AR031799A1 - Derivado de [1,2,4]triazolo[1,5-a]piridina - Google Patents
Derivado de [1,2,4]triazolo[1,5-a]piridinaInfo
- Publication number
- AR031799A1 AR031799A1 ARP010105765A ARP010105765A AR031799A1 AR 031799 A1 AR031799 A1 AR 031799A1 AR P010105765 A ARP010105765 A AR P010105765A AR P010105765 A ARP010105765 A AR P010105765A AR 031799 A1 AR031799 A1 AR 031799A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- substituted
- dihydro
- aryl
- halogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente describe compuestos de la formula general (1), en donde: R1 es alcoxilo inferior, cicloalquilo o arilo, sustituido o no por halogeno o alcoxilo inferior, o es -NR'R'', donde R' y R'' son independientemente uno del otro hidrogeno, alquilo inferior, alquenilo inferior, alquinilo inferior, -(CR2)n-arilo, sustituido o no por uno a tres sustituyentes, seleccionados del grupo, consistente en halogeno o alcoxilo inferior, o son -(CH2)n+1NR2, -(CH2)n-piridinilo, -(CH2)n-indanilo, -(CH2)n-cicloalquilo, -(CH2)n-O-alquilo inferior, -(CH2)n-C(O)-NR2, -(CH2)n-CF3; o R' y R'' son junto al átomo de N al que están unidos pirrolidin-1-ilo, piperidin-1-ilo, 3,4-dihidro-1H-isoquinolin-2-ilo, morfolinilo, azatidin-1-ilo, 3,6-dihidro-2H-piridin-1-ilo, tiomorfolinilo, 2,5-dihidro-pirrol-1-ilo, tiazolidin-3-ilo, piperazinilo, azocan-1-ilo, azepan-1-ilo, octahidroquinolin-1-ilo, octahidroquinolin-2-ilo, 1,3,4,9-tetrahidro-b-carbolin-2-ilo, cuyos anillos pueden estar sustituidos o no por uno a tres sustituyentes, seleccionados del grupo, consistente en alquilo inferior, fenilo, bencilo, piridilo, -C(O)-NR2, -(CH2)n-O-alquilo inferior o -NR-C(O)-alquilo inferior; R2 es arilo o un grupo heteroarilo de 5 o 6 miembros, cuyos anillos están sustituidos o no por alquilo inferior, halogeno, hidroxilo o alcoxilo inferior; X es un enlace o -N(R)CH2-; R es hidrogeno o alquilo inferior; n es 0, 1, 2, 3, 4, 5 o 6; y sus sales farmacéuticamente aceptables. Los compuestos tienen una buena afinidad por el receptor de adenosina y se pueden usar además en el tratamiento de enfermedades relacionadas con este receptor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00127567 | 2000-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR031799A1 true AR031799A1 (es) | 2003-10-01 |
Family
ID=8170683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105765A AR031799A1 (es) | 2000-12-15 | 2001-12-12 | Derivado de [1,2,4]triazolo[1,5-a]piridina |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6506772B1 (es) |
| EP (1) | EP1347974B1 (es) |
| JP (1) | JP4049672B2 (es) |
| KR (1) | KR100540628B1 (es) |
| CN (1) | CN1221551C (es) |
| AR (1) | AR031799A1 (es) |
| AT (1) | ATE281456T1 (es) |
| AU (2) | AU2002231674B2 (es) |
| BR (1) | BR0116193A (es) |
| CA (1) | CA2437006C (es) |
| DE (1) | DE60106974T2 (es) |
| DK (1) | DK1347974T3 (es) |
| ES (1) | ES2230387T3 (es) |
| GT (1) | GT200100253A (es) |
| MX (1) | MXPA03005334A (es) |
| PA (1) | PA8534701A1 (es) |
| PE (1) | PE20020666A1 (es) |
| PT (1) | PT1347974E (es) |
| UY (1) | UY27074A1 (es) |
| WO (1) | WO2002048145A1 (es) |
| ZA (1) | ZA200304481B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4101755B2 (ja) * | 2001-10-08 | 2008-06-18 | エフ．ホフマン−ラ ロシュ アーゲー | ８−アミノ−〔１，２，４〕トリアゾロ〔１，５−ａ〕ピリジン−６−カルボン酸アミド |
| CA2502429A1 (en) * | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
| KR101389246B1 (ko) | 2004-07-15 | 2014-04-24 | 브리스톨-마이어스스퀴브컴파니 | 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| CA2656855A1 (en) * | 2006-07-12 | 2008-01-17 | Christoph Luthy | Triazolopyridine derivatives as herbicides |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| JP5739415B2 (ja) * | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用 |
| EA020553B1 (ru) * | 2009-05-12 | 2014-12-30 | Олбани Молекьюлар Рисерч, Инк. | 7-([1,2,4]ТРИАЗОЛО[1,5-α]ПИРИДИН-6-ИЛ)-4-(3,4-ДИХЛОРФЕНИЛ)-1,2,3,4-ТЕТРАГИДРОИЗОХИНОЛИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ И ПСИХИЧЕСКИХ РАССТРОЙСТВ |
| WO2010132437A1 (en) * | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| WO2013043518A1 (en) | 2011-09-22 | 2013-03-28 | Merck Sharp & Dohme Corp. | Imidazopyridyl compounds as aldosterone synthase inhibitors |
| US9193724B2 (en) | 2011-09-22 | 2015-11-24 | Merck Sharp & Dohme Corp. | Triazolopyridyl compounds as aldosterone synthase inhibitors |
| JP7399589B2 (ja) * | 2018-09-12 | 2023-12-18 | 日本化薬株式会社 | 有害生物防除剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356894A (en) | 1990-05-29 | 1994-10-18 | Rodney Peter W | Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist |
| GB9226735D0 (en) | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
| AU2639299A (en) | 1998-02-24 | 1999-09-15 | Kyowa Hakko Kogyo Co. Ltd. | Remedies/preventives for parkinson's disease |
| US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
-
2001
- 2001-11-30 US US09/998,323 patent/US6506772B1/en not_active Expired - Fee Related
- 2001-12-07 AU AU2002231674A patent/AU2002231674B2/en not_active Ceased
- 2001-12-07 PT PT01991804T patent/PT1347974E/pt unknown
- 2001-12-07 DK DK01991804T patent/DK1347974T3/da active
- 2001-12-07 CA CA002437006A patent/CA2437006C/en not_active Expired - Fee Related
- 2001-12-07 ES ES01991804T patent/ES2230387T3/es not_active Expired - Lifetime
- 2001-12-07 DE DE60106974T patent/DE60106974T2/de not_active Expired - Lifetime
- 2001-12-07 MX MXPA03005334A patent/MXPA03005334A/es active IP Right Grant
- 2001-12-07 EP EP01991804A patent/EP1347974B1/en not_active Expired - Lifetime
- 2001-12-07 AU AU3167402A patent/AU3167402A/xx active Pending
- 2001-12-07 WO PCT/EP2001/014399 patent/WO2002048145A1/en not_active Application Discontinuation
- 2001-12-07 JP JP2002549676A patent/JP4049672B2/ja not_active Expired - Fee Related
- 2001-12-07 BR BR0116193-8A patent/BR0116193A/pt not_active Application Discontinuation
- 2001-12-07 KR KR1020037008004A patent/KR100540628B1/ko not_active IP Right Cessation
- 2001-12-07 AT AT01991804T patent/ATE281456T1/de active
- 2001-12-07 CN CNB018220304A patent/CN1221551C/zh not_active Expired - Fee Related
- 2001-12-12 PE PE2001001245A patent/PE20020666A1/es not_active Application Discontinuation
- 2001-12-12 AR ARP010105765A patent/AR031799A1/es unknown
- 2001-12-12 PA PA20018534701A patent/PA8534701A1/es unknown
- 2001-12-14 GT GT200100253A patent/GT200100253A/es unknown
- 2001-12-14 UY UY27074A patent/UY27074A1/es not_active Application Discontinuation
-
2003
- 2003-06-09 ZA ZA200304481A patent/ZA200304481B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002231674B2 (en) | 2006-07-06 |
| ATE281456T1 (de) | 2004-11-15 |
| CN1221551C (zh) | 2005-10-05 |
| PA8534701A1 (es) | 2002-08-26 |
| EP1347974A1 (en) | 2003-10-01 |
| ES2230387T3 (es) | 2005-05-01 |
| ZA200304481B (en) | 2004-09-09 |
| CN1486314A (zh) | 2004-03-31 |
| DE60106974D1 (de) | 2004-12-09 |
| CA2437006C (en) | 2009-10-27 |
| UY27074A1 (es) | 2002-07-31 |
| KR100540628B1 (ko) | 2006-01-11 |
| GT200100253A (es) | 2002-07-31 |
| DE60106974T2 (de) | 2005-11-03 |
| AU3167402A (en) | 2002-06-24 |
| KR20030061446A (ko) | 2003-07-18 |
| PT1347974E (pt) | 2005-02-28 |
| MXPA03005334A (es) | 2004-04-02 |
| US6506772B1 (en) | 2003-01-14 |
| EP1347974B1 (en) | 2004-11-03 |
| BR0116193A (pt) | 2003-09-23 |
| PE20020666A1 (es) | 2002-07-27 |
| DK1347974T3 (da) | 2005-03-14 |
| WO2002048145A1 (en) | 2002-06-20 |
| JP2004521096A (ja) | 2004-07-15 |
| CA2437006A1 (en) | 2002-06-20 |
| JP4049672B2 (ja) | 2008-02-20 |
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Legal Events
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| FB | Suspension of granting procedure |