PE20030963A1 - Dihidrotiafenantrencarbonilguanidinas y proceso para su preparacion - Google Patents
Dihidrotiafenantrencarbonilguanidinas y proceso para su preparacionInfo
- Publication number
- PE20030963A1 PE20030963A1 PE2003000136A PE2003000136A PE20030963A1 PE 20030963 A1 PE20030963 A1 PE 20030963A1 PE 2003000136 A PE2003000136 A PE 2003000136A PE 2003000136 A PE2003000136 A PE 2003000136A PE 20030963 A1 PE20030963 A1 PE 20030963A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- dioxo
- dihydro
- carbonyl
- formate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A DIHIDROTIAFENANTRENCARBONILGUANIDINAS DE FORMULA I DONDE R1 Y R3 SON H, ALQUILO C1-C4, ALCOXI C1-C4, F, Cl, Br, I, CN, ENTRE OTROS; R2 ES H, HALO, CIANO, ALQUILO C1-C4, METOXI, CICLOALQUILO C3-C4, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C4; R6-R9 SON H, ALQUILO C1-C4, ALCOXI C1-C4, HALO, NR(12)R(13) ENTRE OTROS; R12 Y R13 SON H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS FORMIATO DE N-(6-METIL-9,9-DIOXO-9,10-DIHIDRO-9-TIAFENANTRENO-7-CARBONIL)GUANIDINO, FORMIATO DE N-(2-METIL-5,5-DIOXO-5,6-DIHIDRO-5-TIABENZO[c]FENANTREN-3-CARBONIL)GUANIDINO, FORMIATO DE N-(3,6-DIMETIL-9,9-DIOXO-9,10-DIHIDRO-9-TIAFENANTREN-7-CARBONIL)GUANIDINO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS INHIBEN EL MECANISMO DE INTERCAMBIO CELULAR Na+/H+ Y SON UTILES EN EL TRATAMIENTO DE LESIONES INDUCIDAS POR ISQUEMIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10204989A DE10204989A1 (de) | 2002-02-07 | 2002-02-07 | Dihydro-thia-phenanthren-carbonyl-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030963A1 true PE20030963A1 (es) | 2004-01-12 |
Family
ID=27618378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000136A PE20030963A1 (es) | 2002-02-07 | 2003-02-05 | Dihidrotiafenantrencarbonilguanidinas y proceso para su preparacion |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1474414B1 (es) |
| JP (1) | JP4410564B2 (es) |
| KR (1) | KR20040096555A (es) |
| CN (1) | CN1319963C (es) |
| AR (1) | AR038393A1 (es) |
| AT (1) | ATE380805T1 (es) |
| AU (1) | AU2003208337A1 (es) |
| BR (1) | BR0307495A (es) |
| CA (1) | CA2475093A1 (es) |
| CO (1) | CO5601008A2 (es) |
| DE (2) | DE10204989A1 (es) |
| HK (1) | HK1073656A1 (es) |
| HR (1) | HRP20040721A2 (es) |
| HU (1) | HUP0402595A2 (es) |
| MA (1) | MA27171A1 (es) |
| MX (1) | MXPA04007476A (es) |
| NO (1) | NO20043717L (es) |
| NZ (1) | NZ534536A (es) |
| PE (1) | PE20030963A1 (es) |
| PL (1) | PL370271A1 (es) |
| RS (1) | RS69204A (es) |
| RU (1) | RU2306311C2 (es) |
| TW (1) | TWI268927B (es) |
| WO (1) | WO2003066620A1 (es) |
| ZA (1) | ZA200406015B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200614995A (en) * | 2004-11-10 | 2006-05-16 | Nicholas Piramal India Ltd | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60262887A (ja) * | 1984-06-11 | 1985-12-26 | Mitsubishi Chem Ind Ltd | 液晶組成物 |
| GB8505756D0 (en) * | 1985-03-06 | 1985-04-11 | Erba Farmitalia | Tricyclic dibenzo condensed derivatives |
| US4948806A (en) * | 1988-03-30 | 1990-08-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| JP2002542291A (ja) * | 1999-04-23 | 2002-12-10 | ブリストル−マイヤーズ スクイブ カンパニー | ジ環式アシルグアニジン・ナトリウム／プロトン交換抑制剤および方法 |
| DE10001879A1 (de) * | 2000-01-19 | 2001-07-19 | Aventis Pharma Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
2002
- 2002-02-07 DE DE10204989A patent/DE10204989A1/de not_active Withdrawn
-
2003
- 2003-01-23 BR BR0307495-1A patent/BR0307495A/pt not_active IP Right Cessation
- 2003-01-23 PL PL03370271A patent/PL370271A1/xx not_active Application Discontinuation
- 2003-01-23 CN CNB038035502A patent/CN1319963C/zh not_active Expired - Fee Related
- 2003-01-23 EP EP03706373A patent/EP1474414B1/de not_active Expired - Lifetime
- 2003-01-23 AT AT03706373T patent/ATE380805T1/de not_active IP Right Cessation
- 2003-01-23 JP JP2003565993A patent/JP4410564B2/ja not_active Expired - Fee Related
- 2003-01-23 NZ NZ534536A patent/NZ534536A/en unknown
- 2003-01-23 HU HU0402595A patent/HUP0402595A2/hu unknown
- 2003-01-23 CA CA002475093A patent/CA2475093A1/en not_active Abandoned
- 2003-01-23 RS YU69204A patent/RS69204A/sr unknown
- 2003-01-23 AU AU2003208337A patent/AU2003208337A1/en not_active Abandoned
- 2003-01-23 DE DE50308787T patent/DE50308787D1/de not_active Expired - Lifetime
- 2003-01-23 MX MXPA04007476A patent/MXPA04007476A/es active IP Right Grant
- 2003-01-23 KR KR10-2004-7012241A patent/KR20040096555A/ko not_active Application Discontinuation
- 2003-01-23 RU RU2004126854/04A patent/RU2306311C2/ru not_active IP Right Cessation
- 2003-01-23 WO PCT/EP2003/000653 patent/WO2003066620A1/de active IP Right Grant
- 2003-01-30 TW TW092102087A patent/TWI268927B/zh not_active IP Right Cessation
- 2003-02-05 PE PE2003000136A patent/PE20030963A1/es not_active Application Discontinuation
- 2003-02-05 AR ARP030100363A patent/AR038393A1/es unknown
-
2004
- 2004-07-27 MA MA27802A patent/MA27171A1/fr unknown
- 2004-07-28 ZA ZA200406015A patent/ZA200406015B/en unknown
- 2004-08-06 HR HR20040721A patent/HRP20040721A2/hr not_active Application Discontinuation
- 2004-08-06 CO CO04076743A patent/CO5601008A2/es not_active Application Discontinuation
- 2004-09-06 NO NO20043717A patent/NO20043717L/no not_active Application Discontinuation
-
2005
- 2005-07-21 HK HK05106161A patent/HK1073656A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ534536A (en) | 2006-02-24 |
| BR0307495A (pt) | 2004-12-28 |
| WO2003066620A1 (de) | 2003-08-14 |
| NO20043717L (no) | 2004-11-03 |
| RU2306311C2 (ru) | 2007-09-20 |
| MA27171A1 (fr) | 2005-01-03 |
| EP1474414B1 (de) | 2007-12-12 |
| DE50308787D1 (de) | 2008-01-24 |
| RU2004126854A (ru) | 2006-01-27 |
| AR038393A1 (es) | 2005-01-12 |
| HK1073656A1 (en) | 2005-10-14 |
| KR20040096555A (ko) | 2004-11-16 |
| CN1319963C (zh) | 2007-06-06 |
| AU2003208337A1 (en) | 2003-09-02 |
| CN1630649A (zh) | 2005-06-22 |
| HRP20040721A2 (en) | 2005-06-30 |
| ZA200406015B (en) | 2005-11-14 |
| TW200404792A (en) | 2004-04-01 |
| JP4410564B2 (ja) | 2010-02-03 |
| DE10204989A1 (de) | 2003-08-21 |
| JP2005517015A (ja) | 2005-06-09 |
| PL370271A1 (en) | 2005-05-16 |
| ATE380805T1 (de) | 2007-12-15 |
| CO5601008A2 (es) | 2006-01-31 |
| EP1474414A1 (de) | 2004-11-10 |
| MXPA04007476A (es) | 2004-11-10 |
| TWI268927B (en) | 2006-12-21 |
| HUP0402595A2 (hu) | 2005-04-28 |
| CA2475093A1 (en) | 2003-08-14 |
| RS69204A (en) | 2006-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20020051A1 (es) | Metodos y composiciones que comprenden nucleosidos para tratar flavivirus y pestivirus | |
| PE20051058A1 (es) | Fenilalanina-amidas sustituidas por benzoilo | |
| PE20011001A1 (es) | Compuestos heterociclicos como inhibidores del intercambio de sodio/protones | |
| PE20050131A1 (es) | Derivados de benzoimidazol como agentes antiproliferativos | |
| PE20040165A1 (es) | Uso de analogos del benzimidazol en el tratamiento de la proliferacion celular | |
| PE20050147A1 (es) | Derivados de pirimidina, piridina y tiazol como inhibidores de fosfatidilinositol 3-quinasa | |
| PE20030199A1 (es) | Derivados de n-[benzoil]-fenilsulfonamida | |
| PE20020335A1 (es) | Acetamida de benceno de alfa-acil- y alfa-heteroatomo-sustituido como activadores de la glucoquinasa | |
| PE20061353A1 (es) | Compuestos de sulfonamida-tiazolopiridina como activadores de glucocinasa | |
| PE20020228A1 (es) | Compuestos organicos como inhibidores de 3',5' guanosin monofosfato ciclico fosfodiesterasa | |
| PE20090601A1 (es) | Derivados de piridin-il-oxi-piridinas como inhibidores de alk5 | |
| TR199901055T2 (xx) | Benzimidazol t�revlerinin kristalleri ve bunlar�n �retimi. | |
| PE20011047A1 (es) | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas | |
| PE20011348A1 (es) | Agentes antivirales de imidazopiridina e imidazopimiridina | |
| AR035871A1 (es) | Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4''-sustituidos, intermediario y procedimiento para la preparacion del mismo | |
| PE20020256A1 (es) | Carboxamidas heterociclicas como agentes antivirales | |
| PE20030726A1 (es) | 4-feniltetrahidroisoquinolinas sustituidas, proceso para su preparacion y composiciones farmaceuticas que las contienen | |
| PE20040772A1 (es) | Composicion y actividad antiviral de derivados de piperazina azaindoloxoaceticos | |
| PE20020210A1 (es) | Indoloquinazolinonas como inhibidores de poli(adp-ribosa)polimerasa (parp) | |
| AR007997A1 (es) | Un derivado de distamicina sustituida con acriloilo, sus utilizaciones, un procedimiento para producirlo y una composicion farmaceutica que lo comprende. | |
| PE20050483A1 (es) | Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas | |
| PE20011349A1 (es) | 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales | |
| PE20061141A1 (es) | Imidazoles sustituidos con heterociclilamida | |
| PE20040452A1 (es) | Pentafluorosulfanilbenzoilguanidinas como inhibidores del nhe | |
| PE20060529A1 (es) | Metodo para preparar compuestos de pirrolotriazina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |