WO2008098955A3 - Antibacterial combination of a tricyclic carbapenem and an antibiotic - Google Patents
Antibacterial combination of a tricyclic carbapenem and an antibiotic Download PDFInfo
- Publication number
- WO2008098955A3 WO2008098955A3 PCT/EP2008/051724 EP2008051724W WO2008098955A3 WO 2008098955 A3 WO2008098955 A3 WO 2008098955A3 EP 2008051724 W EP2008051724 W EP 2008051724W WO 2008098955 A3 WO2008098955 A3 WO 2008098955A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibiotic
- antibacterial combination
- tricyclic
- tricyclic carbapenem
- carbapenem
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical class C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 229940041011 carbapenems Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates toa pharmaceutical composition comprising an ethylene derivatives of tricyclic carbapenems of the general Formula (I) in the form of pure diastereoisomers and in the form of pure geometric isomersor a salt, ester or amide derivate thereof and an antibiotic and the use of this composition as a broad band spectrum β-lactamase inhibitior.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009549406A JP2010518142A (en) | 2007-02-13 | 2008-02-13 | Antimicrobial combination of tricyclic carbapenem and antibiotics |
AT08708944T ATE554762T1 (en) | 2007-02-13 | 2008-02-13 | ANTIBACTERIAL COMBINATION AND USE THEREOF |
EP08708944A EP2124935B1 (en) | 2007-02-13 | 2008-02-13 | Antibacterial combination and its use |
US12/525,739 US20100029604A1 (en) | 2007-02-13 | 2008-02-13 | Antibacterial combination and its use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07102241A EP1958630A1 (en) | 2007-02-13 | 2007-02-13 | Antibacterial combination of a tricyclic carbapenem and an antibiotic |
EP07102241.2 | 2007-02-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008098955A2 WO2008098955A2 (en) | 2008-08-21 |
WO2008098955A3 true WO2008098955A3 (en) | 2008-10-02 |
Family
ID=38124122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/051724 WO2008098955A2 (en) | 2007-02-13 | 2008-02-13 | Antibacterial combination of a tricyclic carbapenem and an antibiotic |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100029604A1 (en) |
EP (2) | EP1958630A1 (en) |
JP (1) | JP2010518142A (en) |
AT (1) | ATE554762T1 (en) |
WO (1) | WO2008098955A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2936951B1 (en) * | 2008-10-10 | 2010-12-03 | Novexel | NOVEL COMBINATIONS OF ANTIBACTERIAL NITROGENIC HETEROCYCLIC COMPOUNDS WITH OTHER ANTIBACTERIAL COMPOUNDS AND THEIR USE AS MEDICAMENTS |
EP2714034B1 (en) * | 2011-05-28 | 2018-07-25 | Wockhardt Limited | Compositions comprising cefepime and tazobactam |
US20160175318A1 (en) * | 2013-12-13 | 2016-06-23 | Wockhardt Limited | Compositions comprising antibacterial agent and tazobactam |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998027094A1 (en) * | 1996-12-18 | 1998-06-25 | Lek Tovarna Farmacevtskih In Kemic^¿Nih Izdelkov, D.D. | Ethylidene derivatives of tricyclic carbapenems |
-
2007
- 2007-02-13 EP EP07102241A patent/EP1958630A1/en not_active Withdrawn
-
2008
- 2008-02-13 JP JP2009549406A patent/JP2010518142A/en active Pending
- 2008-02-13 EP EP08708944A patent/EP2124935B1/en not_active Not-in-force
- 2008-02-13 AT AT08708944T patent/ATE554762T1/en active
- 2008-02-13 WO PCT/EP2008/051724 patent/WO2008098955A2/en active Application Filing
- 2008-02-13 US US12/525,739 patent/US20100029604A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998027094A1 (en) * | 1996-12-18 | 1998-06-25 | Lek Tovarna Farmacevtskih In Kemic^¿Nih Izdelkov, D.D. | Ethylidene derivatives of tricyclic carbapenems |
Non-Patent Citations (5)
Title |
---|
COPAR, ANTON ET AL: "Design, synthesis and bioactivity evaluation of tribactam .beta. lactamase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 12(6), 971-975 CODEN: BMCLE8; ISSN: 0960-894X, 2002, XP002478137 * |
GOODMAN G A ET AL: "GOODMAN and GILMAN'S The Pharmacological Basis of Therapeutics , (The cephalosporins)", 2001, GOODMAN AND GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, NEW YORK : MCGRAW-HILL, US, PAGE(S) 1206-1213, ISBN: 0-07-135469-7, XP002438160 * |
PETRI W A ED - HARDMAN J G ET AL: "GOODMAN and GILMAN'S The Pharmacological Basis of Therapeutics , (Other beta-lactam antibiotics), Chapter 45 - Antimicrobial Agents: Penicillins, Cephalosporins, and Other beta-Lactam Antibiotics", 1 January 2001, GOODMAN AND GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, NEW YORK : MCGRAW-HILL, US, PAGE(S) 1206 - 1213, ISBN: 978-0-07-135469-1, XP002451320 * |
PETRI W A ED - HARDMAN J G ET AL: "GOODMAN and GILMAN'S The Pharmacological Basis of Therapeutics , (The penicillins), Chapter 45 - Antimicrobial Agents (continued) Penicillins, Cephalosporins, and Other beta-Lactam Antibiotics", 1 January 2001, GOODMAN AND GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, NEW YORK : MCGRAW-HILL, US, PAGE(S) 1189 - 1206, ISBN: 978-0-07-135469-1, XP002451319 * |
VILAR M ET AL: "Kinetic study of two novel enantiomeric tricyclic [beta]-lactams which efficiently inactivate class C [beta]-lactamases", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2001 UNITED STATES, vol. 45, no. 8, 2001, pages 2215 - 2223, XP008080169, ISSN: 0066-4804 * |
Also Published As
Publication number | Publication date |
---|---|
EP1958630A1 (en) | 2008-08-20 |
WO2008098955A2 (en) | 2008-08-21 |
JP2010518142A (en) | 2010-05-27 |
EP2124935B1 (en) | 2012-04-25 |
ATE554762T1 (en) | 2012-05-15 |
US20100029604A1 (en) | 2010-02-04 |
EP2124935A2 (en) | 2009-12-02 |
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