UY24973A1 - Utilizacion de derivados de tetrahidropiridina para la preparacion de medicamentos para el tratamiento de las enfermedades que provocan una desmielinizacion - Google Patents

Utilizacion de derivados de tetrahidropiridina para la preparacion de medicamentos para el tratamiento de las enfermedades que provocan una desmielinizacion

Info

Publication number
UY24973A1
UY24973A1 UY24973A UY24973A UY24973A1 UY 24973 A1 UY24973 A1 UY 24973A1 UY 24973 A UY24973 A UY 24973A UY 24973 A UY24973 A UY 24973A UY 24973 A1 UY24973 A1 UY 24973A1
Authority
UY
Uruguay
Prior art keywords
group
substituted
tetrahydropyridine
diseases
preparation
Prior art date
Application number
UY24973A
Other languages
English (en)
Inventor
Pierre Casellas
Bourrie Bernard
Pierre Maffrand Jean
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of UY24973A1 publication Critical patent/UY24973A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Utilización de derivados de tetrahidropiridina de fórmula general (I) representada en la figura 1,sustituidos en posición 1 por un radical hidrocarbonado sustituido y en posición 4 por fenilo o piridilo sustituido, o una de sus sales y solvatos farmacéuticamente aceptables, que en particular: R1 es halógeno o un grupo CF3, C1-4-alquilo o C1-4-alcoxi; Y representa un átomo de nitrógeno o un grupo CH; Z' y Z'' representan cada uno hidrógeno o un grupo C1-3-alquilo, o bbien uno representa hidrógeno y el otro un grupo hidroxi, o también ambos, juntos, representan un grupo oxo; Z representa un radical fenilo, el que puede estar monosustituido o disustituido, como también un radical 1-naftilo o 2-naftilo, pudiendo estar sustituidos en las posiciones 5, 6, 7 y/o 8; O bien Z'' es hidrógeno y Z y Z' representan, cada uno, independientemente, un grupo fenilo no sustituido o mono-, di- o trisustituido. Ejemplos no limitantes: 1-(2-naft-2-iletil)-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina; 1-[2-(6,7-dimetoxinaft-2-il)etil]-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina. Estos derivados son útiles en la preparación de medicamentos para el tratamiento de las enfermedades que provocan una desmielinización.
UY24973A 1997-04-29 1998-04-23 Utilizacion de derivados de tetrahidropiridina para la preparacion de medicamentos para el tratamiento de las enfermedades que provocan una desmielinizacion UY24973A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9705275A FR2762514B1 (fr) 1997-04-29 1997-04-29 Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation

Publications (1)

Publication Number Publication Date
UY24973A1 true UY24973A1 (es) 1998-07-16

Family

ID=9506415

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24973A UY24973A1 (es) 1997-04-29 1998-04-23 Utilizacion de derivados de tetrahidropiridina para la preparacion de medicamentos para el tratamiento de las enfermedades que provocan una desmielinizacion

Country Status (18)

Country Link
US (1) US6344464B1 (es)
EP (1) EP0979079B1 (es)
JP (1) JP3956059B2 (es)
AR (1) AR012504A1 (es)
AT (1) ATE269077T1 (es)
AU (1) AU7436498A (es)
BR (1) BR9810234A (es)
CA (1) CA2288241C (es)
DE (1) DE69824576T2 (es)
DK (1) DK0979079T3 (es)
ES (1) ES2222593T3 (es)
FR (1) FR2762514B1 (es)
NO (1) NO325163B1 (es)
PT (1) PT979079E (es)
SI (1) SI0979079T1 (es)
UY (1) UY24973A1 (es)
WO (1) WO1998048802A1 (es)
ZA (1) ZA983602B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2763847B1 (fr) * 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
JP4324382B2 (ja) * 2001-04-20 2009-09-02 サノフィ−アベンティス テトラヒドロピリジル−アルキル−複素環、その製造方法およびそれを含む医薬組成物
PT2087908T (pt) 2001-06-26 2018-07-16 Amgen Inc Anticorpos contra opgl
EP1414517A4 (en) * 2001-06-26 2008-02-06 Photomed Technologies Inc MULTIPLE WAVELENGTH ILLUMINATOR
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
NZ593428A (en) 2002-09-06 2013-01-25 Amgen Inc Therapeutic human anti-il-1r1 monoclonal antibody
JP2006517191A (ja) * 2002-12-30 2006-07-20 アムジエン・インコーポレーテツド 共刺激因子を用いた併用療法
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
AU2005318163B2 (en) 2004-12-21 2011-12-01 Merck Serono Sa Sulfonyl amino cyclic derivatives and use thereof
EA014238B1 (ru) 2005-01-31 2010-10-29 Мерк Сероно Са Производные n-гидроксиамида и их применение
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
AU2006271682B2 (en) * 2005-07-15 2012-07-05 Merck Serono Sa Glepp-1 inhibitors in the treatment of autoimmune and/or inflammatory disorders
WO2007025991A2 (en) 2005-09-01 2007-03-08 Ares Trading S.A. Treatment of optic neuritis
AU2008326309C1 (en) * 2007-11-21 2015-03-12 Decode Genetics Ehf Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders
KR101707597B1 (ko) * 2010-12-07 2017-02-17 한국전자통신연구원 홀 센서리스 ｂｌｄｃ 모터용 전원 공급 모듈
WO2020035482A1 (en) 2018-08-13 2020-02-20 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof
WO2023118544A1 (en) 2021-12-23 2023-06-29 Cilcare Dev 4-phenyl-tetrahydropyridine derivatives for treating hearing diseases
WO2023222565A1 (en) 2022-05-16 2023-11-23 Institut National de la Santé et de la Recherche Médicale Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531707A1 (fr) 1982-08-16 1984-02-17 Midy Spa Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
FR2662355B1 (fr) 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
FR2736053B1 (fr) * 1995-06-28 1997-09-19 Sanofi Sa Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
FR2740343B1 (fr) * 1995-10-26 1999-01-22 Sanofi Sa Utilisation de la 1-(2-napht-2-yl-ethyl)-4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de la sclerose laterale amyotrophique

Also Published As

Publication number Publication date
US6344464B1 (en) 2002-02-05
AR012504A1 (es) 2000-10-18
CA2288241A1 (en) 1998-11-05
JP3956059B2 (ja) 2007-08-08
BR9810234A (pt) 2000-09-19
ZA983602B (en) 1998-11-02
PT979079E (pt) 2004-10-29
DK0979079T3 (da) 2004-10-25
FR2762514A1 (fr) 1998-10-30
NO325163B1 (no) 2008-02-11
ES2222593T3 (es) 2005-02-01
FR2762514B1 (fr) 1999-10-22
CA2288241C (en) 2006-10-03
SI0979079T1 (en) 2004-10-31
JP2002501498A (ja) 2002-01-15
ATE269077T1 (de) 2004-07-15
DE69824576T2 (de) 2005-06-30
EP0979079A1 (fr) 2000-02-16
EP0979079B1 (fr) 2004-06-16
AU7436498A (en) 1998-11-24
NO995245L (no) 1999-12-27
DE69824576D1 (de) 2004-07-22
NO995245D0 (no) 1999-10-27
WO1998048802A1 (fr) 1998-11-05

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Effective date: 20010908