DK1255816T3 - Skræddersyede peptidsyntetaser, fremgangsmåde til deres fremstilling samt deres anvendelse - Google Patents

Skræddersyede peptidsyntetaser, fremgangsmåde til deres fremstilling samt deres anvendelse

Info

Publication number
DK1255816T3
DK1255816T3 DK00972794T DK00972794T DK1255816T3 DK 1255816 T3 DK1255816 T3 DK 1255816T3 DK 00972794 T DK00972794 T DK 00972794T DK 00972794 T DK00972794 T DK 00972794T DK 1255816 T3 DK1255816 T3 DK 1255816T3
Authority
DK
Denmark
Prior art keywords
peptide synthetases
processes
preparation
nrpss
modification
Prior art date
Application number
DK00972794T
Other languages
English (en)
Inventor
Henning Mootz
Dirk Schwarzer
Sascha Doekel
Uwe Linne
Mohamed A Marahiel
Original Assignee
Cubist Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cubist Pharmaceutical Inc filed Critical Cubist Pharmaceutical Inc
Application granted granted Critical
Publication of DK1255816T3 publication Critical patent/DK1255816T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK00972794T 1999-10-22 2000-10-18 Skræddersyede peptidsyntetaser, fremgangsmåde til deres fremstilling samt deres anvendelse DK1255816T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19951196A DE19951196A1 (de) 1999-10-22 1999-10-22 Massgeschneiderte Peptidsynthetasen und ihre Verwendung

Publications (1)

Publication Number Publication Date
DK1255816T3 true DK1255816T3 (da) 2006-10-30

Family

ID=7926708

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00972794T DK1255816T3 (da) 1999-10-22 2000-10-18 Skræddersyede peptidsyntetaser, fremgangsmåde til deres fremstilling samt deres anvendelse

Country Status (13)

Country Link
US (2) US20100297751A1 (da)
EP (1) EP1255816B1 (da)
JP (1) JP2003512835A (da)
KR (1) KR20020069509A (da)
AT (1) ATE331027T1 (da)
AU (1) AU1139901A (da)
CA (1) CA2384972A1 (da)
DE (2) DE19951196A1 (da)
DK (1) DK1255816T3 (da)
ES (1) ES2267579T3 (da)
IL (1) IL149158A0 (da)
NO (1) NO20021810L (da)
WO (1) WO2001030985A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235651B2 (en) 2001-12-26 2007-06-26 Cubist Pharmaceuticals, Inc. Genes and proteins involved in the biosynthesis of lipopeptides
EP1461434A2 (en) * 2001-12-26 2004-09-29 Ecopia Biosciences Inc. Compositions, methods and systems for discovery of lipopeptides
KR100762315B1 (ko) * 2006-01-24 2007-10-04 한국생명공학연구원 푸자리시딘 생합성 효소 및 이를 코딩하는 유전자
US7981685B2 (en) * 2007-04-16 2011-07-19 Modular Genetics, Inc. Generation of acyl amino acids
WO2013113646A1 (en) 2012-01-31 2013-08-08 Dsm Sinochem Pharmaceuticals Netherlands B.V. Mbth-like proteins in the production of semi synthetic antibiotics
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
CN107849542A (zh) 2015-08-05 2018-03-27 默克专利股份公司 人工非核糖体肽合成酶
WO2017137443A1 (en) 2016-02-08 2017-08-17 Johann Wolfgang Goethe-Universität Frankfurt am Main Artificial non-ribosomal peptide synthases and their use
EP3511445A1 (en) 2018-01-15 2019-07-17 Johann Wolfgang Goethe-Universität Frankfurt System for the assembly and modification of non-ribosomal peptide synthases
CN114657155B (zh) * 2021-12-23 2024-01-19 中国农业科学院生物技术研究所 一种新型的非核糖体多肽合成酶拆分表达方法
WO2024038117A1 (en) 2022-08-16 2024-02-22 Johann Wolfgang Goethe-Universität Frankfurt Method and means for engineering non-ribosomal peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264712B1 (it) * 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi
DE19531944A1 (de) * 1995-08-18 1997-02-20 Biopract Gmbh Neue Endo-Xylanasen
DE19909146A1 (de) * 1999-03-03 2000-09-28 Mohamed A Marahiel Verfahren zur gezielten biologischen Synthese von Peptiden

Also Published As

Publication number Publication date
ATE331027T1 (de) 2006-07-15
US20100297751A1 (en) 2010-11-25
DE19951196A1 (de) 2001-05-10
IL149158A0 (en) 2002-11-10
EP1255816A1 (de) 2002-11-13
CA2384972A1 (en) 2001-05-03
NO20021810D0 (no) 2002-04-17
WO2001030985A1 (de) 2001-05-03
EP1255816B1 (de) 2006-06-21
JP2003512835A (ja) 2003-04-08
NO20021810L (no) 2002-06-19
AU1139901A (en) 2001-05-08
KR20020069509A (ko) 2002-09-04
DE50013072D1 (de) 2006-08-03
ES2267579T3 (es) 2007-03-16
US20100285563A1 (en) 2010-11-11

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