AR033262A1 - Procedimiento para la preparacion de 2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano - Google Patents
Procedimiento para la preparacion de 2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromanoInfo
- Publication number
- AR033262A1 AR033262A1 ARP020101480A ARP020101480A AR033262A1 AR 033262 A1 AR033262 A1 AR 033262A1 AR P020101480 A ARP020101480 A AR P020101480A AR P020101480 A ARP020101480 A AR P020101480A AR 033262 A1 AR033262 A1 AR 033262A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- salts
- procedure
- fluorophenyl
- pyridylmethylaminomethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describe un procedimiento para la preparacion de 2-[5-(4-fluorofenil)-3-piridilmetilaminometil]cromano de formula (1) de sus enantiomeros y de sus sales, caracterizado porque (1) se hace reaccionar el 5-(4-fluorofenil)piridin-3-carbaldehido de formula (2) directamente con 2-aminometilcromano o sus sales en condiciones reductivas para obtener el compuesto de formula (1), y (2) si se desea, se transforma el compuesto resultante de formula (1) en una de sus sales aceptables desde el punto de vista fisiologico por tratamiento con un ácido. La ventaja del procedimiento frente al procedimiento descripto en la patente estadounidense 5767132 radica en la disminucion del producto secundario debido a la supresion de la doble alquilacion. Al optar este procedimiento se obtiene un ingrediente activo que no contiene producto secundario con dos radicales de arilpiridina, lo cual facilita la purificacion del ingrediente activo. Además, frente a las aminaciones reductivas que se producen en condiciones estándar el procedimiento mencionado más arriba presenta la ventaja de necesitar de una menor cantidad de reactivos y una menor carga térmica. Esto, a su vez, implica una menor cantidad de impurezas y de reacciones secundarias. El 2-[5-(4-fluorofenil)-3-piridilmetilaminometil]cromano de formula (1) y sus sales son antagonistas selectivos del receptor para dopamina D2 y agonistas del receptor para 5-HT1A.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10120619A DE10120619A1 (de) | 2001-04-26 | 2001-04-26 | 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman |
Publications (1)
Publication Number | Publication Date |
---|---|
AR033262A1 true AR033262A1 (es) | 2003-12-10 |
Family
ID=7682908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020101480A AR033262A1 (es) | 2001-04-26 | 2002-04-24 | Procedimiento para la preparacion de 2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano |
Country Status (24)
Country | Link |
---|---|
US (1) | US7045629B2 (es) |
EP (1) | EP1383763B1 (es) |
JP (1) | JP2004526797A (es) |
KR (1) | KR100839168B1 (es) |
CN (1) | CN100430391C (es) |
AR (1) | AR033262A1 (es) |
AT (1) | ATE306485T1 (es) |
AU (1) | AU2002257763B2 (es) |
BR (1) | BR0209179A (es) |
CA (1) | CA2445207C (es) |
CZ (1) | CZ301615B6 (es) |
DE (2) | DE10120619A1 (es) |
DK (1) | DK1383763T3 (es) |
ES (1) | ES2250647T3 (es) |
HK (1) | HK1077302A1 (es) |
HU (1) | HU229151B1 (es) |
MX (1) | MXPA03009684A (es) |
MY (1) | MY130616A (es) |
PL (1) | PL208705B1 (es) |
RU (1) | RU2288229C2 (es) |
SI (1) | SI1383763T1 (es) |
SK (1) | SK287477B6 (es) |
WO (1) | WO2002088117A2 (es) |
ZA (1) | ZA200309164B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8030336B2 (en) * | 2002-12-13 | 2011-10-04 | Ym Biosciences Australia Pty Ltd | Nicotinamide-based kinase inhibitors |
BRPI0608353A2 (pt) * | 2005-02-17 | 2009-12-01 | Wyeth Corp | derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos |
US7365095B2 (en) * | 2005-04-22 | 2008-04-29 | Wyeth | Chromane and chromene derivatives and uses thereof |
ATE428416T1 (de) * | 2005-06-21 | 2009-05-15 | Merck Patent Gmbh | Feste pharmazeutische zubereitung enthaltend (r)- (-)-2-ä5-(4-fluorophenyl)-3- pyridylmethylaminomethylü-chroman |
JP2009534399A (ja) * | 2006-04-18 | 2009-09-24 | アボット・ラボラトリーズ | バニロイド受容体サブタイプ1型(vr1)の拮抗薬およびその使用 |
SG187146A1 (en) * | 2010-07-20 | 2013-02-28 | Glaxo Group Ltd | Process for preparing pyrano - [2,3-c]pyridine derivatives |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4135474A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
FR2701479B1 (fr) | 1993-02-11 | 1995-05-12 | Pf Medicament | Nouveaux dérivés hétérocycliques de l'aminométhyl-4 pipéridine, leur préparation et leur application en thérapeutique. |
ATE256130T1 (de) * | 1993-08-19 | 2003-12-15 | Janssen Pharmaceutica Nv | Gefässverengende dihydrobenzopyranderivate |
GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
SI0707007T1 (en) * | 1994-10-14 | 2002-04-30 | Merck Patent Gmbh | (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent |
DE10005150A1 (de) | 2000-02-07 | 2001-08-09 | Merck Patent Gmbh | Verfahren zur Herstellung von 5-Arylnicotinaldehyden |
-
2001
- 2001-04-26 DE DE10120619A patent/DE10120619A1/de not_active Withdrawn
-
2002
- 2002-04-08 WO PCT/EP2002/003857 patent/WO2002088117A2/de active IP Right Grant
- 2002-04-08 BR BR0209179-8A patent/BR0209179A/pt not_active Application Discontinuation
- 2002-04-08 JP JP2002585416A patent/JP2004526797A/ja active Pending
- 2002-04-08 AU AU2002257763A patent/AU2002257763B2/en not_active Ceased
- 2002-04-08 US US10/475,988 patent/US7045629B2/en not_active Expired - Lifetime
- 2002-04-08 MX MXPA03009684A patent/MXPA03009684A/es active IP Right Grant
- 2002-04-08 SK SK1433-2003A patent/SK287477B6/sk not_active IP Right Cessation
- 2002-04-08 HU HU0303969A patent/HU229151B1/hu not_active IP Right Cessation
- 2002-04-08 ES ES02727539T patent/ES2250647T3/es not_active Expired - Lifetime
- 2002-04-08 PL PL363281A patent/PL208705B1/pl not_active IP Right Cessation
- 2002-04-08 SI SI200230242T patent/SI1383763T1/sl unknown
- 2002-04-08 CA CA002445207A patent/CA2445207C/en not_active Expired - Lifetime
- 2002-04-08 KR KR1020037012735A patent/KR100839168B1/ko not_active IP Right Cessation
- 2002-04-08 DE DE50204535T patent/DE50204535D1/de not_active Expired - Lifetime
- 2002-04-08 CZ CZ20033214A patent/CZ301615B6/cs not_active IP Right Cessation
- 2002-04-08 CN CNB028088689A patent/CN100430391C/zh not_active Expired - Fee Related
- 2002-04-08 AT AT02727539T patent/ATE306485T1/de active
- 2002-04-08 DK DK02727539T patent/DK1383763T3/da active
- 2002-04-08 EP EP02727539A patent/EP1383763B1/de not_active Expired - Lifetime
- 2002-04-08 RU RU2003132433/04A patent/RU2288229C2/ru not_active IP Right Cessation
- 2002-04-24 MY MYPI20021525A patent/MY130616A/en unknown
- 2002-04-24 AR ARP020101480A patent/AR033262A1/es unknown
-
2003
- 2003-11-25 ZA ZA200309164A patent/ZA200309164B/en unknown
-
2005
- 2005-10-20 HK HK05109355.5A patent/HK1077302A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |