ES2175834T3 - Nuevos analogos tretaciclicos de camptotecinam, sus procedimientos de preparacion, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. - Google Patents
Nuevos analogos tretaciclicos de camptotecinam, sus procedimientos de preparacion, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2175834T3 ES2175834T3 ES98962480T ES98962480T ES2175834T3 ES 2175834 T3 ES2175834 T3 ES 2175834T3 ES 98962480 T ES98962480 T ES 98962480T ES 98962480 T ES98962480 T ES 98962480T ES 2175834 T3 ES2175834 T3 ES 2175834T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- haloalkyl
- radical
- hydroxyalkyl
- naphthyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto, caracterizado porque dicho compuesto es de fórmula (I), **fórmula** en la forma racémica, enantiómera o cualquier combinación de estas formas, en la cual R1 representa un radical alquilo, alquenilo, alquinilo, haloalquilo, alcoxialquilo o alquiltioalquilo; R2, R3 y R4 representan independientemente un radical H, hidroxi, alcoxi, arilalcoxi, halo, haloalquilo, alquilo, alquenilo, ciano, cianoalquilo, nitro, nitroalquilo, amido, amidoalquilo, (CH2)mNR6R7, (CH2)mOR6, (CH2)mSR6, (CH2)mCO2R6, (CH2)mNR6C(O)R8, (CH2)mC(O)R8, (CH2)mOC(O)R8, O(CH2)mNR6R7, OC(O)NR6R7, OC(O)(CH2)mCO2R6, o uno de los radicales fenilo, naftilo, antracilo, bifenilo, indenilo, fenilalquilo, naftilalquilo, antracilalquilo, bifenilalquilo o indenilaquilo eventualmente sustituidos de una a cuatro veces en el núcleo de fenilo, naftilo, antracilo, bifenilo o indenilo con uno o unos radicales escogidos entre un radical alquilo, halo, nitro, amino, alquilamino, haloalquilo, hidroxialquilo, alcoxi o alcoxialquilo, oR2 y R3, oR3 y R4, oR4 y R5, forman independientemente de forma conjunta una cadena de 3 ó 4 eslabones, en la que los elementos de la cadena se seleccionan entre el grupo constituido por CH, CH2, O,S, NoNR9; R5 representa un radical H, halo, haloalquilo, alquilo, alcoxi, alcoxialquilo, alquiltioalquilo, cicloalquilo, cicloalquilalquilo, ciano, cianoalquilo, alcanosulfonilalquilo, hidroxialquilo, nitro, (CH2)mC(O)R8, (CH2)mNR6C(O)R8, (CH2)mNR6R7, (CH2)mN(CH3)(CH2)nNR6R7, (CH2)mOC(O)R8, (CH2)mOC(O)NR6R7 o uno de los radicales fenilo, naftilo, antracilo, bifenilo, indenilo, fenilalquilo, naftilalquilo, antracilalquilo, bifenilalquilo o indenilaquilo eventualmente sustituidos de una a cuatro veces en el núcleo de fenilo, naftilo, antracilo, bifenilo o indenilo con uno o unos radicales escogidos entre un radical alquilo, halo, nitro, amino, alquilamino, haloalquilo, hidroxialquilo, alcoxi o alcoxialquilo; R6 y R7 representan, independientemente, H, un radical alquilo, hidroxialquilo, alquilaminoalquilo, aminoalquilo, cicloalquilo, cicloalquilalquilo, alquenilo, alcoxialquilo, haloalquilo, uno de los radicales fenilo, naftilo, antracilo, bifenilo, indenilo, fenilalquilo, naftilalquilo, antracilalquilo, bifenilalquilo o indenilaquilo eventualmente sustituidos de una a cuatro veces en el núcleo de fenilo, naftilo, antracilo, bifenilo o indenilo con uno o unos radicales escogidos entre un radical alquilo, halo, nitro, amino, alquilamino, haloalquilo, hidroxialquilo, alcoxi o alcoxialquilo, o bien, cuando las cadenas R6 y R7 están unidas a un mismo átomo de nitrógeno, R6 y R7 forman eventualmente de forma conjunta un grupo morfolino, piperazino o piperidino, estando eventualmente sustituido dicho grupo con uno o varios grupos escogidos entre radicales alquilo, fenilo, naftilo, antracilo, bifenilo, indenilo, fenilalquilo, naftilalquilo, antracilalquilo, bifenilalquilo o indenilaquilo, halo, nitro, amino, alquilamino, haloalquilo, hidroxialquilo, alcoxi o alcoxialquilo; R8 representa unradical H, alquilo, hidroxialquilo, amino, alquilamino, alquilaminoalquilo, aminoalquilo, cicloalquilo, cicloalquilalquilo, alquenilo, alcoxi, alcoxialquilo, haloalquilo o uno de los radicales fenilo, naftilo, antracilo, bifenilo, indenilo, fenilalquilo, naftilalquilo, antracilalquilo, bifenilalquilo o indenilaquilo eventualmente sustituidos de una a cuatro veces en el núcleo de fenilo, naftilo, antracilo, bifenilo o indenilo con uno o unos radicales escogidos entre un radical alquilo, halo, nitro, amino, alquilamino, haloalquilo, hidroxialquilo, alcoxi o alcoxialquilo; R9 representa un radical H, alquilo, haloalquilo, o uno de los radicales fenilo, naftilo, antracilo, bifenilo, indenilo, fenilalquilo, naftilalquilo, antracilalquilo, bifenilalquilo o indenilaquilo eventualmente sustituidos con uno de los grupos escogidos entre el radical alquilo, halo, nitro, amino, alquilamino, haloalquilo, hidroxialquilo, alcoxi o alcoxialquilo; R10 representa un radical ciano, C(O)OR11, 1H-1,2,3,4-tetrazo-5-ilo o 1-alquil-1,2,3,4-tetrazo-5-ilo; R11 representa un radical H, alquilo, haloalquilo, hidroxialquilo, alquilcarboniloxialquilo, (CH2)P NR6R7, o uno de los radicales fenilo, naftilo, antracilo, bifenilo, indenilo, fenilalquilo, naftilalquilo, antracilalquilo, bifenilalquilo o indenilaquilo eventualmente sustituidos en el ciclo aromático con uno o varios grupos escogidos entre el radical alquilo, halo, nitro, amino, alquilamino, haloalquilo, hidroxialquilo, alcoxi o alcoxialquilo; m es un número entero comprendido entre 0 y 6; n es un número entero comprendido entre 1 y 4; p es un número entero comprendido entre 2 y 6; debiendo entenderse que: cada uno de los grupos alquilo que entran en las definiciones de los radicales anteriores es lineal o ramicado y comprende de 1 a 6 átomos de carbono; cada uno de los grupos alquenilo o alquinilo que entran en las definiciones de los radicales anteriores es lineal o ramificado y comprende de 2 a 6 átomos de carbono; y cada uno de los grupos cicloalquilo que entran en las definiciones de los radicales anteriores comprende de 3 a 7 átomos de carbono; o una sal farmacéuticamente aceptable de este último.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9716461A FR2772763B1 (fr) | 1997-12-24 | 1997-12-24 | Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175834T3 true ES2175834T3 (es) | 2002-11-16 |
Family
ID=9515095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98962480T Expired - Lifetime ES2175834T3 (es) | 1997-12-24 | 1998-12-16 | Nuevos analogos tretaciclicos de camptotecinam, sus procedimientos de preparacion, su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. |
Country Status (22)
Country | Link |
---|---|
US (2) | US6436951B1 (es) |
EP (1) | EP1042323B1 (es) |
JP (1) | JP2001527075A (es) |
AR (1) | AR016440A1 (es) |
AT (1) | ATE215951T1 (es) |
AU (1) | AU749224B2 (es) |
CA (1) | CA2315897C (es) |
DE (1) | DE69804856T2 (es) |
DK (1) | DK1042323T3 (es) |
ES (1) | ES2175834T3 (es) |
FR (1) | FR2772763B1 (es) |
HU (1) | HUP0004628A3 (es) |
IL (1) | IL136732A0 (es) |
MY (1) | MY117585A (es) |
NO (1) | NO316676B1 (es) |
NZ (1) | NZ505339A (es) |
PL (1) | PL193468B1 (es) |
PT (1) | PT1042323E (es) |
RU (1) | RU2220144C2 (es) |
TW (1) | TW513429B (es) |
WO (1) | WO1999033829A1 (es) |
ZA (1) | ZA9811796B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003074524A2 (en) * | 2002-03-01 | 2003-09-12 | University Of Pittsburgh | Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs |
RS84904A (en) * | 2002-03-26 | 2006-12-15 | Bany Pharmaceutical Co.Ltd. | Combined use of antitumor indolopyrrolocarbazole derivative and other antitumor agent |
US20080003455A1 (en) * | 2004-12-08 | 2008-01-03 | Fuji Electric Holdings Co., Ltd. | Organic El Device |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
JP5126707B2 (ja) * | 2007-04-23 | 2013-01-23 | 有機合成薬品工業株式会社 | α−ヒドロキシアシルピリジンの製造方法 |
PT2203439E (pt) | 2007-09-14 | 2011-02-11 | Ortho Mcneil Janssen Pharm | 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'- onas 1',3'-dissubstituídas |
BRPI0918055A2 (pt) | 2008-09-02 | 2015-12-01 | Addex Pharmaceuticals Sa | derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato. |
JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
CN102439015B (zh) | 2009-05-12 | 2015-05-13 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途 |
NZ596078A (en) | 2009-05-12 | 2013-06-28 | Janssen Pharmaceuticals Inc | 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
CA2814998C (en) | 2010-11-08 | 2019-10-29 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
US8993591B2 (en) | 2010-11-08 | 2015-03-31 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
JP2016510000A (ja) | 2013-02-20 | 2016-04-04 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物およびその使用 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
CA2928658A1 (en) | 2013-11-01 | 2015-05-07 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
CN103588660B (zh) * | 2013-11-18 | 2016-06-01 | 中国医学科学院生物医学工程研究所 | 一种新型的酰基苯胺化合物及用途 |
JP6219523B2 (ja) | 2013-12-13 | 2017-10-25 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトンチロシンキナーゼの阻害剤 |
SI3096790T1 (sl) | 2014-01-21 | 2019-11-29 | Janssen Pharmaceutica Nv | Kombinacije, ki vsebujejo pozitivne aleostrične modulatorje ali ortosterične agoniste metabotropnega glutamatergičnega receptorja podtipa 2 in njihova uporaba |
ME03518B (me) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena |
AU2017324251A1 (en) | 2016-09-08 | 2019-03-21 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US10392399B2 (en) | 2016-09-08 | 2019-08-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1251125T3 (da) * | 1995-06-21 | 2006-04-18 | Sod Conseils Rech Applic | Hidtil ukendte camptothecin-analoger, fremgangsmåde til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
-
1997
- 1997-12-24 FR FR9716461A patent/FR2772763B1/fr not_active Expired - Fee Related
-
1998
- 1998-12-14 TW TW087120746A patent/TW513429B/zh not_active IP Right Cessation
- 1998-12-15 MY MYPI98005659A patent/MY117585A/en unknown
- 1998-12-16 DK DK98962480T patent/DK1042323T3/da active
- 1998-12-16 WO PCT/FR1998/002751 patent/WO1999033829A1/fr active IP Right Grant
- 1998-12-16 HU HU0004628A patent/HUP0004628A3/hu unknown
- 1998-12-16 PT PT98962480T patent/PT1042323E/pt unknown
- 1998-12-16 PL PL98341288A patent/PL193468B1/pl not_active IP Right Cessation
- 1998-12-16 RU RU2000119731/04A patent/RU2220144C2/ru not_active IP Right Cessation
- 1998-12-16 JP JP2000526510A patent/JP2001527075A/ja not_active Ceased
- 1998-12-16 ES ES98962480T patent/ES2175834T3/es not_active Expired - Lifetime
- 1998-12-16 CA CA002315897A patent/CA2315897C/fr not_active Expired - Fee Related
- 1998-12-16 IL IL13673298A patent/IL136732A0/xx not_active IP Right Cessation
- 1998-12-16 EP EP98962480A patent/EP1042323B1/fr not_active Expired - Lifetime
- 1998-12-16 NZ NZ505339A patent/NZ505339A/xx active IP Right Revival
- 1998-12-16 DE DE69804856T patent/DE69804856T2/de not_active Expired - Lifetime
- 1998-12-16 AU AU17645/99A patent/AU749224B2/en not_active Ceased
- 1998-12-16 US US09/582,068 patent/US6436951B1/en not_active Expired - Fee Related
- 1998-12-16 AT AT98962480T patent/ATE215951T1/de not_active IP Right Cessation
- 1998-12-21 AR ARP980106556A patent/AR016440A1/es unknown
- 1998-12-22 ZA ZA9811796A patent/ZA9811796B/xx unknown
-
2000
- 2000-06-23 NO NO20003314A patent/NO316676B1/no not_active IP Right Cessation
- 2000-12-12 US US09/734,167 patent/US6632946B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT1042323E (pt) | 2002-09-30 |
NZ505339A (en) | 2003-01-31 |
HUP0004628A3 (en) | 2001-11-28 |
AU749224B2 (en) | 2002-06-20 |
EP1042323A1 (fr) | 2000-10-11 |
ATE215951T1 (de) | 2002-04-15 |
AR016440A1 (es) | 2001-07-04 |
DK1042323T3 (da) | 2002-08-05 |
FR2772763B1 (fr) | 2004-01-23 |
US6632946B2 (en) | 2003-10-14 |
NO316676B1 (no) | 2004-03-29 |
CA2315897C (fr) | 2010-01-19 |
ZA9811796B (en) | 1999-06-29 |
WO1999033829A1 (fr) | 1999-07-08 |
JP2001527075A (ja) | 2001-12-25 |
TW513429B (en) | 2002-12-11 |
NO20003314L (no) | 2000-06-30 |
PL341288A1 (en) | 2001-04-09 |
US6436951B1 (en) | 2002-08-20 |
IL136732A0 (en) | 2001-06-14 |
DE69804856D1 (de) | 2002-05-16 |
AU1764599A (en) | 1999-07-19 |
NO20003314D0 (no) | 2000-06-23 |
EP1042323B1 (fr) | 2002-04-10 |
CA2315897A1 (fr) | 1999-07-08 |
FR2772763A1 (fr) | 1999-06-25 |
US20010000521A1 (en) | 2001-04-26 |
RU2220144C2 (ru) | 2003-12-27 |
DE69804856T2 (de) | 2002-11-07 |
HUP0004628A1 (hu) | 2001-05-28 |
MY117585A (en) | 2004-07-31 |
PL193468B1 (pl) | 2007-02-28 |
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