BR0116193A - Derivados de aminotriazolpiridina como ligandos de receptores de adenosina - Google Patents

Derivados de aminotriazolpiridina como ligandos de receptores de adenosina

Info

Publication number
BR0116193A
BR0116193A BR0116193-8A BR0116193A BR0116193A BR 0116193 A BR0116193 A BR 0116193A BR 0116193 A BR0116193 A BR 0116193A BR 0116193 A BR0116193 A BR 0116193A
Authority
BR
Brazil
Prior art keywords
lower alkyl
unsubstituted
substituted
dihydro
aryl
Prior art date
Application number
BR0116193-8A
Other languages
English (en)
Inventor
Bernd Brodbeck
Matthias Heinrich Nettekoven
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0116193A publication Critical patent/BR0116193A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"DERIVADOS DE AMINOTRIAZOLPIRIDINA COMO LIGANDOS DE RECEPTORES DE ADENOSINA". A presente invenção refere-se a compostos da fórmula geral (I) onde R^ 1^ é alcóxi inferior, cicloalquila ou arila, não-substituídos ou substituídos com halogênio ou alcóxi inferior ou é -NR'R", onde R' e R" são independentemente um do outro hidrogênio, alquila inferior, alquenila inferior, alquinila inferior, -(CH~ 2~)~ n~-arila, não-substituídas ou substituídas com um a três substituintes selecionados do grupo que consiste de halogênio ou alcóxi inferior, ou são -(CH~ 2~)~ n+1~NR~ 2~, -(CH~ 2~)~ n~-piridinila, -(CH~ 2~)~ n~-indanila, -(CH~ 2~)~ n~-cicloalquila, -(CH~ 2~)~ n~-O-alquila inferior, -(CH~ 2~)~ n~-C(O)-NR~ 2~, -(CH~ 2~)~ n~-CF~ 3~ ou R' e R", junto com o átomo de N ao qual estão ligados, são pirrolidin-1-ila, piperidin-1-ila, 3,4-dihidro-1H-isoquinolin-2-ila, morfolinila, azatidin-1-ila, 3,6-dihidro-2H-piridin-1-ila, tiomorfolinila, 2,5-dihidro-pirrol-1-ila, tiazolidin-3-ila, piperazinila, azocan-1-ila, azepan-1-ila, octahidroquinolin-1-ila, octahidro-quinolin-2-ila, 1,3,4,9-tetrahidro-b-carbolin-2-ila, cujos anéis podem ser não-substituídos ou substituídos com um a três substituintes selecionados do grupo que consiste de alquila inferior, fenila, benzila, piridila, -C(O)-NR~ 2~, -(CH~ 2~)~ n~-O-alquila inferior ou -NR-C(O)-alquila inferior; R^ 2^ é arila ou um grupo heteroarila de 5 ou 6 membros, cujos anéis são não-substituídos ou substituídos com alquila inferior, halogênio, hidróxi ou alcóxi inferior; X é uma ligação ou -N(R)CH~ 2~-; R é hidrogênio ou alquila inferior; n é 0, 1, 2, 3, 4, 5 ou 6; e seus sais farmaceuticamente aceitáveis. Os compostos possuem boa afinidade para o receptor de adenosina e portanto podem ser usados no tratamento de doenças relacionadas com este receptor.
BR0116193-8A 2000-12-15 2001-12-07 Derivados de aminotriazolpiridina como ligandos de receptores de adenosina BR0116193A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00127567 2000-12-15
PCT/EP2001/014399 WO2002048145A1 (en) 2000-12-15 2001-12-07 Aminotriazolopyridiine derivatives as adenosine receptor ligands

Publications (1)

Publication Number Publication Date
BR0116193A true BR0116193A (pt) 2003-09-23

Family

ID=8170683

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116193-8A BR0116193A (pt) 2000-12-15 2001-12-07 Derivados de aminotriazolpiridina como ligandos de receptores de adenosina

Country Status (21)

Country Link
US (1) US6506772B1 (pt)
EP (1) EP1347974B1 (pt)
JP (1) JP4049672B2 (pt)
KR (1) KR100540628B1 (pt)
CN (1) CN1221551C (pt)
AR (1) AR031799A1 (pt)
AT (1) ATE281456T1 (pt)
AU (2) AU3167402A (pt)
BR (1) BR0116193A (pt)
CA (1) CA2437006C (pt)
DE (1) DE60106974T2 (pt)
DK (1) DK1347974T3 (pt)
ES (1) ES2230387T3 (pt)
GT (1) GT200100253A (pt)
MX (1) MXPA03005334A (pt)
PA (1) PA8534701A1 (pt)
PE (1) PE20020666A1 (pt)
PT (1) PT1347974E (pt)
UY (1) UY27074A1 (pt)
WO (1) WO2002048145A1 (pt)
ZA (1) ZA200304481B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04003277A (es) * 2001-10-08 2004-07-23 Hoffmann La Roche Amida del acido 8-amino-?1,2,4?triazolo?1,5-a?piridina-6-carboxilico.
AU2003270701B2 (en) * 2002-10-31 2009-11-12 Amgen Inc. Antiinflammation agents
CN101119969B (zh) 2004-07-15 2014-04-09 阿尔巴尼分子研究公司 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和血清素的重摄取的应用
WO2008006540A1 (en) * 2006-07-12 2008-01-17 Syngenta Participations Ag Triazolopyridine derivatives as herbicides
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
ES2528404T3 (es) * 2009-05-12 2015-02-10 Bristol-Myers Squibb Company Formas cristalinas de (S)-7-([1,2,4]triazol[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y sus usos
ES2446971T3 (es) * 2009-05-12 2014-03-11 Albany Molecular Research, Inc. Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
ES2662072T3 (es) * 2009-05-12 2018-04-05 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma
WO2013043518A1 (en) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
EP2757883B1 (en) * 2011-09-22 2021-01-13 Merck Sharp & Dohme Corp. Triazolopyridyl compounds as aldosterone synthase inhibitors
WO2020054712A1 (ja) * 2018-09-12 2020-03-19 日本化薬株式会社 有害生物防除剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226735D0 (en) 1992-12-22 1993-02-17 Ici Plc Azole derivatives
US5356894A (en) 1990-05-29 1994-10-18 Rodney Peter W Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
AU2639299A (en) 1998-02-24 1999-09-15 Kyowa Hakko Kogyo Co. Ltd. Remedies/preventives for parkinson's disease
US6355653B1 (en) 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives

Also Published As

Publication number Publication date
AR031799A1 (es) 2003-10-01
ES2230387T3 (es) 2005-05-01
CA2437006A1 (en) 2002-06-20
DE60106974T2 (de) 2005-11-03
CN1486314A (zh) 2004-03-31
DE60106974D1 (de) 2004-12-09
DK1347974T3 (da) 2005-03-14
KR20030061446A (ko) 2003-07-18
PE20020666A1 (es) 2002-07-27
UY27074A1 (es) 2002-07-31
EP1347974B1 (en) 2004-11-03
EP1347974A1 (en) 2003-10-01
AU2002231674B2 (en) 2006-07-06
PA8534701A1 (es) 2002-08-26
GT200100253A (es) 2002-07-31
WO2002048145A1 (en) 2002-06-20
AU3167402A (en) 2002-06-24
ZA200304481B (en) 2004-09-09
CN1221551C (zh) 2005-10-05
MXPA03005334A (es) 2004-04-02
CA2437006C (en) 2009-10-27
PT1347974E (pt) 2005-02-28
JP4049672B2 (ja) 2008-02-20
ATE281456T1 (de) 2004-11-15
US6506772B1 (en) 2003-01-14
KR100540628B1 (ko) 2006-01-11
JP2004521096A (ja) 2004-07-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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