TW200738235A - Tricyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic - Google Patents

Tricyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic

Info

Publication number
TW200738235A
TW200738235A TW095127308A TW95127308A TW200738235A TW 200738235 A TW200738235 A TW 200738235A TW 095127308 A TW095127308 A TW 095127308A TW 95127308 A TW95127308 A TW 95127308A TW 200738235 A TW200738235 A TW 200738235A
Authority
TW
Taiwan
Prior art keywords
penem
alkylidene
tricyclic
antibiotic
broad spectrum
Prior art date
Application number
TW095127308A
Other languages
English (en)
Inventor
Tarek S Mansour
Aranapakam M Venkatesan
Patricia Bradford
Peter J Petersen
Steven J Projan
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of TW200738235A publication Critical patent/TW200738235A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW095127308A 2005-07-27 2006-07-26 Tricyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic TW200738235A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70280805P 2005-07-27 2005-07-27

Publications (1)

Publication Number Publication Date
TW200738235A true TW200738235A (en) 2007-10-16

Family

ID=37809337

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095127308A TW200738235A (en) 2005-07-27 2006-07-26 Tricyclic 6-alkylidene-penem β-lactamase inhibitors and β-lactam antibiotic combination: a broad spectrum antibiotic

Country Status (13)

Country Link
US (1) US20070027130A1 (zh)
EP (1) EP1909786A2 (zh)
JP (1) JP2009502932A (zh)
CN (1) CN101257902A (zh)
AR (1) AR055097A1 (zh)
AU (1) AU2006285308A1 (zh)
BR (1) BRPI0613928A2 (zh)
CA (1) CA2616468A1 (zh)
GT (1) GT200600332A (zh)
MX (1) MX2008001083A (zh)
PE (1) PE20070342A1 (zh)
TW (1) TW200738235A (zh)
WO (1) WO2007027323A2 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039475A1 (es) 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
CN101798315B (zh) * 2008-10-06 2012-07-04 山东轩竹医药科技有限公司 含有环丙烷并氮杂环的头孢菌素衍生物
US20110288063A1 (en) * 2010-05-19 2011-11-24 Naeja Pharmaceutical Inc. Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206067A (en) * 1978-10-02 1980-06-03 Chevron Research Company Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base
DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
WO1995028935A1 (en) * 1994-04-25 1995-11-02 Smithkline Beecham Plc Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections
US5464616A (en) * 1994-08-04 1995-11-07 Synphar Laboratories, Ind. 6β-substituted penicillanic acids as beta-lactamase inhibitors
OA11666A (en) * 1998-10-15 2004-12-08 Sarawak Medichem Pharmaceuticals Inc Method and composition for treating and preventingtuberculosis.
GB9928290D0 (en) * 1999-12-01 2000-01-26 Univ Belfast Process for preparing ambient temperature ionic liquids
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos

Also Published As

Publication number Publication date
CN101257902A (zh) 2008-09-03
AU2006285308A1 (en) 2007-03-08
EP1909786A2 (en) 2008-04-16
AR055097A1 (es) 2007-08-08
BRPI0613928A2 (pt) 2011-02-15
PE20070342A1 (es) 2007-05-08
JP2009502932A (ja) 2009-01-29
WO2007027323A3 (en) 2007-05-31
CA2616468A1 (en) 2007-03-08
MX2008001083A (es) 2008-03-19
WO2007027323A2 (en) 2007-03-08
GT200600332A (es) 2007-03-14
US20070027130A1 (en) 2007-02-01

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