AR032592A1 - Aminoalcoxicarbazoles y el uso de los mismos para la manufactura de un medicamento para el tratamiento de enfermedades del snc - Google Patents
Aminoalcoxicarbazoles y el uso de los mismos para la manufactura de un medicamento para el tratamiento de enfermedades del sncInfo
- Publication number
- AR032592A1 AR032592A1 ARP000104632A ARP000104632A AR032592A1 AR 032592 A1 AR032592 A1 AR 032592A1 AR P000104632 A ARP000104632 A AR P000104632A AR P000104632 A ARP000104632 A AR P000104632A AR 032592 A1 AR032592 A1 AR 032592A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- independently
- optionally substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Aminoalcoxicarbazoles, que proporcionan compuestos de la formula (1) o su sal farmacéuticamente aceptable, racemato, solvato, tautomero, isomero optico o su derivado profármaco; en donde R1 es H, halo, o C1-6 alquilo; cada R2 es independientemente H, halo, -OH, -CN, CF3, -O C1-6 alquilo, C1-6 alquilo, C3-6cicloalquilo, -NR5R6, -CONR5R6, -SO2NR5R6, -COOR7, -OCF3,o fenilo opcionalmente sustituido con halo, OH, O C1-4 alquilo, o C1-6 alquilo; cada R3 es independientemente H, C1-6 alquilo, o C3-6 cicloalquilo; R4 es arilo, o heteroarilo; R5 y R6 son independientemente H, C1-6 alquilo, o C3-6 cicloalquilo, R7 es H, C1-6 alquilo, o C1-3 alquil-fenilo en donde el fenilo puede estar sustituido con R3; R8 y R9 son independientemente H, C1-6 alquilo, opcionalmente sustituido con arilo, heteroarilo, o C3-6 cicloalquilo, C2-6 alqueno, C3-6 cicloalquilo, C2-6 alquilo sustituido con R10, -CHO, siempre que solamente uno de R8 y R9 sea CHO, y el otro sea H, arilo, heterociclo, en donde el heterociclo está unido a través de un átomo de carbono al nitrogeno al cual está unido, o R8 y R9 conjuntamente con el nitrogeno al cual están unidos forman un anillo heterocíclico en donde el anillo heterocíclico puede tener uno o dos heteroátomos seleccionados del grupo integrado por oxígeno, azufre y N(Y) y en donde los átomos de carbono del anillo heterocíclico están opcionalmente sustituidos con uno o dos R14; R10 es -OH, -O (C1-4 alquilo, ), opcionalmente el alquilo está sustituido con OH, -O(C1-4 alquil)-NR11R12, heterociclo, o -CO2R5; R11 y R12 son independientemente, H o C1-4 alquilo, arilo es fenilo o naftilo, opcionalmente sustituido con uno o más R13; heteroarilo es un radical que es un anillo aromático monocíclico de 5 o 6 miembros, con uno o dos heteroátomos, cada uno seleccionado del grupo integrado por oxígeno, azufre, y N(X), o un radical que es un anillo aromático bicíclico ortofusionado de 9 o 10 miembros, que tiene uno, dos o tres heteroátomos, cada uno seleccionado del grupo integrado por oxígeno, azufre, y N(X); en donde los átomos de carbono del heteroarilo pueden estar sustituidos con R13; heterociclo es un radical que es un anillo heterocíclico parcialmente saturado o no saturado, de 5, 6 o 7 miembros, con uno, dos o tres heteroátomos seleccionados del grupo integrado por oxígeno, azufre y N(Y), en donde los átomos de carbono del anillo heterocíclico pueden estar sustituidos con R14; X está ausente, o es H o C1-4 alquilo, Y es H, C1-6 alquilo, opcionalmente sustituido con arilo o heteroarilo, C3-6 cicloalquilo, o C2-6 alquilo sustituido con -OH, -O(C1-4 alquilo), -O(C1-4 alquil)-NR11R12, -CO2R5, o NHCHO, o -OH; R13 es halo, -OH, -CN, -CF3, -O C1-6 alquilo, C1-6 alquilo, C3-6 cicloalquilo, -NR5R6, -CONR5R6, -SO2NR5R6, -COOR7, -OCF3, o fenilo, opcionalmente sustituido con halo, OH, O C1-4 alquilo, o C1-6 alquilo; R14 es C1-6 alquilo, C3-6 cicloalquilo, C2-6 alquilo sustituido con -OH, -O (C1-4 alquilo), -O(C1-4 alquil)-NR11R12, o -CO2R5, -OH, u oxo (=O); m es 1, 2, 3 o 4; n es 1, 2, 3 o 4; en el C3-6 cicloalquilo de cada una de las definiciones anteriores, cada uno puede estar sustituido independientemente con -OH, C1-4 alquilo, u oxo (=O), y con las siguientes condiciones: (a) cuando R4 es 4-fluorofenilo, n es 1, m es 1, cada R3 es independientemente hidrogeno, R8 y R9 es independientemente -CH2CH3, entonces R2 no puede ser fluoro o cloro en la posicion C1-6 de la formula (1); (b) cuando n es 1, m es 1, R2, R3, R8 o R9 son hidrogeno, R4 es 4-tiazolilo, entonces dicho 4-tiazolilo no puede estar sustituido con 4-clorofenilo; (c) cuando n es 1, m es 1, R2, R3, R8 o R9 son hidrogeno, entonces R4 no es 4-piridilo; (d) cuando n es 1, m es 1, R2, R3, R8 o R9 son hidrogeno, entonces R4 no es 2-bromofenilo o 4-bromofenilo. Estos compuestos son ligandos de la 5-HT, y son utiles para tratar enfermedades en donde se desee modular la actividad de la 5-HT. Además se describe el uso de los mismos para la manufactura de un medicamento para tratar una enfermedad o condicion tal como ansiedad, depresion, esquizofrenia, una enfermedad relacionada con el estrés, un trastorno por pánico, una fobia, trastorno obsesivo-compulsivo, síndrome de estrés postraumático, depresion del sistema inmunologico, psicosis, parafrenia, manía, trastornos convulsivos, trastornos de la personalidad, cefalea por migrana, drogadiccion, alcoholismo, obesidad, trastornos de la alimentacion, o trastornos del sueno.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15263899P | 1999-09-07 | 1999-09-07 | |
US20377100P | 2000-05-12 | 2000-05-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR032592A1 true AR032592A1 (es) | 2003-11-19 |
Family
ID=26849726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000104632A AR032592A1 (es) | 1999-09-07 | 2000-09-05 | Aminoalcoxicarbazoles y el uso de los mismos para la manufactura de un medicamento para el tratamiento de enfermedades del snc |
Country Status (15)
Country | Link |
---|---|
US (1) | US6514968B1 (es) |
EP (1) | EP1210329A2 (es) |
JP (1) | JP2003508518A (es) |
KR (1) | KR20020027622A (es) |
CN (1) | CN1169789C (es) |
AR (1) | AR032592A1 (es) |
AU (1) | AU780190B2 (es) |
BR (1) | BR0013767A (es) |
CA (1) | CA2380763A1 (es) |
CO (1) | CO5190697A1 (es) |
MX (1) | MXPA02002496A (es) |
MY (1) | MY125942A (es) |
NZ (1) | NZ517661A (es) |
PE (1) | PE20010522A1 (es) |
WO (1) | WO2001017963A2 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9902987D0 (sv) * | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
PL209872B1 (pl) | 2002-03-27 | 2011-10-31 | Glaxo Group Ltd | Pochodna chinolinowa, sposób jej wytwarzania i jej zastosowanie oraz zawierająca ją farmaceutyczna kompozycja |
AU2003292508A1 (en) * | 2002-11-28 | 2004-06-18 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
RS20060035A (en) | 2003-07-22 | 2008-08-07 | Arena Pharmaceuticals Inc., | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
US7011871B2 (en) * | 2004-02-20 | 2006-03-14 | E. I. Du Pont De Nemours And Company | Charge transport compounds and electronic devices made with such compounds |
WO2006046779A1 (ja) * | 2004-10-29 | 2006-05-04 | Zeria Pharmaceutical Co., Ltd. | カルバゾール誘導体、その溶媒和物、又は薬学的に許容されるその塩 |
WO2006085510A1 (ja) * | 2005-02-08 | 2006-08-17 | Astellas Pharma Inc. | 過敏性腸症候群の治療薬 |
GT200600078A (es) * | 2005-02-17 | 2007-04-12 | Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquil condensados | |
CA2617473A1 (en) * | 2005-08-08 | 2007-02-15 | Astellas Pharma Inc. | Acylguanidine derivative or salt thereof |
WO2007077111A1 (en) * | 2005-12-30 | 2007-07-12 | F. Hoffmann-La Roche Ag | Compounds and methods for carbazole synthesis |
CA2642610A1 (en) * | 2006-02-20 | 2007-08-30 | Astellas Pharma Inc. | Amide derivative or salt thereof |
WO2009074607A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
KR101528658B1 (ko) * | 2008-12-12 | 2015-06-12 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 광활성 조성물, 및 그 조성물로 제조된 전자 소자 |
US9095572B2 (en) | 2009-01-09 | 2015-08-04 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
CN102405043B (zh) | 2009-01-09 | 2017-08-22 | 得克萨斯州大学系统董事会 | 前神经原性化合物 |
US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US8362277B2 (en) * | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
US8617720B2 (en) | 2009-12-21 | 2013-12-31 | E I Du Pont De Nemours And Company | Electroactive composition and electronic device made with the composition |
US9701676B2 (en) | 2012-08-24 | 2017-07-11 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US9902713B2 (en) | 2013-11-11 | 2018-02-27 | Board Of Regents Of The University Of Texas System | Neuroprotective compounds and use thereof |
WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
CN109562085A (zh) | 2015-06-12 | 2019-04-02 | 阿速万科学有限责任公司 | 用于预防和治疗rem睡眠行为障碍的二芳基和芳基杂芳基脲衍生物 |
AU2016291673A1 (en) | 2015-07-15 | 2018-01-25 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease |
CN106045972B (zh) * | 2016-06-03 | 2018-11-16 | 中山大学 | 咔唑-利凡斯的明二联体及其药物组合物和应用 |
CN107325143B (zh) * | 2017-08-07 | 2019-09-10 | 连云港恒运药业有限公司 | 氟维司群中间体合成方法 |
CN108707104A (zh) * | 2018-08-07 | 2018-10-26 | 北京恒信卓元科技有限公司 | 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法 |
Family Cites Families (12)
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US3932424A (en) | 1970-06-15 | 1976-01-13 | Richardson-Merrell Inc. | Bis-basic ethers of carbazole |
DE2815926A1 (de) | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US3896145A (en) | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
US5464746A (en) * | 1991-12-17 | 1995-11-07 | Abbott Laboratories | Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives |
EP0708767B1 (en) | 1993-07-20 | 2001-02-14 | Abbott Laboratories | Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives |
DE4330175A1 (de) | 1993-08-31 | 1995-03-02 | Schering Ag | Alkoxy-substituierte beta-Carboline |
DK139593D0 (da) * | 1993-12-16 | 1993-12-16 | Lundbeck & Co As H | Compounds |
FR2731222A1 (fr) * | 1995-03-02 | 1996-09-06 | Pf Medicament | Nouveaux derives de piperazine aminoindoles cycliques, leur procede de preparation et leur utilisation a titre de medicaments |
US5668167A (en) | 1995-06-07 | 1997-09-16 | Duke University | Methods of treating microbial infections |
BR9713261A (pt) | 1996-10-30 | 2000-03-28 | Lilly Co Eli | Tricìclicos substituìdos |
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2000
- 2000-08-24 MY MYPI20003905A patent/MY125942A/en unknown
- 2000-08-28 PE PE2000000882A patent/PE20010522A1/es not_active Application Discontinuation
- 2000-08-31 NZ NZ517661A patent/NZ517661A/en unknown
- 2000-08-31 AU AU70532/00A patent/AU780190B2/en not_active Ceased
- 2000-08-31 BR BR0013767-7A patent/BR0013767A/pt not_active IP Right Cessation
- 2000-08-31 JP JP2001521710A patent/JP2003508518A/ja active Pending
- 2000-08-31 MX MXPA02002496A patent/MXPA02002496A/es active IP Right Grant
- 2000-08-31 CA CA002380763A patent/CA2380763A1/en not_active Abandoned
- 2000-08-31 WO PCT/US2000/020809 patent/WO2001017963A2/en not_active Application Discontinuation
- 2000-08-31 KR KR1020027002955A patent/KR20020027622A/ko not_active Application Discontinuation
- 2000-08-31 CN CNB008123195A patent/CN1169789C/zh not_active Expired - Fee Related
- 2000-08-31 EP EP00959165A patent/EP1210329A2/en not_active Withdrawn
- 2000-08-31 US US09/652,768 patent/US6514968B1/en not_active Expired - Fee Related
- 2000-09-05 CO CO00066777A patent/CO5190697A1/es not_active Application Discontinuation
- 2000-09-05 AR ARP000104632A patent/AR032592A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2001017963A3 (en) | 2001-11-15 |
CO5190697A1 (es) | 2002-08-29 |
AU7053200A (en) | 2001-04-10 |
BR0013767A (pt) | 2002-06-25 |
NZ517661A (en) | 2004-02-27 |
MXPA02002496A (es) | 2002-07-30 |
WO2001017963A2 (en) | 2001-03-15 |
CN1169789C (zh) | 2004-10-06 |
JP2003508518A (ja) | 2003-03-04 |
CA2380763A1 (en) | 2001-03-15 |
KR20020027622A (ko) | 2002-04-13 |
EP1210329A2 (en) | 2002-06-05 |
AU780190B2 (en) | 2005-03-03 |
PE20010522A1 (es) | 2001-04-28 |
US6514968B1 (en) | 2003-02-04 |
MY125942A (en) | 2006-09-29 |
CN1372547A (zh) | 2002-10-02 |
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