AR025815A1 - MÉTODO PARA CONTROLAR LA PERMEACIoN DE UN FÁRMACO DURANTE UN PERíODO PROLONGADO MEDIANTE EL USO DE UN ELASToMERO BASADO EN SILOXANO. - Google Patents

MÉTODO PARA CONTROLAR LA PERMEACIoN DE UN FÁRMACO DURANTE UN PERíODO PROLONGADO MEDIANTE EL USO DE UN ELASToMERO BASADO EN SILOXANO.

Info

Publication number
AR025815A1
AR025815A1 ARP990105742A ARP990105742A AR025815A1 AR 025815 A1 AR025815 A1 AR 025815A1 AR P990105742 A ARP990105742 A AR P990105742A AR P990105742 A ARP990105742 A AR P990105742A AR 025815 A1 AR025815 A1 AR 025815A1
Authority
AR
Argentina
Prior art keywords
control
elastomer
trifluoropropyl
siloxano
permeation
Prior art date
Application number
ARP990105742A
Other languages
English (en)
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of AR025815A1 publication Critical patent/AR025815A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/2036—Silicones; Polysiloxanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Silicon Polymers (AREA)
  • Materials For Medical Uses (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)

Abstract

Una matriz o membrana, hecha de un elastomero basado en siloxano, y destinada a controlar la penetracion de fármacos, en donde dicho elastomero comprendegrupos 3,3,3-trifluoropropilo unidos a los átomos de Si de las unidades de siloxano. Un métodopa ra la preparacion de un elastomero basado en siloxano quecomprende sustituyentes de 3,3,3-trifluoropropilo, en el que dicho elastomero está destinado a controlar la penetracion de fármacos. En el método: i) uncomponente de polisiloxano confuncionali dad de vinilo sustituido con 3,3,3-trifluoropropilo y un agente reticulante con funcionalidad de hidruro de silicioson reticulados en presencia de un catalizador, o bien ii) un componente de polisiloxano sustituido con 3,3,3-trifluoropropilo es retic ulado en presencia de uncatalizador de peroxido.
ARP990105742A 1998-11-12 1999-11-11 MÉTODO PARA CONTROLAR LA PERMEACIoN DE UN FÁRMACO DURANTE UN PERíODO PROLONGADO MEDIANTE EL USO DE UN ELASToMERO BASADO EN SILOXANO. AR025815A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/190,608 US6056976A (en) 1998-11-12 1998-11-12 Elastomer, its preparation and use

Publications (1)

Publication Number Publication Date
AR025815A1 true AR025815A1 (es) 2002-12-18

Family

ID=22702039

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990105742A AR025815A1 (es) 1998-11-12 1999-11-11 MÉTODO PARA CONTROLAR LA PERMEACIoN DE UN FÁRMACO DURANTE UN PERíODO PROLONGADO MEDIANTE EL USO DE UN ELASToMERO BASADO EN SILOXANO.

Country Status (25)

Country Link
US (1) US6056976A (es)
EP (1) EP1151030A1 (es)
JP (1) JP2002530447A (es)
KR (1) KR20010075701A (es)
CN (1) CN1127535C (es)
AR (1) AR025815A1 (es)
AU (1) AU756089B2 (es)
BG (1) BG105499A (es)
BR (1) BR9915325A (es)
CA (1) CA2351091A1 (es)
CZ (1) CZ291399B6 (es)
DE (1) DE1151030T1 (es)
EE (1) EE05528B1 (es)
HK (1) HK1041895B (es)
HU (1) HUP0104380A3 (es)
ID (1) ID29223A (es)
IL (2) IL142525A0 (es)
NO (1) NO20012045L (es)
NZ (1) NZ511215A (es)
PE (1) PE20001019A1 (es)
PL (1) PL348115A1 (es)
RU (1) RU2231531C2 (es)
SK (1) SK5142001A3 (es)
WO (1) WO2000029464A1 (es)
ZA (1) ZA200103297B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214926B1 (en) * 1999-04-01 2001-04-10 Rhodia Inc. Silicone membranes formed without the use of 1-1-1 trichloroethane
US6436428B1 (en) * 2000-03-21 2002-08-20 Enhance Pharmaceuticals, Inc. Device and method for treating urinary incontinence in females
WO2001085132A1 (en) * 2000-05-10 2001-11-15 Leiras Oy Drug delivery device, especially for the delivery of levonorgestrel
US6299894B1 (en) * 2000-05-10 2001-10-09 Leiras Oy Drug delivery device, especially for the delivery of gestodene
US6550480B2 (en) * 2001-01-31 2003-04-22 Numed/Tech Llc Lumen occluders made from thermodynamic materials
EP1438942A1 (en) 2003-01-17 2004-07-21 Schering Oy An otorhinological drug delivery device
US20050038183A1 (en) * 2003-08-14 2005-02-17 Dongchan Ahn Silicones having improved surface properties and curable silicone compositions for preparing the silicones
US7045586B2 (en) * 2003-08-14 2006-05-16 Dow Corning Corporation Adhesives having improved chemical resistance and curable silicone compositions for preparing the adhesives
US20050038188A1 (en) * 2003-08-14 2005-02-17 Dongchan Ahn Silicones having improved chemical resistance and curable silicone compositions having improved migration resistance
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
US20090168013A1 (en) * 2007-12-27 2009-07-02 Kunzler Jay F Trimethylsilyl-Capped Polysiloxane Macromonomers Containing Polar Fluorinated Side-Chains
EA021615B1 (ru) 2008-02-04 2015-07-30 Тева Вимен'С Хелс, Инк. Цельное интравагинальное кольцо, содержащее прогестерон, и способ изготовления и применения такого кольца
EP2140860A1 (en) 2008-07-03 2010-01-06 Bayer Schering Pharma Oy An improved method of contraception
FI20080524A0 (fi) 2008-09-17 2008-09-17 Bayer Schering Pharma Oy Insertteri
FI20080523A0 (fi) 2008-09-17 2008-09-17 Bayer Schering Pharma Oy Insertteri
KR101612579B1 (ko) 2008-09-17 2016-04-14 베이어 오와이 삽입기
US11992431B2 (en) 2008-09-17 2024-05-28 Bayer Oy Inserter
FI122579B (fi) 2010-10-29 2012-03-30 Bayer Oy Insertteri
US10028858B2 (en) 2011-07-11 2018-07-24 Medicines360 Intrauterine systems, IUD insertion devices, and related methods and kits therefor
WO2013160200A1 (de) 2012-04-23 2013-10-31 Bayer Pharma Aktiengesellschaft ANWENDUNG VON 18-METHYL-15ß,16ß-METHYLEN-19-NOR-20-SPIROX-4-EN-3-ONEN BEI DER THERAPIE DER MENORRHAGIA, SOWIE 18-METHYL-15ß,16ß-METHYLEN-19-NOR-20-SPIROX-4-EN-3-ONE ENTHALTENDE INTRAUTERINE SYSTEME FÜR DIE THERAPIE UTERINEN BLUTUNGSSTÖRUNGEN
TW201350122A (zh) 2012-04-23 2013-12-16 Bayer Pharma AG １８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內用途，包含１８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內系統，及其於避孕及婦科治療之用途
JP2016539088A (ja) * 2013-10-18 2016-12-15 バイエル・オサケユキテュアＢａｙｅｒ Ｏｙ 子宮内送達システム
EP3040388B1 (en) 2014-12-31 2017-08-23 LG Display Co., Ltd. Touch sensitive device comprising electroactive film, display device comprising the same, and method of manufacturing the electroactive film
KR102431597B1 (ko) * 2014-12-31 2022-08-11 엘지디스플레이 주식회사 전기활성 필름을 포함하는 접촉 감응 소자, 이를 포함하는 표시 장치 및 전기활성 필름의 제조 방법
JP6898856B2 (ja) 2015-05-13 2021-07-07 バイエル・オーイュー 長時間作用型薬物送達装置および避妊におけるその使用
WO2018202574A1 (en) 2017-05-04 2018-11-08 Bayer Oy Intravaginal drug delivery system, method for manufacturing such system and its use in gynecological therapies and contraception
WO2019119059A1 (en) 2017-12-22 2019-06-27 Alyra Biotech Pty Ltd Treatment of pain and/or pain related symptoms associated with dysmenorrhea
US11571328B2 (en) 2018-04-09 2023-02-07 Medicines360 IUD insertion devices
US20200261258A1 (en) 2019-02-19 2020-08-20 Medicines360 Devices, systems, methods and kits for insertion and removal of iuds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179619A (en) * 1965-04-20 Xow swell, high temperature organosi- loxane rubbeks containing silicon- bonded fluokjnated aliphatic radicals
US3050492A (en) * 1962-08-21 Degrees of twist at indicated centigrade temperature
US3279996A (en) * 1962-08-28 1966-10-18 Jr David M Long Polysiloxane carrier for controlled release of drugs and other agents
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3661833A (en) * 1970-07-09 1972-05-09 Dow Corning Fast curing organosiloxane resins
US3974120A (en) * 1975-05-05 1976-08-10 General Electric Company Fluorosilicone copolymers and process for the preparation thereof
CH657779A5 (de) * 1982-10-05 1986-09-30 Sandoz Ag Galenische zusammensetzungen enthaltend calcitonin.
US4525528A (en) * 1983-10-11 1985-06-25 General Electric Company Peroxide-curable fluorosilicone copolymer compositions
NZ217844A (en) * 1985-10-11 1989-10-27 Sumitomo Pharma A sustained release pharmaceutical composition containing silicone elastomer and an albumin
US5310572A (en) * 1987-02-03 1994-05-10 Dow Corning Corporation Process for forming a coated active agent-containing article
GB8704755D0 (en) * 1987-02-28 1987-04-01 Dow Corning Ltd Pharmaceutical delivery device
FR2643572A1 (fr) * 1988-12-22 1990-08-31 Rhone Poulenc Chimie Procede d'encapsulation de particules par pelliculage au moyen d'un copolymere silicone thermoplastique
JPH07216233A (ja) * 1992-09-21 1995-08-15 Toray Dow Corning Silicone Co Ltd フルオロシリコーンゴム組成物
US5492993A (en) * 1994-02-03 1996-02-20 Dow Corning Corporation Strain-crystallizing poly(methyl(3,3,3-trifluoropropyl)-siloxane) elastomers and methods for making
DE69511180T2 (de) * 1994-06-20 1999-12-23 Dow Corning Corp., Midland Verfahren zur Steuerung der Freisetzung einer Wirksubstanz oder eines Arzneistoffs aus einer Silikongummi-Matrix

Also Published As

Publication number Publication date
JP2002530447A (ja) 2002-09-17
IL142525A (en) 2006-07-05
NO20012045D0 (no) 2001-04-26
NZ511215A (en) 2002-04-26
DE1151030T1 (de) 2002-04-04
AU756089B2 (en) 2003-01-02
EP1151030A1 (en) 2001-11-07
RU2231531C2 (ru) 2004-06-27
ZA200103297B (en) 2001-10-25
BR9915325A (pt) 2001-10-09
CN1326478A (zh) 2001-12-12
CN1127535C (zh) 2003-11-12
HK1041895A1 (en) 2002-07-26
WO2000029464A1 (en) 2000-05-25
CZ20011570A3 (cs) 2001-09-12
PL348115A1 (en) 2002-05-06
SK5142001A3 (en) 2001-11-06
EE05528B1 (et) 2012-04-16
ID29223A (id) 2001-08-16
BG105499A (bg) 2001-12-29
NO20012045L (no) 2001-06-28
PE20001019A1 (es) 2000-10-12
HK1041895B (zh) 2004-07-23
HUP0104380A2 (hu) 2002-03-28
US6056976A (en) 2000-05-02
CA2351091A1 (en) 2000-05-25
EE200100257A (et) 2002-12-16
IL142525A0 (en) 2002-03-10
KR20010075701A (ko) 2001-08-09
AU1048900A (en) 2000-06-05
CZ291399B6 (cs) 2003-02-12
HUP0104380A3 (en) 2003-04-28

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed, e.g., due to non-payment of fee