AR038393A1 - Dihidrotiafenantrencarbonilguanidinas, proceso para su preparacion, su uso como medicamento o auxiliar de diagnostico y medicamento que las comprende - Google Patents
Dihidrotiafenantrencarbonilguanidinas, proceso para su preparacion, su uso como medicamento o auxiliar de diagnostico y medicamento que las comprendeInfo
- Publication number
- AR038393A1 AR038393A1 ARP030100363A ARP030100363A AR038393A1 AR 038393 A1 AR038393 A1 AR 038393A1 AR P030100363 A ARP030100363 A AR P030100363A AR P030100363 A ARP030100363 A AR P030100363A AR 038393 A1 AR038393 A1 AR 038393A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- independently
- alkyl
- medicinal
- dihydrotiafenantrencarbonilguanidinas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se refiere a dihidrotiafenantrencarbonilguanidinas de fórmula (1) que son adecuadas como medicamentos antiarrítmicos con un componente cardioprotector para la profilaxis del infarto y el tratamiento del infarto, y para el tratamiento de la angina de pecho. Inhiben también de manera preventiva los procesos patofisiológicos implicados en el desarrollo de una lesión inducida por la isquemia, especialmente en la iniciación de arritmias cardíacas inducidas por la isquemia. Reivindicación 1: Una dihidrotiafenantrencarbonilguanidina de fórmula (1) en la que los significados son: R1 y R3 independientemente entre sí H, alquilo de 1, 2, 3, o 4 átomos de C, alcoxi de 1, 2, 3, o 4 átomos de C , F, Cl, Br, I, CN, NR10R11, -Op-(CH2)n-(CF2)x-CF3 o -(SOm)p-(CH2)n-(CF2)x-CF3; R10 y R11 independientemente entre sí H, alquilo de 1, 2, 3, o 4 átomos de C o -(CH2)n-(CF2)x-CF3; m es 0, 1 o 2; m es 0, 1, 2, 3, 4, 5 o 6; x y p independientemente entre sí 0 o 1; R2 H, F, Cl, Br, I, CN, alquilo de 1, 2, 3 o 4 átomos de C, metoxi, cicloalquilo de 3, 4, 5, 6, 7 u 8 átomos de C, R4 y R5 independientemente entre sí H, alquilo de 1, 2, 3, o 4 átomos de C, R6, R7, R8 y R9, independientemente entre sí H, alquilo de 1, 2, 3 o 4 átomos de C; alcoxi de 1, 2, 3 o 4 átomos de C, F, Cl, Br, I, CN, NR12R13, -Oq-(CH2)r-(CF2)s-CF3 o -(SOw)t-(CH2)u-(CF2)v-CF3; R12 y R13 independientemente entre sí H, alquilo de 1, 2, 3 o 4 átomos de C; w es 0, 1 o 2; r y u son 0, 1, 2, 3, 4, 5 o 6; q, s, t, y v independientemente entre sí 0 o 1; o R6 y R7 o R7 y R8 o R8 y R9 junto con el anillo de fenilo que los lleva un sistema naftaleno; A -S-, -SO- o -SO2- y las sales farmacéuticamente adecuadas de las mismas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10204989A DE10204989A1 (de) | 2002-02-07 | 2002-02-07 | Dihydro-thia-phenanthren-carbonyl-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038393A1 true AR038393A1 (es) | 2005-01-12 |
Family
ID=27618378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030100363A AR038393A1 (es) | 2002-02-07 | 2003-02-05 | Dihidrotiafenantrencarbonilguanidinas, proceso para su preparacion, su uso como medicamento o auxiliar de diagnostico y medicamento que las comprende |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1474414B1 (es) |
| JP (1) | JP4410564B2 (es) |
| KR (1) | KR20040096555A (es) |
| CN (1) | CN1319963C (es) |
| AR (1) | AR038393A1 (es) |
| AT (1) | ATE380805T1 (es) |
| AU (1) | AU2003208337A1 (es) |
| BR (1) | BR0307495A (es) |
| CA (1) | CA2475093A1 (es) |
| CO (1) | CO5601008A2 (es) |
| DE (2) | DE10204989A1 (es) |
| HK (1) | HK1073656A1 (es) |
| HR (1) | HRP20040721A2 (es) |
| HU (1) | HUP0402595A2 (es) |
| MA (1) | MA27171A1 (es) |
| MX (1) | MXPA04007476A (es) |
| NO (1) | NO20043717L (es) |
| NZ (1) | NZ534536A (es) |
| PE (1) | PE20030963A1 (es) |
| PL (1) | PL370271A1 (es) |
| RS (1) | RS69204A (es) |
| RU (1) | RU2306311C2 (es) |
| TW (1) | TWI268927B (es) |
| WO (1) | WO2003066620A1 (es) |
| ZA (1) | ZA200406015B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200614995A (en) * | 2004-11-10 | 2006-05-16 | Nicholas Piramal India Ltd | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60262887A (ja) * | 1984-06-11 | 1985-12-26 | Mitsubishi Chem Ind Ltd | 液晶組成物 |
| GB8505756D0 (en) * | 1985-03-06 | 1985-04-11 | Erba Farmitalia | Tricyclic dibenzo condensed derivatives |
| US4948806A (en) * | 1988-03-30 | 1990-08-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| CA2370607A1 (en) * | 1999-04-23 | 2000-11-02 | Bristol-Myers Squibb Company | Bicyclic acyl guanidine sodium/proton exchange inhibitors and method |
| DE10001879A1 (de) * | 2000-01-19 | 2001-07-19 | Aventis Pharma Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
2002
- 2002-02-07 DE DE10204989A patent/DE10204989A1/de not_active Withdrawn
-
2003
- 2003-01-23 KR KR10-2004-7012241A patent/KR20040096555A/ko not_active Application Discontinuation
- 2003-01-23 RS YU69204A patent/RS69204A/sr unknown
- 2003-01-23 AT AT03706373T patent/ATE380805T1/de not_active IP Right Cessation
- 2003-01-23 EP EP03706373A patent/EP1474414B1/de not_active Expired - Lifetime
- 2003-01-23 WO PCT/EP2003/000653 patent/WO2003066620A1/de active IP Right Grant
- 2003-01-23 DE DE50308787T patent/DE50308787D1/de not_active Expired - Lifetime
- 2003-01-23 MX MXPA04007476A patent/MXPA04007476A/es active IP Right Grant
- 2003-01-23 BR BR0307495-1A patent/BR0307495A/pt not_active IP Right Cessation
- 2003-01-23 HU HU0402595A patent/HUP0402595A2/hu unknown
- 2003-01-23 RU RU2004126854/04A patent/RU2306311C2/ru not_active IP Right Cessation
- 2003-01-23 PL PL03370271A patent/PL370271A1/xx not_active Application Discontinuation
- 2003-01-23 AU AU2003208337A patent/AU2003208337A1/en not_active Abandoned
- 2003-01-23 CN CNB038035502A patent/CN1319963C/zh not_active Expired - Fee Related
- 2003-01-23 JP JP2003565993A patent/JP4410564B2/ja not_active Expired - Fee Related
- 2003-01-23 CA CA002475093A patent/CA2475093A1/en not_active Abandoned
- 2003-01-23 NZ NZ534536A patent/NZ534536A/en unknown
- 2003-01-30 TW TW092102087A patent/TWI268927B/zh not_active IP Right Cessation
- 2003-02-05 AR ARP030100363A patent/AR038393A1/es unknown
- 2003-02-05 PE PE2003000136A patent/PE20030963A1/es not_active Application Discontinuation
-
2004
- 2004-07-27 MA MA27802A patent/MA27171A1/fr unknown
- 2004-07-28 ZA ZA200406015A patent/ZA200406015B/en unknown
- 2004-08-06 HR HR20040721A patent/HRP20040721A2/hr not_active Application Discontinuation
- 2004-08-06 CO CO04076743A patent/CO5601008A2/es not_active Application Discontinuation
- 2004-09-06 NO NO20043717A patent/NO20043717L/no not_active Application Discontinuation
-
2005
- 2005-07-21 HK HK05106161A patent/HK1073656A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL370271A1 (en) | 2005-05-16 |
| DE10204989A1 (de) | 2003-08-21 |
| NZ534536A (en) | 2006-02-24 |
| HK1073656A1 (en) | 2005-10-14 |
| JP2005517015A (ja) | 2005-06-09 |
| HUP0402595A2 (hu) | 2005-04-28 |
| JP4410564B2 (ja) | 2010-02-03 |
| CN1319963C (zh) | 2007-06-06 |
| PE20030963A1 (es) | 2004-01-12 |
| RS69204A (en) | 2006-12-15 |
| KR20040096555A (ko) | 2004-11-16 |
| HRP20040721A2 (en) | 2005-06-30 |
| RU2004126854A (ru) | 2006-01-27 |
| MA27171A1 (fr) | 2005-01-03 |
| TWI268927B (en) | 2006-12-21 |
| AU2003208337A1 (en) | 2003-09-02 |
| DE50308787D1 (de) | 2008-01-24 |
| EP1474414B1 (de) | 2007-12-12 |
| TW200404792A (en) | 2004-04-01 |
| CA2475093A1 (en) | 2003-08-14 |
| CO5601008A2 (es) | 2006-01-31 |
| EP1474414A1 (de) | 2004-11-10 |
| CN1630649A (zh) | 2005-06-22 |
| NO20043717L (no) | 2004-11-03 |
| ATE380805T1 (de) | 2007-12-15 |
| RU2306311C2 (ru) | 2007-09-20 |
| WO2003066620A1 (de) | 2003-08-14 |
| ZA200406015B (en) | 2005-11-14 |
| BR0307495A (pt) | 2004-12-28 |
| MXPA04007476A (es) | 2004-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |