BR9911270A - Métodos e meios para expressão de polipeptìdeos de mamìferos em plantas monocotiledÈneas - Google Patents

Métodos e meios para expressão de polipeptìdeos de mamìferos em plantas monocotiledÈneas

Info

Publication number
BR9911270A
BR9911270A BR9911270-1A BR9911270A BR9911270A BR 9911270 A BR9911270 A BR 9911270A BR 9911270 A BR9911270 A BR 9911270A BR 9911270 A BR9911270 A BR 9911270A
Authority
BR
Brazil
Prior art keywords
expression
methods
mammalian polypeptides
plants
mammalian
Prior art date
Application number
BR9911270-1A
Other languages
English (en)
Inventor
Paul Christou
Eva Stoger
Julian K-C Ma
Rainer Fischer
Carmen Martin-Vaquero
Stefan Schillberg
Original Assignee
Rainer Fischer
John Innes Ct
Carmen Martin Vaquero
King S College London
Stefan Schillberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rainer Fischer, John Innes Ct, Carmen Martin Vaquero, King S College London, Stefan Schillberg filed Critical Rainer Fischer
Publication of BR9911270A publication Critical patent/BR9911270A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8221—Transit peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"MéTODOS E MEIOS PARA EXPRESSãO DE POLIPEPTìDEOS DE MAMìFEROS EM PLANTAS MONOCOTILEDÈNEAS"<D>. Arroz, trigo e outras plantas monocotiledóneas sã transformadas com cassetes de expressão para produção de polipeptídeos de mamíferos tais como anticorpos. Sinais de retenção de retículo endoplasmático (ER), regiões não-traduzidas 5' e peptídeos líderes são empregados em várias combinações para fornecer alto rendimento de expressão. Complexos de multicadeias tais como anticorpos secretores de quatro-cadeias são produzidos por expressão de polipeptídeos dos componentes provenientes de vetores separados todos induzidos na mesma célula por transformação.
BR9911270-1A 1998-06-15 1999-06-15 Métodos e meios para expressão de polipeptìdeos de mamìferos em plantas monocotiledÈneas BR9911270A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8932298P 1998-06-15 1998-06-15
PCT/US1999/013584 WO1999066026A2 (en) 1998-06-15 1999-06-15 Methods and means for expression of mammalian polypeptides in monocotyledonous plants

Publications (1)

Publication Number Publication Date
BR9911270A true BR9911270A (pt) 2001-03-13

Family

ID=22217017

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911270-1A BR9911270A (pt) 1998-06-15 1999-06-15 Métodos e meios para expressão de polipeptìdeos de mamìferos em plantas monocotiledÈneas

Country Status (8)

Country Link
US (2) US20020078472A1 (pt)
EP (1) EP1088061A4 (pt)
AR (1) AR020090A1 (pt)
AU (1) AU4571699A (pt)
BR (1) BR9911270A (pt)
CA (1) CA2330933A1 (pt)
MX (1) MXPA00012520A (pt)
WO (1) WO1999066026A2 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69926647T2 (de) * 1998-10-16 2006-11-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Durch molekulares pathogenicid vermittelte krankheitsresistenz in pflanzen
ATE553117T1 (de) * 2000-02-29 2012-04-15 Univ Auburn Mehrfache genexpression zur einrichtung von neuen synthesewegen und überexpression von fremdproteinen in pflanzen
CA2401965A1 (en) * 2000-02-29 2001-09-07 Auburn University Production of antibodies in transgenic plastids
US20020174453A1 (en) * 2001-04-18 2002-11-21 Henry Daniell Production of antibodies in transgenic plastids
US20030041353A1 (en) 2001-04-18 2003-02-27 Henry Daniell Mutiple gene expression for engineering novel pathways and hyperexpression of foreign proteins in plants
US7304208B2 (en) * 2000-05-02 2007-12-04 Ventria Bioscience Expression of human serum albumin (HSA) in monocot seeds
GB2364705A (en) * 2000-07-14 2002-02-06 Icgeb Fusion protein expression in plastids
US6472176B2 (en) * 2000-12-14 2002-10-29 Genvec, Inc. Polynucleotide encoding chimeric protein and related vector, cell, and method of expression thereof
WO2002099067A2 (en) 2001-06-05 2002-12-12 Oishi Karen K Gene expression and production of tgf-b proteins including bioactive mullerian inhibiting substance from plants
US8558058B2 (en) * 2001-12-06 2013-10-15 Applied Biotechnology Institute Monocotyledonous seed expressing exo-1,4B-glucanase
ES2224792B1 (es) * 2002-06-28 2007-02-16 Era Plantech, S.L. Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas.
CA2548749A1 (en) * 2003-12-09 2005-06-23 Ventria Bioscience High-level expression of fusion polypeptides in plant seeds utilizing seed-storage proteins as fusion carriers
JP2008507258A (ja) * 2004-04-22 2008-03-13 フラウンホーファー・ゲゼルシャフト ツーァ フェルデルンク デァ アンゲヴァンテン フォルシュンク エー ファウ 連鎖球菌表面抗原ｉ／ｉｉに特異的に結合する二重特異性抗体および前記の使用の方法
JP2008515454A (ja) * 2004-10-13 2008-05-15 プロタリクス リミテッド 植物細胞培養における抗体製造のシステムおよび方法
WO2006066340A1 (en) * 2004-12-21 2006-06-29 Grain Biotech Australia Pty Ltd A method for the high expression of immunoglobulin in plants
US20100047164A1 (en) * 2008-04-11 2010-02-25 Duke University Anti-Tumor Antibodies
US10308948B2 (en) 2011-07-27 2019-06-04 Applied Biotechnology Institute, Inc. Method of increasing expression of nucleic acid molecules in plants using multiple transcription units
JP2023515684A (ja) * 2020-03-02 2023-04-13 ベントリア、バイオサイエンス、インコーポレイテッド 真核生物における免疫グロブリンの発現収率の改善

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693506A (en) * 1993-11-16 1997-12-02 The Regents Of The University Of California Process for protein production in plants
US5824870A (en) * 1995-11-06 1998-10-20 Baszczynski; Chris Commercial production of aprotinin in plants
WO1998010062A1 (en) * 1996-09-03 1998-03-12 Monsanto Company Monocot seed gene expression system

Also Published As

Publication number Publication date
WO1999066026A3 (en) 2000-01-27
WO1999066026A2 (en) 1999-12-23
EP1088061A4 (en) 2005-03-16
EP1088061A2 (en) 2001-04-04
MXPA00012520A (es) 2002-05-08
AR020090A1 (es) 2002-04-10
US20030051275A1 (en) 2003-03-13
US20020078472A1 (en) 2002-06-20
AU4571699A (en) 2000-01-05
CA2330933A1 (en) 1999-12-23

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