AP903A - Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties. - Google Patents
Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties. Download PDFInfo
- Publication number
- AP903A AP903A APAP/P/1998/001426A AP9801426A AP903A AP 903 A AP903 A AP 903A AP 9801426 A AP9801426 A AP 9801426A AP 903 A AP903 A AP 903A
- Authority
- AP
- ARIPO
- Prior art keywords
- purin
- ylamino
- diol
- pyrrolidin
- hydroxymethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2136696P | 1996-07-08 | 1996-07-08 | |
PCT/US1997/011320 WO1998001426A1 (en) | 1996-07-08 | 1997-07-01 | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
Publications (2)
Publication Number | Publication Date |
---|---|
AP9801426A0 AP9801426A0 (en) | 1998-12-31 |
AP903A true AP903A (en) | 2000-11-24 |
Family
ID=21803790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
APAP/P/1998/001426A AP903A (en) | 1996-07-08 | 1997-07-01 | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties. |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0912520B1 (de) |
JP (1) | JP4202421B2 (de) |
KR (1) | KR20000023635A (de) |
CN (1) | CN1228770A (de) |
AP (1) | AP903A (de) |
AT (1) | ATE239725T1 (de) |
AU (1) | AU746590B2 (de) |
BG (1) | BG103135A (de) |
BR (1) | BR9710156A (de) |
CA (1) | CA2259538C (de) |
CZ (1) | CZ291785B6 (de) |
DE (1) | DE69721776T2 (de) |
EA (1) | EA001801B1 (de) |
ES (1) | ES2199365T3 (de) |
HU (1) | HUP9903815A3 (de) |
IL (1) | IL127890A0 (de) |
NO (1) | NO313671B1 (de) |
OA (1) | OA10953A (de) |
PL (1) | PL331036A1 (de) |
SK (1) | SK2299A3 (de) |
UA (1) | UA51716C2 (de) |
WO (1) | WO1998001426A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376472B1 (en) * | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
GB9723590D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
GB9813554D0 (en) | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
HUP0103025A3 (en) | 1998-06-23 | 2002-04-29 | Glaxo Group Ltd | A2a agonist 2-(purin-9-yl)tetrahydrofuran-3,4-diol derivatives, medicaments containing the same, process for producing them and the useful intermediates |
JP3598332B2 (ja) * | 1998-11-25 | 2004-12-08 | 株式会社第一ラジオアイソトープ研究所 | N−アシルオキシ環状アルキル化合物を有効成分とする医薬品および試薬 |
BR9917000A (pt) * | 1998-12-31 | 2001-12-11 | Aventis Pharm Prod Inc | Processo para preparar derivados dedesaza-adenosina n6-substituìda |
GB0106867D0 (en) | 2001-03-20 | 2001-05-09 | Glaxo Group Ltd | Process |
JP2005507371A (ja) * | 2001-05-10 | 2005-03-17 | アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | アデノシン化合物およびその中間体の新規な製造方法 |
EP1258247A1 (de) * | 2001-05-14 | 2002-11-20 | Aventis Pharma Deutschland GmbH | Adenosin-Analoga für die Behandlung Von Insulinresistenz und Diabetes |
FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
HUP0200849A2 (hu) * | 2002-03-06 | 2004-08-30 | Sanofi-Synthelabo | N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra |
EP1375508A1 (de) * | 2002-06-27 | 2004-01-02 | Aventis Pharma Deutschland GmbH | N6-Substituierte Adenosin Derivate und ihre Verwendung als pharmazeutische Mittel |
US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
FR2862969A1 (fr) | 2003-11-28 | 2005-06-03 | Oreal | Procede de preparation de derives paraphenylenediamine a groupement pyrrolidinyle, substitue par un radical azote, et composes intermediaires |
EP1574508A1 (de) | 2004-01-30 | 2005-09-14 | Lonza AG | Verfahren zur Herstellung von Acetalen und Ketalen von 3-Amino-5-(hydroxymethyl)-cyclopentan-1,2-diolen, sowie deren Derivaten und Salzen |
AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
JP2006022045A (ja) * | 2004-07-08 | 2006-01-26 | Kaneka Corp | 光学活性1−t−ブトキシカルボニル−3−アミノピロリジン塩の単離精製方法 |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
US7671062B2 (en) | 2006-07-28 | 2010-03-02 | Bristol-Myers Squibb Company | Modulators of chemokine receptor activity, crystalline forms and process |
US7687508B2 (en) | 2006-07-28 | 2010-03-30 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US7629351B2 (en) | 2006-07-28 | 2009-12-08 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino) pyrrolidin-1-yl)cyclohexyl)acetamide and other modulators of chemokine receptor activity, crystalline forms and process |
DE102007002260A1 (de) | 2007-01-16 | 2008-07-31 | Sanofi-Aventis | Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms |
US8383812B2 (en) | 2009-10-13 | 2013-02-26 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes |
RU2737157C2 (ru) * | 2016-01-14 | 2020-11-25 | Хандок Инк. | Соединения, являющиеся антагонистами а3-аденозинового рецептора, способ их получения и их медицинское применение |
CN110627765B (zh) * | 2019-10-14 | 2021-08-20 | 浙江乐普药业股份有限公司 | 一种替卡格雷关键中间体的制备方法 |
CN112047919B (zh) * | 2020-09-16 | 2021-06-18 | 常州制药厂有限公司 | 一种替卡格雷中间体及其制备方法 |
KR102308854B1 (ko) * | 2021-02-26 | 2021-10-05 | 퓨쳐메디신 주식회사 | 카보사이클릭 뉴클레오사이드 유도체를 포함하는 코로나바이러스감염증-19 예방 및 치료용 약학적 조성물 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0550631B1 (de) * | 1990-09-25 | 1997-01-02 | Rhone-Poulenc Rorer International (Holdings) Inc. | Verbindungen welche antihypertensive und antiischemische eigenschaften besitzen |
US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
WO1995018817A1 (fr) * | 1994-01-07 | 1995-07-13 | Laboratoires Upsa | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant |
US5554746A (en) * | 1994-05-16 | 1996-09-10 | Isis Pharmaceuticals, Inc. | Lactam nucleic acids |
-
1997
- 1997-01-07 UA UA99020643A patent/UA51716C2/uk unknown
- 1997-07-01 SK SK22-99A patent/SK2299A3/sk unknown
- 1997-07-01 AU AU36454/97A patent/AU746590B2/en not_active Ceased
- 1997-07-01 WO PCT/US1997/011320 patent/WO1998001426A1/en not_active Application Discontinuation
- 1997-07-01 PL PL97331036A patent/PL331036A1/xx unknown
- 1997-07-01 DE DE69721776T patent/DE69721776T2/de not_active Expired - Lifetime
- 1997-07-01 EP EP97933212A patent/EP0912520B1/de not_active Expired - Lifetime
- 1997-07-01 EA EA199900092A patent/EA001801B1/ru not_active IP Right Cessation
- 1997-07-01 BR BR9710156A patent/BR9710156A/pt not_active IP Right Cessation
- 1997-07-01 HU HU9903815A patent/HUP9903815A3/hu unknown
- 1997-07-01 CZ CZ199924A patent/CZ291785B6/cs not_active IP Right Cessation
- 1997-07-01 ES ES97933212T patent/ES2199365T3/es not_active Expired - Lifetime
- 1997-07-01 JP JP50524798A patent/JP4202421B2/ja not_active Expired - Fee Related
- 1997-07-01 IL IL12789097A patent/IL127890A0/xx unknown
- 1997-07-01 AP APAP/P/1998/001426A patent/AP903A/en active
- 1997-07-01 AT AT97933212T patent/ATE239725T1/de not_active IP Right Cessation
- 1997-07-01 CN CN97197444A patent/CN1228770A/zh active Pending
- 1997-07-01 CA CA002259538A patent/CA2259538C/en not_active Expired - Fee Related
-
1999
- 1999-01-06 OA OA9900003A patent/OA10953A/en unknown
- 1999-01-07 NO NO19990063A patent/NO313671B1/no not_active IP Right Cessation
- 1999-01-08 KR KR1019997000085A patent/KR20000023635A/ko not_active Application Discontinuation
- 1999-02-01 BG BG103135A patent/BG103135A/bg unknown
Non-Patent Citations (1)
Title |
---|
J. HETEROCYCLIC CHEM, V. 27, PP 1527-1536 * |
Also Published As
Publication number | Publication date |
---|---|
AP9801426A0 (en) | 1998-12-31 |
SK2299A3 (en) | 2000-10-09 |
NO313671B1 (no) | 2002-11-11 |
CA2259538A1 (en) | 1998-01-15 |
KR20000023635A (ko) | 2000-04-25 |
IL127890A0 (en) | 1999-10-28 |
ATE239725T1 (de) | 2003-05-15 |
CN1228770A (zh) | 1999-09-15 |
ES2199365T3 (es) | 2004-02-16 |
OA10953A (en) | 2001-10-26 |
AU3645497A (en) | 1998-02-02 |
EA199900092A1 (ru) | 1999-08-26 |
JP4202421B2 (ja) | 2008-12-24 |
NO990063D0 (no) | 1999-01-07 |
DE69721776D1 (de) | 2003-06-12 |
EP0912520A4 (de) | 1999-10-06 |
PL331036A1 (en) | 1999-06-21 |
CZ2499A3 (cs) | 1999-05-12 |
CA2259538C (en) | 2006-12-19 |
AU746590B2 (en) | 2002-05-02 |
NO990063L (no) | 1999-03-08 |
WO1998001426A1 (en) | 1998-01-15 |
BG103135A (bg) | 1999-11-30 |
HUP9903815A1 (hu) | 2001-04-28 |
BR9710156A (pt) | 1999-08-10 |
JP2000514801A (ja) | 2000-11-07 |
EP0912520A1 (de) | 1999-05-06 |
EP0912520B1 (de) | 2003-05-07 |
EA001801B1 (ru) | 2001-08-27 |
UA51716C2 (uk) | 2002-12-16 |
HUP9903815A3 (en) | 2002-04-29 |
DE69721776T2 (de) | 2004-03-25 |
CZ291785B6 (cs) | 2003-05-14 |
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