PE20070342A1 - 6-ALQUILIDEN-PENEM TRICICLICOS COMO INHIBIDORES DE ß-LACTAMASA Y COMBINACION DE ANTIBIOTICOS DE ß-LACTAMA: UN ANTIBIOTICO DE AMPLIO ESPECTRO - Google Patents

6-ALQUILIDEN-PENEM TRICICLICOS COMO INHIBIDORES DE ß-LACTAMASA Y COMBINACION DE ANTIBIOTICOS DE ß-LACTAMA: UN ANTIBIOTICO DE AMPLIO ESPECTRO

Info

Publication number
PE20070342A1
PE20070342A1 PE2006000908A PE2006000908A PE20070342A1 PE 20070342 A1 PE20070342 A1 PE 20070342A1 PE 2006000908 A PE2006000908 A PE 2006000908A PE 2006000908 A PE2006000908 A PE 2006000908A PE 20070342 A1 PE20070342 A1 PE 20070342A1
Authority
PE
Peru
Prior art keywords
formula
inhibitors
wide
alkyliden
penems
Prior art date
Application number
PE2006000908A
Other languages
English (en)
Inventor
Tarek S Mansour
Aranapakam M Venkatesan
Peter J Petersen
Steven J Projan
Patricia Bradford
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070342A1 publication Critical patent/PE20070342A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDA A UNA COMPOSICION QUE COMPRENDE CEFEPIME Y UN COMPUESTO PENEM DE FORMULA (I) DONDE A Y B SON H, UN GRUPO HETEROARILO TRICICLICO FUSIONADO DE FORMULA (16-A) EN DONDE Y ES O Y n ES 0 O 1, ENTRE OTROS; X ES S U O; R5 ES H, ALQUILO C1-C6, CICLOALQUILO C5-C6, ENTRE OTROS. SON COMPUESTOS DE FORMULA I PREFERIDOS: SAL DE SODIO DEL ACIDO (5R),(6Z)-6-(6,7-DIHIDRO-5H-CICLOPENTA[d]IMIDAZO[2,1-b][1,3]TIAZOL-2-ILMETILENO)-7-OXO-4-TIA-1-AZABICICLO[3.2.0]HEPT-2-ENO-2-CARBOXILICO Y ACIDO (5R),(6Z)-6-(5,8-DIHIDRO-6H-IMIDAZO[2,1-b]PIRANO[4,3-d][1,3]TIAZOL-2-ILMETILENO)-7-OXO-4-TIA-1-AZABICICLO[3.2.0]HEPT-2-ENO-2-CARBOXILICO. DICHOS COMPUESTOS DE FORMULA I SON INHIBIDORES DE BETA LACTAMASA DE AMPLIO ESPECTRO Y JUNTO CON EL CEFEPIME SON UTILES PARA EL TRATAMIENTO DE INFECCIONES O ENFERMEDADES BACTERIANAS
PE2006000908A 2005-07-27 2006-07-26 6-ALQUILIDEN-PENEM TRICICLICOS COMO INHIBIDORES DE ß-LACTAMASA Y COMBINACION DE ANTIBIOTICOS DE ß-LACTAMA: UN ANTIBIOTICO DE AMPLIO ESPECTRO PE20070342A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70280805P 2005-07-27 2005-07-27

Publications (1)

Publication Number Publication Date
PE20070342A1 true PE20070342A1 (es) 2007-05-08

Family

ID=37809337

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000908A PE20070342A1 (es) 2005-07-27 2006-07-26 6-ALQUILIDEN-PENEM TRICICLICOS COMO INHIBIDORES DE ß-LACTAMASA Y COMBINACION DE ANTIBIOTICOS DE ß-LACTAMA: UN ANTIBIOTICO DE AMPLIO ESPECTRO

Country Status (13)

Country Link
US (1) US20070027130A1 (es)
EP (1) EP1909786A2 (es)
JP (1) JP2009502932A (es)
CN (1) CN101257902A (es)
AR (1) AR055097A1 (es)
AU (1) AU2006285308A1 (es)
BR (1) BRPI0613928A2 (es)
CA (1) CA2616468A1 (es)
GT (1) GT200600332A (es)
MX (1) MX2008001083A (es)
PE (1) PE20070342A1 (es)
TW (1) TW200738235A (es)
WO (1) WO2007027323A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039475A1 (es) 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
CN101798315B (zh) * 2008-10-06 2012-07-04 山东轩竹医药科技有限公司 含有环丙烷并氮杂环的头孢菌素衍生物
US20110288063A1 (en) * 2010-05-19 2011-11-24 Naeja Pharmaceutical Inc. Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206067A (en) * 1978-10-02 1980-06-03 Chevron Research Company Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base
DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
DE69532032T2 (de) * 1994-04-25 2004-07-22 Smithkline Beecham P.L.C., Brentford Pharmazeutische formulierung, die ein beta-lactamase hemmendes penem in kombination mit einem beta-laktam-antibiotikum enthalten und ihre verwendung zur behandlung von bakteriellen infektionen
US5464616A (en) * 1994-08-04 1995-11-07 Synphar Laboratories, Ind. 6β-substituted penicillanic acids as beta-lactamase inhibitors
ID29547A (id) * 1998-10-15 2001-09-06 Sarawak Medichem Pharmaceuticals Inc Metoda dan komposisi untuk pencegahan dan pengobatan tuberkulosis
GB9928290D0 (en) * 1999-12-01 2000-01-26 Univ Belfast Process for preparing ambient temperature ionic liquids
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos

Also Published As

Publication number Publication date
GT200600332A (es) 2007-03-14
WO2007027323A3 (en) 2007-05-31
US20070027130A1 (en) 2007-02-01
EP1909786A2 (en) 2008-04-16
JP2009502932A (ja) 2009-01-29
CA2616468A1 (en) 2007-03-08
WO2007027323A2 (en) 2007-03-08
MX2008001083A (es) 2008-03-19
TW200738235A (en) 2007-10-16
AR055097A1 (es) 2007-08-08
BRPI0613928A2 (pt) 2011-02-15
CN101257902A (zh) 2008-09-03
AU2006285308A1 (en) 2007-03-08

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