos cicloalquilo, arilo, heteroarilo o heterociclilo pueden estar opcionalmente sustituidos por 1-4 sustituyentes elegidos con independencia entre el grupo formado por hidroxi, halogeno, alquilo inferior, alcoxi inferior, fluor-alquilo inferior y fluor-alcoxi inferior; R2 es hidrogeno o alquilo inferior; R3 es cicloalquilo, alquilo inferior, cicloalquil-alquilo inferior, arilo, heteroaril-alquilo inferior, heterociclilo o heterociclil-alquilo interior, dichos cicloalquilo, arilo, heteroarilo o heterociclilo pueden estar opcionalmente sustituidos por 1-4 sustituyentes elegidos con independencia entre el grupo formado por hidroxi, halogeno, alquilo inferior, alcoxi interior, fluor-alquilo inferior, fluor-alcoxi inferior y alcoxi inferior-carbonilo; R4 es arilo, cicloalquilo, heteroarilo o heterociclilo, dichos arilo, cicloalquilo, heteroarilo o heterociclilo pueden estar opcionalmente sustituidos por 1-4 sustituyentes elegidos con independencia entre el grupo formado por halogeno, alquilo inferior, alcoxi inferior, hidroxi, dioxo-alquileno inferior, fluor-alquilo inferior y fluor-alcoxi inferior; R5 y R6 con independencia entre sí son hidrogeno, hidroxi, hidroxi-alquilo inferior, alcoxi inferior, alquilo inferior, fluor-alquilo inferior o fluor-alcoxi inferior; R7, R8, R9 y R10 con independencia entre sí son hidrogeno, halogeno, hidroxi, alquilo inferior, alcoxi inferior, fluor-alquilo inferior o fluor-alcoxi inferior; y las sales y ésteres - farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07120737 | 2007-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR069306A1 true AR069306A1 (es) | 2010-01-13 |
Family
ID=40551982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080104952A AR069306A1 (es) | 2007-11-15 | 2008-11-13 | Derivados de metil- bencimidazol como moduladores de receptor x de farnesoide(fxr) |
Country Status (16)
Country | Link |
---|---|
US (2) | US7825258B2 (es) |
EP (1) | EP2222645B1 (es) |
JP (1) | JP5222953B2 (es) |
KR (1) | KR101176721B1 (es) |
CN (1) | CN101855214B (es) |
AR (1) | AR069306A1 (es) |
AU (1) | AU2008323017B2 (es) |
BR (1) | BRPI0818813A2 (es) |
CA (1) | CA2704074A1 (es) |
CL (1) | CL2008003372A1 (es) |
ES (1) | ES2403592T3 (es) |
IL (1) | IL205207A0 (es) |
MX (1) | MX2010005164A (es) |
PE (1) | PE20090999A1 (es) |
TW (1) | TW200924755A (es) |
WO (1) | WO2009062874A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2734034A1 (en) * | 2008-09-11 | 2010-03-18 | F. Hoffmann-La Roche Ag | New benzimidazole derivatives |
CN102186830A (zh) | 2008-10-15 | 2011-09-14 | 霍夫曼-拉罗奇有限公司 | 新型苯并咪唑衍生物 |
US8309581B2 (en) * | 2009-09-29 | 2012-11-13 | Hoffmann-La Roche Inc. | Benzimidazole derivatives |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
SG10201607230SA (en) * | 2012-06-19 | 2016-10-28 | Intercept Pharmaceuticals Inc | Preparation, Uses And Solid Forms Of Obeticholic Acid |
US9895380B2 (en) | 2013-09-11 | 2018-02-20 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of hepatitis B virus infection |
WO2018153933A1 (en) | 2017-02-21 | 2018-08-30 | Genfit | Combination of a ppar agonist with a fxr agonist |
JP2020515564A (ja) | 2017-03-30 | 2020-05-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | エピソーマルウイルスの持続性及び発現を低下させるための方法及び医薬組成物 |
TW202143958A (zh) * | 2020-03-18 | 2021-12-01 | 美商梅塔克林公司 | 用於治療疾病之法尼醇x(farnesoid x)受體促效劑 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2338147A1 (en) * | 1998-07-20 | 2000-02-03 | Kuo-Long Yu | Substituted benzimidazole antiviral agents |
RU2004126671A (ru) | 2002-02-06 | 2005-04-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероарилсоединения, полезные в качестве ингибиторов gsk-3 |
WO2005002520A2 (en) * | 2003-07-01 | 2005-01-13 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
CN101479249B (zh) * | 2006-06-29 | 2012-10-10 | 霍夫曼-拉罗奇有限公司 | 苯并咪唑衍生物、其制备方法、它们作为fxr激动剂的用途及含有它们的药物制剂 |
CA2697167C (en) * | 2007-08-27 | 2013-07-16 | F. Hoffmann-La Roche Ag | Benzimidazole derivatives used as fxr agonists |
-
2008
- 2008-11-05 WO PCT/EP2008/065012 patent/WO2009062874A2/en active Application Filing
- 2008-11-05 US US12/265,049 patent/US7825258B2/en not_active Expired - Fee Related
- 2008-11-05 BR BRPI0818813 patent/BRPI0818813A2/pt not_active IP Right Cessation
- 2008-11-05 AU AU2008323017A patent/AU2008323017B2/en not_active Expired - Fee Related
- 2008-11-05 MX MX2010005164A patent/MX2010005164A/es active IP Right Grant
- 2008-11-05 ES ES08849394T patent/ES2403592T3/es active Active
- 2008-11-05 CN CN2008801158570A patent/CN101855214B/zh not_active Expired - Fee Related
- 2008-11-05 JP JP2010533538A patent/JP5222953B2/ja not_active Expired - Fee Related
- 2008-11-05 EP EP08849394A patent/EP2222645B1/en not_active Not-in-force
- 2008-11-05 KR KR1020107010507A patent/KR101176721B1/ko not_active IP Right Cessation
- 2008-11-05 CA CA2704074A patent/CA2704074A1/en not_active Abandoned
- 2008-11-12 PE PE2008001917A patent/PE20090999A1/es not_active Application Discontinuation
- 2008-11-13 AR ARP080104952A patent/AR069306A1/es unknown
- 2008-11-13 CL CL2008003372A patent/CL2008003372A1/es unknown
- 2008-11-14 TW TW097144263A patent/TW200924755A/zh unknown
-
2010
- 2010-04-19 IL IL205207A patent/IL205207A0/en unknown
- 2010-08-25 US US12/862,823 patent/US8008503B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7825258B2 (en) | 2010-11-02 |
AU2008323017B2 (en) | 2012-12-20 |
CL2008003372A1 (es) | 2010-01-04 |
KR101176721B1 (ko) | 2012-08-23 |
AU2008323017A1 (en) | 2009-05-22 |
BRPI0818813A2 (pt) | 2015-04-22 |
CA2704074A1 (en) | 2009-05-22 |
IL205207A0 (en) | 2010-12-30 |
WO2009062874A3 (en) | 2009-07-09 |
JP5222953B2 (ja) | 2013-06-26 |
ES2403592T3 (es) | 2013-05-20 |
US20100331371A1 (en) | 2010-12-30 |
CN101855214A (zh) | 2010-10-06 |
US20090131482A1 (en) | 2009-05-21 |
PE20090999A1 (es) | 2009-07-20 |
CN101855214B (zh) | 2012-12-26 |
WO2009062874A2 (en) | 2009-05-22 |
EP2222645A2 (en) | 2010-09-01 |
TW200924755A (en) | 2009-06-16 |
MX2010005164A (es) | 2010-05-27 |
JP2011503136A (ja) | 2011-01-27 |
EP2222645B1 (en) | 2013-03-20 |
KR20100071102A (ko) | 2010-06-28 |
US8008503B2 (en) | 2011-08-30 |
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