AR040293A1 - Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulo endoplasmico en plantas - Google Patents
Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulo endoplasmico en plantasInfo
- Publication number
- AR040293A1 AR040293A1 ARP030102330A ARP030102330A AR040293A1 AR 040293 A1 AR040293 A1 AR 040293A1 AR P030102330 A ARP030102330 A AR P030102330A AR P030102330 A ARP030102330 A AR P030102330A AR 040293 A1 AR040293 A1 AR 040293A1
- Authority
- AR
- Argentina
- Prior art keywords
- nucleic acid
- protein
- endoplasmic
- reticle
- peptides
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 238000009825 accumulation Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000002472 endoplasmic reticulum Anatomy 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 229920002494 Zein Polymers 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000005019 zein Substances 0.000 abstract 1
- 229940093612 zein Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C07K14/425—Zeins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8221—Transit peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
Se describe una molécula de ácido nucleico como que contiene una primera secuencia de ácido nucleico que comprende una secuencia de nucleótidos que codifica la proteína zeína g, o un fragmento de la misma capaz de dirigir y retener una proteína en retículo endoplásmico (ER) de una célula vegetal; una segunda secuencia de ácido nucleico que contiene una secuencia de nucleótidos que codifica una secuencia de aminoácidos que se puede escindir enzimáticamente por medios enzimáticos o químicos; y una tercera secuencia de ácidos nucleicos que contiene la secuencia de nucleótidos que codifica un péptido o una proteína de interés. También se describen los procedimientos de uso de esta molécula de ácido nucleico para transformar las células huéspedas vegetales y producir el péptido o la proteína de interés.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200201508A ES2224792B1 (es) | 2002-06-28 | 2002-06-28 | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR040293A1 true AR040293A1 (es) | 2005-03-23 |
Family
ID=29797406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP030102330A AR040293A1 (es) | 2002-06-28 | 2003-06-27 | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulo endoplasmico en plantas |
Country Status (16)
Country | Link |
---|---|
US (2) | US7575898B2 (es) |
EP (1) | EP1523558B1 (es) |
JP (2) | JP4610334B2 (es) |
KR (2) | KR100987946B1 (es) |
CN (1) | CN100460510C (es) |
AR (1) | AR040293A1 (es) |
AT (1) | ATE366317T1 (es) |
AU (1) | AU2002333330B2 (es) |
CA (1) | CA2490348A1 (es) |
DE (1) | DE60221051T2 (es) |
DK (1) | DK1523558T3 (es) |
ES (2) | ES2224792B1 (es) |
MX (1) | MXPA05000290A (es) |
RU (1) | RU2381275C2 (es) |
UY (1) | UY27864A1 (es) |
WO (1) | WO2004003207A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
ES2224792B1 (es) * | 2002-06-28 | 2007-02-16 | Era Plantech, S.L. | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
US7951557B2 (en) | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
GB0426161D0 (en) * | 2004-11-29 | 2004-12-29 | Era Plantech S L | Protein isolation and purification |
GB0426160D0 (en) * | 2004-11-29 | 2004-12-29 | Era Plantech S L | Production of proteins |
US20090249513A1 (en) * | 2005-03-07 | 2009-10-01 | National University Corporation Nagoya University | Method for Expression and Accumulation of Peptide in Plant |
US8163880B2 (en) | 2006-02-23 | 2012-04-24 | Era Biotech S.A. | Production of biologically active proteins |
US7732569B2 (en) * | 2006-10-19 | 2010-06-08 | E.I. Du Pont De Nemours And Company | Zein-based peptide tags for the expression and purification of bioactive peptides |
EP2150608B1 (en) | 2007-05-07 | 2017-11-29 | Protalix Ltd. | Large scale disposable bioreactor |
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
PT2610345E (pt) | 2007-11-27 | 2016-01-11 | Medicago Inc | Partículas semelhantes ao vírus (vlps) da gripe recombinantes produzidas em plantas transgénicas que expressam hemaglutinina |
AU2009267769B2 (en) * | 2008-07-08 | 2015-07-16 | Medicago Inc. | Soluble recombinant influenza antigens |
KR20110084906A (ko) | 2008-10-10 | 2011-07-26 | 에라 바이오테크, 에스.에이. | 면역원-특이적 면역보강제로서의 재조합 단백질체들 |
CA2762042C (en) | 2009-06-24 | 2012-11-20 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
EP2418284A1 (en) | 2010-08-13 | 2012-02-15 | ERA Biotech, S.A. | Protein body-inducing polypeptide sequences |
EP2468872A1 (en) | 2010-12-23 | 2012-06-27 | Philip Morris Products S.A. | Method for producing mullerian inhibitor substance in plants |
EP2468871A1 (en) | 2010-12-23 | 2012-06-27 | Philip Morris Products S.A. | Method for producing apolipoprotein in plants |
EP2468870A1 (en) * | 2010-12-23 | 2012-06-27 | Philip Morris Products S.A. | Method for expressing desxoyribonuclease in plants |
JP6037395B2 (ja) | 2011-01-17 | 2016-12-07 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 植物におけるタンパク質発現 |
FI20115704L (fi) | 2011-07-01 | 2013-01-02 | Teknologian Tutkimuskeskus Vtt Oy | Vierasproteiinien tuoton parantaminen |
US9603906B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Inhalable liquid formulations of DNase I |
CA2969891A1 (en) * | 2014-12-05 | 2016-06-09 | Planet Biotechnology Inc. | Dpp4 immunoadhesin compositions and methods |
DE102015107846A1 (de) | 2015-05-19 | 2016-11-24 | Johann Wolfgang Goethe-Universität Frankfurt | Synthetische Organellen in Hefe |
KR101848082B1 (ko) * | 2017-05-11 | 2018-04-12 | 주식회사 바이오앱 | 셀룰로오즈 결합 도메인을 포함하는 재조합 벡터 및 상기 벡터를 사용하여 단백질을 분리정제하는 방법 |
EP3629709A4 (en) | 2017-05-30 | 2021-06-30 | Agrivida, Inc. | IMMUNOMODULATOR TRANSGENIC PLANTS AND RELATED PROCESSES |
CA3191387A1 (en) | 2020-09-30 | 2022-04-07 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
CN113683669B (zh) * | 2021-03-25 | 2023-05-16 | 中国农业大学 | 基于与醇溶蛋白的互作在植物中积累目标蛋白的方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4215040A (en) * | 1978-12-22 | 1980-07-29 | The Procter & Gamble Company | Density separation process |
WO1989003887A1 (en) | 1987-10-20 | 1989-05-05 | Plant Genetic Systems N.V. | A process for the production of biologically active peptide via the expression of modified storage seed protein genes in transgenic plants |
ATE316144T1 (de) * | 1987-10-20 | 2006-02-15 | Bayer Bioscience Nv | 5'-flankierende region eines genes von arabidopsis, das für einen 2s albumin-prekursor kodiert |
US5589615A (en) | 1988-10-14 | 1996-12-31 | Plant Genetic Systems N.V. | Process for the production of transgenic plants with increased nutritional value via the expression of modified 2S storage albumins |
US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
US5948682A (en) * | 1991-02-22 | 1999-09-07 | Sembiosys Genetics Inc. | Preparation of heterologous proteins on oil bodies |
US5650554A (en) | 1991-02-22 | 1997-07-22 | Sembiosys Genetics Inc. | Oil-body proteins as carriers of high-value peptides in plants |
AU691707B2 (en) | 1994-10-24 | 1998-05-21 | The Administrators Of The Tulane Eductional Fund | Oral immunization with transgenic plants |
US5935822A (en) | 1995-03-21 | 1999-08-10 | The Regents Of The University Of Colorado | Product and process for membrane and soluble polypeptide segregation |
FR2744134B1 (fr) | 1996-01-29 | 1998-04-03 | Biocem | Proteines de reserve de plantes enrichies en acides amines, notamment alpha-zeine de mais enrichie en lysine plantes exprimant ces proteines |
US5990384A (en) | 1996-05-31 | 1999-11-23 | New Mexico State University | Co-expression of proteins |
DE69836552T3 (de) * | 1997-09-30 | 2014-10-09 | The Regents Of The University Of California | Herstellung von proteinen in pflanzensamen |
AR020090A1 (es) | 1998-06-15 | 2002-04-10 | John Innes Ct | Celula vegetal monocotiledonea o semilla de ella,planta o parte de una planta, metodo para hacer una celula vegetal monocotiledonea, metodo para hacer unaplanta, uso de una construccion de expresion para producir una celula de planta o semilla monocotiledonea, y uso de una construccion de expresion |
JP2002541768A (ja) * | 1998-12-31 | 2002-12-10 | ニュー メキシコ ステイト ユニバーシティ テクノロジー トランスファー コーポレーション | 蛋白質の共発現 |
US20020061309A1 (en) * | 2000-03-08 | 2002-05-23 | Garger Stephen J. | Production of peptides in plants as N-terminal viral coat protein fusions |
US7417178B2 (en) | 2000-05-02 | 2008-08-26 | Ventria Bioscience | Expression of human milk proteins in transgenic plants |
WO2002086077A2 (en) | 2001-04-18 | 2002-10-31 | New Mexico State University Technology Transfer Corporation | Co-expression of zein proteins |
JP3940793B2 (ja) | 2002-05-15 | 2007-07-04 | 独立行政法人農業生物資源研究所 | 任意のペプチドを植物のタンパク顆粒で蓄積させる方法 |
ATE452137T1 (de) * | 2002-05-24 | 2010-01-15 | Restoragen Inc | Verfahren und konstrukte zur expression von clostripain mit hoher ausbeute |
ES2224792B1 (es) | 2002-06-28 | 2007-02-16 | Era Plantech, S.L. | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
US20070150976A1 (en) | 2003-12-09 | 2007-06-28 | Ventria Bioscience | High-level expression of fusion polypeptides in plant seeds utilizing seed-storage proteins as fusion carriers |
CA2558621C (en) | 2004-03-08 | 2013-04-30 | Syngenta Participations Ag | Promoter from maize prolamin seed storage protein and uses thereof |
WO2005113775A1 (en) | 2004-05-21 | 2005-12-01 | Simon Fraser University | Pproduction of a protein localized to the endoplasmic reticulum protein bodies in a transgenic plant and seed |
GB0426161D0 (en) | 2004-11-29 | 2004-12-29 | Era Plantech S L | Protein isolation and purification |
GB0426160D0 (en) | 2004-11-29 | 2004-12-29 | Era Plantech S L | Production of proteins |
WO2008078730A1 (ja) * | 2006-12-26 | 2008-07-03 | Translational Research, Ltd. | 経鼻投与用製剤 |
-
2002
- 2002-06-28 ES ES200201508A patent/ES2224792B1/es not_active Expired - Fee Related
- 2002-08-05 MX MXPA05000290A patent/MXPA05000290A/es active IP Right Grant
- 2002-08-05 DE DE60221051T patent/DE60221051T2/de not_active Expired - Lifetime
- 2002-08-05 EP EP02807566A patent/EP1523558B1/en not_active Expired - Lifetime
- 2002-08-05 WO PCT/EP2002/008716 patent/WO2004003207A1/en active IP Right Grant
- 2002-08-05 JP JP2004516544A patent/JP4610334B2/ja not_active Expired - Fee Related
- 2002-08-05 KR KR1020047021412A patent/KR100987946B1/ko not_active IP Right Cessation
- 2002-08-05 AU AU2002333330A patent/AU2002333330B2/en not_active Ceased
- 2002-08-05 RU RU2005101738/13A patent/RU2381275C2/ru not_active IP Right Cessation
- 2002-08-05 CA CA002490348A patent/CA2490348A1/en not_active Abandoned
- 2002-08-05 KR KR1020097024928A patent/KR20100017491A/ko not_active Application Discontinuation
- 2002-08-05 ES ES02807566T patent/ES2289185T3/es not_active Expired - Lifetime
- 2002-08-05 CN CNB028293754A patent/CN100460510C/zh not_active Expired - Fee Related
- 2002-08-05 DK DK02807566T patent/DK1523558T3/da active
- 2002-08-05 AT AT02807566T patent/ATE366317T1/de not_active IP Right Cessation
- 2002-08-06 US US10/213,462 patent/US7575898B2/en not_active Expired - Fee Related
-
2003
- 2003-06-25 UY UY27864A patent/UY27864A1/es not_active Application Discontinuation
- 2003-06-27 AR ARP030102330A patent/AR040293A1/es active IP Right Grant
-
2009
- 2009-08-17 US US12/542,514 patent/US8802825B2/en not_active Expired - Fee Related
-
2010
- 2010-05-12 JP JP2010110481A patent/JP2010213713A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN100460510C (zh) | 2009-02-11 |
ES2224792B1 (es) | 2007-02-16 |
ATE366317T1 (de) | 2007-07-15 |
CN1639342A (zh) | 2005-07-13 |
DE60221051T2 (de) | 2008-03-13 |
ES2289185T3 (es) | 2008-02-01 |
KR20050024419A (ko) | 2005-03-10 |
AU2002333330A1 (en) | 2004-01-19 |
EP1523558A1 (en) | 2005-04-20 |
KR20100017491A (ko) | 2010-02-16 |
US20100083403A1 (en) | 2010-04-01 |
WO2004003207A9 (en) | 2005-02-10 |
CA2490348A1 (en) | 2004-01-08 |
AU2002333330B2 (en) | 2007-07-12 |
US20040005660A1 (en) | 2004-01-08 |
US8802825B2 (en) | 2014-08-12 |
DK1523558T3 (da) | 2007-11-05 |
UY27864A1 (es) | 2003-09-30 |
RU2005101738A (ru) | 2006-07-20 |
RU2381275C2 (ru) | 2010-02-10 |
KR100987946B1 (ko) | 2010-10-18 |
JP4610334B2 (ja) | 2011-01-12 |
JP2005531309A (ja) | 2005-10-20 |
US7575898B2 (en) | 2009-08-18 |
EP1523558B1 (en) | 2007-07-04 |
ES2224792A1 (es) | 2005-03-01 |
MXPA05000290A (es) | 2005-03-31 |
DE60221051D1 (de) | 2007-08-16 |
JP2010213713A (ja) | 2010-09-30 |
WO2004003207A1 (en) | 2004-01-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR040293A1 (es) | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulo endoplasmico en plantas | |
PE20140867A1 (es) | Axmi-115, axmi-113, axmi-005, axmi-163 y axmi-184: proteinas insecticidas y metodos para su uso | |
BRPI0512396A (pt) | polipeptìdeos biossintéticos utilizando aminoácidos codificados não naturalmente | |
DK1422237T3 (da) | Fremgangsmåder til rekombinant frembringelse af antifusogene peptider | |
CO5601037A2 (es) | Anticuerpos anti-a beta y sus usos | |
DK1863920T3 (da) | Fremgangsmåde til forbedret isolering af rekombinant producerede proteiner | |
BRPI0511868A (pt) | peptìdeo isolado, polipeptìdeo de fusão, moléculas de ácido nucléico isoladas, vetores, métodos de direcionamento de polipeptìdeos e método de identificação de peptìdeos | |
NO20052276D0 (no) | Sirkulaert DNA-molekyl med en kondisjonell replikasjonsorigo, fremgangsmate for deres fremstilling og deres anvendelse i genterapi | |
AR047345A1 (es) | Vacuna para mejorar el crecimiento de animales a base de epitopos neutralizantes | |
NO20062709L (no) | Stamceller som er egnet for transplantasjon, fremstilling derav og farmasoytiske preperater omfattende nevnte stamceller | |
AR036272A1 (es) | Genes de metiltransferasas y usos de los mismos | |
BRPI0410562A (pt) | molécula recombinante e veìculo para expressão, liberação e purificação de polipeptìdeos alvo | |
PE20120401A1 (es) | Proteina de enlace de il-13 | |
BRPI0512798A (pt) | molécula de ácido nucleico recombinante, célula, método para produzir uma proteìna de interesse, uso de uma seqüência de ácido nucleico tendo atividade anti-repressora, métodos para gerar uma célula hospedeira expressando dois polipeptìdios de interesse, e para expressar dois polipeptìdios de interesse | |
Martina et al. | Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor | |
Unno et al. | Heterologous expression of a cryptic gene cluster from Grimontia marina affords a novel tricyclic peptide grimoviridin | |
AR026571A1 (es) | Genes del musgo de la physcomitrella patens que codifican proteinas que participan en la sintesis de los acidos grasos poliinsaturados y lipidos | |
AR087719A2 (es) | Celula de planta transformada, cultivo de tejidos y planta transgenica | |
WO2006088492A3 (en) | High throughput proteomics | |
DK1576157T3 (da) | Fluorescerende proteiner fra Copepode-arter og fremgangsmåder til anvendelse af samme | |
WO2003074706A1 (fr) | Proteine ou polypeptide ayant une activite de synthase de type substance lacrymogene, adn codant la proteine ou le polypeptide, procede d'obtention de ladite proteine ou dudit polypeptide, et molecule d'acides nucleiques inhibant la translation de l'arn messager concernant la proteine ou le peptide | |
BR0313083A (pt) | moléculas de adamts4 modificadas,polinucleotìdeo, vetor, processos para produção, composição farmacêutica, bem como uso das mesmas | |
AR053285A1 (es) | Tratamiento de enfemedades usando un sistema mejorado de expresion regulada | |
DK1255816T3 (da) | Skræddersyede peptidsyntetaser, fremgangsmåde til deres fremstilling samt deres anvendelse | |
Ervin et al. | Proline Behavior in Model Prebiotic Peptides Formed by Wet–Dry Cycling |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal | ||
FG | Grant, registration |