AR026059A1 - Virus de plantas modificadas y metodos para su uso - Google Patents
Virus de plantas modificadas y metodos para su usoInfo
- Publication number
- AR026059A1 AR026059A1 ARP000105444A ARP000105444A AR026059A1 AR 026059 A1 AR026059 A1 AR 026059A1 AR P000105444 A ARP000105444 A AR P000105444A AR P000105444 A ARP000105444 A AR P000105444A AR 026059 A1 AR026059 A1 AR 026059A1
- Authority
- AR
- Argentina
- Prior art keywords
- level
- virus
- methods
- modified plants
- immune response
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14311—Parvovirus, e.g. minute virus of mice
- C12N2750/14322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
La presente se relaciona con modular la naturaleza y/o el nivel de una respuesta inmune a una molécula. En particular, la presente se relaciona conefectuar un aumento en la respuesta inmune TH1 a moléculas tales como, pero sin limitarse a, antígenoso inmunogenos. También se relaciona con reducir larespuesta inmune TH2 a las moléculas. Más particularmente, se relaciona con alterar el nivel de inmunoglobulinas asociadas con TH1 y TH2, el nivel deproliferacion de citocinas asociadas con TH1 y TH2,y el nivel de proliferacion de células TH1 y TH2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9924351.1A GB9924351D0 (en) | 1999-10-14 | 1999-10-14 | Immunomodulation methods and compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
AR026059A1 true AR026059A1 (es) | 2002-12-26 |
Family
ID=10862752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000105444A AR026059A1 (es) | 1999-10-14 | 2000-10-17 | Virus de plantas modificadas y metodos para su uso |
Country Status (15)
Country | Link |
---|---|
US (2) | US7267963B1 (es) |
EP (1) | EP1223977B1 (es) |
JP (1) | JP2003514775A (es) |
AR (1) | AR026059A1 (es) |
AU (1) | AU784425B2 (es) |
CA (1) | CA2387629A1 (es) |
CO (1) | CO5270015A1 (es) |
CZ (1) | CZ20021304A3 (es) |
DE (1) | DE60033043T2 (es) |
GB (1) | GB9924351D0 (es) |
HR (1) | HRP20000701A2 (es) |
IL (1) | IL149078A0 (es) |
MX (1) | MXPA02003788A (es) |
WO (1) | WO2001026682A2 (es) |
ZA (1) | ZA200202816B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9924351D0 (en) * | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
US7115264B2 (en) * | 2001-11-05 | 2006-10-03 | Inhibitex | Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections |
DK1523329T3 (da) * | 2002-07-05 | 2013-10-14 | Folia Biotech Inc | Viruspartikeladjuvant |
US8101189B2 (en) | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
CN101227920A (zh) * | 2005-07-19 | 2008-07-23 | 陶氏环球技术公司 | 重组流感疫苗 |
US20090093019A1 (en) * | 2007-04-27 | 2009-04-09 | Phelps Jamie P | Production and in vivo assembly of soluble recombinant icosahedral virus-like particles |
EP2734226A2 (en) * | 2011-07-20 | 2014-05-28 | Samuel Bogoch | Peptides shared among lethal cancers and therapeutic compositions comprising said peptides |
WO2014059021A1 (en) | 2012-10-09 | 2014-04-17 | Case Western Reserve University | Rod-shaped plant virus nanoparticles as imaging agent platforms |
WO2014113203A1 (en) | 2013-01-17 | 2014-07-24 | Case Western Reserve University | Viral nanoparticle multimers |
US10590394B2 (en) | 2013-02-22 | 2020-03-17 | Case Western Reserve University | Non-covalent loading of plant picornavirus particles |
US9925281B2 (en) | 2014-08-05 | 2018-03-27 | Case Western Reserve University | Coated plant virus imaging agents |
EP3215520B1 (en) | 2014-11-07 | 2022-01-05 | Case Western Reserve University | Cancer immunotherapy using virus particles |
WO2017004123A1 (en) | 2015-06-29 | 2017-01-05 | Case Western Reserve University | Anticancer drug-containing plant virus particles |
WO2017011826A1 (en) | 2015-07-16 | 2017-01-19 | Case Western Reserve University | Plant virus particles for delivery of antimitotic agents |
EP3487527A4 (en) | 2016-07-21 | 2020-03-11 | Case Western Reserve University | PARTICLES OF VEGETABLE OR VIRAL-LIKE PARTICLES |
CA3042695A1 (en) | 2016-11-03 | 2018-05-11 | Case Western Reserve University | Melt processed viral nanoparticle constructs |
US11590183B2 (en) | 2017-03-10 | 2023-02-28 | Case Western Reserve University | Cancer immunotherapy using virus particles |
WO2018213587A1 (en) | 2017-05-17 | 2018-11-22 | Case Western Reserve University | Anticancer trail-targeted plant virus particles |
US11739301B2 (en) | 2017-10-27 | 2023-08-29 | Case Western Reserve University | Tymovirus virus and virus-like particles as nanocarriers for imaging and therapeutic agents |
US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
US11390853B2 (en) | 2019-04-26 | 2022-07-19 | Case Western Reserve University | Freeze dried viral nanoparticle constructs |
US11896676B2 (en) | 2019-08-07 | 2024-02-13 | Case Western Reserve University | Targeting cancer cells and tissue using filamentous plant virus particles |
Family Cites Families (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3919411A (en) | 1972-01-31 | 1975-11-11 | Bayvet Corp | Injectable adjuvant and compositions including such adjuvant |
DE2461439C3 (de) | 1974-12-24 | 1980-03-20 | Behringwerke Ag, 3550 Marburg | Verfahren zur Herstellung eines schützenden Antigens von Bordetella Pertussis sowie jenes enthaltendes Mittel |
US4342832A (en) | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
FR2522967B1 (fr) | 1982-03-15 | 1986-03-07 | Anvar | Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant |
US4702909A (en) | 1982-05-05 | 1987-10-27 | Louisiana State University A & M | Non-A, non-B hepatitis antigen, antigen compositions, vaccine and diagnostic reagent |
US5151511A (en) | 1982-09-16 | 1992-09-29 | Amgen Inc. | DNA encoding avian growth hormones |
DE3479158D1 (en) | 1983-03-04 | 1989-08-31 | Noctech Ltd | Diagnostic agent, a process for its preparation and its use in diagnostic methods |
US5639639A (en) | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
US4839275A (en) | 1983-12-01 | 1989-06-13 | The Jewish Hospital | Circulating antigens of dirofilaria immitis, monoclonal antibodies specific therefor and methods of preparing such antibodies and detecting such antigens |
DK219084D0 (da) | 1984-05-02 | 1984-05-02 | Frederik Carl Peter Lindberg | Antigen |
EP0173254B1 (en) | 1984-08-23 | 1991-07-24 | Hans Joachim Wolf | Dna sequences of the ebv genome, recombinant dna molecules, processes for producing ebv-related antigens, diagnostic compositions and pharmaceutical compositions containing said antigens |
CA1268437A (en) | 1984-12-21 | 1990-05-01 | Haruo Fujita | Method for purification of hbc antigen and method for measurement of hbc antibody by using said purified hbc antigen |
US4837306A (en) | 1985-02-25 | 1989-06-06 | The Ontario Cancer Institute | Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen |
US5268265A (en) | 1986-01-22 | 1993-12-07 | Institut Pasteur | Immunological complex comprising an antigen of Simian Immunodeficiency Virus (SIV) and an antibody against human immunodeficiency virus type 2 (HIV 2), and method and kit for detecting antibodies to HIV-2 reactive with antigens of SIV |
US7115363B1 (en) | 1986-01-22 | 2006-10-03 | Institut Pasteur | Retrovirus capable of causing AIDS, means and methods for detecting it in vitro |
US6025477A (en) | 1986-03-31 | 2000-02-15 | Calenoff; Emanuel | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
GB8610983D0 (en) | 1986-05-06 | 1986-06-11 | Connaught Lab | Enhancement of antigen immunogenicity |
US5194254A (en) | 1986-05-06 | 1993-03-16 | Connaught Laboratories Limited | Enhancement of antigen immunogenicity |
US6007806A (en) | 1986-08-13 | 1999-12-28 | Transgene S.A. | Expression of a tumor-specific antigen by a recombinant vector virus and use thereof in preventive or curative treatment of the corresponding tumor |
US5096906A (en) | 1986-12-31 | 1992-03-17 | University Of Virginia Alumni Patents Foundation | Method of inhibiting the activity of leukocyte derived cytokines |
US5614366A (en) | 1986-12-31 | 1997-03-25 | Genelabs Technologies, Inc. | HTLV-I peptide antigens and kit |
GB8713240D0 (en) | 1987-06-05 | 1987-07-08 | Proteus Biotech Ltd | Hormones |
EP0362290A4 (en) | 1987-06-17 | 1991-09-25 | Princess Margaret Children's Medical Research Foundation (Inc.) | Cloning of mite allergens |
IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
US5212085A (en) | 1987-12-09 | 1993-05-18 | The General Hospital Corporation | Sf-25 colon adenocarcinoma antigen, and antibodies with recognize this antigen |
US4956278A (en) | 1988-02-23 | 1990-09-11 | Louisiana State University | Anaplasma marginale antigen, antigen compositions, vaccine and process for the production of said antigen, antigen compositions and vaccine |
US5977438A (en) * | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
DE69027022T2 (de) | 1989-02-17 | 1996-11-28 | Liposome Co Inc | Lipidhilfstoffe für verabreichung durch die nase und örtliche anwendung |
US5049655A (en) | 1989-03-22 | 1991-09-17 | The Salk Institute For Biological Studies | Melanin-concentrating hormones |
JP2896580B2 (ja) | 1989-08-25 | 1999-05-31 | チッソ株式会社 | アミロース―リゾチームハイブリッドと活性化糖およびその製造法 |
US5468286A (en) | 1989-10-25 | 1995-11-21 | National Starch And Chemical Investment Holding Corporation | Enzymatically debranched starches as tablet excipients |
EP0678744B1 (en) | 1989-11-03 | 1999-09-15 | MORTON, Donald L. | Method for detecting urinary tumor associated antigens |
US5547669A (en) | 1989-11-03 | 1996-08-20 | Immulogic Pharma Corp | Recombinant peptides comprising T cell epitopes of the cat allergen, Fel d I |
US5766867A (en) | 1990-02-09 | 1998-06-16 | Immuno Japan Inc. | Non-A, non-B hepatitis related nucleic acids, proteins, peptides, antigens, and antibodies |
US5942220A (en) | 1990-03-16 | 1999-08-24 | Chiron Corporation | Inhibitor of cytokine activity and applications thereof |
JP2596466B2 (ja) | 1990-03-03 | 1997-04-02 | アサヒビール株式会社 | ダニの主要アレルゲンの還伝情報を有するdnaおよび該アレルゲンの製造方法 |
DE4007315A1 (de) | 1990-03-08 | 1991-09-12 | Behringwerke Ag | Verwendung von zink-calciumhydroxid, lecithin und pao zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen |
US5712087A (en) | 1990-04-04 | 1998-01-27 | Chiron Corporation | Immunoassays for anti-HCV antibodies employing combinations of hepatitis C virus (HCV) antigens |
EP0484621A3 (en) | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
US5693495A (en) | 1990-08-08 | 1997-12-02 | Biomay Produktions- Und Handelsgesellschaft M.B.H. | Allergens of alder pollen and applications thereof |
ATE178940T1 (de) | 1990-09-11 | 1999-04-15 | Inst Child Health Research | Klonierung und sequenzierung von dermatophagoiden-antigenen (hausstaubmilben) |
US5736362A (en) | 1990-10-26 | 1998-04-07 | The University Of Melbourne | Ryegrass pollen allergen |
GB9108386D0 (en) | 1991-04-19 | 1991-06-05 | Agricultural Genetics Co | Modified plant viruses as vectors |
CA2084876A1 (fr) | 1991-04-26 | 1992-10-27 | Guy Serre | Antigenes specifiquement reconnus par des anticorps specifiques de la polyarthrite rhumatoide, leurs proteines constitutives, leur preparation et leurs applications |
US6013433A (en) | 1991-04-26 | 2000-01-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus |
DE4116249A1 (de) | 1991-05-17 | 1992-11-19 | Biotechnolog Forschung Gmbh | Hybrid-plasmid fuer m.-tuberculosis-antigen, e. coli als wirt und antigen |
US6090386A (en) | 1991-07-12 | 2000-07-18 | Griffith; Irwin J. | T cell peptides of the CRX JII allergen |
US5965379A (en) | 1991-07-19 | 1999-10-12 | Cytimmune Sciences Inc. | Method for measuring endogenous cytokines |
US5993826A (en) | 1993-03-02 | 1999-11-30 | Board Of Regents, The University Of Texas | Methods and compositions relating to useful antigens of moraxella catarrhalis |
CA2123811C (en) | 1991-11-22 | 2005-07-05 | Ali Ibrahim Fattom | Type i and type ii surface antigens associated with staphylococcus epidermidis |
US5227471A (en) | 1992-01-30 | 1993-07-13 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma |
IL105325A (en) | 1992-04-16 | 1996-11-14 | Minnesota Mining & Mfg | Immunogen/vaccine adjuvant composition |
US5589452A (en) | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
US5736146A (en) | 1992-07-30 | 1998-04-07 | Yeda Research And Development Co. Ltd. | Conjugates of poorly immunogenic antigens and synthetic peptide carriers and vaccines comprising them |
US5460810A (en) | 1992-09-02 | 1995-10-24 | Genetics Institute, Inc. | Method for maintaining gut epithelial cells by treatment with a cytokine such as interleukin 11 |
EP0666926A4 (en) | 1992-10-30 | 1998-04-29 | Gen Hospital Corp | INTERACTIVE POLYPEPTIDES FROM CELL CORE AND RELATED MOLECULES AND METHOD WITH HORMONE RECEPTORS. |
EP0599303A3 (en) | 1992-11-27 | 1998-07-29 | Takeda Chemical Industries, Ltd. | Peptide conjugate |
US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
US5558869A (en) | 1992-12-30 | 1996-09-24 | University Of Arkansas | Major peanut allergen ara h II |
DK17093D0 (da) | 1993-02-15 | 1993-02-15 | Lyfjathroun H F | Farmaceutisk praeparat til topisk administrering af antigener og/eller vacciner til pattedyr via slimhinder |
US6849427B1 (en) | 1993-03-12 | 2005-02-01 | Immulogic Pharmaceutical Corp. | Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor |
US5532133A (en) | 1993-06-02 | 1996-07-02 | New York University | Plasmodium vivax blood stage antigens, PvESP-1, antibodies, and diagnostic assays |
US5444167A (en) | 1993-07-07 | 1995-08-22 | Wallac Oy | Variant luteinizing hormone encoding DNA |
US6013481A (en) | 1993-07-22 | 2000-01-11 | Ludwig Institute For Cancer Research | Isolated, nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof |
EP0640348A1 (en) | 1993-07-26 | 1995-03-01 | Akzo Nobel N.V. | Oil-based and water-based adjuvant mixture |
WO1995005850A1 (en) | 1993-08-27 | 1995-03-02 | Enteric Research Laboratories, Inc. | Campylobacter jejuni antigens, and methods for their production and use |
US5904925A (en) | 1993-12-09 | 1999-05-18 | Exner; Heinrich | Adjuvant for antigens, and process for making |
US5597709A (en) | 1994-01-27 | 1997-01-28 | Human Genome Sciences, Inc. | Human growth hormone splice variants hGHV-2(88) and hGHV-3(53) |
US5688506A (en) | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
US5571515A (en) | 1994-04-18 | 1996-11-05 | The Wistar Institute Of Anatomy & Biology | Compositions and methods for use of IL-12 as an adjuvant |
US5874560A (en) | 1994-04-22 | 1999-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Melanoma antigens and their use in diagnostic and therapeutic methods |
AU2404695A (en) | 1994-05-04 | 1995-11-29 | Mount Sinai Hospital Corporation | Modulators of cytokines of the tgf-beta superfamily and methods for assaying for same |
US6110892A (en) | 1994-06-20 | 2000-08-29 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
IT1266740B1 (it) | 1994-07-01 | 1997-01-14 | Maria Paola Landini | Materiale proteico ricombinante legante anticorpi contro il citomegalovirus umano, reagenti diagnostici derivati da tale |
GB9414118D0 (en) | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
EP1181937A3 (en) | 1994-08-09 | 2004-02-04 | Cytrx Corporation | Novel vaccine adjuvant and vaccine |
FR2723740B1 (fr) | 1994-08-16 | 1996-11-08 | Pasteur Merieux Serums Vacc | Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications |
US5585115A (en) | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
GB9501826D0 (en) | 1995-01-31 | 1995-03-22 | St Thomas Hosp Med School | Polypeptide fragments |
US6034227A (en) | 1995-04-06 | 2000-03-07 | Yeda Research And Development Co. Ltd. | DNA molecule encoding a mast cell function-associated antigen (MAFA) |
US6004760A (en) | 1995-05-19 | 1999-12-21 | Chugai Seiyaku Kabushiki Kaisha | Method of assaying antigens related to autoimmune diseases |
US5922836A (en) | 1995-05-31 | 1999-07-13 | Washington University | Mammaglobin antigens |
AR003125A1 (es) | 1995-06-01 | 1998-07-08 | Astra Ab | Antigenos bacterianos para el diagnostico de infecciones con helicobacter pylori, una molecula de adn que lo codifica, un vector, una celula huesped,procedimiento para producir el polipeptido, composiciones para vacunas adecuadas para uso terapeutico y profilactico, el uso del polipeptido en la |
US6063402A (en) | 1995-06-07 | 2000-05-16 | Venture Lending, A Division Of Cupertino National Bank | Purified galactomannan as an improved pharmaceutical excipient |
FR2737209B1 (fr) | 1995-07-25 | 1997-09-19 | Bio Merieux | Peptide capable d'etre reconnu par des anticorps reconnaissant l'antigene c33 du virus de l'hepatite c |
US5869288A (en) | 1995-08-18 | 1999-02-09 | The University Of Virginia Patent Foundation | Molecular cloning of cockroach allergens, amino acid and nucleotide sequences therefore and recombinant expression thereof |
US5834592A (en) | 1995-09-22 | 1998-11-10 | Corixa Corporation | Leishmania antigens for use in the therapy and diagnosis of Leishmaniasis |
EP0776906A3 (de) | 1995-10-19 | 1998-02-25 | Imtec Immundiagnostika Gmbh | Peptide des Antigens Sm-D und ihre Verwendung, insbesondere für die Diagnostik des SLE |
US5763400A (en) | 1996-01-03 | 1998-06-09 | The Regents Of The University Of California | Ecdysis-triggering hormone compositions |
ES2212071T3 (es) | 1996-01-05 | 2004-07-16 | The Government Of The United States Of America, As Represented By The Secretary, Department Of | Antigeno de mesotelio y kits para marcarlo como diana. |
US6083703A (en) | 1996-02-09 | 2000-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes |
US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
US6124436A (en) | 1996-02-13 | 2000-09-26 | Schering Corporation | Purified mammalian monocyte antigens and related reagents |
US5804201A (en) | 1996-03-11 | 1998-09-08 | The Rockefeller University | Immunomodulatory peptides of vespid antigen 5 |
US6033864A (en) | 1996-04-12 | 2000-03-07 | The Regents Of The University Of California | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens |
AU720802B2 (en) | 1996-07-03 | 2000-06-15 | Millenium Pharmaceuticals, Inc. | Detection of cancer by assaying for cancer-specific antigens having linked oligosaccharides which are at least triantennary |
US5840585A (en) | 1996-09-17 | 1998-11-24 | Baylor College Of Medicine | Rh blood group antigen compositions and methods of use |
US6074833A (en) | 1996-09-30 | 2000-06-13 | Ramot University Authority | Osteoblast and fibroblast antigen and antibodies recognizing it |
US6069233A (en) | 1996-10-03 | 2000-05-30 | Memorial Sloan-Kettering Cancer Center | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
US6071532A (en) | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
EP0878541A4 (en) | 1996-10-18 | 2001-10-17 | Univ Osaka Res Found | ROTAVIRUS ANTIGENS, VACCINES AND MEDICINES FOR DIAGNOSING ROTAVIRUS INFECTION AND METHODS OF PREPARING THE SAME |
US6117631A (en) | 1996-10-29 | 2000-09-12 | Polyprobe, Inc. | Detection of antigens via oligonucleotide antibody conjugates |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US5910306A (en) | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
US6100444A (en) | 1997-02-11 | 2000-08-08 | University Of Rochester Medical Center | Prostate specific regulatory nucleic acid sequences and transgenic non-human animals expressing prostate specific antigen |
US5807575A (en) | 1997-02-14 | 1998-09-15 | Rougier Inc. | Manufacture of cross-linked amylose useful as a excipient for control release of active compounds |
US6020478A (en) | 1997-02-28 | 2000-02-01 | Incyte Pharmaceuticals, Inc. | Human tumor-associated antigen |
US5849307A (en) | 1997-03-26 | 1998-12-15 | The Picower Institute For Medical Research | Vaccine adjuvant |
US5922566A (en) | 1997-05-13 | 1999-07-13 | Incyte Pharmaceuticals, Inc. | Tumor-associated antigen |
US5885783A (en) | 1997-07-02 | 1999-03-23 | Yoo; Tai-June | Autoimmune inner ear disease antigen and diagnostic assay |
US6103501A (en) | 1997-11-17 | 2000-08-15 | Washington University | Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof |
US5955476A (en) | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
US6033673A (en) | 1998-03-18 | 2000-03-07 | The Administrators Of Tulane Educational Fund | Double mutant enterotoxin for use as an adjuvant |
US6017537A (en) | 1998-12-18 | 2000-01-25 | Connaught Laboratories, Inc. | Formyl methionyl peptide vaccine adjuvant |
GB9924351D0 (en) * | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
-
1999
- 1999-10-14 GB GBGB9924351.1A patent/GB9924351D0/en not_active Ceased
-
2000
- 2000-10-13 CZ CZ20021304A patent/CZ20021304A3/cs unknown
- 2000-10-13 JP JP2001529743A patent/JP2003514775A/ja active Pending
- 2000-10-13 AU AU80221/00A patent/AU784425B2/en not_active Ceased
- 2000-10-13 US US10/110,683 patent/US7267963B1/en not_active Expired - Fee Related
- 2000-10-13 WO PCT/US2000/028443 patent/WO2001026682A2/en active IP Right Grant
- 2000-10-13 EP EP00970905A patent/EP1223977B1/en not_active Expired - Lifetime
- 2000-10-13 DE DE60033043T patent/DE60033043T2/de not_active Expired - Lifetime
- 2000-10-13 IL IL14907800A patent/IL149078A0/xx unknown
- 2000-10-13 CA CA002387629A patent/CA2387629A1/en not_active Abandoned
- 2000-10-13 MX MXPA02003788A patent/MXPA02003788A/es unknown
- 2000-10-17 AR ARP000105444A patent/AR026059A1/es unknown
- 2000-10-17 CO CO00078907A patent/CO5270015A1/es not_active Application Discontinuation
- 2000-10-19 HR HR20000701A patent/HRP20000701A2/hr not_active Application Discontinuation
-
2002
- 2002-04-10 ZA ZA200202816A patent/ZA200202816B/xx unknown
-
2007
- 2007-07-20 US US11/880,195 patent/US7666624B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2387629A1 (en) | 2001-04-19 |
WO2001026682A3 (en) | 2001-12-13 |
DE60033043D1 (de) | 2007-03-08 |
US20080124358A1 (en) | 2008-05-29 |
US7666624B2 (en) | 2010-02-23 |
ZA200202816B (en) | 2003-06-10 |
CZ20021304A3 (cs) | 2003-12-17 |
MXPA02003788A (es) | 2002-09-30 |
US7267963B1 (en) | 2007-09-11 |
DE60033043T2 (de) | 2007-10-18 |
EP1223977A2 (en) | 2002-07-24 |
WO2001026682A2 (en) | 2001-04-19 |
IL149078A0 (en) | 2002-11-10 |
HRP20000701A2 (en) | 2002-04-30 |
GB9924351D0 (en) | 1999-12-15 |
JP2003514775A (ja) | 2003-04-22 |
EP1223977B1 (en) | 2007-01-17 |
AU8022100A (en) | 2001-04-23 |
AU784425B2 (en) | 2006-03-30 |
CO5270015A1 (es) | 2003-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR026059A1 (es) | Virus de plantas modificadas y metodos para su uso | |
ES2184769T3 (es) | Metodos y composiciones para microencapsulacion de antigenos para utilizar como vacunas. | |
CR7875A (es) | Variantes de inmunoglobina y usos de esto | |
MX9300766A (es) | Piridonas sustituidas por sulfonilbencilo, procedimiento para su obtencion y medicamentos que las contienen. | |
FI932678A (fi) | Pao alfavirus baserande dna expressionssystem | |
DE602004028468D1 (de) | Haltung von immunantworten gegen mhc-klasse-i-beschränkte epitope, für prophylaktische oder therapeutische zwecke | |
MX9400166A (es) | Microesferas de proteina vegetal, hidrolizada, modificada y metodos para su preparacion y su uso. | |
AR033574A1 (es) | Una cepa bacteriana del grupo de las bacterias lacticas capaces de reducir la tendencia de un individuo a desarrollar reacciones alergicas, las composiciones alimenticias y farmaceuticas que la contienen y las vacunas que la contienen | |
PA8481501A1 (es) | 4-carboxiamino-2-metil-1,2,3,4-tetrahidroquinolinas | |
CO6751287A2 (es) | Composición antigénetica de micobacteria | |
PT1411908E (pt) | Tratamento de infeccoes da unha com no | |
CO5700784A2 (es) | Polipeptidos de virus de papiloma humano y composiciones in- munogenas | |
ES2173314T3 (es) | Metodos y composiciones para la modificacion selectiva de acidos nucleicos. | |
EA201290199A1 (ru) | Способы и композиции для получения сквалена с применением дрожжей | |
DE60144240D1 (de) | Zusammensetzung mit immunogenen mikroteilchen | |
DK0914114T3 (da) | Fremgangsmåder til behandling af type I-hypersensitivitet under anvendelse af monophosphoryl-lipid A | |
ES2197500T3 (es) | Uso de cloruro de n,n-bis(fenilcarbamoilmetil)dimetilamonio y sus usos derivados en el tratamiento del dolor cronico. | |
CU20210041A7 (es) | Péptidos inmunogénicos con motivos de oxidorreductasa | |
EA200200808A1 (ru) | Модифицированные цитокины, предназначенные для применения в терапии рака | |
BRPI0516314A (pt) | uso de hiv inteiro e método de tratamento de um indivìduo cronicamente infectado com hiv | |
ES2168287T3 (es) | Vacuna capaz de provocar una respuesta inmunitaria contra los gangliosidos n-glicolados y su aplicacion anti-cancerosa. | |
DK0563085T3 (da) | Hidtil ukendte præparater | |
BRPI0514884A (pt) | composição vacinal para gerar resposta imune celular e humoral protetora contra a infecção pelo vìrus de hepatite c | |
WO2018120843A9 (zh) | 一种三功能分子及其应用 | |
AR039982A1 (es) | Composicion vacunal contra las alergias, metodo para su obtencion y empleo en el tratamiento de las mismas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |