AR029432A1 - Derivados de imidazol 1-sustituido que poseen afinidad con los alfa2-adrenorreceptores, uso de dichos derivados como medicamentos y/o para la preparacion de composiciones farmaceuticas formuladas con dichos compuestos de 1-imidazol sustituido, proceso para preparar dichos derivados - Google Patents
Derivados de imidazol 1-sustituido que poseen afinidad con los alfa2-adrenorreceptores, uso de dichos derivados como medicamentos y/o para la preparacion de composiciones farmaceuticas formuladas con dichos compuestos de 1-imidazol sustituido, proceso para preparar dichos derivadosInfo
- Publication number
- AR029432A1 AR029432A1 ARP010100140A ARP010100140A AR029432A1 AR 029432 A1 AR029432 A1 AR 029432A1 AR P010100140 A ARP010100140 A AR P010100140A AR P010100140 A ARP010100140 A AR P010100140A AR 029432 A1 AR029432 A1 AR 029432A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- derivatives
- imidazol
- halo
- cycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen y reivindican compuestos de imidazol de formula (1) donde X es ûCH2(CH2)p-, -O-, =NH o ûS-; R1 es fenilo, naftilo, 1,2,3,4-tetrahidronaftilo, C3-7-cicloalquilo, C5-7-cicloalquinilo o grupo heterocíclico parcialmente o completamente saturado aromático mono o bicíclico con 5 a 10 átomos anillo que consisten de átomos de carbono y uno a tres heteroátomos seleccionados de N, O y S; donde dicho fenilo, naftilo, 1,2,3,4-tetrahidronaftilo, C3-7-cicloalquilo, C5-7-cicloalquilo o grupo heterocíclico parcialmente o completamente saturado aromático mono o bicíclico es opcionalmente sustituido con uno a tres sustituyentes seleccionados independientemente de halogeno ûOH, -NH2, halo-C1-6-alquilo, C1-6-alquilo, C2-6-alquenilo, C2-6-alquinilo, C1-6-alcoxi, OH-(C1-6)-alquilo, NH2-(C1-6)-alquilo y mono o di(C1-6-alquilo)amino; R2 es H o C1-6-alquilo; R3 es H o C1-6 alquilo, y R4 es H o C1-6-alquilo; R5 H o R5 y R7 juntos forman una union; Cada R6 es independientemente halogeno, -OH, -NH2, Halo ûC1-6-alquilo, C1-6-alquilo, C1-6-alcoxi u OH-(C1-6)-alquilo; R7 es H, OH o C1-4-alquilo o R7 y R5 juntos forman una union; Cada R8 es independientemente OH, C1-6-alquilo, Halo-C1-C6-alquilo, C1-6-alcoxi; m es 0, 1, 2 o 3;n es 0 o 1; p es 0 o 1; r es 0 o 1; t es 0 1, o 2; ésteres o sales farmacéuticamente aceptables de los mismos. Los compuestos mencionados son utiles, en vista de su afinidad con los adrenorreceptores alfa 2 en el tratamiento de enfermedades y desordenes relacionados con dichos adrenorreceptores, v.gr.: desordenes del sistema periférico central (SNC); desordenes neurologicos, psiquiátricos, cognitivos, diabetes, disfuncion sexual, hipotension ortostática. También se reivindican los objetos restantes mencionados en el título.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20000073A FI20000073A0 (fi) | 2000-01-14 | 2000-01-14 | Uusia imidatsolijohdannaisia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029432A1 true AR029432A1 (es) | 2003-06-25 |
Family
ID=8557065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010100140A AR029432A1 (es) | 2000-01-14 | 2001-01-12 | Derivados de imidazol 1-sustituido que poseen afinidad con los alfa2-adrenorreceptores, uso de dichos derivados como medicamentos y/o para la preparacion de composiciones farmaceuticas formuladas con dichos compuestos de 1-imidazol sustituido, proceso para preparar dichos derivados |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1261588B1 (es) |
| JP (1) | JP2003519688A (es) |
| KR (1) | KR20020084091A (es) |
| CN (1) | CN1187336C (es) |
| AR (1) | AR029432A1 (es) |
| AT (1) | ATE280161T1 (es) |
| AU (1) | AU769896B2 (es) |
| BR (1) | BR0107644A (es) |
| CA (1) | CA2397283A1 (es) |
| CZ (1) | CZ20022358A3 (es) |
| DE (1) | DE60106572T2 (es) |
| DK (1) | DK1261588T3 (es) |
| EE (1) | EE200200389A (es) |
| ES (1) | ES2228884T3 (es) |
| FI (1) | FI20000073A0 (es) |
| GC (1) | GC0000218A (es) |
| HK (1) | HK1049999B (es) |
| HU (1) | HUP0301008A3 (es) |
| IL (1) | IL150506A0 (es) |
| MX (1) | MXPA02006872A (es) |
| NO (1) | NO323117B1 (es) |
| NZ (1) | NZ519919A (es) |
| PE (1) | PE20011230A1 (es) |
| PL (1) | PL207281B1 (es) |
| PT (1) | PT1261588E (es) |
| RU (1) | RU2265598C2 (es) |
| SI (1) | SI1261588T1 (es) |
| SK (1) | SK286320B6 (es) |
| WO (1) | WO2001051472A1 (es) |
| ZA (1) | ZA200205301B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20002756A0 (fi) * | 2000-12-15 | 2000-12-15 | Orion Yhtymae Oyj | Uusi hoitomenetelmä |
| TW200930291A (en) * | 2002-04-29 | 2009-07-16 | Bayer Cropscience Ag | Pesticidal heterocycles |
| FI20022159A0 (fi) | 2002-12-05 | 2002-12-05 | Orion Corp | Uusia farmaseuttisia yhdisteitä |
| DE102004035322A1 (de) * | 2004-07-21 | 2006-02-16 | Universität des Saarlandes | Selektive Hemmstoffe humaner Corticoidsynthasen |
| AU2007312390B2 (en) | 2006-10-19 | 2013-03-28 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| RU2456281C2 (ru) | 2006-11-16 | 2012-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные 4-имидазолы, способ их получения и их применение |
| US20080146523A1 (en) | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
| AR090557A1 (es) * | 2012-04-02 | 2014-11-19 | Orion Corp | DERIVADOS IMIDAZOLICOS AGONISTAS ADRENERGICOS a2 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2225782A (en) * | 1988-12-09 | 1990-06-13 | Farmos Group Limited | Imidazole derivatives useful for treatment of diabetes |
| GB2244431A (en) * | 1990-05-31 | 1991-12-04 | Farmos Oy | Treatment of age related memory impairment and other cognitive disorders |
| US5541211A (en) * | 1991-06-18 | 1996-07-30 | Orion-Yhtyma Oy | Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission |
| GB9127050D0 (en) * | 1991-12-20 | 1992-02-19 | Orion Yhtymae Oy | Substituted imidazole derivatives and their preparation and use |
| GB9520150D0 (en) * | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
| AU744798B2 (en) * | 1997-12-04 | 2002-03-07 | Allergan, Inc. | Substituted imidazole derivatives having agonist-like activity at alpha 2B or 2B/2C adrenergic receptors |
| US6503935B1 (en) * | 1998-08-07 | 2003-01-07 | Abbott Laboratories | Imidazoles and related compounds as α1A agonists |
| TWI283669B (en) * | 1999-06-10 | 2007-07-11 | Allergan Inc | Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors |
-
2000
- 2000-01-14 FI FI20000073A patent/FI20000073A0/fi unknown
-
2001
- 2001-01-10 GC GCP20011133 patent/GC0000218A/en active
- 2001-01-12 NZ NZ519919A patent/NZ519919A/en unknown
- 2001-01-12 KR KR1020027009037A patent/KR20020084091A/ko not_active Application Discontinuation
- 2001-01-12 JP JP2001551854A patent/JP2003519688A/ja active Pending
- 2001-01-12 CA CA002397283A patent/CA2397283A1/en not_active Abandoned
- 2001-01-12 SK SK998-2002A patent/SK286320B6/sk not_active IP Right Cessation
- 2001-01-12 PT PT01942360T patent/PT1261588E/pt unknown
- 2001-01-12 IL IL15050601A patent/IL150506A0/xx not_active IP Right Cessation
- 2001-01-12 HU HU0301008A patent/HUP0301008A3/hu unknown
- 2001-01-12 PL PL356884A patent/PL207281B1/pl not_active IP Right Cessation
- 2001-01-12 MX MXPA02006872A patent/MXPA02006872A/es active IP Right Grant
- 2001-01-12 DE DE60106572T patent/DE60106572T2/de not_active Expired - Lifetime
- 2001-01-12 DK DK01942360T patent/DK1261588T3/da active
- 2001-01-12 BR BR0107644-2A patent/BR0107644A/pt not_active Application Discontinuation
- 2001-01-12 SI SI200130256T patent/SI1261588T1/xx unknown
- 2001-01-12 CN CNB018037194A patent/CN1187336C/zh not_active Expired - Fee Related
- 2001-01-12 AR ARP010100140A patent/AR029432A1/es unknown
- 2001-01-12 PE PE2001000029A patent/PE20011230A1/es not_active Application Discontinuation
- 2001-01-12 WO PCT/FI2001/000030 patent/WO2001051472A1/en active IP Right Grant
- 2001-01-12 EE EEP200200389A patent/EE200200389A/xx unknown
- 2001-01-12 ES ES01942360T patent/ES2228884T3/es not_active Expired - Lifetime
- 2001-01-12 CZ CZ20022358A patent/CZ20022358A3/cs unknown
- 2001-01-12 AT AT01942360T patent/ATE280161T1/de not_active IP Right Cessation
- 2001-01-12 EP EP01942360A patent/EP1261588B1/en not_active Expired - Lifetime
- 2001-01-12 AU AU28532/01A patent/AU769896B2/en not_active Ceased
- 2001-01-12 RU RU2002121777/04A patent/RU2265598C2/ru not_active IP Right Cessation
-
2002
- 2002-07-02 ZA ZA200205301A patent/ZA200205301B/xx unknown
- 2002-07-08 NO NO20023298A patent/NO323117B1/no not_active IP Right Cessation
-
2003
- 2003-03-19 HK HK03102023.4A patent/HK1049999B/zh not_active IP Right Cessation
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