AR019482A1 - DERIVADOS SUSTITUIDOS DEL 2-IMIDAZO(5,1-b)TIAZOL-CARBAPENEM, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS PARA LAPREPARACION DE MEDICAMENTOS - Google Patents

DERIVADOS SUSTITUIDOS DEL 2-IMIDAZO(5,1-b)TIAZOL-CARBAPENEM, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS PARA LAPREPARACION DE MEDICAMENTOS

Info

Publication number
AR019482A1
AR019482A1 ARP990103683A ARP990103683A AR019482A1 AR 019482 A1 AR019482 A1 AR 019482A1 AR P990103683 A ARP990103683 A AR P990103683A AR P990103683 A ARP990103683 A AR P990103683A AR 019482 A1 AR019482 A1 AR 019482A1
Authority
AR
Argentina
Prior art keywords
carbapenem
derivatives
imidazo
tiazol
medicines
Prior art date
Application number
ARP990103683A
Other languages
English (en)
Original Assignee
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha filed Critical Meiji Seika Kaisha
Publication of AR019482A1 publication Critical patent/AR019482A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/18Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se revela un nuevo derivado de carbapenem que posee un grupo imidazo[5,1-b]tiazol sustituido en la posicion 2-en el anillo de carbapenem que posee una granactividad antimicrobiana contra las bacterias que porducen beta-lactamasa, MRSA, Pseudomonas aeruginosa resistente, PRSP, enterococos e influenza y, una granestabilidad a DHP-1. De acuerdo con la presente invencion, se proporciona un compuesto representado por la formula (1) o una sal farmacéuticamente aceptable deéste o un éster en la posicion 3- de su anillo de carbapenem, de la formula (1) en la cual los sustituyentes R a R5 tiene los significados que constan en ladescripcion.
ARP990103683A 1998-07-27 1999-07-27 DERIVADOS SUSTITUIDOS DEL 2-IMIDAZO(5,1-b)TIAZOL-CARBAPENEM, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS PARA LAPREPARACION DE MEDICAMENTOS AR019482A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21053498 1998-07-27

Publications (1)

Publication Number Publication Date
AR019482A1 true AR019482A1 (es) 2002-02-20

Family

ID=16590961

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990103683A AR019482A1 (es) 1998-07-27 1999-07-27 DERIVADOS SUSTITUIDOS DEL 2-IMIDAZO(5,1-b)TIAZOL-CARBAPENEM, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS PARA LAPREPARACION DE MEDICAMENTOS

Country Status (10)

Country Link
US (2) US6458780B1 (es)
EP (1) EP1101766A4 (es)
KR (1) KR20010085302A (es)
CN (1) CN1315955A (es)
AR (1) AR019482A1 (es)
AU (1) AU771876B2 (es)
BR (1) BR9912490A (es)
CA (1) CA2338816A1 (es)
ID (1) ID29173A (es)
WO (1) WO2000006581A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010085302A (ko) * 1998-07-27 2001-09-07 기따자또 이찌로 신규한 카르바페넴 유도체
JP2005231997A (ja) * 2000-01-24 2005-09-02 Meiji Seika Kaisha Ltd カルバペネム誘導体の製造法
US6825187B2 (en) 2000-01-26 2004-11-30 Meiji Seika Kaisha, Ltd. Carbapenem derivatives of quarternary salt type
ES2228896T3 (es) * 2000-01-26 2005-04-16 Meiji Seika Kaisha, Ltd. Nuevos derivados de carbapenem.
HUP0400652A2 (hu) * 2000-11-24 2004-06-28 Meiji Seika Kaisha Ltd. Új karbapenemszármazékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1582522A4 (en) * 2002-12-13 2007-08-08 Meiji Seika Kaisha INTERMEDIARY FOR SUBSTITUTED CARBAPENEME DERIVED IN POSITION 2 AND METHOD OF PRODUCING THE SAME
WO2006077919A1 (ja) 2005-01-19 2006-07-27 Meiji Seika Kaisha, Ltd. イミダゾチアゾール誘導体およびその製造方法
JP2009544683A (ja) * 2006-07-24 2009-12-17 メルク シャープ エンド ドーム リミテッド Markインヒビターとなるイミダゾチアゾール誘導体
WO2008085913A1 (en) * 2007-01-04 2008-07-17 Rib-X Pharmaceuticals, Inc. Methods for treating, preventing, or reducing the risk of opthalmic, otic, and nasal infections
US20120022040A1 (en) * 2008-12-01 2012-01-26 Mutz Mitchell W Antimicrobials
PL221806B1 (pl) * 2013-03-21 2016-05-31 Inst Chemii Bioorg Polskiej Akademii Nauk Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu
US10526343B2 (en) * 2018-03-26 2020-01-07 University Of Sharjah Heterocyclic systems and pharmaceutical applications thereof
CN114790157B (zh) * 2022-02-28 2024-06-21 开封大地农化生物科技有限公司 一种高含量乙蒜素的合成方法
CN114805280B (zh) * 2022-05-17 2023-06-02 苏州华一新能源科技股份有限公司 碳酸亚乙烯酯的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011932A1 (en) 1994-10-14 1996-04-25 Smithkline Beecham Plc 2-(imidazol-4-yl)carbapeneme derivatives, intermediates thereof and use as antibacterials
CA2189995C (en) 1995-03-10 2001-01-23 Kazuhiro Aihara Novel carbapenem derivatives
JP3527003B2 (ja) 1995-03-10 2004-05-17 明治製菓株式会社 新規イミダゾ[5,1−b]チアゾール誘導体
JPH09249667A (ja) 1996-01-12 1997-09-22 Takeda Chem Ind Ltd カルバペネム化合物、その製造法および剤
WO1998032760A1 (fr) * 1997-01-28 1998-07-30 Meiji Seika Kaisha, Ltd. Nouveaux derives de carbapenem
KR20010085302A (ko) * 1998-07-27 2001-09-07 기따자또 이찌로 신규한 카르바페넴 유도체
ES2228896T3 (es) * 2000-01-26 2005-04-16 Meiji Seika Kaisha, Ltd. Nuevos derivados de carbapenem.
US6825187B2 (en) * 2000-01-26 2004-11-30 Meiji Seika Kaisha, Ltd. Carbapenem derivatives of quarternary salt type
HUP0400652A2 (hu) * 2000-11-24 2004-06-28 Meiji Seika Kaisha Ltd. Új karbapenemszármazékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Also Published As

Publication number Publication date
CA2338816A1 (en) 2000-02-10
US20030149016A1 (en) 2003-08-07
AU4802499A (en) 2000-02-21
EP1101766A1 (en) 2001-05-23
US6677331B2 (en) 2004-01-13
BR9912490A (pt) 2001-06-05
EP1101766A4 (en) 2001-11-21
US6458780B1 (en) 2002-10-01
WO2000006581A1 (fr) 2000-02-10
KR20010085302A (ko) 2001-09-07
ID29173A (id) 2001-08-09
AU771876B2 (en) 2004-04-01
CN1315955A (zh) 2001-10-03

Similar Documents

Publication Publication Date Title
AR019482A1 (es) DERIVADOS SUSTITUIDOS DEL 2-IMIDAZO(5,1-b)TIAZOL-CARBAPENEM, LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS PARA LAPREPARACION DE MEDICAMENTOS
CL2011000009A1 (es) Composicion farmaceutica que comprende un compuesto derivado de (diaza)- u (oxa-aza)-biciclo-octano en combinacion con un antibiotico de beta-lactamina; y el uso de la composicion para inhibir la produccion de beta-lactamasa en una terapia antibacteriana. (divisional de la solicitud 134-2003)
TR199901127T2 (xx) Antibakteriyel etkili 6-O-ikameli ketolitler.
BRPI0921701B8 (pt) Cefarosporina tendo um grupo catecol, seu uso e composição farmacêutica que a compreende
AR005597A1 (es) Derivados de benzoxazina , composiciones farmaceuticas para el tratamiento de infecciones bacterianas, y metodo para la preparacion de dichos derivados.
UY25780A1 (es) Nuevos antibióticos macrólidos
PA8524501A1 (es) Antibioticos macrolidos
SV1999000194A (es) Preparado farmaceuticio de moxifloxacina ref. lea 33327-sv
ES2129078T3 (es) Preparacion farmaceutica que comprende un compuesto capaz de degradar los antibioticos beta-lactamicos y su utilizacion.
FI864825A (fi) Cefalosporinderivat.
ATE480538T1 (de) 2-arylmethylazetidincarbapenemderivate und deren herstellung
ES2136124T3 (es) Derivados de carbapenem como antibioticos y sus productos intermedios.
SE8306882L (sv) 7-karboximetoxifenylacetamido-3-cefem-derivat, forfaranden for framstellning derav och antibakteriella beredningar innehallande dem
CL2022000893A1 (es) Derivados de 2-azaspiro[3,4]octano como agonistas de m4
CO4810376A1 (es) Derivados de eritromicina triciclicos
AR121878A1 (es) DERIVADOS DE BENZODIAZEPINA COMO PAM DE GABAA g1
EA199800949A1 (ru) Антибактериальные соединения карбапенема, содержащие их фармацевтические композиции и способы лечения
EP0760370A4 (en) NEW CARBAPENEMIC DERIVATIVES
KR970702723A (ko) 베타-락탐 항생 물질과 조합하여 베타-락타마아제를 억제하는 페넴을 함유하는 약제학적 제형물 및 박테리아 감염의 치료에서 상기 제형물을 사용하는 방법(pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections)
PT1289998E (pt) Novo processo para a preparacao de derivados de vinil-pirrolidinona cefalosporina
ATE192927T1 (de) Neue cephem-derivate
ES2181159T3 (es) Nuevos derivados de carbapenem.
HUP0400652A2 (hu) Új karbapenemszármazékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
PE20070342A1 (es) 6-ALQUILIDEN-PENEM TRICICLICOS COMO INHIBIDORES DE ß-LACTAMASA Y COMBINACION DE ANTIBIOTICOS DE ß-LACTAMA: UN ANTIBIOTICO DE AMPLIO ESPECTRO
ES2070790B1 (es) Derivados de carbapenem 1-beta-metil-2-tiolicos.