WO2008098955A3 - Antibacterial combination of a tricyclic carbapenem and an antibiotic - Google Patents

Antibacterial combination of a tricyclic carbapenem and an antibiotic Download PDF

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Publication number
WO2008098955A3
WO2008098955A3 PCT/EP2008/051724 EP2008051724W WO2008098955A3 WO 2008098955 A3 WO2008098955 A3 WO 2008098955A3 EP 2008051724 W EP2008051724 W EP 2008051724W WO 2008098955 A3 WO2008098955 A3 WO 2008098955A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibiotic
antibacterial combination
tricyclic
tricyclic carbapenem
carbapenem
Prior art date
Application number
PCT/EP2008/051724
Other languages
French (fr)
Other versions
WO2008098955A2 (en
Inventor
Andrej Prezelj
Uros Urleb
Tomaz Solmajer
Original Assignee
Lek Pharmaceuticals
Andrej Prezelj
Uros Urleb
Tomaz Solmajer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals, Andrej Prezelj, Uros Urleb, Tomaz Solmajer filed Critical Lek Pharmaceuticals
Priority to JP2009549406A priority Critical patent/JP2010518142A/en
Priority to AT08708944T priority patent/ATE554762T1/en
Priority to EP08708944A priority patent/EP2124935B1/en
Priority to US12/525,739 priority patent/US20100029604A1/en
Publication of WO2008098955A2 publication Critical patent/WO2008098955A2/en
Publication of WO2008098955A3 publication Critical patent/WO2008098955A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates toa pharmaceutical composition comprising an ethylene derivatives of tricyclic carbapenems of the general Formula (I) in the form of pure diastereoisomers and in the form of pure geometric isomersor a salt, ester or amide derivate thereof and an antibiotic and the use of this composition as a broad band spectrum β-lactamase inhibitior.
PCT/EP2008/051724 2007-02-13 2008-02-13 Antibacterial combination of a tricyclic carbapenem and an antibiotic WO2008098955A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009549406A JP2010518142A (en) 2007-02-13 2008-02-13 Antimicrobial combination of tricyclic carbapenem and antibiotics
AT08708944T ATE554762T1 (en) 2007-02-13 2008-02-13 ANTIBACTERIAL COMBINATION AND USE THEREOF
EP08708944A EP2124935B1 (en) 2007-02-13 2008-02-13 Antibacterial combination and its use
US12/525,739 US20100029604A1 (en) 2007-02-13 2008-02-13 Antibacterial combination and its use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07102241A EP1958630A1 (en) 2007-02-13 2007-02-13 Antibacterial combination of a tricyclic carbapenem and an antibiotic
EP07102241.2 2007-02-13

Publications (2)

Publication Number Publication Date
WO2008098955A2 WO2008098955A2 (en) 2008-08-21
WO2008098955A3 true WO2008098955A3 (en) 2008-10-02

Family

ID=38124122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/051724 WO2008098955A2 (en) 2007-02-13 2008-02-13 Antibacterial combination of a tricyclic carbapenem and an antibiotic

Country Status (5)

Country Link
US (1) US20100029604A1 (en)
EP (2) EP1958630A1 (en)
JP (1) JP2010518142A (en)
AT (1) ATE554762T1 (en)
WO (1) WO2008098955A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2936951B1 (en) * 2008-10-10 2010-12-03 Novexel NOVEL COMBINATIONS OF ANTIBACTERIAL NITROGENIC HETEROCYCLIC COMPOUNDS WITH OTHER ANTIBACTERIAL COMPOUNDS AND THEIR USE AS MEDICAMENTS
EP2714034B1 (en) * 2011-05-28 2018-07-25 Wockhardt Limited Compositions comprising cefepime and tazobactam
US20160175318A1 (en) * 2013-12-13 2016-06-23 Wockhardt Limited Compositions comprising antibacterial agent and tazobactam

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027094A1 (en) * 1996-12-18 1998-06-25 Lek Tovarna Farmacevtskih In Kemic^¿Nih Izdelkov, D.D. Ethylidene derivatives of tricyclic carbapenems

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027094A1 (en) * 1996-12-18 1998-06-25 Lek Tovarna Farmacevtskih In Kemic^¿Nih Izdelkov, D.D. Ethylidene derivatives of tricyclic carbapenems

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
COPAR, ANTON ET AL: "Design, synthesis and bioactivity evaluation of tribactam .beta. lactamase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 12(6), 971-975 CODEN: BMCLE8; ISSN: 0960-894X, 2002, XP002478137 *
GOODMAN G A ET AL: "GOODMAN and GILMAN'S The Pharmacological Basis of Therapeutics , (The cephalosporins)", 2001, GOODMAN AND GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, NEW YORK : MCGRAW-HILL, US, PAGE(S) 1206-1213, ISBN: 0-07-135469-7, XP002438160 *
PETRI W A ED - HARDMAN J G ET AL: "GOODMAN and GILMAN'S The Pharmacological Basis of Therapeutics , (Other beta-lactam antibiotics), Chapter 45 - Antimicrobial Agents: Penicillins, Cephalosporins, and Other beta-Lactam Antibiotics", 1 January 2001, GOODMAN AND GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, NEW YORK : MCGRAW-HILL, US, PAGE(S) 1206 - 1213, ISBN: 978-0-07-135469-1, XP002451320 *
PETRI W A ED - HARDMAN J G ET AL: "GOODMAN and GILMAN'S The Pharmacological Basis of Therapeutics , (The penicillins), Chapter 45 - Antimicrobial Agents (continued) Penicillins, Cephalosporins, and Other beta-Lactam Antibiotics", 1 January 2001, GOODMAN AND GILMAN'S THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, NEW YORK : MCGRAW-HILL, US, PAGE(S) 1189 - 1206, ISBN: 978-0-07-135469-1, XP002451319 *
VILAR M ET AL: "Kinetic study of two novel enantiomeric tricyclic [beta]-lactams which efficiently inactivate class C [beta]-lactamases", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2001 UNITED STATES, vol. 45, no. 8, 2001, pages 2215 - 2223, XP008080169, ISSN: 0066-4804 *

Also Published As

Publication number Publication date
EP1958630A1 (en) 2008-08-20
WO2008098955A2 (en) 2008-08-21
JP2010518142A (en) 2010-05-27
EP2124935B1 (en) 2012-04-25
ATE554762T1 (en) 2012-05-15
US20100029604A1 (en) 2010-02-04
EP2124935A2 (en) 2009-12-02

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