IL205207A0 - Benzimidazole derivatives and their use as fxr agonists - Google Patents
Benzimidazole derivatives and their use as fxr agonistsInfo
- Publication number
- IL205207A0 IL205207A0 IL205207A IL20520710A IL205207A0 IL 205207 A0 IL205207 A0 IL 205207A0 IL 205207 A IL205207 A IL 205207A IL 20520710 A IL20520710 A IL 20520710A IL 205207 A0 IL205207 A0 IL 205207A0
- Authority
- IL
- Israel
- Prior art keywords
- benzimidazole derivatives
- fxr agonists
- fxr
- agonists
- benzimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07120737 | 2007-11-15 | ||
PCT/EP2008/065012 WO2009062874A2 (en) | 2007-11-15 | 2008-11-05 | Benzimidazole derivatives and their use as fxr agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
IL205207A0 true IL205207A0 (en) | 2010-12-30 |
Family
ID=40551982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL205207A IL205207A0 (en) | 2007-11-15 | 2010-04-19 | Benzimidazole derivatives and their use as fxr agonists |
Country Status (16)
Country | Link |
---|---|
US (2) | US7825258B2 (en) |
EP (1) | EP2222645B1 (en) |
JP (1) | JP5222953B2 (en) |
KR (1) | KR101176721B1 (en) |
CN (1) | CN101855214B (en) |
AR (1) | AR069306A1 (en) |
AU (1) | AU2008323017B2 (en) |
BR (1) | BRPI0818813A2 (en) |
CA (1) | CA2704074A1 (en) |
CL (1) | CL2008003372A1 (en) |
ES (1) | ES2403592T3 (en) |
IL (1) | IL205207A0 (en) |
MX (1) | MX2010005164A (en) |
PE (1) | PE20090999A1 (en) |
TW (1) | TW200924755A (en) |
WO (1) | WO2009062874A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2321282B1 (en) * | 2008-09-11 | 2013-03-27 | F. Hoffmann-La Roche AG | New benzimidazole derivatives |
ES2444791T3 (en) | 2008-10-15 | 2014-02-26 | F. Hoffmann-La Roche Ag | New benzimidazole derivatives |
US8309581B2 (en) * | 2009-09-29 | 2012-11-13 | Hoffmann-La Roche Inc. | Benzimidazole derivatives |
WO2011107494A1 (en) | 2010-03-03 | 2011-09-09 | Sanofi | Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof |
DK3336097T3 (en) * | 2012-06-19 | 2020-09-28 | Intercept Pharmaceuticals Inc | Preparation of non-crystalline obeticholic acid |
CA2923090C (en) | 2013-09-11 | 2018-08-21 | Poxel | Methods and pharmaceutical compositions for the treatment of hepatitis b virus infection |
JP2020508316A (en) | 2017-02-21 | 2020-03-19 | ジェンフィGenfit | Combination of PPAR agonist and FXR agonist |
WO2018178260A1 (en) | 2017-03-30 | 2018-10-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for reducing persistence and expression of episomal viruses |
WO2021188690A1 (en) * | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Farnesoid x receptor agonists for the treatment of disease |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2338147A1 (en) * | 1998-07-20 | 2000-02-03 | Kuo-Long Yu | Substituted benzimidazole antiviral agents |
SG159380A1 (en) | 2002-02-06 | 2010-03-30 | Vertex Pharma | Heteroaryl compounds useful as inhibitors of gsk-3 |
WO2005002520A2 (en) * | 2003-07-01 | 2005-01-13 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
AU2007263807B2 (en) * | 2006-06-29 | 2011-06-02 | F. Hoffmann-La Roche Ag | Benzimidazole derivatives, method for the production thereof, their use as FXR agonists and pharmaceutical preparations containing the same |
CN102083799B (en) * | 2007-08-27 | 2013-10-16 | 霍夫曼-拉罗奇有限公司 | Benzimidazole derivatives used as FXR agonists |
-
2008
- 2008-11-05 EP EP08849394A patent/EP2222645B1/en not_active Not-in-force
- 2008-11-05 BR BRPI0818813 patent/BRPI0818813A2/en not_active IP Right Cessation
- 2008-11-05 AU AU2008323017A patent/AU2008323017B2/en not_active Expired - Fee Related
- 2008-11-05 MX MX2010005164A patent/MX2010005164A/en active IP Right Grant
- 2008-11-05 US US12/265,049 patent/US7825258B2/en not_active Expired - Fee Related
- 2008-11-05 CN CN2008801158570A patent/CN101855214B/en not_active Expired - Fee Related
- 2008-11-05 CA CA2704074A patent/CA2704074A1/en not_active Abandoned
- 2008-11-05 KR KR1020107010507A patent/KR101176721B1/en not_active IP Right Cessation
- 2008-11-05 WO PCT/EP2008/065012 patent/WO2009062874A2/en active Application Filing
- 2008-11-05 JP JP2010533538A patent/JP5222953B2/en not_active Expired - Fee Related
- 2008-11-05 ES ES08849394T patent/ES2403592T3/en active Active
- 2008-11-12 PE PE2008001917A patent/PE20090999A1/en not_active Application Discontinuation
- 2008-11-13 CL CL2008003372A patent/CL2008003372A1/en unknown
- 2008-11-13 AR ARP080104952A patent/AR069306A1/en unknown
- 2008-11-14 TW TW097144263A patent/TW200924755A/en unknown
-
2010
- 2010-04-19 IL IL205207A patent/IL205207A0/en unknown
- 2010-08-25 US US12/862,823 patent/US8008503B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP5222953B2 (en) | 2013-06-26 |
CN101855214B (en) | 2012-12-26 |
CL2008003372A1 (en) | 2010-01-04 |
BRPI0818813A2 (en) | 2015-04-22 |
AR069306A1 (en) | 2010-01-13 |
MX2010005164A (en) | 2010-05-27 |
KR20100071102A (en) | 2010-06-28 |
TW200924755A (en) | 2009-06-16 |
US8008503B2 (en) | 2011-08-30 |
EP2222645B1 (en) | 2013-03-20 |
AU2008323017B2 (en) | 2012-12-20 |
KR101176721B1 (en) | 2012-08-23 |
US7825258B2 (en) | 2010-11-02 |
US20100331371A1 (en) | 2010-12-30 |
PE20090999A1 (en) | 2009-07-20 |
WO2009062874A2 (en) | 2009-05-22 |
CN101855214A (en) | 2010-10-06 |
ES2403592T3 (en) | 2013-05-20 |
US20090131482A1 (en) | 2009-05-21 |
WO2009062874A3 (en) | 2009-07-09 |
AU2008323017A1 (en) | 2009-05-22 |
CA2704074A1 (en) | 2009-05-22 |
JP2011503136A (en) | 2011-01-27 |
EP2222645A2 (en) | 2010-09-01 |
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