AR016440A1 - Analogos tetraciclicos de camptotecina sus procedimientos de preparacion, productos intermediarios utilizados en dichos procedimientos, preparacion dedichos productos intermedios, uso de dichos analogos tetraciclicos para la preparacion de medicamentos y medicamentos y composiciones farmaceuticas qu - Google Patents
Analogos tetraciclicos de camptotecina sus procedimientos de preparacion, productos intermediarios utilizados en dichos procedimientos, preparacion dedichos productos intermedios, uso de dichos analogos tetraciclicos para la preparacion de medicamentos y medicamentos y composiciones farmaceuticas quInfo
- Publication number
- AR016440A1 AR016440A1 ARP980106556A ARP980106556A AR016440A1 AR 016440 A1 AR016440 A1 AR 016440A1 AR P980106556 A ARP980106556 A AR P980106556A AR P980106556 A ARP980106556 A AR P980106556A AR 016440 A1 AR016440 A1 AR 016440A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- preparation
- alkoxyalkyl
- analogs
- tetraciclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
El objeto de la solicitud son análogos tetracíclicos de camptotecina, que responden a la formula (I) en forma racémica o enantiomérica o cualquiercombinacion de estas formas, donde R1 representa un radical alquilo inferior, alquenilo inferior,alquin ilo inferior, halogenoalquilo inferior, alcoxialquiloinferior o alquiltioalquilo inferior; R2, R3 y R4 independientemente, representan un radical H, hidroxi, alcoxi inferior, arilalcoxi, halogeno, halogénoalquiloinferior, alquilo inferior,alquenilo inferior, ciano, cianoalquilo inferior, nitro, nitroalquilo inferior, amido, amidalquilo inferior (CH2)mNR6R7, (CH2)mOR6,(CH2)mSR6, (CH2)mCO2R6, (CH2)mNR6C(O)R8, (CH2)mC(O)R8, (CH2)mOC(O)R8, O(CH2)mNR6R7, OC(O)NR6R7, OC(O)(CH2)mCO2R6,arilo o arilalq uilo inferior sustituido (esdecir sustituido de una a cuatro veces en el grupo arilo) o no sustituido, donde el sustituyente es un alquilo inferior, halogeno, nitro, amino, alquilaminoinferior, halogenoalquilo inferior,hidroxialquilo inferior, alcox i inferior o alcoxialquilo inferior o R2 y R3 o R3 y R4 o R4 y R5, independientemente, formanjuntos una cadena de 3 o 4 eslabones, donde los elementos de la cadena están seleccionados del grupo constituido por CH, CH2,O, S, N o NR9; R5 representa un radical H, halogeno, halogenoalquilo inferior, alquilo inferior, alcoxi inferior, alcoxialquilo inferior, alquiltioalquilo inferior, cicloalquilo,cicloalquilalquilo inferior, ciano, ciano alquilo,alcanosulfonilalquilo inferior, hidroxialquilo inferi or, nitro (CH2)mC(O)R8, (CH2)mNR6C(O)R8, (CH2)mNR6R7,(CH2)mN(CH3)(CH2)nNR6R7, (CH2)mOC(O)R8, (CH2)NOC(O)NR6R7, arilo o arilalquilo inferior sustituido (es decir, de una a cuatro veces en el grupoarilo) o nosustituido, donde el sustituyente es un alq uilo inferior, halogeno, nitro, amino, alquilamino inferior, halogenoalquilo inferior, hidroxialquilo inferior,alcoxi inferior o alqoxialquilo inferior; R6 y R7 independientemetnte, representanH, un radical alquilo inferior, hidroxialquilo inferior, alquilaminoalquiloinferior, aminoalquilo inferior, cicloalquilo, cicloalquialquilo inferior, alquenilo inferior, alcoxialquilo inferior, halogenoalquilo inferior, o arilo o
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9716461A FR2772763B1 (fr) | 1997-12-24 | 1997-12-24 | Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR016440A1 true AR016440A1 (es) | 2001-07-04 |
Family
ID=9515095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106556A AR016440A1 (es) | 1997-12-24 | 1998-12-21 | Analogos tetraciclicos de camptotecina sus procedimientos de preparacion, productos intermediarios utilizados en dichos procedimientos, preparacion dedichos productos intermedios, uso de dichos analogos tetraciclicos para la preparacion de medicamentos y medicamentos y composiciones farmaceuticas qu |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6436951B1 (es) |
| EP (1) | EP1042323B1 (es) |
| JP (1) | JP2001527075A (es) |
| AR (1) | AR016440A1 (es) |
| AT (1) | ATE215951T1 (es) |
| AU (1) | AU749224B2 (es) |
| CA (1) | CA2315897C (es) |
| DE (1) | DE69804856T2 (es) |
| DK (1) | DK1042323T3 (es) |
| ES (1) | ES2175834T3 (es) |
| FR (1) | FR2772763B1 (es) |
| HU (1) | HUP0004628A3 (es) |
| IL (1) | IL136732A0 (es) |
| MY (1) | MY117585A (es) |
| NO (1) | NO316676B1 (es) |
| NZ (1) | NZ505339A (es) |
| PL (1) | PL193468B1 (es) |
| PT (1) | PT1042323E (es) |
| RU (1) | RU2220144C2 (es) |
| TW (1) | TW513429B (es) |
| WO (1) | WO1999033829A1 (es) |
| ZA (1) | ZA9811796B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003225642A1 (en) * | 2002-03-01 | 2003-09-16 | Fluorous Techonologies Inc | Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs |
| UA80552C2 (en) * | 2002-03-26 | 2007-10-10 | Combined drug of the antitumoral derivative indolopyrrolocarbazole and other antitumoral agent and its application at cancer treatment | |
| GB2436226A (en) * | 2004-12-08 | 2007-09-19 | Fuji Electric Holdings Co | Organic EL element |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| JP5126707B2 (ja) * | 2007-04-23 | 2013-01-23 | 有機合成薬品工業株式会社 | α−ヒドロキシアシルピリジンの製造方法 |
| JP5133416B2 (ja) | 2007-09-14 | 2013-01-30 | オルソー−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド． | １’，３’−二置換−４−フェニル−３，４，５，６−テトラヒドロ−２ｈ，１’ｈ−［１，４’］ビピリジニル−２’−オン |
| US8691849B2 (en) | 2008-09-02 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
| ES2409006T3 (es) | 2009-05-12 | 2013-06-24 | Janssen Pharmaceuticals Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2 |
| MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| AU2014216178B2 (en) | 2013-02-15 | 2018-06-28 | KALA BIO, Inc. | Therapeutic compounds and uses thereof |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| EP3763710A1 (en) | 2013-02-20 | 2021-01-13 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| NZ719185A (en) | 2013-11-01 | 2017-11-24 | Kala Pharmaceuticals Inc | Crystalline forms of therapeutic compounds and uses thereof |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CN103588660B (zh) * | 2013-11-18 | 2016-06-01 | 中国医学科学院生物医学工程研究所 | 一种新型的酰基苯胺化合物及用途 |
| CA2931189C (en) | 2013-12-13 | 2017-09-26 | F. Hoffmann-La Roche Ag | Inhibitors of bruton's tyrosine kinase |
| ES2860298T3 (es) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso |
| BR112016016390B1 (pt) | 2014-01-21 | 2023-04-11 | Janssen Pharmaceutica Nv | Produto compreendendo modulador alostérico positivo do receptor glutamatérgico metabotrópico do subtipo 2 e ligante da proteína de vesícula sináptica 2a |
| CA3036340A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3036065A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| EP3509422A4 (en) | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1251125T3 (da) * | 1995-06-21 | 2006-04-18 | Sod Conseils Rech Applic | Hidtil ukendte camptothecin-analoger, fremgangsmåde til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse |
| GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
-
1997
- 1997-12-24 FR FR9716461A patent/FR2772763B1/fr not_active Expired - Fee Related
-
1998
- 1998-12-14 TW TW087120746A patent/TW513429B/zh not_active IP Right Cessation
- 1998-12-15 MY MYPI98005659A patent/MY117585A/en unknown
- 1998-12-16 HU HU0004628A patent/HUP0004628A3/hu unknown
- 1998-12-16 PT PT98962480T patent/PT1042323E/pt unknown
- 1998-12-16 EP EP98962480A patent/EP1042323B1/fr not_active Expired - Lifetime
- 1998-12-16 JP JP2000526510A patent/JP2001527075A/ja not_active Ceased
- 1998-12-16 PL PL98341288A patent/PL193468B1/pl not_active IP Right Cessation
- 1998-12-16 RU RU2000119731/04A patent/RU2220144C2/ru not_active IP Right Cessation
- 1998-12-16 ES ES98962480T patent/ES2175834T3/es not_active Expired - Lifetime
- 1998-12-16 DE DE69804856T patent/DE69804856T2/de not_active Expired - Lifetime
- 1998-12-16 WO PCT/FR1998/002751 patent/WO1999033829A1/fr active IP Right Grant
- 1998-12-16 DK DK98962480T patent/DK1042323T3/da active
- 1998-12-16 CA CA002315897A patent/CA2315897C/fr not_active Expired - Fee Related
- 1998-12-16 NZ NZ505339A patent/NZ505339A/xx active IP Right Revival
- 1998-12-16 AU AU17645/99A patent/AU749224B2/en not_active Ceased
- 1998-12-16 US US09/582,068 patent/US6436951B1/en not_active Expired - Fee Related
- 1998-12-16 IL IL13673298A patent/IL136732A0/xx not_active IP Right Cessation
- 1998-12-16 AT AT98962480T patent/ATE215951T1/de not_active IP Right Cessation
- 1998-12-21 AR ARP980106556A patent/AR016440A1/es unknown
- 1998-12-22 ZA ZA9811796A patent/ZA9811796B/xx unknown
-
2000
- 2000-06-23 NO NO20003314A patent/NO316676B1/no not_active IP Right Cessation
- 2000-12-12 US US09/734,167 patent/US6632946B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2220144C2 (ru) | 2003-12-27 |
| NO20003314L (no) | 2000-06-30 |
| MY117585A (en) | 2004-07-31 |
| US6632946B2 (en) | 2003-10-14 |
| NO316676B1 (no) | 2004-03-29 |
| DE69804856D1 (de) | 2002-05-16 |
| AU1764599A (en) | 1999-07-19 |
| HUP0004628A3 (en) | 2001-11-28 |
| NO20003314D0 (no) | 2000-06-23 |
| ATE215951T1 (de) | 2002-04-15 |
| IL136732A0 (en) | 2001-06-14 |
| FR2772763A1 (fr) | 1999-06-25 |
| ES2175834T3 (es) | 2002-11-16 |
| FR2772763B1 (fr) | 2004-01-23 |
| HUP0004628A1 (hu) | 2001-05-28 |
| PL341288A1 (en) | 2001-04-09 |
| PT1042323E (pt) | 2002-09-30 |
| ZA9811796B (en) | 1999-06-29 |
| AU749224B2 (en) | 2002-06-20 |
| US20010000521A1 (en) | 2001-04-26 |
| DK1042323T3 (da) | 2002-08-05 |
| DE69804856T2 (de) | 2002-11-07 |
| NZ505339A (en) | 2003-01-31 |
| EP1042323B1 (fr) | 2002-04-10 |
| CA2315897C (fr) | 2010-01-19 |
| CA2315897A1 (fr) | 1999-07-08 |
| PL193468B1 (pl) | 2007-02-28 |
| JP2001527075A (ja) | 2001-12-25 |
| US6436951B1 (en) | 2002-08-20 |
| WO1999033829A1 (fr) | 1999-07-08 |
| EP1042323A1 (fr) | 2000-10-11 |
| TW513429B (en) | 2002-12-11 |
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