AP877A - Tetrahydroquinoline derivatives as EAA antagonists. - Google Patents
Tetrahydroquinoline derivatives as EAA antagonists. Download PDFInfo
- Publication number
- AP877A AP877A APAP/P/1999/001459A AP9901459A AP877A AP 877 A AP877 A AP 877A AP 9901459 A AP9901459 A AP 9901459A AP 877 A AP877 A AP 877A
- Authority
- AP
- ARIPO
- Prior art keywords
- group
- formula
- compound
- carboxylic acid
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9617305.9A GB9617305D0 (en) | 1996-08-17 | 1996-08-17 | Heterocyclic compounds |
PCT/EP1997/004440 WO1998007704A1 (en) | 1996-08-17 | 1997-08-14 | Tetrahydroquinoline derivatives as eaa antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
AP9901459A0 AP9901459A0 (en) | 1999-03-31 |
AP877A true AP877A (en) | 2000-09-27 |
Family
ID=10798623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
APAP/P/1999/001459A AP877A (en) | 1996-08-17 | 1997-08-14 | Tetrahydroquinoline derivatives as EAA antagonists. |
Country Status (34)
Country | Link |
---|---|
US (1) | US6479488B1 (sh) |
EP (1) | EP0922034B1 (sh) |
JP (1) | JP4108129B2 (sh) |
KR (1) | KR100552864B1 (sh) |
CN (1) | CN1131214C (sh) |
AP (1) | AP877A (sh) |
AR (1) | AR008296A1 (sh) |
AT (1) | ATE221052T1 (sh) |
AU (1) | AU724473B2 (sh) |
BR (1) | BR9711311B1 (sh) |
CA (1) | CA2264118C (sh) |
CO (1) | CO4900066A1 (sh) |
CZ (1) | CZ296250B6 (sh) |
DE (1) | DE69714265T2 (sh) |
DK (1) | DK0922034T3 (sh) |
EA (1) | EA001704B1 (sh) |
ES (1) | ES2181030T3 (sh) |
GB (1) | GB9617305D0 (sh) |
HU (1) | HU225797B1 (sh) |
ID (1) | ID18095A (sh) |
IL (1) | IL128141A0 (sh) |
IS (1) | IS4953A (sh) |
MY (1) | MY116952A (sh) |
NO (1) | NO312241B1 (sh) |
NZ (1) | NZ333812A (sh) |
PE (1) | PE107098A1 (sh) |
PL (1) | PL194532B1 (sh) |
PT (1) | PT922034E (sh) |
SI (1) | SI0922034T1 (sh) |
TR (1) | TR199900336T2 (sh) |
TW (1) | TW449582B (sh) |
WO (1) | WO1998007704A1 (sh) |
YU (1) | YU6799A (sh) |
ZA (1) | ZA977326B (sh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9706294D0 (en) * | 1997-03-26 | 1997-05-14 | Glaxo Wellcome Spa | Heterocyclic compound |
MY125037A (en) * | 1998-06-10 | 2006-07-31 | Glaxo Wellcome Spa | 1,2,3,4 tetrahydroquinoline derivatives |
US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
GB9929037D0 (en) * | 1999-12-08 | 2000-02-02 | Glaxo Wellcome Spa | Heterocyclic derivatives |
DE10132725A1 (de) | 2001-07-05 | 2006-08-03 | Grünenthal GmbH | Substituierte γ-Lactonverbindungen |
CN100402032C (zh) * | 2001-12-28 | 2008-07-16 | 阿卡蒂亚药品公司 | 用作毒蕈碱激动剂的四氢喹啉类似物 |
US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
WO2004064753A2 (en) * | 2003-01-23 | 2004-08-05 | Acadia Pharmaceuticals Inc | Use of n-desmethylclozapine to treat human neuropsychiatric disease |
US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
US20060233843A1 (en) * | 2003-02-19 | 2006-10-19 | Conn P J | Treatment of psychosis with a muscarinic m1 receptor ectopic activator |
NZ547911A (en) * | 2003-12-22 | 2010-06-25 | Acadia Pharm Inc | Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders |
BRPI0509524A (pt) * | 2004-04-01 | 2007-09-18 | Acadia Pharm Inc | formas cristalinas de n-desmetilclozapina |
BRPI0613771B1 (pt) | 2005-07-22 | 2021-11-23 | Mochida Pharmaceutical Co., Ltd | Composto derivado de heterociclideno acetamida, composição farmacêutica e antagonista de receptor de tipo i vaniloide com potencial de receptor transitório (trpv1) |
RU2451014C2 (ru) * | 2005-07-22 | 2012-05-20 | Мотида Фармасьютикал Ко., Лтд. | Новое производное гетероциклиден ацетамида |
AU2006291134C1 (en) | 2005-09-12 | 2013-08-15 | Abela Pharmaceuticals, Inc. | Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same |
WO2007033180A1 (en) | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds |
US8480797B2 (en) | 2005-09-12 | 2013-07-09 | Abela Pharmaceuticals, Inc. | Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors |
WO2007033082A2 (en) * | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Compositions comprising dimethyl sulfoxide (dmso) |
US20070105836A1 (en) * | 2005-10-31 | 2007-05-10 | Lars Pettersson | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
BRPI0921494A2 (pt) | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
US9839609B2 (en) | 2009-10-30 | 2017-12-12 | Abela Pharmaceuticals, Inc. | Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis |
EP2763676B1 (en) | 2011-10-03 | 2019-12-25 | The University of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0386839A2 (en) * | 1989-03-08 | 1990-09-12 | Merck Sharp & Dohme Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA000875B1 (ru) * | 1995-09-29 | 2000-06-26 | ГЛАКСО ВЕЛЛКАМ С.п.А. | Тетрагидрохинолины в качестве антагонистов nmda (n-метил-d-аспарагиновой кислоты) |
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1996
- 1996-08-17 GB GBGB9617305.9A patent/GB9617305D0/en active Pending
-
1997
- 1997-08-14 AP APAP/P/1999/001459A patent/AP877A/en active
- 1997-08-14 CZ CZ0052999A patent/CZ296250B6/cs not_active IP Right Cessation
- 1997-08-14 AU AU45518/97A patent/AU724473B2/en not_active Ceased
- 1997-08-14 CA CA002264118A patent/CA2264118C/en not_active Expired - Fee Related
- 1997-08-14 NZ NZ333812A patent/NZ333812A/xx active Application Revival
- 1997-08-14 AR ARP970103703A patent/AR008296A1/es active IP Right Grant
- 1997-08-14 YU YU6799A patent/YU6799A/sh unknown
- 1997-08-14 DK DK97943809T patent/DK0922034T3/da active
- 1997-08-14 CO CO97046782A patent/CO4900066A1/es unknown
- 1997-08-14 ZA ZA977326A patent/ZA977326B/xx unknown
- 1997-08-14 EA EA199900121A patent/EA001704B1/ru not_active IP Right Cessation
- 1997-08-14 TR TR1999/00336T patent/TR199900336T2/xx unknown
- 1997-08-14 HU HU9903108A patent/HU225797B1/hu not_active IP Right Cessation
- 1997-08-14 BR BRPI9711311-5A patent/BR9711311B1/pt not_active IP Right Cessation
- 1997-08-14 PL PL97331562A patent/PL194532B1/pl not_active IP Right Cessation
- 1997-08-14 PE PE1997000718A patent/PE107098A1/es not_active Application Discontinuation
- 1997-08-14 ES ES97943809T patent/ES2181030T3/es not_active Expired - Lifetime
- 1997-08-14 CN CN97197233A patent/CN1131214C/zh not_active Expired - Fee Related
- 1997-08-14 MY MYPI97003742A patent/MY116952A/en unknown
- 1997-08-14 EP EP97943809A patent/EP0922034B1/en not_active Expired - Lifetime
- 1997-08-14 AT AT97943809T patent/ATE221052T1/de not_active IP Right Cessation
- 1997-08-14 ID IDP972834A patent/ID18095A/id unknown
- 1997-08-14 PT PT97943809T patent/PT922034E/pt unknown
- 1997-08-14 US US09/147,568 patent/US6479488B1/en not_active Expired - Fee Related
- 1997-08-14 IL IL12814197A patent/IL128141A0/xx not_active IP Right Cessation
- 1997-08-14 SI SI9730404T patent/SI0922034T1/xx unknown
- 1997-08-14 WO PCT/EP1997/004440 patent/WO1998007704A1/en active IP Right Grant
- 1997-08-14 DE DE69714265T patent/DE69714265T2/de not_active Expired - Lifetime
- 1997-08-14 JP JP51037298A patent/JP4108129B2/ja not_active Expired - Fee Related
- 1997-08-14 KR KR1019997001280A patent/KR100552864B1/ko not_active IP Right Cessation
- 1997-08-30 TW TW086112442A patent/TW449582B/zh not_active IP Right Cessation
-
1999
- 1999-01-22 IS IS4953A patent/IS4953A/is unknown
- 1999-02-16 NO NO19990723A patent/NO312241B1/no not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0386839A2 (en) * | 1989-03-08 | 1990-09-12 | Merck Sharp & Dohme Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
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